PP-31-029 Background/Aims: A significant portion of urban air pollution derives from motor vehicle exhaust on highways and busy streets. Recent studies have shown that the near-highway environment contains elevated concentrations of ultrafine particles (UFP; diameter <0.1 micrometer), which is a concern, because UFP is generally more toxic than larger particles. We are involved in a 5-year, observational, cross-sectional, community-based participatory research study (titled Community Assessment of Freeway Exposure and Health [CAFEH]) of exposure and cardiovascular health outcomes in neighborhoods immediately adjacent to major highways in the Boston, Massachusetts, area. Methods: We are conducting environmental monitoring of particle number concentration and other air pollutants in Somerville (just north of Boston) near Interstate-93 (>1.5 × 105 vehicles/d), using a mobile monitoring platform and 2 fixed sites. The residents aged ≥40 living <100, 100–400, and 1000 m have been selected for participation. Participants complete a survey of demographics, time-activity, cardiovascular diagnoses, and potential confounders. A subset of these participants agreed to have blood pressure measurements taken and to donate blood samples for C-reactive protein (CRP), lipids, and fibrinogen analysis. Results: Data collection is ongoing, and we have preliminary results for the first set of participants. The cohort is predominately female and white, with a mean age of 58 years. Prevalence of hypertension and pre-hypertension based on measurement is 36% and 78%, respectively. The mean levels of CRP and fibrinogen are 1.9 and 455 mg/dL, respectively. Mean systolic and diastolic blood pressure in the left arm is 135 and 77 mm Hg, respectively. There are weak correlations between systolic blood pressure and both hypertension and cardiovascular diagnosis. In addition, there is a weak association between distance-to-highway and CRP. Conclusion: There are associations of interest in this near-highway cohort; however, definitive conclusions cannot be drawn at this time. Continued recruitment will allow us to more accurately evaluate associations between exposure and outcomes of interest.
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