Otolaryngology Research Articles

Effect of Adenotonsillectomy on Symptomatology and Growth of Children with Obstructive Adenotonsillar Enlargement

Background: Obstructive adenotonsillar enlargement, a common childhood disorder in Ear, Nose and Throat (ENT) practice, is associated with obstructive sleep apnea syndrome (OSAS) and growth failure. Objective: To assess the effect of adenotonsillectomy on symptomatology and somatic and biochemical markers of growth in children with obstructive adenotonsillar enlargement. Setting and design: A prospective interventional and controlled study was conducted among children 2-8 years old with the diagnosis of adenotonsillar enlargement who attended the ENT Clinic of a Teaching Hospital in Nigeria. Methods: The study group consisted of 43 children who underwent adenotonsillectomy, while the control group consisted of 43 age and sex-matched children without features of obstructive adenotonsillar enlargement. The symptomatology score, weight, height, serum growth hormone (GH), and insulin-like growth factor-1 (IGF-1) were measured pre-surgery and six months post-surgery among the study and the control groups. Results: There was a statistically significant difference in symptomatology scores among the study group six months post-surgery (p <0.001). The weight, height, and serum levels of GH and IGF-1 significantly increased in the study group six months after the surgery. Conclusion: Adenotonsillectomy positively affects the symptomatology, somatic growth and biochemical markers of growth in children with obstructive adenotonsillar enlargement.

Management of Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) Intratympanic Platelet-Rich Plasma (PRP) Versus Intratympanic Steroid Injections: A Cross-Sectional Study

<b><br>Introduction:</b> Idiopathic sensorineural hearing loss of 30 decibels (dB) or more over at least three contiguous audiometric frequencies with an onset of less than 3 days is referred to as sudden sensorineural hearing loss (ISSNHL) and is known as an ENT (ear, nose, and throat) emergency. When a patient’s hearing suddenly deteriorates, they become confused, anxious, and worried. One of the primary therapies for sudden sensorineural hearing loss is intratympanic steroids. Intratympanic injections of platelet-rich plasma (PRP) improve inner ear hair cells, which enhances hearing.</br> <b><br>Aim:</b> To show the safety and efficacy of intratympanic PRP injection in the management of ISSNHL in comparison with intratympanic steroid injection.</br> <b><br>Methods:</b> The study group was comprised of 100 patients who had experienced ISSNHL within 30 days with no retrocochlear pathology, as demonstrated by a negative MRI scan. 50 patients received 6 intratympanic steroid injections, while the remaining 50 patients received 2 intratympanic injections of PRP at a 1-week interval.</br> <b><br>Results:</b> A total of 39 patients with PRP injection noted an improvement in their hearing of 25 db after 2 weeks and of 30 db after 2 months, with improved speech discrimination of 26% after 2 weeks and of 28% after 2 months. 31 patients with intratympanic steroid injection noted an improvement in their hearing of 18 db after 2 weeks and of 22 db after 2 months, with improved speech discrimination of 21% after 2 weeks and of 24% after 2 months.</br> <b><br>Conclusions:</b> PRP appears safe and efficient for the treatment of ISSNHL, with a low cost and no systemic side effects, as with oral steroids. Therefore, such research should be continued.</br>

Does a junior doctor focused ‘Bootcamp’ improve the confidence and preparedness of newly appointed ENT registrars to perform their job roles?

BackgroundTo assess changes in confidence and preparedness after conducting a 2-day induction bootcamp for novice Ear Nose and Throat (ENT) first year specialty trainee registrars (ST3s) in the United Kingdom (UK). The bootcamp covered common ENT presentations on the ward, and in the elective and emergency settings.MethodsA total of 32 trainees (ST3 or research fellow) voluntarily registered via an online application form to the Southern ST3 accelerated learning course bootcamp through ENT UK. ENT UK is a membership body that supports ENT trainees throughout their careers. They completed a two-day bootcamp that was hosted at St Mary’s Hospital, London and 10 skills sessions were delivered by either a senior ENT registrar or an ENT consultant. A pre-session questionnaire was distributed to all participants and a post-session questionnaire was provided that assessed the changes in confidence and preparedness of the participants, if any. The responses were scored by a 10-point Likert scale. Only participants who fully completed the pre and post questionnaire were included, which was 29 in total.ResultsParticipants self-reported a significant increase in confidence (p < 0.001) and preparedness (p < 0.001) following the bootcamp course. The greatest improvements in comparison to all other stations were self-preparedness in the rigid bronchoscopy station and self-confidence in the sphenopalatine artery (SPA) ligation station.ConclusionThe use of a two-day bootcamp improved confidence and preparedness of managing common ENT presentations in the ward, elective and emergency settings for ENT ST3s. It provides a useful adjunct in the acquisition of technical and non-technical skills alongside the traditional surgical apprenticeship. In the future, more work is required to assess the impact of bootcamps on patient outcomes and long-term benefits on trainees’ skill retention and clinical proficiency.

Development and validation of a smartphone-based deep-learning-enabled system to detect middle-ear conditions in otoscopic images

Middle-ear conditions are common causes of primary care visits, hearing impairment, and inappropriate antibiotic use. Deep learning (DL) may assist clinicians in interpreting otoscopic images. This study included patients over 5 years old from an ambulatory ENT practice in Strasbourg, France, between 2013 and 2020. Digital otoscopic images were obtained using a smartphone-attached otoscope (Smart Scope, Karl Storz, Germany) and labeled by a senior ENT specialist across 11 diagnostic classes (reference standard). An Inception-v2 DL model was trained using 41,664 otoscopic images, and its diagnostic accuracy was evaluated by calculating class-specific estimates of sensitivity and specificity. The model was then incorporated into a smartphone app called i-Nside. The DL model was evaluated on a validation set of 3,962 images and a held-out test set comprising 326 images. On the validation set, all class-specific estimates of sensitivity and specificity exceeded 98%. On the test set, the DL model achieved a sensitivity of 99.0% (95% confidence interval: 94.5–100) and a specificity of 95.2% (91.5–97.6) for the binary classification of normal vs. abnormal images; wax plugs were detected with a sensitivity of 100% (94.6–100) and specificity of 97.7% (95.0–99.1); other class-specific estimates of sensitivity and specificity ranged from 33.3% to 92.3% and 96.0% to 100%, respectively. We present an end-to-end DL-enabled system able to achieve expert-level diagnostic accuracy for identifying normal tympanic aspects and wax plugs within digital otoscopic images. However, the system’s performance varied for other middle-ear conditions. Further prospective validation is necessary before wider clinical deployment.

Evaluation of the Effectiveness of Otorhinolaryngology Examination and Hearing Evaluation Training for Family Physicians

Objective: In our study, we aimed to investigate the level of knowledge of family physicians working in primary health care organizations about ENT diseases, to examine how they manage frequently admitted ENT patients, to identify the problems they experience during examination and to examine the effect of the training given. Method: Participants were first administered a 30-question pre-test created by the researcher based on the literature. Then, a collective training lasting 2 days and 1.5 hours per day was given by an ENT specialist from the researchers and a post-test was applied. Afterwards, the topics in which the researchers made the most mistakes or remained uninterpreted were recorded and a training program including these topics was created and training was given. Results: Of the 21 family physicians over 30 years of age, 2 (14.29%) were male and 18 (85.71%) were female. When the time of graduation from medical school of the family physicians in the study was analyzed, the number of family physicians with 5-10 years of medical school graduation was 4 (19.05%), 10 (47.62%) with 10-20 years of medical school graduation, and 7 (33.33%) with more than 20 years of medical school graduation. All of the family physicians who participated in the study think that ENT education is important for primary care medicine. Conclusion: ENT diseases are common in primary care. In order for family physicians to manage their patients more comfortably, we believe that rotations in the field of ENT diseases in the postgraduate period would be appropriate.

Towards Interdisciplinary Collaboration: Surveying Dentists' and Orthodontists' Perspectives on Orofacial Myofunctional Disorders and Therapy.

Children with malocclusion, combined with orofacial myofunctional disorders (OMDs), show increased risk of developing orthodontic problems and needs later in life. Speech-language therapists typically provide orofacial myofunctional therapy (OMT) after referral by dentists, orthodontists or ENT specialists. Interdisciplinary treatment is often advisable to prevent relapse after orthodontic treatment. OMDs and OMT are often found to be controversial topics by dentistry professionals. This study aimed to investigate self-reported knowledge and attitudes of Flemish dentists and orthodontists towards OMDs and OMT. A survey containing 32 items on demographics, self-reported knowledge of OMDs and OMT, attitudes towards OMDs, OMT, and its use in clinical practice, and referral behaviour was filled out by 48 general dentists (48/79, 61%) and 31 orthodontists (31/79, 39%). The impact of specialization, degree of experience and educational programme was also evaluated. Fifty-six percent of all participants (44/79) reported insufficient to non-existent knowledge of OMT. Nevertheless, the general attitude towards the use of OMT was neutral (47%, 37/79) to (very) positive (48%, 38/79). Although they found correct, evidence-based knowledge on OMDs and OMT important, the majority indicated their formal training did not provide adequate information on OMDs (52%, 41/79) and OMT (62%, 49/79). Specialization showed significant effects, as orthodontists reported themselves knowledgeable on this topic significantly more often than general dentists (p &lt; 0.001), and generally reported a more positive stance towards OMT (p = 0.022). Dentists and orthodontists indicated a general interest in the topic of OMDs and OMT, alongside an overall lack of information provided by formal education. Current findings suggest the necessity of re-evaluating current curricula on OMDs and OMT.

Pattern of Diseases Presenting in ENT Outpatient Department in a Postgraduate Teaching Hospital in S.I.T.E. Area Karachi

Ear, Nose and Throat (ENT) diseases are one of the public health problems and affect a huge number of the patient around the globe. Objective: To determine the pattern of ENT disorders or diseases in those patients who were attended outpatient department of ORL in a postgraduate teaching hospital of Karachi. Methods: Patients presenting at ENT OPD were selected randomly for the study. Data about ENT problems and information were collected through well structured questionnaire. After data collection, it was entered and analyzes by using software SPSS-23. Variables were age, sex, residence, socioeconomic status and different ENT diseases including wax, otitis media, allergic rhinitis, pharyngitis, tonsillitis, Deviated Nasal Septum (DNS) etc. Results: Male patients were 585 (46.8%) while female patients were 665 (53.2%) out of 1250 patients. Most of the patients were from industrial areas 775 (62%) and 475 (38%) were from city areas. 355 (28%) were suffering from wax followed by acute otitis media 300 (24%), acute tonsillitis and deviated nasal septum each in 225 (18%), otitis externa 150 (12%) and acute pharyngitis 145 (11%). In our study, a huge number of 72% of cases had ear disorders. 43.2% of patients had nasal issues, while 45.2% were related to laryngopharyngeal issues. Conclusions: Majority of the patients attending outpatient ENT department were related to ear wax followed by acute otitis media, acute tonsillitis, DNS, otitis externa, acute pharyngitis and many patients have multiple diseases.

A Novel Approach to Treat Dental Implant-related Maxillary Sinusitis via Intentional Oroantral Fistula: Case Series

The recent increase in dental implant placement and advances in maxillary sinus bone grafting have improved the oral environment and greatly benefited patients, but there has also been an increase in dental implant-related maxillary sinusitis. Implant-related maxillary sinusitis is a form of odontogenic maxillary sinusitis, which usually presents as a chronic form of maxillary sinusitis. While acute (4 weeks or less) maxillary sinusitis is treated with removal of the associated implant, decontamination of the contaminated bone graft materials, and antibiotics. However, implant-related maxillary sinusitis is most often diagnosed as a chronic maxillary sinusitis condition that has been present for more than 12 weeks and should be treated similarly to chronic maxillary sinusitis. Treatment for chronic implant-related maxillary sinusitis is accompanied by endoscopic sinus surgery (ESS) to open the obstructed maxillary ostium. ESS is usually performed by referral to an ENT specialist and can be a burdensome treatment for patients due to the discomfort of surgery and the risk of orbital and cranial complications.In this case series, we aim to help dentists treating chronic implant-related maxillary sinusitis by reporting the complete cure of implant-related maxillary sinusitis without performing ESS by creating an intentional oroantral fistula after removing the causative implant. We also report important pathologies that should be differentiated from typical implant-related maxillary sinusitis.

Barbed Pharyngoplasty simulation using a 3D-printed model: design and validation study.

Learning how to use barbed sutures and perform Barbed Pharyngoplasty (BP) is challenging due to limited surgical training opportunities. This work aims to design, develop, and validate a new 3D surgical simulator to train ENT residents and specialists in performing BP. The Barbed Pharyngoplasty Simulator (BPS) was designed using diagnostic images of the facial mass and testing different materials to replicate the mucosal and bony tissues. ENT specialists with experience in BP and ENT residents were included in the validation study and were asked to perform the Alianza BP. After the simulation, they compiled the Face and Content Validity Questionnaires. The BPS consists of a reusable cranial structure that contains the disposable palatopharyngeal structure, replicating the palatal structures and the tongue. Fifteen experienced ENT specialists and nine residents were included in the study. Findings demonstrated that the BPS faithfully replicated the muscular and fibrous-bony palatopharyngeal structures, with only 11% of residents having a negative opinion of the mucosal tissue. All the participants positively rated the sensation of using surgical instruments on the simulator. Also, ENT residents rated all aspects of the content validity test from normal to excellent, while specialists rated the BPS as a general training tool from normal to excellent; for lateral pharyngoplasty, BP, and Alianza, only 6.7% of participants disagreed with its usefulness, and 13.3% disagreed with it for anterior pharyngoplasty. The BPS proposed in this preliminary study can potentially be a valuable tool in BP surgical training for residents and young otolaryngologists.

Proximie in the operating theatre: evaluation of a virtual operating platform for medical student education.

Medical students often hesitate to enter the operating theatre because of poor visibility of the surgical field and anxiety about the theatre environment. In addition, ear, nose and throat (ENT) surgery is underrepresented in many medical curricula. Virtual systems like Proximie offer flexible viewing of surgeries with surgeon commentary, potentially addressing these issues. This descriptive survey study aimed to evaluate the use of Proximie as a surgical education tool for delivering ENT teaching to medical students. Live ENT procedures were recorded at the ENT Department of the John Radcliffe Hospital and shared with interested clinical medical students through Proximie accounts. Students were added to a private group chat to ask questions and provided feedback through structured forms, assessing procedural effectiveness and the platform's technology. Live-streaming and recording of procedures were facilitated by ENT surgeons providing commentary. Conducted over four virtual theatre days, the study gathered 52 responses: 96% of students rated Proximie's educational value as 4 of 5 or higher; 57% preferred the virtual experience over physical attendance because of its convenience and the improved view of the surgical field. Students valued the live commentary and showed interest in using Proximie for a broader range of surgeries. Suggested improvements included fixing technical issues, better communication of theatre lists, and expanding surgical specialty coverage. Proximie has been highly rated by medical students for its effective and engaging approach in the instruction of surgical skills, underscoring its value as an educational tool. Future research is needed to formally assess knowledge acquisition and retention across multiple surgical subspecialties. This work is the first step towards evaluating the utility of virtual operating theatre platforms for medical student education.

#1271 Risk of primary infections in patients with IgA nephropathy: a Swedish population-based cohort study

Abstract Background and Aims IgA nephropathy (IgAN) is the most common global kidney disease with a highly variable clinical presentation. Diagnosis IgAN requires a biopsy, and the immunohistologic examination is dominated by depositions of aberrant IgA1 antibodies. Since IgA antibodies are mainly produced by the mucosal associated lymphoid tissue the relationship between the mucosal immune system and IgAN has long been considered. The current theories on the origin of the disease involve genetic and environmental factors, with mucosal infections potentially playing a role. In some IgAN patients gastrointestinal and/or upper respiratory infections can aggravate the disease with episodic macrohematuria and/or increased proteinuria. Coincidently, these infections are also more common among patients with selective IgA deficiency. The aim of this study was to investigate whether the presence of IgAN confers an increased risk of infections in general to the IgAN patient. Method IgAN was defined by a computerized biopsy record from 1997 to 2011 in Sweden. Each IgAN patient was matched with up to five reference individuals based on age, sex, calendar year, and county of residence. Exclusions included those with organ transplants, HIV, immunodeficiency, or end-stage kidney disease before study entry, and follow-up data were censored for subsequent occurrences. Linear and Cox regressions, adjusted for age, sex, and education, were performed to analyze total infections and antimicrobial treatments in both patient and reference groups. Sibling analyses were also performed, adjusted for baseline age, sex and educational attainment. Results The linear regression analysis revealed a significant association between IgA nephropathy (IgAN) and the overall frequency of infections compared to the general population (β = 0.45; 95% CI: 0.37–0.54), women (β = 0.35; 95% CI: 0.19–0.50), men (β = 0.50; 95% CI: 0.40–0.60), and siblings (β = 0.37; 95% CI: 0.25–0.49) for women (β = 0.24; 95% CI: 0.06–0.41) and men (β = 0.43; 95% CI: 0.27–0.60). Similarly, a significant association was found for the frequency of prescribed antimicrobial agents compared to the general population (β = 0.66; 95% CI: 0.51–0.82), women (β = 0.92; 95% CI: 0.56–1.27), men (β = 0.55; 95% CI: 0.39–0.71), with similar estimates in the sibling analyses. The subtypes with the strongest association were urinary tract infections (β = 0.09; 95% CI: 0.07–0.11), ENT (ear, nose, and throat) infections (β = 0.08; 95% CI: 0.04–0.12), muscular infections (β = 0.08; 95% CI: 0.05–0.12), and infections in the GI (gastrointestinal) tract (β = 0.06; 95% CI: 0.04–0.09). Infections in the lower respiratory tract, skin and mycoses also had a significant positive association, however, no associations to infections in the central nervous system or infections caused by helminths and protozoans were identified. Cox regression showed an elevated risk of any infection with an adjusted hazard ratio (HR) of 2.05 (95% CI: 1.88–2.23), especially for sepsis (aHR = 3.13; 95% CI: 2.14–4.59), and time to the first prescription of antimicrobials with an aHR of 1.37 (95% CI: 1.30–1.45). Linear regression of prescribed antimicrobial treatments showed an overall β = 0.67; 95% CI: 0.51–0.82, and specifically for antibiotics (β = 0.64; 95% CI: 0.49–0.78). Conclusion Our study demonstrates an increased prevalence of infections and antibiotic prescriptions in IgAN patients compared to the general population and their siblings. Further studies on the potential impact of IgAN and its immunological aberrations on overall infection susceptibility is warranted.

Perception of Young European Otolaryngologists toward Transoral Robotic Surgery in Head and Neck Oncology and Surgery.

Background: To investigate the perception of young European otolaryngologists (OTOs), i.e., head and neck surgeons, toward transoral robotic surgery (TORS). Methods: Members of the Young Confederation of European Otorhinolaryngology-Head and Neck Surgery and Young Otolaryngologists of International Federation of Otorhinolaryngological Societies were surveyed about TORS perception and practice. Results: The survey was completed by 120 young OTOS (26%). The most important barriers to TORS were robot availability (73%), cost (69%), and lack of training (37%). The participants believed that the main benefits include better surgical filed view (64%), shorter hospital stay (62%), and better postoperative outcomes (61%) than the conventional approach. Head and neck surgeons considered cT1-T2 oropharyngeal cancers (94%), resection of base of tongue for sleep apnea (86%), or primary unknown cancer (76%) as the most appropriate indications. A total of 67% of TORS surgeons assessed themselves as adequately trained in TORS. Conclusions: Young European OTOs report positive perception, adoption, and knowledge of TORS. The cost-related unavailability and the lack of training or access are reported to be the most important barriers for the spread of TORS.

Iatrogenic Full-length Rupture of Posterior Trachea: A Multidsciplinary Management

Iatrogenic trachealis muscle rupture (ITR) following elective intubation is a potentially fatal complication with a low incidence of 0.05-0.37%. Tears involving the whole length has not been reported. We report a case of a 26-year-old lady with seropositive rheumatoid arthritis who underwent total thyroidectomy for Hashimoto Thyroiditis. Intraoperatively, a complete linear trachealis muscle rupture from the carina to the first tracheal ring was diagnosed by the Otorhinolaryngology (ORL) team by tracheoscopy through the endotracheal tube (ETT). Unlike the common presentation of subcutaneous emphysema or pneumomediastinum, the surgeon noticed the ETT cuff in the left operative field. Initial repair of the lateral defect was performed immediately by opposing the sternocleidomastoid muscle to the adjacent infrahyoid muscles. However, serial computed tomography and flexible tracheoscopy showed complete tear of the trachealis muscle with presence of pneumomediastinum and dynamic changes of the injury. We illustrate a concerted effort of multidisciplinary teams of ORL, Cardiothoracic Surgery, Intensivist, Anaesthetist, Radiologist and Speech Therapist in the steps of management which involved series of tracheoscopy and imaging prior to extubation. In view of extensive trachealis muscle tear with hemodynamically stable patient, conservative management was opted for this patient as it outweighs the benefit of the surgery. We include the outpatient management until the patient’s trachea fully healed 6 months after the injury. The management is compared to the management review in the literature. This case has taught multiple new important lessons in the management of challenging tracheal rupture in a patient.International Journal of Human and Health Sciences Supplementary Issue 01: 2024 Page: S54

Epidemiological Profile of Hearing Deficiency in a Tertiary Care Hospital (2019-2022)

Abstract Introduction This study is an attempt to view the demographic profile of individuals presenting with hearing loss in an urban referral hospital with the help of available database of pure tone audiometry results over a three years period. Materials and methods It is adescriptive epidemiologicalstudy over a period of 3 years conducted in the Department of Otorhinolaryngology (ORL) of an urban referral hospital.The subjects presented with a complain of hearing loss were investigated with pure tone audiometry. Subjects below 10 years of age or with gross mental or physical disabilities were excluded. The results of pure tone audiometry done were analyzed followed by systematic analysis. Results A total number of 3536individuals inclusive of1980 males and1556 females were studied. Nearly, 570 individuals suffered B/L hearing loss (16%) which was again mostly Sensori-neural. Sensori-neural hearing loss was the most common hearing loss near about 52%.Mixed Hearing loss accounted for 13%.Conductive hearing loss accounted for 35 %. Mild hearing loss (25-40dB) accounted for maximum bulk of the patients.The bulk of the population comprised of people in their middle age (30-60) and elderly (&gt;60 years). Conclusion The demographic profile of hearing loss in an urban population is the ground work for any comprehensive planning to resolve the issue. In our study the increased burden of mild to moderate sensorineural hearing loss as seen in the elderly population and increased prevalence of conductive hearing loss as seen in the young population shows us how respective management protocols can be instituted for the target populations.

How Variable are Patient Comorbidity Profiles Among Practicing Otolaryngologists?

To determine whether certain groups of otolaryngologists (ORLs) are treating cohorts of patients with more comorbidities. Cross-sectional population-based analysis. 2019 Medicare Provider Utilization and Payment Dataset. Each ORL's average Medicare hierarchical condition category (HCC) risk score, a comorbidity index calculated from a patient's comorbidities, was collected. These were stratified and compared by various physician characteristics, including practice region and rurality, years in practice, gender, subspecialty, and setting (academic vscommunity). Among 8959 ORLs, the mean HCC risk score for Medicare patients was 1.35 ± 0.35. On univariate analysis, ORLs practicing in urban (compared to rural), ORLs in academic settings (compared to community), and early career ORLs all had a patient population with a higher HCC risk score (P < .001 for all). On multivariate analysis controlling for gender, rurality, graduation year, and region, rural setting was associated with decreased odds of having a high-risk patient population (odds ratio: 0.58 [95% confidence interval,CI: 0.48-0.71]; P < .001), while those more recently graduated has an increased risk (2000-2009: 1.41 [1.01-1.96], P = .046; 2010-2015: 2.30 [1.63-3.25], P < .001). In a separate subgroup analysis, subspecialty differences were seen and community setting was associated with decreased odds of having a high-risk patient population (0.36 [0.23-0.55]; P < .001). There is variability in patient comorbidity profiles among ORLs, with those in urban settings, those more recently graduated, and those in academic settings treating a group with more comorbidities. As the comorbidity burden may increase the cost of practice and complications, these findings may have important implications for health inequity.

Care pathways in childhood neurodevelopmental disorders: Toward greater awareness of KBG syndrome among pediatricians

IntroductionKBG syndrome is an autosomal dominant, polymalformative genetic syndrome that is mainly associated with neurodevelopmental and learning disorders, intellectual disability, behavioral disorders, and epilepsy as well as characteristic dysmorphic features, short stature, and ENT (ear, nose, and throat) abnormalities. However, the diagnostic pathway of these individuals is an element that has not been broadly evaluated. The main aim of this study was therefore to characterize the diagnostic pathway for these individuals, by assessing the different healthcare professionals involved and the main referral elements. MethodThis was a multicenter, retrospective, descriptive study. A cohort of 30 individuals with KBG syndrome who were followed up at Poitiers University Hospital and Bordeaux University Hospital we recruited. ResultsPediatricians were the main healthcare professionals who referred individuals for genetic consultation, and the main reason for referral was an assessment of learning delays or intellectual disability, in association with other abnormalities. ConclusionPediatricians play a crucial role in the diagnostic guidance of individuals with KBG syndrome, and the main reason for referral remains the assessment of a learning delay or intellectual disability. Healthcare professionals must therefore remain attentive to the child's development and the various anomalies associated with it, in particular characteristic dysmorphic features, behavioral disorders, and statural growth.

Challenges and directions for digital twin implementation in otorhinolaryngology.

Digital twin technology heralds a transformative era in Otorhinolaryngology (ORL), merging the physical and digital worlds to offer dynamic, virtual models of physical entities or processes. These models, capable of simulating, predicting, and optimizing real-world counterparts, are evolving from static replicas to intelligent, adaptive systems. Fueled by advancements in communication, sensor technology, big data analytics, Internet of Things (IoT), and simulation technologies, artificial intelligence (AI), digital twins in ORL promise personalized treatment planning, virtual experimentation, and therapeutic intervention optimization. Despite their potential, the integration of digital twins in ORL faces challenges including data privacy and security, data integration and interoperability, computational demands, model validation and accuracy, ethical and regulatory considerations, patient engagement, and cost and accessibility issues. Overcoming these challenges requires robust data protection measures, seamless data integration, substantial computational resources, rigorous validation studies, ethical transparency, patient education, and making the technology accessible and affordable. Looking ahead, the future of digital twins in ORL is bright, with advancements in AI and machine learning, omics data integration, real-time monitoring, virtual clinical trials, patient empowerment, seamless healthcare integration, longitudinal data analysis, and collaborative research. These developments promise to refine diagnostic and treatment strategies, enhance patient care, and facilitate more efficient and tailored ORL research, ultimately leading to more effective and personalized ORL management.

Audiology-led model provides efficient and effective access to grommet surgery

ABSTRACT Children with otitis media who are referred to paediatric otorhinolaryngology (ORL) departments often experience significant delays in treatment. Alternate models of care utilising audiologists with extended scopes of practice can potentially improve outcomes in services experiencing difficulties with high demand and insufficient ORL capacity. An Advanced Audiology Practitioner (AAP) service was implemented in Counties Manukau to combat known long wait times for children with otitis media. This study aimed to retrospectively evaluate the clinical and service outcomes of the 165 children referred to the AAP service during the initial 3 month period of operation. Engagement with the AAP service was high, with a 96% attendance rate at the first appointment. The proportion of children waiting longer than recommended (>120 days) for paediatric ORL appointments was reduced by 33%, and the average wait time for children seen in the AAP service was reduced from 196 to 14 days. The AAP model provided an efficient and effective clinical service, with 55% of children seen in a single visit and 91% of waitlisted children having middle ear effusion on myringotomy. In conclusion, the AAP model improves access to ORL treatment, particularly for children at risk for otitis media and associated hearing loss.

Multi-Disciplinary Expert Perspective on the Management of Type 2 Inflammation-Driven Severe CRSwNP: A Brief Overview of Pathophysiology and Recent Clinical Insights.

Severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disabling airway disease that significantly impacts patients' lives through the severity of symptoms, the need for long-term medical treatment and the high risk of recurrence post-surgery. Biological agents targeting type 2 immune responses underlying the pathogenesis of CRSwNP have shown effectiveness in reducing polyp size and eosinophilic infiltrate, and in decreasing the need for additional sinus surgeries. However, despite recent progress in understanding and treating the disease, type 2 inflammation-driven severe CRSwNP continues to pose challenges to clinical management due to several factors such as persistent inflammation, polyp recurrence, heterogeneity of disease, and comorbidities. This article presents the findings of a scientific discussion involving a panel of ear, nose and throat (ENT) specialists and pulmonologists across Sweden and Finland. The discussion aimed to explore current management practices for type 2 inflammation-driven severe CRSwNP in the Nordic region. The main topics examined encompassed screening and referral, measurements of disease control, treatment goals, and future perspectives. The experts emphasized the importance of a collaborative approach in the management of this challenging patient population. The discussion also revealed a need to broaden treatment options for patients with type 2 inflammation-driven CRSwNP and comorbid conditions with shared type 2 pathophysiology. In light of the supporting evidence, a shift in the disease model from the presence of polyps to that of type 2 inflammation may be warranted. Overall, this discussion provides valuable insights for the scientific community and can potentially guide the future management of CRSwNP.

Burnout in ENT France: Update and risk factors; a STROBE analysis

BackgroundBurnout can significantly impact practitioners and their co-workers, and hence patients. There are no data for the prevalence of burnout in French ENT specialists, or for associated risk factors. Material and methodsA French national cross-sectional online survey was performed on the initiative of the ENT National Professional Council (CNPORL), contacting all ENT specialists whose e-mail address was known to the French Society of ENT, the National Professional Council or the National ENT Union. The 22-question Maslach Burnout Inventory (MBI) was sent out, along with 16 extra questions on possible risk factors. ObjectivesThe study sought to assess the prevalence and severity of burnout, using the MBI, and to analyze risk factors. ResultsAmong the 1936 physicians, 406 contacted responded to the questionnaire (21%). Mean age was 47±14 years (range, 25–77 years); 53% male, 47% female. 196 (48%) reported burnout, including 20 (5%) severe burnout. Independent risk factors for burnout of whatever severity, comprised social interaction issues, history of identified burnout, and medicolegal pressures. Social interaction issues were independently associated with specifically severe burnout. ConclusionsBurnout affected almost half of respondents. There are identifiable risk factors, for which improvements could be implemented.