Orthodontically Induced Inflammatory Root Resorption Research Articles

Apical root resorption during orthodontic treatment

To investigate the incidence and severity of root resorption during orthodontic treatment by means of cone beam computed tomography (CBCT) and to explore factors affecting orthodontically induced inflammatory root resorption (OIIRR). CBCT examinations were performed on 152 patients with Class I malocclusion. All roots from incisors to first molars were assessed on two or three occasions. At treatment end, 94% of patients had ≥1 root with shortening >1 mm, and 6.6% had ≥1 tooth where it exceeded 4 mm. Among teeth, 56.3% of upper lateral incisors had root shortening >1 mm. Of upper incisors and the palatal root of upper premolars, 2.6% showed root shortenings >4 mm. Slanted surface resorptions of buccal and palatal surfaces were found in 15.1% of upper central and 11.5% of lateral incisors. Monthly root shortening was greater after 6-month control than before. Upper jaw teeth and anterior teeth were significantly associated with the degree of root shortening. Gender, root length at baseline, and treatment duration were not. Practically all patients and up to 91% of all teeth showed some degree of root shortening, but few patients and teeth had root shortenings >4 mm. Slanted root resorption was found on root surfaces that could be evaluated only by a tomographic technique. A CBCT technique can provide more valid and accurate information about root resorption.

Orthodontics and root resorption part 2

The aim of this second article in this series of two is to outline the treatment-related factors, which are understood to play an important role in orthodontically-induced inflammatory root resorption (OIIRR). This article will highlight the importance of patient assessment, as well as the long-term effects of OIIRR. It will also discuss future developments, which may improve our understanding of the mechanisms of tooth movement and root resorption. Clinical Relevance: The orthodontic practitioner should be aware of the iatrogenic effects of treatment mechanics and the need for detailed patient assessment prior to the start of treatment to reduce harmful consequences.

Orthodontics and root resorption part 1

The first article in this series of two aims to outline the biological processes which form the basis of orthodontically-induced inflammatory root resorption (OIIRR). It will also provide an overview of patient-related factors associated with OIIRR.

Root Resorption Following Treatment with Aligners

Can orthodontically induced inflammatory root resorption (OIIRR) be the result of Invisalign treatment? Since OIIRR was first described in the literature, orthodontists have been looking for a treatment procedure where no root shortening will occur. In the past decade, Invisalign orthodontic treatment has become very popular, and there is no description of OIIRR after this treatment. Therefore, it might be incorrectly concluded that the body is immune to this type of orthodontic treatment modality and no OIIRR appears as a result of this treatment. The following case report demonstrates an aspect of the complexity of OIIRR.

Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption

The objective of this study was to determine the extent to which substance P (SP) increases proinflammatory cytokine production and osteoclast formation of human dental pulp fibroblasts (HDPF) in patients with severe orthodontically induced inflammatory root resorption (OIIRR). HDPF were obtained from 5 patients with severe apical root resorption after orthodontic treatment. The levels of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha were determined after 24 hours by using ELISA kits. Furthermore, culture supernatants were added to cultured human osteoclasts, and osteoclast formation was observed after tartrate-resistant acid phosphatase (TRAP) staining and the formation of resorption cavities. Stimulation with SP increased the levels of IL-1beta, IL-6, and TNF-alpha, in a time- and concentration-dependent manner, although the increase was greater in the severe root resorption (SRR) group than in the nonresorption (NR) group (P < 0.001, 3-way repeated measures ANOVA). As for osteoclast formation, the numbers of TRAP-positive multinucleate cells and resorptive pits were significantly increased in the SRR group compared with the NR group (P < 0.001, 2-way repeated measures ANOVA). These results suggest that HDPF stimulated with SP might be deeply involved in the progress of inflammation in pulp tissue and the incidence of SRR during orthodontic treatment.

Orthodontically induced inflammatory root resorption. Part II: The clinical aspects.

Over the past 10 years, orthodontically induced inflammatory root resorption (OIIRR) has been increasingly recognized as an iatrogenic consequence of orthodontic treatment. With this in mind, orthodontists should take all known measures to reduce the occurrence of OIIRR. The evidence that we present in this review suggests several procedures known today that can avert this phenomenon; however, none of them can be relied on to completely prevent OIIRR. We believe that future studies might clarify the exact cause and course of OIIRR and, hopefully, help eliminate it. In Part I, we discussed the basic sciences aspects of OIIRR; in Part II, we present the clinical aspects of this phenomenon.

3. Studies with cells derived from growing deer antler

Introduction: The objective of this study was to determine the extent to which substance P (SP) increases proinflammatory cytokine production and osteoclast formation of human dental pulp fibroblasts (HDPF) in patients with severe orthodontically induced inflammatory root resorption (OIIRR). Methods: HDPF were obtained from 5 patients with severe apical root resorption after orthodontic treatment. The levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α were determined after 24 hours by using ELISA kits. Furthermore, culture supernatants were added to cultured human osteoclasts, and osteoclast formation was observed after tartrate-resistant acid phosphatase (TRAP) staining and the formation of resorption cavities. Results: Stimulation with SP increased the levels of IL-1β, IL-6, and TNF-α, in a time- and concentration-dependent manner, although the increase was greater in the severe root resorption (SRR) group than in the nonresorption (NR) group (P <0.001, 3-way repeated measures ANOVA). As for osteoclast formation, the numbers of TRAP-positive multinucleate cells and resorptive pits were significantly increased in the SRR group compared with the NR group (P <0.001, 2-way repeated measures ANOVA). Conclusions: These results suggest that HDPF stimulated with SP might be deeply involved in the progress of inflammation in pulp tissue and the incidence of SRR during orthodontic treatment.