The paper considers the issues of production safety control in the context of reforming of the technical regulation system in Russia. In machine building, safety control of machine building products is a critical task, which is caused by the requirements of technical regulations (provisions of standards or conditions of contracts. The authors carried out the analysis of literature on the development of systems of the products and services safety management, systems of the food products safety management with the HACCP elements, systems of traffic safety management (in the sphere of rail transport traffic safety at the Joint Stock Company “Russian Railways”), as well as the systems of information security management. The paper considers the issues of machine building products safety control based on the development of systems of its safety management including the subsystems of organization quality management. The developed system allows, on one side, ensuring products and services safety, and on the other side, is the important evidential material when declaring the compliance of the products and services with the specified safety requirements. The authors analyzed the steps of development of the products safety management system, which are the following sequence of actions: scheduling, system designing, system implementation, system qualification process, determination and implementation of corrective actions according to the results of the system analysis by the top management. The authors present the developed model of the machine building products safety management system, as well as identify the main processes of the system of machine building products safety management: safety control at the stage of designing, safety control at the stage of pre-production, safety control at the stage of production.