Introduction There are many actual donors that after first steps of detection, primary care and management, receiving family consent and transfer to organ procurement unit, their organs are rejected. Here is our experience in this situation. Methods We reviewed the reason of final failure for organ retrieval after transferring the actual donor to our center retrospectively. Results During one year 188 actual donors transferred to our organ procurement unit after detection, management and family consent for donation. Thirty out of these no organ retrieval was done. The most common cause was rejection of organ after surgeon assessment in operation room (14 cases), other reasons were cardiac arrest before retrieval (9 cases), rejection of suitable organ after transfer to unit (5 cases), brain death rule out after transfer (1 case) and family consent cancellation after primary acceptance (1 case). The most common rejected organ was liver (17 cases). Conclusion Although in our center we try to confirm suitability of organs for donation by biochemistry laboratory test and abdominal sonography, still there is the risk of rejection of organs for donation after direct assessment of surgeon in the operation room. After that cardiac arrest before retrieval is the second most common reason. The question is what is the best way to assess suitable organ before transferring an actual donor and what are the ways to decrease mortality before retrieval?