The results of a comprehensive analysis of the limits on mixings between ordinary fermions and possible heavy fermions with exotic SU(2)\ifmmode\times\else\texttimes\fi{}U(1) assignments (e.g., left-handed singlets and/or right-handed doublets) are presented. A general formalism for describing such mixings is given. It is shown that a variety of constraints, including the relation between the W and Z masses and the Fermi constant, charged-current universality, limits on induced right-handed charged currents, and flavor-diagonal neutral currents suffice to limit all directions in parameter space that are not excluded by the absence of flavor-changing neutral currents. Limits on ${s}^{2}$, the square of the mixing between ordinary and exotic fermions, are quite stringent for the ${\ensuremath{\nu}}_{\ensuremath{\mu}L}$, ${\ensuremath{\mu}}_{L}^{\mathrm{\ensuremath{-}}}$, ${u}_{L}$, and ${d}_{L}$ (${s}^{2}$\ensuremath{\le}0.002--0.005) if only one particle is allowed to mix at a time, but are weaker by an order of magnitude if fine-tuned cancellations between different mixings are allowed. Similar statements apply to quark mixings with heavy sequential doublets. Limits on ${s}^{2}$ for the other light fermions (${\ensuremath{\nu}}_{\mathrm{eL}}$, ${\mathit{e}}_{\mathit{L}}^{\mathrm{\ensuremath{-}}}$,${\mathit{e}}_{\mathit{R}}^{\mathrm{\ensuremath{-}}}$,${\mathrm{\ensuremath{\mu}}}_{\mathit{R}}^{\mathrm{\ensuremath{-}}}$, ${\mathit{u}}_{\mathit{R}}$,${\mathit{d}}_{\mathit{R}}$) are in the range 0.02--0.06, while those for the s, c, b, ${\ensuremath{\nu}}_{\ensuremath{\tau}}$, and ${\ensuremath{\tau}}^{\mathrm{\ensuremath{-}}}$ are considerably weaker. Slightly stronger limits are found in specific models (e.g., ${\mathrm{E}}_{6}$). Implications for the masses of the heavy exotic fermions are discussed.
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