Aim: To see the efficacy of titanium mesh in orbital floor reconstruction to correct the post-traumatic enophthalmos in orbito-zygomatic complex fractures. Methods: This retrospective study was carried out in the department of Oral and Maxillofacial Surgery, University College of Medicine & Dentistry, University of Lahore, Pakistan from January 2017 to January 2020. All patients who had enophthalmos after orbito-zygomatic fractures and were treated for orbital floor reconstruction with titanium mesh were included in the study. Computer tomography (CT scan) was done to diagnose and measure the orbital floor defect. Pre-operative and post-operative hertalex ophthalmometry was done to measure and compare the enophthalmos. Results: Among the 30 patients, 23 were male and 7 were female. The mean age of the patients was 30±5.80 years. Fourteen patients had right and 16 patients had left side orbitozygomatic complex fracture. The mean orbital floor defect size was 1.72±0.78 cm preoperatively measured by CT scan. There was a correction of enophthalmos in 23 patients out of 30(76.66%). Conclusion: Titanium mesh is a commonly used and easily available material for the correction of orbital floor defects. It is efficacious in terms of the correction of post-traumatic enophthalmos resulting from orbito-zygomatic complex fracture. Keywords: Enophthalmos, titanium mesh, orbitozygomatic fractures