Proton exchange membrane water electrolyzers (PEMWEs) will share more than 40 % of green hydrogen production market by 2050. Currently, iridium catalyst in the anode catalyst layers amounts to 1 mg/cm2. To enable low-loading (0.4 mg/cm2) or ultra-low loading (<0.1 mg/cm2) designs we need to better understand both integration of catalysts into catalyst layer and their durability. At low loadings catalyst layer in-plane electric conductivity can be compromised, requiring either supported catalyst layers or the need for microporous layer (MPL) design. For durability study it is necessary to understand the pathway of surface of IrOx transformation during accelerated stress tests (ASTs) and identify optimal beginning of life (BOL) structure for long-duration deployment. In this work we evaluate the structure and performance of amorphous and crystalline IrOx catalysts at the BOL and EOL to build structure-to-property relations. Rheology studies are conducted to identify the optimal ink recipe for each of the catalysts for blade coating deposition method. We use operando x-ray diffraction technique to evaluate catalyst structure evolution during AST cycling. X-ray computed tomography (CT) was used to evaluate catalyst layer – MPL interfaces under various operando conditions. The morphological information was integrated into the two-dimensional model to better understand interfaces for the low-loading PEMWEs.