The option to switch patients to more cost-effective biosimilar insulins has been available since 2014, and the market share for these medicines has been slowly increasing since then. This scoping review aimed to identify the current knowledge around stakeholder perception and experience of biosimilar insulin switches. A systematic search strategy of the published literature was conducted using several bibliographic databases including PubMed, Web of Science and CINAHL Ultimate to identify relevant articles. A grey literature search and reference scouring were also employed. A thematic analysis of the literature was then conducted to identify and synthesize findings in a narrative format. The search identified a total of 184 records, with 20 deemed eligible for inclusion. These comprised research studies, reviews, guidance and opinion pieces with several themes identified, including healthcare professional, patient and health service administrator perspectives. Healthcare professional concerns about switching established patients, as well as patient perceptions and experiences, were highlighted as key barriers to biosimilar insulin adoption, although patients expressing strong opinions against switching were in the minority. The established nature and proven efficacy of the reference products served as a barrier to patient acceptance. Financial considerations, especially in the context of publicly funded healthcare systems, and factors expected to facilitate biosimilar insulin switches were also identified as key themes. There is considerable uncertainty about how stakeholders perceive biosimilar insulin switches, particularly managed switch programmes. Almost no literature related to the experience of stakeholders who have already engaged in biosimilar insulin switching was identified. More research is needed to provide guidance on how healthcare systems can implement biosimilar insulin switch programmes in a manner acceptable to healthcare professionals and patients.

Chinese medicines as therapeutic options for treating prostate cancer: Therapeutic effects and underlying mechanisms.

Best Practices for the Design and Evaluation of Bathing Spaces for Older Adults With Cognitive Impairment in Residential Care Settings: A Scoping Review.

Predatory journals have emerged as a growing challenge to academic integrity worldwide, driven by increasing publication pressures and ongoing changes in scholarly publishing. Although numerous lists, warning signs, and checklists have been proposed to identify such journals, the lack of consensus and standardized approaches has created confusion among researchers and institutions. This paper is presented as an opinion piece that reflects on existing debates and practical experiences related to predatory publishing. Drawing on the literature and the authors’ analytical perspectives, the paper discusses common misunderstandings surrounding predatory journals and highlights limitations of list-based evaluation approaches. It argues for a more cautious, context-sensitive, and process-oriented approach to assessing journals, emphasizing transparency, peer-review practices, editorial governance, and publisher credibility. By offering reflective insights rather than empirical findings, this article aims to stimulate critical discussion and support more informed decision-making in journal evaluation.

Background: Musculoskeletal (MSK) medicine has undergone a rapid transformation in recent years, with artificial intelligence (AI) emerging as a key driver of innovation. Existing literature has predominantly explored AI in diagnostic imaging, predictive analytics, and Natural Language Processing for clinical decision support. While several studies have touched upon AI’s potential in medical education, there remains limited evidence specifically evaluating its role in MSK teaching, the pedagogical outcomes, and integration into established curricula. This gap is critical given the changing dynamics of healthcare delivery, the need for scalable training solutions, and the increasing emphasis on personalised, technology-driven learning. The current work addresses this shortfall by synthesising recent evidence and examining how AI-based tools can enhance MSK education. Methods: A comprehensive literature search (2018–2025) was conducted across PubMed, Scopus, and Web of Science using predefined keywords relating to AI and MSK teaching. Eligible studies were peer-reviewed articles, case studies, and trials in English that met specific inclusion criteria. From the 342 screened articles, 43 were selected for detailed analysis. Data extraction focused on AI applications in MSK training, reported benefits, limitations, and integration strategies. Non-peer-reviewed and opinion-based sources were excluded. Inclusion criteria: Peer-reviewed articles, case studies, and trials published in English between January 2018 and 2025, focusing on AI applications in MSK education among healthcare professionals in training. Both qualitative and quantitative studies were included. Exclusion criteria: Non-peer-reviewed articles, editorials, opinion pieces without empirical evidence, studies on non-human/animal subjects, and studies unrelated to AI or MSK systems. Results: The literature reveals that AI has enhanced MSK training through immersive technologies such as 3D modelling, augmented reality (AR), and virtual reality (VR). These innovations reduce reliance on traditional cadaveric and apprenticeship-based models, offering cost-effective, scalable, and interactive learning. AI-driven platforms facilitate personalised case-based learning, improve diagnostic accuracy, and support tailored intervention planning. However, significant challenges remain—most notably, limited longitudinal data on educational outcomes, barriers to large-scale adoption (cost, infrastructure), data privacy concerns, and the absence of standardised frameworks for integrating AI into formal MSK curricula. Conclusion: While AI shows considerable promise in transforming MSK teaching, the field lacks robust, outcome-focused research to guide evidence-based adoption. Addressing these gaps through targeted studies, standardisation of teaching protocols, and blended integration with conventional training will be essential to realising AI’s full potential in enhancing both learner competence and patient care outcomes.

This article examines how two mainstream Indonesian newspapers—Kompas and Republika—construct competing discourses around the prospect of female royal leadership in the Yogyakarta Sultanate. Focusing on the 2015 succession controversy triggered by Sultan Hamengku Buwono X’s decision to open the throne to his eldest daughter, the study investigates how media narratives invoke Islamic law, royal tradition, and gendered authority. Using Norman Fairclough’s three-dimensional Critical Discourse Analysis, the article analyses news reports and opinion pieces published between March and May 2015 to uncover how linguistic choices, sources, and intertextual references are mobilised to legitimise or contest a woman’s claim to the throne. The findings show that Republika frames the issue through a conservative Sharia-based perspective, emphasising religious orthodoxy and patriarchal norms. On the other hand, Kompas adopts a more pluralist and constitutionalist framing that normalises female leadership as congruous with democratic and cultural change. The primary argument advanced in this article is that the core site of contention is not Islamic law per se, but the way Sharia is selectively interpreted and circulated through media discourse to support competing hegemonic projects concerning gender and authority. Theoretically, the study demonstrates that media discourse serves as a critical arena in which Sharia, gender authority, and cultural legitimacy are negotiated, thereby making an essential contribution to Islamic legal studies and critical media analysis.

Blinded by the lights? Re-examining the adaptive role of transposable elements in plants with population genomics.

Education is increasingly under attack in situations of armed conflict, with increasing incidence of schools bombed, repurposed for military use, education politicized, and children denied access to learning. This 1 opinion piece examines how the UN Committee on the Rights of the Child (CRC Committee) is responding to these violations by integrating international humanitarian law (IHL), international human rights law (IHRL), international criminal law (ICL) and global accountability mechanisms into its recommendations. Drawing on recent concluding observations to the Russian Federation and Israel, the article highlights the Committee's evolving role in protecting children's right to education in conflict zones. It argues that the Committee is not only interpreting the Convention on the Rights of the Child (CRC) as a living instrument but also asserting its relevance within a broader legal and political context. The analysis concludes that the Committee remains a vital actor in the global effort to strengthen accountability in responding to attacks on education.

ObjectiveThe purpose of this scoping review is to map the existing evidence that describes strategies to improve handover from the acute care to rehabilitation settings.IntroductionPoor handover processes have been associated with preventable errors, delays in care, and adverse patient outcomes. Effective physician-to-physician handover during transitions of care is critical to ensuring patient safety and optimizing clinical outcomes. Physician handover between acute and rehabilitation care settings is particularly complicated, as it requires transferring detailed and timely information for continuity of care for medically and/or surgically complex patients between components of healthcare systems with different cultures and goals of care. Despite numerous studies being published on handover, there has yet to be a synthesis of the existing literature that seeks to explore handovers across acute to rehabilitation settings as well as how care transitions can be improved. This scoping review aims to map the existing evidence on physician-to-physician handover from acute care to rehabilitation.MethodsThis review will be conducted following the Joanna Briggs Institute (JBI) framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. A comprehensive search will be performed across the following electronic databases: MEDLINE(R) ALL (Ovid), Embase Classic + Embase (Ovid), APA PsycINFO (Ovid), Cochrane Central Register of Controlled Trials (Ovid), Emcare (Ovid), CINAHL Ultimate (EBSCO) and Web of Science (Clarivate). All rounds of screening, data extraction, and data synthesis will be conducted independently with each stage performed in duplicate. The extracted data will be summarized both quantitively with descriptive statistics and qualitatively using content analysis.Eligibility CriteriaQualitative and quantitative studies published in English that discuss physician-physician handover from acute care to rehabilitation settings will be included. All geographical areas will be considered. Case reports, case series, commentaries, protocols, opinion pieces (editorials), or abstracts from conferences will be excluded.

Hybrid educational delivery models are increasingly prevalent in professional healthcare programmes, reflecting a growing commitment to accessible learning environments. However, tensions surrounding hybrid professional education, especially in Healthcare, remain. Hybrid education blends in-person and online learning (Hunter et al., 2025). This opinion piece asserts that our hybrid Occupational Therapy (OT) programme offers a replicable model combining virtual flexibility with hands-on skill acquisition. The number of OT programmes delivering content in a hybrid format continues to grow. The versatility of this model holds broader implications for Learning Development professionals across healthcare and graduate disciplines. Building on pandemic-era innovations and emerging workforce demands, we examine challenges in hybrid OT education, such as facilitating practical training, supporting digital equity, and preserving community. We also propose solutions transferable to other practice-based fields. Finally, we call on Educational Developers and Learning Developers to adopt intentional, evidence-based hybrid instructional designs with support for student learning that reflects the realities of contemporary education and professional practice in an increasingly digital world.

ABSTRACT This article investigates how selected media commentators in Aotearoa New Zealand framed the Treaty Principles Bill (TPB). Drawing on a discourse analysis of opinion pieces in The New Zealand Herald, Stuff and Newstalk ZB, this paper examines the rhetorical and ideological work in selected media commentaries by prominent media professionals in Aotearoa. The analysis identifies three dominant media frames – hegemony of logocentrism, spectacle of the indigenous other and weaponization of multiculturalism – that collectively manufactures a settler-colonial consensus around the TPB.

This opinion piece argues for the transformative value of Model United Nations (MUN) simulations, particularly SimONU, in higher education as a powerful means for experiential learning, global citizenship education, and Learning Development. Drawing on observations from the SimONU event hosted by a European higher education institution in partnership with the United Nations Regional Information Centre (UNRIC), the article highlights the pedagogical, social, and developmental benefits of engaging students in structured, role-based international diplomacy. This piece is grounded in educational theory and explores how such simulations foster essential skills including research, negotiation, collaboration, and critical thinking in higher education contexts, while simultaneously offering inclusive, context-rich learning environments. The piece concludes with a call for broader integration of experiential, globally oriented pedagogies within higher education to better prepare students for the complexities of a multipolar, interdependent world.

This opinion piece examines how professional development initiatives in higher education can facilitate transformation grounded in Te Tiriti o Waitangi. Drawing on experiences at Massey University, we explore how resistance, relationality, and contextual approaches can advance meaningful engagement with Te Tiriti o Waitangi beyond compliance frameworks. We argue that resistance offers productive entry points for deeper dialogue when met with pedagogical approaches centred in manaakitanga and whakawhanaungatanga. Tuakana-teina relationships provide essential relational structures that honour both experienced voices and emerging perspectives, creating communities of practice where treaty literacy evolves through reciprocal exchange. Context-specific approaches that connect treaty principles to disciplinary practices and institutional systems foster sustainable transformation across research, teaching, and leadership domains. This work moves beyond simplified interpretations toward an understanding that centres both the provisions and principles of Te Tiriti o Waitangi, acknowledging its political, cultural, and legal significance. These insights contribute to global conversations about decolonising education, supporting Indigenous rights, and reimagining higher education as sites of relational justice where collective responsibility replaces symbolic gestures and compliance checklists.

Higher education staff and students are beginning to emerge from the liminal space created by the exponential rise in generative artificial intelligence technologies such as large language models. Both groups exhibit a low or developing understanding of the issues related with the use of such tools. On one hand, staff in many institutions are concerned about critical skills development, academic integrity, ethical implications and the long-term cognitive effects of the use of such tools. Equally, students are concerned about the acceptability of the use of such tools at university and the need to develop work-related GenAI skills. On the other hand, foundational large language models are being trained on larger and better data sets and have evolved into ‘reasoning’ models that can allegedly ‘think’. Furthermore, with the emergence of agentic AI, systems that can ‘act’ independently, claims of shifting agency away from humans to machines are common. This has implications for the world of work and for higher education institutions. This opinion piece presents a new framework that I have developed for enhancing the GenAI literacy of staff and students and to empower and augment themselves with GenAI tools in a balanced, meaningful and collaborative way, whilst maintaining their agency. The mind-metaphors framework includes techniques such as mind-surfing, mind-mending, mind-bending, mind-gaming, mind-storming and mind-stretching, which can help staff and students to develop trust in their chosen GenAI models and master co-inference and collaborative GenAI use.

Abstract Although a strict gluten-free diet (GFD) significantly improves the health of individuals with coeliac disease (CD), it is currently the only treatment. However, it also brings significant challenges, such as the higher cost of gluten-free (GF) foods compared to their gluten-containing counterparts, limited availability of GF products, compromised sensory quality of GF foods, and the anxiety associated with travelling and eating out for work or leisure. These challenges are particularly pronounced for coeliac individuals travelling by air due to the complexities of in-flight food services and the limited availability of GF foods at airports. Providing food on board requires extensive planning, logistics, and execution before and during air travel. Catering to passengers with specific dietary requirements adds additional complexity to this process. This opinion piece highlights the challenges faced by the food industry and airlines for the provision of GF foods and experiences of coeliac individuals during air travel – from pre-ordering meals to consumption onboard – including issues related to food availability, cost, quality and taste. It also offers recommendations for airlines to enhance their food-related services, aiming to provide a better flying experience for coeliac individuals and allergy sufferers. The overarching goal of this paper is to raise awareness of CD and encourage stakeholders – including airlines, the catering and food industry and the general public – to implement changes that enhance the food consumption experience for coeliac individuals whilst travelling and dining out.

INTRODUCTIONIn a context of growing international debate over gender-affirming healthcare (GAHC) for youth, South African stakeholders require an up-to-date, locally grounded, evidence-informed assessment of health outcomes associated with gender-affirming interventions for transgender and gender-diverse (TGD) young people. This rapid review synthesises research indexed between January 2021 and August 2025 to evaluate whether new evidence supports, updates, or recommends changes to, South African GAHC guidelines.​METHODSA rapid review approach was adopted to balance rigour with timeliness. Searches spanning January 2021 to August 2025 were conducted across 12 databases via EBSCO Host (University of Pretoria), supplemented by targeted searches for recent systematic reviews, with date limits of 2021-01-01 to 2025-12-31. Eligible reports included peer-reviewed primary studies (N ≥ 5) using any empirical design that reported psychosocial or physical health outcomes of psychosocial, endocrine, surgical, non-medical, or policy/legal interventions involving TGD youth under 18 (or a family with a TGD youth). Systematic, scoping, narrative, and grey literature reviews with transparent and reproducible search protocols were also eligible. Commentaries, opinion pieces, editorials, very small case series (N < 5), reviews lacking reproducible search strategies, and studies without intervention-related outcomes for TGD youth < 18 were excluded. Formal de novo risk-of-bias or certainty grading across individual studies was not undertaken; instead, existing methodological and certainty appraisals from included systematic reviews were used qualitatively to inform interpretation, and findings were synthesised narratively by intervention domain.​ The review was not registered in any registry.RESULTSThe final dataset comprised 200 primary studies, 29 academic systematic reviews, and four grey literature systematic reviews, covering psychosocial, endocrine, surgical, non-medical, and policy/legal interventions for TGD youth. Consistent evidence shows that affirming psychosocial interventions, including family engagement, school inclusion, and social transition, are associated with reductions in distress, anxiety, and suicidality, alongside improved functioning and sense of belonging. Puberty pausers and gender-affirming hormone therapy produced expected and desired physiological outcomes under specialist monitoring, with adverse events generally mild, reversible, and consistent with known paediatric endocrine profiles, and mental-health outcomes ranging from neutral to improved. Evidence for surgical interventions under age 18 remains limited and focuses mainly on masculinising chest reconstruction, for which complication and revision rates were very low, regret was exceedingly rare, and patient satisfaction and short term psychosocial benefit were high. Restrictive or hostile policy environments were associated with increased distress, self-harm, suicidality, and social withdrawal, whereas protective policies such as anti-discrimination regulations, legal gender recognition, and inclusive school protocols were linked with improved mental health and reduced risk behaviours. Most studies were small and observational, with short follow-up, limited representation of Global South populations, and heterogeneous outcome measures, constraining causal inference and comparability.​DISCUSSIONThis Rapid Review affirms the safety and effectiveness of gender-affirming healthcare for TGD youth. It highlights the importance of affirming psychosocial care, timely access to endocrine and surgical interventions when indicated, and protective policy environments. Opportunities to strengthen GAHC within South Africa's legal, historical, and health-system context will support realisation of South Africa’s constitutional affirmations of bodily autonomy and access to healthcare.The primary source of support for this review was volunteer effort from a South African queer- and trans-led team, with partial financial support for three authors provided by Gender DynamiX.​

Erratum to: Opinion Pieces of the BTW 2025 Workshop On Advances in Cloud Data Management

This opinion piece discusses the challenges of managing a person with sight-threatening papilloedema due to idiopathic intracranial hypertension (IIH). With no available randomised controlled trials, clinicians often choose locally available surgical intervention. An increasing number of studies have advocated using dural venous sinus stenting in IIH. Big data studies show that shunts have been the mainstay of surgical treatment for IIH, and recent evidence shows improved outcomes and fewer revision surgeries. There remains genuine equipoise in the choice of intervention between shunting and dural venous stenting in IIH. The IIH Intervention Trial funded by the National Institute of Health Research is underway in the UK, the first randomised control trial to evaluate both of these surgical interventions in people with sight-threatening IIH.

Abstract As the field of cultural evolution marks its fiftieth anniversary, it has an opportunity not only to evolve in theory and scope, but also in ethics of practice. This theme issue contributes to that shift by showcasing projects supported by the Cultural Evolution Society’s Transformation Fund (CES-TF), which centred equity, diversity and inclusion (EDI). This opinion piece draws on our CES-TF projects, conducted across diverse cultural and geographical settings, to reflect on the challenges and possibilities of making cultural evolution—and human research more broadly—more just. We focus on three relational dimensions in which cultural evolution research can become more inclusive and equitable: fostering equitable cross-cultural research collaborations; building mutually beneficial researcher community collaborations; and cultivating supportive funding and institutional relationships. Our collective reflections, written by grant recipients and the CES-TF lead, emphasize that, while there is no universal model for ethical research, attending to positionality, power dynamics and diverse knowledge systems can foster responsible and impactful research. Striving to make the field more globally representative will enhance our capacity to critically reflect and improve, but real progress requires time, resources and structural reform, supported by institutions, funders and journals committed to embedding EDI at the core of research. This article is part of the theme issue ‘Transforming cultural evolution research and its application to global futures’.

This opinion piece is based on a study that investigated the contribution of Rehabilitation `Care Workers in strengthening rehabilitation in community-based services at the primary level of care level and a collaborative inquiry with the rehabilitation teams responsible fofr outreach community services in a rural district. We are of the opinion that rural contexts require a different set of community-based rehabilitation (CPR) competencies than those applicable in better-resourced urban and per-urban settings. We investigated the health system strengthening benefits of CBR as a facet of community orientated primary care (COPC), which focuses on the inter-sectoral services that rehabilitation care workers who are supervised by rehabilitation therapists can offer to persons with disabilities. We endorse extant public health literature on the urgent need to build rural inclusive health workforce capacity, suggesting that human resource shortages for rehabilitation n rural areas can be addressed through training mid-level, multi-skilled workers who are part of the ward-based teams with rehabilitation therapists. Community health workers (CHWs0 in rural areas who upgrade their skills set to include competencies in community-based disability inclusive development practice and address the rehabilitation service gaps faced by persons with disabilities and their families. Implications for practice: Embedding community-based disability inclusive development practices in COPC will promote access to rehabilitation services in rural communities. In addition to nurse-led, ward-based teams of CHWs, ward-based teams of RCWs led by rehabilitation therapists will strengthen the primary level rural health system. Health outcomes of rural populations withn disability will be improved by access to RCWs with competencies in inter-sectoral collaboration.