Open Wounds Research Articles

Effect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment.

Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model. Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20µg/mL) for 72h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration/proliferation potential of oxyresveratrol under lipopolysaccharide stimulation. Periodontal ligament cell toxicity was not observed in oxyresveratrol treatment. Oxyresveratrol treatment significantly inhibited nitric oxide production and reduced MMP-2, MMP-9, TNF-α, IL-6, and IL-8 expressions after lipopolysaccharide stimulation. Regarding cell migration/proliferation, open wound area in oxyresveratrol (33.28 ± 6.80%) was the lowest (p < 0.05). Within the limits of this study, oxyresveratrol inhibited lipopolysaccharide-induced inflammation in periodontal ligament cells and promoted periodontal ligament cell migration/proliferation. These findings suggest that oxyresveratrol could be valuable for the management of periodontal diseases.

Paediatric Hand Fractures - A Review.

Paediatric hand fractures account for approximately 25% of hand-related emergency department visits, making them the second most common childhood fractures after distal forearm fractures. These injuries are more prevalent in boys and peak ages between 9 and 14 years. Hand fractures in children are primarily caused by crushing injuries and, increasingly in older children, by sports-related activities. The little finger (52%) and thumb (23%) are the most frequently fractured digits, with phalangeal fractures, especially of the proximal phalanx, being common. Metacarpal fractures are more prevalent in adolescents (13-16 years) compared to younger children. Accurate diagnosis in the paediatric population is complicated by difficult clinical examinations and the presence of growth plates, leading to an 8% misdiagnosis rate, mainly due to misinterpretation of the ossification centres and physes. High-quality radiographic evaluation combined with a thorough clinical assessment is critical for correct diagnosis and appropriate management. The robust periosteum and high remodelling potential of paediatric bones allow most hand fractures to be managed non-operatively with splinting or casting. However, fractures with significant angulation, rotation, intra-articular involvement or open wounds may require surgical intervention, such as closed or open reduction and internal fixation with Kirschner wires. Most paediatric hand fractures heal well with excellent functional outcomes due to the high remodelling capacity of paediatric bones. Early mobilisation and appropriate immobilisation are key to preventing stiffness. Despite the generally favourable prognosis, certain fractures remain challenging to diagnose and treat, highlighting the need for specialised care. The aim of this review article is to discuss the epidemiology, fracture patterns, diagnostic challenges and management strategies essential for optimising functional outcomes and minimising long-term complications in treating paediatric hand fractures. Level of Evidence: Level V (Therapeutic).

2024 American Heart Association and American Red Cross Guidelines for First Aid.

Codeveloped by the American Heart Association and the American Red Cross, these guidelines represent the first comprehensive update of first aid treatment recommendations since 2010. Incorporating the results of structured evidence reviews from the International Liaison Committee on Resuscitation, these guidelines cover first aid treatment for critical and common medical, traumatic, environmental, and toxicological conditions. This update emphasizes the continuous evolution of evidence evaluation and the necessity of adapting educational strategies to local needs and diverse community demographics. Existing guidelines remain relevant unless specifically updated in this publication. Key topics that are new, are substantially revised, or have significant new literature include opioid overdose, bleeding control, open chest wounds, spinal motion restriction, hypothermia, frostbite, presyncope, anaphylaxis, snakebite, oxygen administration, and the use of pulse oximetry in first aid, with the inclusion of pediatric-specific guidance as warranted.

Validation of a methodology for post-construction Energy Yield Assessment of an operational wind farm

The uncertainty associated with the prospective Energy Yield Assessment (EYA) of a wind farm may be reduced by re-estimating the energy yield after it enters normal operation. This study aims to validate a simple methodology for conducting post-construction EYA of an operational wind farm. The proposed methodology derives a linear relationship between a historical source of wind speed data and the observed wind farm production on a monthly basis.In the first stage, the impact of different data sources on the accuracy of the Long-Term energy yield estimate was assessed. Results suggest that the determination coefficient R is a reliable indicator for selecting the most adequate source of historical wind speed data to be used in the Long-Term energy yield estimate.In the second stage, the model was validated from a statistical point of view by testing the premises of the linear regression model, namely the significance of the linear correlation (ANOVA test), and the normally-distributed (Shapiro-Wilk test), non-self-correlated (Durbin-Watson), and homoscedastic (Breusch-Pagan test) residuals. Results show these premises are verified for most test cases, indicating that the model is statistically robust for most test cases.

Effectiveness of Mango Gedong Gincu Peel Extract Gel (&lt;i&gt;Mangifera indica&lt;/i&gt; L.) on Cut Wounds in Male Wistar White Rats (&lt;i&gt;Rattus norvegicus&lt;/i&gt;)

Background: A wound is an injury to a part of the body where the skin and the underlying tissue lose continuity. The wound healing is a complex process consisting inflammatory phase, proliferation phase, and maturation phase. Open wounds often occur in everyday life and if left behind and untreated can potentially lead to bacterial infection. Mango gedong gincu peel extract (Mangifera indica L.) contains flavonoids, tannins, phenols, triterpenoids, steroids, alkaloids, and saponins which have roles in wound healing. Aims: To analyses the effectiveness of mango gedong gincu peel extract gel (Mangifera indica L.) against the healing of cut wounds in male wistar white rats (Rattus norvegicus). Methods: The study was an experimental study with a post-test only control group design using 25 male wistar white rat as the subject and was carried out in the FK UGJ Research Laboratory. The study used five groups : negative control group, positive control group, and treatment group using mango gedong gincu peel extract gel (Mangifera indica L.) with concentrations of 5%, 10%, and 15%. Results: The results of the study revealed that mango (Mangifera indica L.) gedong gincu peel is a source of various phytochemical such as flavonoids, tannins, phenols, triterpenoids, steroids, alkaloids, and saponins. This study showed that the 5% and 10% concentration treatment groups had the same average length measurement wound of 0.86 cm. The fastest observation of erythema was the 5% concentration group with a healing rate of 8 days, in the observation of edema the 10% concentration group was the fastest of 6 days, and the observation long of healing time was 5% and 10% concentration had the same rate of 11 days. Conclusion: Mango gedong gincu peel extract gel (Mangifera indica L.) was effective against wound healing with optimum concentrations of 5% and 10% which gives the best healing effect against wounds in male wistar white rats (Rattus norvegicus). Received: 25 September 2024 | Reviewed: 22 October 2024 | Revised: 05 November 2024 | Accepted: 09 November 2024.

Transparent and Mechanically Robust Janus Nanofiber Membranes for Open Wound Healing and Monitoring.

The electrospun nanofiber membrane has demonstrated great potential for wound management due to its porous structure, large surface area, mechanical strength, and barrier properties. However, there is a need to develop transparent bioactive nanofibers with strong mechanical properties to facilitate the monitoring of the healing process. In this study, we present an electrospinning-based method for creating transparent (∼80-90%), strong (∼11-13 MPa), and Janus nanofiber membranes. The innovative square pattern architecture of the membrane includes a thin hydrophobic polycaprolactone layer on top of a layer of hydrophilic ethylene-vinyl alcohol nanofiber, which enables the absorption of excess biofluid from the wound and exhibits Janus wettability for water. Furthermore, incorporating 5% chitosan into the composition of the nanofibers accelerates the healing process through its antioxidant properties and antimicrobial activity against various bacteria, including drug-resistant strains. The developed membrane also demonstrates skin-repairing function, quick blood clotting (around 145 ± 12 s), and biocompatibility with keratinocyte (≥90%), as well as in vitro quick cell migration (∼24 h). With a tensile strength of 11-13 MPa, the membrane effectively adheres to the knee joint even after running 4 km. These optimal properties of the electrospun nanofiber membrane make it suitable for effective wound management and inspection of the healing process, without the need for frequent dressing changes.

Infrared Thermography of Turbulence Patterns of Operational Wind Turbine Rotor Blades Supported With High‐Resolution Photography: KI‐VISIR Dataset

Infrared Thermography of Turbulence Patterns of Operational Wind Turbine Rotor Blades Supported With High‐Resolution Photography: KI‐VISIR Dataset

Comparison of outcome of Simple Excision vs Limberg Flap of pilonidal sinus in terms of post operative pain, operative time, wound infection and hospital stay.

Objective: To compare post operative pain, wound infection, intraoperative time and length of hospital stay in both groups of simple excision and Limberg flap. Study Design: Comparative Prospective study. Setting: CMA Teaching and Research Hospital/Azra Naheed Medical and Dental College, Lahore, Pakistan. Period: 1st September 2021 to 1st September 2023. Methods: After approval from the Institutional review board of Azra Naheed Medical &amp; Dental College/CMA Hospital, the sample was 120 patients was raised using non-convenience probability sampling divided into 2 groups. Group A patients underwent simple excision while Group B patients underwent Limberg flap Inclusion criteria include all the patients with age more than 13 years and diagnosed as case of pilonidal sinus. All the data was entered and processed by using SPSS 26. Comparison of two groups was done by apply independent sample t-test. A p-value of ≤ 0.05 was considered significant. Results: The average age of the patients was 45.88 ± 9.78 years with minimum and maximum ages were 15 &amp; 59 year respectively. Mean post operative pain was 2.6 ± 1.9 in group A while 3.9 ± 2.7 in group B (p value = &lt;0.05). Similarly wound infection, duration of surgery and length of hospital stay were also less in group A patients as compared to group B patients. Conclusion: Simple excision of pilonidal sinus is better from Limberg flap in terms of post operative pain, wound infection, duration of surgery and length of hospital stay.

025. Brain Corpal Evacuation Caused by Air Gun: Management and Surgical Approach Evacuation with Neuronavigation Guiding

Background: In Indonesia, cases of injury from airgun are relatively common and do not immediately result in death because the projectile velocity of airgun is slower compared to the gunshot. Consequently, if the pellet hits the brain (brain injury), it may cause the patient to live with disabilities or infection problems due to the non-sterile of the airgun pellet. Surgical procedures often difficulties in determining the location of the pellet or foreign body, especially if the pellet of air gun penetrates to the contralateral side of the entry point. Neuronavigation is a modern system in neurosurgery that helps surgeons precisely locate targets with minimal disruption to critical brain and spinal structures. This allows for more precise and easier pellet evacuation. Report a patient who had a gunshot wound with the bullet entering from the left parietal region and penetrating through to the right parietal surface of the head, managed comprehensively with neuronavigation guidance. Case: A 5-year-old female patient presented to the emergency department with an open wound on the left parietal region of the head. Her Glasgow Coma Scale score was 8 (GCS: Eye: 2, Verbal: 2, Motor: 4), indicating a sedated state. Initial and specific treatments were administered to prevent deterioration and improve the patient’s prognosis. Surgical management, using neuronavigation guidance, was employed to determine the exact location of the foreign body. The procedure included debridement of the entry point in the parietal region and evacuation of the foreign body using neuronavigation guidance. Conclusion: Early management of gunshot injuries is crucial for improving prognosis. Neuronavigation guidance proved effective, and minimally invasive neurosurgical techniques may be a safe option for treating traumatic brain injuries caused by gunshots. This approach facilitates easier, faster, and more precise incision and evacuation of foreign bodies.

Severe Vulvar Myiasis Case In A Crossbreed Limousin Cow

Background: Myiasis is caused by the infestation of Diptera fly larvae in vertebrate animals. In cases of myiasis, larvae will eat living or dead tissue, thereby expanding the infestation and infection of the host. Myiasis is a significant economic problem due to decreased productivity and tissue damage. Purpose: This study seeks to provide insights regarding managing and treating myiasis cases in cattle. Cases(s): The 4-year-old female Limousin cow was in the gestation period and kept in Buluagung Village, Pesanggaran, Banyuwangi. Based on the owner's statement, the cow experienced a decrease in appetite, and there were wounds in the vulva area accompanied by larvae, which had been present for five days. The clinical findings revealed an open wound that was red in color and soft in consistency, and there was an unpleasant odor in the vulva area. An infestation of Diptera fly larvae accompanied this. After the initial extraction of maggots, necrotic tissue, edema, friable tissue, and erythema were evident in the vulvar region and introitus. Case Management: Treatment carried out on the case cow involved cleaning the wound using 0.9% NaCl and removing both necrotic tissue and any larvae from the vulva wound using tweezers. The cow received an intramuscular injection of an analgesic and antipyretic (Sulprodon®) 7 mL, antihistamine (Prodryl®) 3 mL intramuscular injection, antibiotic (Limoxin-LA®) 10 mL, and multivitamin (Injectamin®) 7 mL. Conclusion: The vulvar myiasis in this cow was successfully cured with no more larvae found, and the wound dried out.

Antimicrobial resistance: Biofilms, small colony variants, and intracellular bacteria

Soft tissue and bone infections continue to be a serious complication in orthopedic and trauma surgery. Both can lead to a high burden for the patients and the healthcare system. Musculoskeletal infections can be induced by intraoperative contamination, bacterial contamination of open wounds or hematogenous bacterial spread. During the recent decades, advances were achieved in the understanding of pathogenesis and antibiotic resistance. Despite some progress in the diagnosis and advancing of therapeutic concepts, groundbreaking successful improvement of treatment concepts is still missing. Current therapy concepts are based on the two pillars consisting of surgical debridement with joint or bone reconstruction as well as prolonged antibiotic therapy. An improved understanding of both host and pathogen-related factors leading to treatment failure is essential in musculoskeletal infections. Therefore, this review aims to give an overview of pathogen-related pathophysiology in musculoskeletal infections. It describes defense strategies of pathogens such as (1) biofilm, its development, characteristics, and treatment options. In addition, (2) characteristics of small colony variants and (3) intracellular bacteria are highlighted. Lastly (4) an outlook for potential and promising future therapeutic strategies is provided.

AI-driven predictive maintenance and optimization of renewable energy systems for enhanced operational efficiency and longevity

The rapid growth of renewable energy systems necessitates advanced strategies for maintenance and optimization to ensure long-term operational efficiency and sustainability. Traditional approaches often fall short in predicting failures and optimizing performance across diverse and dynamic renewable energy infrastructures. This study investigates the application of artificial intelligence (AI) techniques for predictive maintenance and optimization of renewable energy systems, with the aim of enhancing operational efficiency and extending system longevity. We employ a combination of machine learning algorithms, including deep neural networks and reinforcement learning, to develop predictive models and optimization strategies. These models are trained on large-scale datasets collected from operational wind farms, solar installations, and hydroelectric plants. Our results demonstrate that AI-driven approaches can predict equipment failures with 92% accuracy, reducing unplanned downtime by 35% compared to traditional methods. Moreover, AI-optimized operational parameters improved overall energy output by 8.5% across the studied systems. The proposed framework also showed adaptability to various environmental conditions and system configurations, suggesting broad applicability across the renewable energy sector. This research underscores the significant potential of AI in revolutionizing maintenance practices and operational strategies in renewable energy systems, paving the way for more reliable, efficient, and sustainable clean energy production.

Present and Future Actions of CETYS University to Mitigate Climate Action

The strategic location of CETYS University, in Baja California state in the northwest of Mexico, gives it exceptional conditions for the use of renewable energies. With an installed photovoltaic solar energy capacity of 1.37 MW, it is the academic institution with the greatest generation potential in Latin America. The importance that CETYS University gives to the subject has stimulated the institution since 2015 to offer a degree and master's degree in renewable energy to have greater and better collaboration with solar and wind energy technology companies located in the state. With a vision of the future, in 2023 the CETYS Institute for Sustainability Studies (ISS) was created to promote and coordinate, among other actions, those related to energy and climate change. With a planning horizon until 2036, the ISS, looking forward, has proposed the following actions: a) an internal audit to increase the energy efficiency of their buildings and classrooms; b) support for research projects to build on-campus operational small-scale wind energy systems; c) the deployment of the 300 x 500 program, which seeks to plant at least 300 native trees in the region with low water consumption each year, to offset the atmospheric emissions of 500 vehicles; d) a policy to achieve 80% carbon neutrality, and e) the incorporation of CETYS to the network of Mexican universities for climate action. Among many others, these actions position CETYS as a leading institution in sustainable development at the regional level.

Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract

Abstract Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (&lt;10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (&gt;300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch .Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics

Aeolus Winds Improve Arctic Weather Prediction

AbstractIt has been proven that assimilating winds from the Aeolus global Doppler Wind Lidar (DWL) would enhance the predictive skill of weather forecast models. In this study, we use a series of observing system experiments to examine how currently assimilated “operational” wind products and Aeolus winds impact environment and climate change Canada's global forecast system over the data‐sparse Arctic region. Aeolus winds improve the tropospheric wind and temperature forecasts by about 0.7%–0.9% of error reduction (a 15%–20% effect compared to the impact of operational wind products) while having little impact on specific humidity. In particular, Aeolus winds have an impact on forecasts of strong wind days on the wind and temperature fields that is double the impact for weaker wind days. On the other hand, the operational wind products do not show as large a discrepancy in impact between forecasts of disturbed and normal days. These findings suggest significant potential for global DWL observations to enhance severe weather prediction in polar regions.

Performing Magnetic Boundary Modulation to Broaden the Operational Wind Speed Range of a Piezoelectric Cantilever-Type Wind Energy Harvester

Small piezoelectric wind-induced vibration energy harvesting systems have been widely studied to provide long-term sustainable green energy for a large number of wireless sensor network nodes. Piezoelectric materials are commonly utilized as transducers because of their ability to produce high output power density and their simple structure, but they are prone to material fracture under large deformation conditions. This paper proposes a magnetic boundary modulated stepped beam wind energy harvesting system. On the one hand, the design incorporates a composite stepped beam with both high- and low-stiffness components, allowing for efficient vibration and electrical energy output at low wind speeds. On the other hand, a magnetic boundary constraint mechanism is constructed to prevent the piezoelectric sheet from breaking due to excessive deformation. Experiments have confirmed that the effective operational wind speed range of the harvester with magnetic boundary constraints is doubled compared to that of the harvester without magnetic boundary constraints. Furthermore, by adjusting the magnetic pole spacing of the boundary, the harvesting system can generate sufficiently high output power under high-wind-speed conditions without damaging the piezoelectric sheet.

DO NEURO ONCOLOGY PATIENTS FEEL SUffiCIENTLY SUPPORTED TO MANAGE THEIR SURGICAL WOUNDS AFTER SURGERY?

Abstract AIMS Establish if neuro oncology patients feel they are sufficiently well supported to manage their wounds post operatively. Is there any correlation to patient wound care management and developing wound infections. METHOD There was an anecdotal rise in wound infections in the neuro oncology department, which led to the team investigation a cause. This project was looking to see if patients felt they were sufficiently supported to manage their wounds post operatively. A survey was sent via email to 94 patient’s who had undergone neurosurgery under the neuro oncology team at a London teaching Hospital in December 2023, January 2024, and February 2024. RESULTS There was a response rate of 23.5%. Overall 96% of patients felt able to manage their wound post operatively. 76% of people wished to have the information on wound care at discharge from hospital. 68% advised that they would like to receive information about wound care via printed material and 76% would like verbal instruction with questions. Patients commented that ‘there was a conflict of information’, and ‘the information at discharge could have been better’. They would like information on’ how to clean it [the wound]. 3 patients had a suspect infection but did not have treatment, and 1 had a confirmed infection with treatment. CONCLUSION Neuro oncology patients are able to manage their wounds post operatively, but they feel that they would benefit from extra support via written material, and verbal instructions. Future projects may include developing an evidence based post operative wound care information leaflet and instructions for wound care. Although in this cohort there was only 1 confirmed infection, further investigation is needed to establish the cause for the apparent increase.

Chromobacterium violaceum: An incidental finding in a neonate.

Chromobacterium violaceum is a gram-negative saprophytic bacterium causing human infection in tropical and subtropical countries. Such infections are uncommon but cause high mortality when the bacterium enters the bloodstream through an open wound. We present a case of C. violaceum infection isolated from a blood culture sample in a neonate identified at a tertiary care teaching hospital in North East Uttar Pradesh. Timely diagnosis by microbiological methods and antimicrobial treatment led to a successful cure for this life-threatening infection. Thus, such bacteria should be included in the routine spectrum for differential diagnosis of sepsis, to provide a chance of cure.

Clinical Evaluation of a Novel Compression Device For Ultrasound-Guided Repair of Femoral Artery Pseudoaneurysms: A Double-Blind Clinical Trial

Background: Femoral artery pseudoaneurysm is a well-known complication after conventional angiography. Today, the treatment of choice for this condition is noninvasive repair using manual ultrasound-guided compression. Objectives: This study aimed to evaluate the efficacy of a novel compression device in improving angiography-induced pseudoaneurysm treatment compared to manual ultrasound-guided compression repair. Patients and Method: A double-blind, randomized clinical trial was performed on patients with femoral angiography-induced pseudoaneurysm in the Radiology Department of Ghaem Hospital, Mashhad, Iran. Based on color Doppler ultrasound exams, patients diagnosed with a pseudoaneurysm within 72 hours of angiography were included in the study. Patients were excluded if they had complete blockage, complete pseudoaneurysm thrombosis, abscess, surface tissue infection, or open wound in the area. The patients were allocated to a manual ultrasound-guided compression group or a device-assisted compression group using simple randomization with a sealed envelope method. After collecting demographic data, the patients underwent an ultrasound exam of the groin to determine and record the size of the pseudoaneurysm and the ratio of thrombosis to open lumen. The therapeutic success rate was defined as complete lumen thrombosis after conducting the compression procedure one to three times. Also, the pain score was measured during compression using the Visual Analog Scale based on a scale of 0 - 10. The duration of successful procedures was also documented. The patients were monitored for 6 hours for any side effects. The level of statistical significance was set at P &lt; 0.05 for all tests. Results: The study was performed on 22 patients (13 males/9 females) with a mean age of 65.5 ± 3.5 years divided into two groups of device-assisted (n = 11) and manual ultrasound-guided (n = 11) compression repair. The two groups did not differ significantly in terms of demographic variables or initial ultrasound variables associated with the pseudoaneurysm. The device-assisted compression group was found to have lower pain intensity (5.0 ± 1.0 vs. 6.0 ± 0.8; P = 0.024) and a significantly higher success rate (100% vs. 45.5%; P = 0.004) compared to the manual compression group. None of the patients showed any side effects. Conclusion: This preliminary study showed that the proposed device is completely safe and may improve the success rate while decreasing pain scores during ultrasound-guided compression procedures. Using a large multicenter study design, evaluating the efficacy of the novel device for hemostasis during sheath removal and adding new equipment to the device, such as manometers to apply controlled pressure, are suggested for future studies.

The effectiveness of massage gun treatment combined with passive stretching in reducing non-specific lower back pain

Non-specific lower back pain is a common condition characterized by strain, muscle spasms, or weakness of the paraspinal muscles, particularly the multifidus muscle, which affects adjacent musculature such as the gluteus, hamstrings, and quadriceps. This study aimed to investigate whether massage gun treatment combined with passive stretching could reduce non-specific low back pain in patients experiencing subacute and chronic phases of this condition. This pseudo-experimental research employed a one-group pretest-posttest design with three treatments. Participants were selected using purposive sampling based on inclusion criteria: suffering from non-specific low back pain, willingness to participate, and age between 20 and 65 years. Exclusion criteria included anatomical abnormalities of the spine, fractures, open wounds, and specific spinal disorders. The visual analog scale (VAS) was used to measure pain intensity before and after each treatment session. Initial VAS scores averaged 65.6 units. Following the first treatment, scores decreased significantly to 52.1 units; subsequent reductions occurred at 42.1 units post-second treatment and 33.5 units post-third treatment. Statistical analysis revealed a significant difference across all three treatment sessions (p = 0.000 0.05), indicating a progressive improvement in pain control over time. Massage gun therapy coupled with passive stretching demonstrated efficacy in reducing non-specific lower back pain among participants. These findings suggest that repeated application of these interventions can lead to sustained improvements in pain management for individuals suffering from subacute and chronic non-specific low back pain conditions