1598 Background: Previous studies have documented higher cancer-related mortality in individuals with mental illness, compared to their healthier counterparts. The aim of this study was to identify the anatomic cancer sites for which mortality is higher in individuals with mental illness. Methods: We used a linked dataset comprised of death certificate data for the state of Ohio for the years—2004-2007 and data from the publicly funded mental health system in Ohio. Decedents with mental illness were those identified concomitantly in both data sets. We used age-adjusted standardized mortality ratios (SMRs) in race- and sex-specific strata to estimate excess deaths for each of the anatomic cancer sites. Results: Overall, there was excess mortality from cancer associated with having mental illness in Non-Black men and women (SMR: 1.14 (95% confidence interval [CI] = 1.05-1.22), and 1.13 (95% CI= 1.05-1.20, respectively), but lower mortality in Black men, likely due to premature mortality from other causes (0.71 (95% CI= 0.61-0.83). In Black women, we observed no excess mortality from cancer that was associated with having mental illness. There was excess mortality from hepatobiliary cancer in Non-Black men (SMR= 1.65; 95% CI =1.15-2.29), but not in any other sex- and race- stratum. In addition, we observed excess mortality from lung and laryngeal cancers among Non-Black men and women (SMRs for lung cancer of 1.28 (95% CI= 1.13-1.45), and 1.45 (95% CI= 1.29-1.62), respectively; and for laryngeal cancer (2.01 (95% CI= 1.19-3.18 for men, and 2.47 (95% CI= 1.08-4.89) for women). Black women experienced excess mortality from cancer of the kidney and renal pelvis (SMR= 2.91; 95% CI =1.53-5.06), while Non-Black women experienced excess mortality from urinary bladder cancers (SMR=1.89; 95% CI=1.15- 2.92). Conclusions: Compared to the general population in Ohio, individuals with mental illness experienced excess mortality from certain cancers. In part, this excess mortality may be mediated by a higher prevalence of smoking or substance abuse in individuals with mental illness. Further investigation is needed to explain the observed racial variation in cancer mortality, and to examine mortality for specific cancers based on severity of mental illness.