Ocular Hypertonia Research Articles

Epidemiological profil of post contusive hyphaema experience of the paediatric ophthalmology department of Casablanca

Aims/Purpose: Hyphaema is defined as the presence of blood in the anterior chamber. It occurs after a contusive or perforating ocular trauma or in the aftermath of ocular surgery. The aim of our work is to analyse the clinical, therapeutic and evolutionary profile of post‐contusive hyphaema.Methods: A retrospective study was conducted on 66 children (33 eyes) admitted to the ophthalmologic emergency room for post‐contusive hyphaema followed and treated in the paediatric ophthalmology department of the 20 August hospital in Casablanca between January 2015 and January 2023.Results: There was a male predominance with 67% of boys affected. The average age was 9.5 years. The main cause of consultation was visual acuity (VA) loss in 49%. On examination, the initial VA was <1/10 in 38% of cases, the ocular tone was >20 in 30% of cases. Hyphaema was classified as stage I in 26.4%, stage II in 52%, stage III in 15.2%, stage IV in 6.4%. Post‐traumatic cataract was present in 50% of the cases, lens dislocation in 22% of the cases, angle recession in 6%. Intravitreal haemorrhage was present in 2 patients, berlin oedema in 3 patients. The treatment prescribed in all patients was strict rest, abundant drinks, oral and local corticotherapy and dilatation with atropine. In addition, a hypotonizing treatment was prescribed for the patients who presented an ocular hypertonia. The evolution was marked by the total resorption of the hyphaema in 90% of the cases. Surgical treatment (hyphaema lavage) in 10% of cases. The final VA was >6/10 in 60% of cases. The most serious complication was haematocornea in 6% of cases.Conclusions: Frequent and serious condition in children that can jeopardize the functional prognosis of the eye. When the diagnosis is made, the management must be early in order to avoid complications.

Traumatic Anterior Dislocation of a Clear Crystalline Lens

We present a case study of a 41-year-old patient who was admitted to the ophthalmological emergency department complaining of ocular pain and redness following trauma of the right eye. Slit-lamp examination of the right eye revealed visual acuity limited to "counting fingers", diffuse conjunctival hyperemia, anterior dislocation of a clear crystalline lens in the anterior chamber with endothelial contact (Figure 1) , and ocular hypertonia measured at 35 mm Hg. Medical treatment was swiftly initiated, incorporating both local and systemic hypotensive agents. After the eye pressure has been normalized, the patient underwent phacoemulsification lens extraction with anterior vitrectomy. Postoperative outcome was marked by normalization of intraocular pressure and by the absence of optic nerve and corneal endothelial cell damage.

Urrets-Zavalia Syndrome after Penetrating Keratoplasty: A Case Report

Urrets-Zavalia syndrome is a dreaded complication of anterior segment surgery and the most common in patients undergoing corneal transplantation. Avoiding the prescription of mydriatic eye drops during the postoperative period is the mainstay of its therapy, which focuses on prevention. One month after having keratoplasty in the left eye, a 42-year-old man presented with Urrets-Zavalia syndrome and ocular hypertonia at 35 mmgh. Medical and surgical management were required in this situation.
 The purpose of our presentation is to describe a real-world instance of Urrets-Zavalia syndrome.

The Prevalence of Ocular Surface Disease in Glaucoma Patients

Introduction: Glaucoma is the third cause of blindness in developed countries after age-related macular degeneration (AMD) and diabetic retinopathy. The aim of this study was to determine the prevalence of ocular surface disease in patients treated for glaucoma or ocular hypertonia. Patients and methods: We conducted a one-year observational study including glaucoma patients older than 15 years, diagnosed and treated for more than six months. The impact of anti-glaucoma treatment on the ocular surface was assessed by a questionnaire derived from the Ocular Surface Disease Index (OSDI). Results: Antiglaucoma treatment caused an alteration of the ocular surface in 59% of patients. 61.7% of patients had a mean epithelial thickness below normal. Discussion: Several observational studies have shown a high prevalence of ocular surface disease in glaucoma patients. The prevalence of surface involvement in our study is close to most studies in the literature. The strong correlation between the number of eye drops prescribed and the severity of ocular surface involvement has been proven. This correlation is attributed to the preservative benzalkonium chloride (BAK). Among the cellular alterations, we noted a decrease in mucus cells with a decrease and instability of the thickness of the tear film, which was more important in patients under BAK preserved eye drops than in those without BAK. Conclusion: Our study allowed us to determine the frequency of ocular surface damage in patients treated long-term with hypotonizing eye drops. The mechanisms of this damage are multiple. Preservatives seem to play a central role in the genesis of these reactions.

Luxation antérieure d’un cristallin clair post-traumatique

We here report the case of a 52-year-old patient admitted to the ophthalmic emergency department with ocular pain and redness following right ocular trauma. Ophthalmologic examination of the right eye revealed impaired near visual acuity of counting fingers, diffuse conjunctival hyperaemia, dislocation of the clear crystalline lens into the anterior chamber in front of the iris with contact with endothelial cells and ocular hypertonia 40 mmHg. Ocular ultrasound was normal. The patient received emergency medical treatment based on both local and general hypotonizing drug. Then phacoemulsification including direct surgical removal of the entire lens associated with anterior vitrectomy were performed. Postoperative outcome was marked by normalization of intraocular pressure and by the absence of optic nerve and corneal endothelial cell damage.

Fatty liver and atherogenic dyslipidemia have opposite effects on diabetic micro- and macrovascular disease

Background and aimsNon-alcoholic fatty liver (FL) is comorbid with obesity, metabolic syndrome and type 2 diabetes. Atherogenic dyslipidaemia (AD), frequent in FL, is associated with risk of micro- and macrovascular complications. Given the paradoxical ocular protection of FL in T2DM, we studied how FL modulates micro- and macrovascular complications as a function of AD. MethodsCross-sectional factorial analysis of 744 diabetic patients in whom FL, identified by ultrasonography, was present in 68%. AD, defined by low HDL-C plus elevated TG, was present in 45%. Four groups were analysed as regards cardiometabolic features, micro-/macroangiopathies, cataract and ocular hypertonia: FL[-]AD[-] (n = 171); FL[-]AD[+] (n = 66); FL[+]AD[-] (n = 235); and FL[+]AD[+] (n = 272). ResultsAge, gender and glycemic control were similar across groups. Prevalence of overall macroangiopathy and coronary artery disease were higher in patients with AD, irrespective of FL. Overall macroangiopathy was higher, by 64% in FL[-]AD[+] and by 38% in FL[+]AD[+]. Coronary artery disease was higher, by 128%, in FL[-]AD[+], and by 67%, in FL[+]AD[+]. (Micro)albuminuria was more frequent (+55%) in FL[-] AD[+] compared to FL[-] AD[-]. Retinopathy prevalence was 35% in FL[-], unaffected by AD. Retinopathy frequency was much lower in FL[+], irrespective of AD, decreased by −47% in FL[+]AD[-] and −32% in FL[+]AD[+] (vs. FL[-]AD[-]). Ocular hypertonia was present in 13%, and its prevalence was also markedly lower (−31%) in FL[+]. Cataract frequency was 29%, also lesser in FL[+] (24% vs. 39%), irrespective of AD. ConclusionsMulti-level eye protection in diabetes is linked to non-alcoholic fatty liver independently of atherogenic dyslipidemia.

Incidence of Primary Open-Angle Glaucoma at the Flamboyants Communal Medical Center of Conakry, Guinea

Background: Primary Open-Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin defined by alterations in the visual field, progressive loss of optic nerve fibers and ganglion cells, and an open iridocorneal angle in gonioscopy. It is the world’s leading cause of irreversible blindness. There is no epidemiological study in Guinea that allows us to locate the real level of the problem. The objective of this study is to determine the hospital incidence of POAG at the Centre Médical Communal (CMC) in the Flamboyants. Patients and Method: This was a descriptive cross-sectional study with a prospective collection for one year, from April 1, 2020 to March 31, 2021, in patients aged at least 40 years, received in consultation at the CMC in the Flamboyants. The diagnostic criterion for a new case of glaucoma was the presence in a patient of the following two signs: (excavation of the optical disc C/D ≥ 0.5 and alteration of the visual field) with an open angle at least stage 4 of the Shaffer and Etienne classification associated or not with ocular hypertonia and having never received anti glaucoma treatment. We described variables related to sociodemographic characteristics, visual acuity, intraocular pressures, papillary excavations, and visual field surveys. Informed consent from patients was sought and obtained. The confidentiality of the files was guaranteed. Results: 68 new cases of POAG were diagnosed out of 3220 consultations, an incidence rate of 2.11%. The average age was 58.2 years (10.64 with a male predominance of 63.23%. A family history of glaucoma was present in 11.36% of cases. Visual acuity was poor < 1/10 in 79 eyes/136, average between 1/10 and 3/10 in 11 eyes/136, and good ≥ 3/10 in 46 eyes/136. The mean intraocular pressure (IOP) was 26.5 mm Hg in the right eye and 25.9 mm Hg in the left eye with extremes of 18 and 38 mm Hg. The cup/disk ratio was above 0.5 in 97.1% at OD and 95.58% at OG. The visual field was impaired in all patients. Conclusion: This study has shown us that POAG in our environment is relatively common, early onset, and rapidly evolving. The implementation of a rapid and reliable screening strategy by the Eye Health Program will make it possible to manage glaucoma from the earliest stages.

Urrets-Zavalia syndrome: report of 2 cases

Urrets-Zavalia syndrome characterized by areflexic mydriasis followed by progressive atrophy of the iris can occur afterfull thickness cornea transplant (penetrating keratoplasty). This is often associated with ocular hypertonia. We here report two cases. A 14-year-old girl with bilateral stage IV keratoconus, who underwent penetrating keratoplasty in the right eye. Immediate postoperative outcome was marked by the appearance of an inflammatory reaction of the anterior chamber with double-cross tyndall effect and pupillary fibrin membrane formation characterized by a tone of 23 mm hg at day21.

Tonometric profile of patients at Kara University Teaching Hospital in Togo

Aim: Our study aimed to describe the tonometric profile of patients consulting in the Ophthalmology department of University Teaching Hospital of Kara (UTH Kara). Study method: This is a descriptive cross-sectional retrospective study on the files of patients who consulted in the ophthalmology department of the CHU Kara and who performed a tonometric examination over the period from January 1, 2019 to June 30, 2021 i.e. a period of 02 and a half years. Results: During this 30-month study period, 225 patients consulted in the ophthalmology department of University Teaching Hospital of Kara, which corresponds to a six-monthly frequency of 20% (45 patients). The mean age of our patients was 29.78 ± 13.39 years with extremes of 5 and 69 years. The 11 to 21 age group was in the majority. the female sex was predominant (65.78%) with an M / F ratio of 0.52. Pupils / students (48.90%) and civil servants (31.20%) were the majority of the consultants. Eye pain (23.6%), blurring of vision (21.3%), Headache (17.8%) and reduced visual acuity (13.3%) were the main reasons for consultation. The mean intraocular pressure of our patients was 15.46 mm Hg. It was 15.52 mm Hg ± 4.26 in the right eye (OD) and 15.41 mm Hg ± 4.70 in the left eye (OG). In 4.4% of cases, ocular hypertonia between 22 and 29 mmHg was noted. Conclusion: The prevention of the occurrence of glaucoma in isolated hypertonia and better management of known glaucomatous patients seem to justify rigorous tonometric monitoring at all ages.

Impact of Hypotonizing Treatment in Patients with Glaucoma on the Ocular Surface: About 52 Patients

Ocular surface disease (OSD) and glaucoma are common comorbidities in the same patient. Thus, the long-term instillation of topical intraocular pressure lowering drops induces changes in the ocular surface. For this, we have realized a cross-sectional study of 52 patients, collected at the ophthalmology department of the Hassan II University Hospital Center at Fez, Morocco. We have included all patients with glaucoma or ocular hypertonia on hypotonizing treatment for at least 06 months. They have answered the Ocular Surface Disease Index (OSDI) after their consent. All patients have been then examined with a slit lamp by the same ophthalmologist to assess the severity of the OSD. A total of 101 eyes from 52 patients were analyzed. Thirty-six (69%) patients treated with hypotonizing eye drops required multitherapy. Only nine (17%) patients were on preservative-free eye drops. The average OSDI score was 32.4/100 (0—82.5). According to clinical classification, 27 (52%) patients had severe OSD. This study confirms the high frequency of the OSD in patients medically treated for glaucoma or ocular hypertonia. Damage on the ocular surface is responsible for disabling symptoms that can affect both the quality of life of patients and adherence to the treatment. Thus, any ophthalmologist should systematically include the evaluation of the ocular surface in glaucomatous patients.

Diagnosis of Large Papillary Excavations in Developing Countries: From Automated Visual Field to OCT of the Ganglion Complex. About a Case

Background: Large papillary excavations constitute a true differential diagnosis of glaucoma in our environments. Aim: To present a clinical case of large papillary excavation simulating glaucomatous optic neuropathy in a young subject. Case Presentation: The ophthalmologic examination made it possible to note a visual acuity of LogMar 0.00, ocular hypertonia and a large papillary excavation in both eyes. The visual field noted bilateral perimetric involvement suggesting optic neuropathy. Optical coherence tomography (OCT) of the ganglion complex revealed an absence of involvement of the ganglion complex and the ganglion ridge essential to evoke optic neuropathy. An ocular hypotonizing treatment made it possible to normalize the intraocular pressure. Conclusion: The particularity of this observation lies in the fact that the perimeter involvement that preceded any involvement can simulate a glaucomatous involvement. Functional damage to the visual field must be correlated with structural damage to suggest glaucomatous damage in our ophthalmic patients.

Venous Branch Occlusion: What If It Was Not Just Hypertension!

We report the case of a hypertensive patient who has macular edema, secondary to retinal vein occlusions, revealing pigmentary glaucoma.&#x0D; 54-year-old man had a visual impairment in the left eye. In connection with an retinal vein occlusion; the interview reported hypertension and diabetes, The diagnosis of occlusion of the old retinal vein branch associated with pigmentary glaucoma in a strong myopic is made. Before hypertension, the search for glaucomatous ocular hypertonia must be systematic because it is a particular cause of retinal vein occlusions Related to papillary excavation.

Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure

Aqueous humor drainage is essential for the regulation of intraocular pressure (IOP), a major risk factor for glaucoma. The Schlemm’s canal and the non-conventional uveoscleral pathway are known to drain aqueous humor from the eye anterior chamber. It has recently been reported that lymphatic vessels are involved in this process, and that the Schlemm’s canal responds to some lymphatic regulators. We have previously shown a critical role for bone morphogenetic protein 9 (BMP9) in lymphatic vessel maturation and valve formation, with repercussions in drainage efficiency. Here, we imaged eye lymphatic vessels and analyzed the consequences of Bmp9 (Gdf2) gene invalidation. A network of lymphatic vessel hyaluronan receptor 1 (LYVE-1)-positive lymphatic vessels was observed in the corneolimbus and the conjunctiva. In contrast, LYVE-1-positive cells present in the ciliary bodies were belonging to the macrophage lineage. Although enlarged conjunctival lymphatic trunks and a reduced valve number were observed in Bmp9-KO mice, there were no morphological differences in the Schlemm’s canal compared to wild type animals. Moreover, there were no functional consequences on IOP in both basal control conditions and after laser-induced ocular hypertonia. Thus, the BMP9-activated signaling pathway does not constitute a wise target for new glaucoma therapeutic strategies.

Efficacy of rituximab in patients with Graves' orbitopathy: a retrospective multicenter nationwide study.

The clinical utility of rituximab (RTX) in Graves' orbitopathy (GO) treatment remains controversial since the discrepant results from 2 prospective randomized studies (Stan M et al. J Clin Endocrinol Metab 2015; Salvi M et al. J Clin Endocrinol Metab 2015). The aim of this study was to assess in real life the characteristics and the clinical outcomes of patients with GO treated with RTX in cases of corticosteroid resistance or corticosteroid dependence. Multicenter French retrospective study including patients with moderate-to-severe GO requiring second-line treatment with RTX. Patients were classified according to three main baseline characteristics: clinical inflammation (CAS ≥ 3), oculomotor limitation, and visual dysfunction. Patients were considered as responders if, at 24weeks (week 24), at least 1 of these 3 parameters improved with no worsening elsewhere. Forty patients were included (65% smokers, 38% dysthyroidism). Thirty-two patients were treated with RTX alone (one patient excluded owing to side effects): 64.5% had favorable responses at week 24 and significant reduction in baseline CAS (3.29 ± 1.6) at 12weeks (1.93 ± 1.1; P < 0.001) and at week 24 (1.59 ± 1.1; P < 0.001); reduction in anti-TSH receptor antibodies at week 24 (P < 0.01); and significant improvement of visual acuity (P = 0.04) and ocular hypertonia (P = 0.04) at week 12, but no improvement in oculomotor dysfunction. Eight patients needed emergency treatment with concomitant RTX and orbital decompression, with favorable outcome for 5 patients. Predictive factors for a poor response to RTX were low baseline CAS, smoker, and baseline ocular hypertonia. All patients reported good tolerance except one serious side effect (a cytokine release syndrome). The efficiency results of RTX in reducing CAS in this cohort are just between those of Stan and Salvi. This could be explained by our delay before treatment initiation, quicker than Stan but longer than Salvi. RTX appears to be effective as a second-line treatment for the inflammatory component of GO, especially if the disease is highly active and recent.

Management of orbital cellulitis: a retrospective study

Background: Orbital cellulitis is an infectious involvement of the tissues posterior to the orbital septum causing severe local and general complications. Material and methods: The aim of our work was to study the clinical, paraclinical and therapeutic characteristics of orbital cellulitis through a retrospective study of 89 cases collected between 2015 and 2019. The diagnosis of orbital cellulitis was based on clinical and imaging elements. Results: The average age was 17.5 years. Exophthalmos was noted in 33% of cases, ophthalmoplegia in 18% of cases, diplopia in 4.5% of cases and ocular hypertonia in 11% of cases. Orbital CT scan allowed the diagnosis of subperiosteal abscess in 20% of cases and orbital abscess in 10% of cases. Sinusitis was the main infectious origin in children, while dacryocystitis predominated in adults. All patients received parenteral antibiotherapy combined with corticotherapy after 48 hours. Complications occurred in 10 cases, dominated by exposure keratitis, panophthalmitis and optic atrophy with permanent blindness. Conclusions: We emphasize the importance of rapid diagnosis and urgent treatment of orbital cellulitis.

Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

Purpose: Non-alcoholic fatty liver (NAFL) is comorbid to obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM). It is unclear whether NAFLD constitutes a direct risk factor for macrovascular disease in T2DM. This study aimed at revisiting the cardiometabolic traits linked to NADL and micro-/ macrovascular complications in a biethnic Caucasian and African cohort. Methods: Cross-sectional analysis of 568 of T2DM patients (515 Caucasians; 53 Africans) in whom the presence of NAFL was identified by ultrasonography and the cardiometabolic phenotype was exhaustively characterized, including carbohydrate homeostasis, comprehensive lipidogram including Lp(a), cumulative exposure to hyperglycemia, and prevalent micro/macrovascular complications. Results: FL was present in 73% of Caucasians and 36% of Africans (p − in both groups. A marked reduction in diabetic retinopathy (DR), ocular hypertonia and cataracts were found in FL+ of the two ethnicities. In FL+ Caucasians, relative risk of DR was −38%, cataracts −35%, and ocular hypertonia −42%. In FL+ Africans, risk of overall microangiopathy was −66% and that of DR −86%. Conclusions: An inverse association was observed between NAFL and the presence of diabetic retinopathy, cataract and ocular hypertonia. The ophthalmoprotection conferred by liver steatosis was found in Caucasians and Africans. Among the latter, hepatic steatosis was linked to lower lipoprotein(a) levels. There was no association between hepatic steatosis and prevalent macrovascular complications in neither of the two ethnic groups.

Primary Open Angle Glaucoma: Epidemiological, Clinical and Therapeutic Aspects of 63 Cases at National Hospital Center in Mauritania

Introduction: Primary open angle glaucoma (POAG) is an anterior optic neuropathy of chronic and progressive course, characterized by perimeter alteration and excavation of the specific optic disc. This neuropathy is usually accompanied by ocular hypertonia. The iridocorneal angle remains open in gonioscopy. POAG is the primary cause of irreversible blindness in adults around the world, posing a real public health and quality of life problem as well as an economic problem. The progressive and irreversible loss of vision makes POAG a disease that can lead to blindness. The main objective of our study is to describe the epidemiological, clinical and therapeutic aspects of primary open angle glaucoma in the ophthalmology department of the National Hospital Center of Nouakchott. Materials and Methods: It was a prospective descriptive study of 6 months (March 1st 2017 to August 30th 2017), on patients with a POAG with the presence of at least one of the three signs (intraocular pressure > 21 mmHg, papillary cup/disc vertical excavation ≥ 0.5 and a field altered apart from all other causes). All glaucoma patients seen during the study period benefited from a complete eye examination. The studied variables were the family history of glaucoma, age, intra ocular pressure (IOP) and pachymeter. Results: The mean age was 58.7 years. About 2/3 of the patients had a lower pachymeter to normal (63% of cases), a genetically thinner cornea results in an underestimation of the IOP measurement. The male was the most represented with a sex ratio M/F (1.42), the main characteristic factors were family history of glaucoma (39.7%), artery hypertension, diabetic and headache. The success rate of surgery was 69.8%, while 11% of our patients had refused any kind of treatment, no complications were noted, Conclusion: POAG is a multifactorial condition which can lead to blindness if not early diagnosed or if treatment is poorly conducted, hence the importance of prevention by screening and informing the population about this pathology.

Bilateral acute iris transillumination (BAIT) syndrome: literature review.

The authors conducted a literature review about bilateral acute iris transillumination (BAIT) syndrome, a new and relatively unknown syndrome that should be described and made known to the greatest number to avoid potential diagnostic and therapeutic errors. The first cases date back only to 2004 and a total of 79 cases have been published to date, mainly in Europe and especially in Turkey and Belgium. It mainly affects young women between the ages of 30 and 50, and symptoms are often preceded by an upper airway infection. There is also a majority of cases where the onset of the syndrome follows oral intake of moxyfloxacin. The clinical signs are dominated by strong photophobia, secondary to a spectacular transillumination of the iris. Other classical symptoms are conjunctival infection, eye pain, blurred vision, temporary ocular hypertonia, fixed mid-dilated pupils, and pigment dispersion in the anterior chamber with pigmentary deposits in the trabecular meshwork in gonioscopy, symptoms that may be mistaken for uveitis. After a few weeks or months of evolution, persistent sequelae were pupillary atony and chronic and bilateral transillumination of the iris, leading to significant photophobia and sometimes persistent ocular hypertension. The BAIT syndrome is close to the bilateral acute depigmentation of the iris (BADI) syndrome, which is similar to BAIT but lacks associated transillumination. A few cases of patients with BAIT syndrome on one eye and BADI syndrome on the contralateral eye have been described, which confirms some form of link between the two clinical entities.

Subcyclo laser procedure results in patients with glaucoma

Purpose. To analyse the results of subCyclo (subliminal transscleral cyclophotocoagulation) laser procedure for patients with glaucoma. Material and methods. The study included 50 eyes of 32 patients diagnosed with various subtypes of glaucoma for which we performed subliminal transscleral cyclophotocoagulation under retrobulbar anesthesia. After the procedure, all patients were advised to continue their antiglaucoma medication until further notice and we added a topical steroid for 2 weeks. The minimum follow-up period was 6 months. Results. The mean IOP (intraocular pressure) decreased from the preoperative value of 26.27 mmHg (±6.52) to 15.9 mmHg (±5.72) one day after the treatment. At 7 days, the average IOP was 13.72 mmHg (±4.31), 15.81 mmHg (±3.69) at 6 weeks, 15.94 mmHg (±5.66) at 3 months and 16.32 mmHg (±5.24) at 6 months. The second intervention was performed in 9 eyes due to poor IOP control after the first procedure, two eyes developed ocular hypertonia 6-8 hours after the procedure and one eye presented mydriasis after the procedure. Conclusions. Early results for this study showed that subCyclo laser procedure could determine a satisfactory decrease of the IOP with a low risk of complications. Abbreviations: IOP = intraocular pressure, TSCPC = transscleral cyclophotocoagulation, POAG = primary open-angle glaucoma, NVG = neovascular glaucoma, BCVA = best corrected visual acuity.

Efficacy of vitrectomy for the pseudophakic retinal detachment

Objective To observe efficacy of 25 G+ vitrectomy system with non contact wide angle lens in the treatment of pseudophakic retinal detachment. Methods A total of 71 eyes of 71 cases with pseudophakic retinal detachment were enrolled and underwent 25 G+ vitrectomy with non contact wide angle lens. The postoperative condition of retina, postoperative vision and complications were observed and analyzed. Results The follow-up time was 3-12 months, the retina was reattached successfully after once operation in 66 eyes (92.96%). Two eyes received second operations and a third in 1 eye to achieve retinal reattachment.The retinal detachment of severe PVR occurred was untreatable in 2 eyes. Finally there were 69 eyes (97.18%) achieved retinal reattachment. Preoperative mean visual acuity (logMAR) was (1.95±0.95) compared with (1.69±0.81) at 3 months after surgery, the difference was significant between them (t=7.535, P=0.000). At 6 months after surgery, the mean visual acuity was (1.35±0.75) compared with the preoperative one the difference was statistically significant (t=14.547, P=0.000). The postoperative complications were ocular hypertonia in 2 eyes, 1 eye with macular epiretinal membrane and 1 eye with silicone oil in anterior chamber. Conclusion 25 G+ vitrectomy system with non contact wide angle lens for the treatment of pseudophakic retinal detachment is a safe and effective therapy to achieve a high anatomic and functional success rate with few complications. Key words: Retinal detachment; Pseudophakic eye; Non contact wide angle lens; Vitrectomy, 25G+