Background: Twisted pouch syndrome (TPS), in which ileoanal (IPAA) patients is constructed in a twisted manner, was described as the develop the triad of small bowel obstructive (SBO) symptoms inlcuding obstructive defecation, erratic bowel habits, and severe abdominopelvic pain due to torsion of the pouch. Despite an exhaustive work-up, TPS was often not diagnosed until the time of redo pouch surgery, which requires disconnecting and reconnecting the pouch in a non-twisted manner, or neo-IPAA construction. Preoperative 3-dimensional (3D) reconstruction of IPAA radiographic computed tomography (CT) imaging has not previously been described. We aimed to determine if manual segmentation of staple-lines is feasible to aid in the preoperative diagnosis of otherwise occult IPAA pathology. Methods: This study represents a proof-of-concept cases series of patients undergoing surgical management of severe pouch dysfunction to determine if 3D manual segmentation of the linear pouch staple-line morphology could be used to diagnose variations of TPS. Manual segmentation of preoperative CT images was performed using standard, commercially available software to construct preoperative 3D video clips. Results: Patient 1 was a 35-year-old female with recurrent midgut volvulus resulting in SBO’s despite multiple laparotomies. Standard preoperative imaging did not reveal an obvious cause. Preoperative endoscopy suggested a chronic pouch volvulus, and 3D reconstruction revealed a 360-degree spiraling of the upper half of her pouch, and this was confirmed to be the lead point at the time of pelvic adhesiolysis, secondary to a occult tip of the J leak which caused the tip of the J to volvulize behind the pouch. The volvulus was reduced, pouch pexied, and she was diverted with intentional tension. After this staged surgical correction, there was no recurrence of her volvulus or SBO at 14 months. Patient 2 was a 19-year-old female with recurrent SBOs every several weeks, presumed secondary to pelvic floor dysfunction. Preoperative imaging was unrevealing, and preoperative endoscopy revealed a tip of the J on the left. 3D reconstruction revealed straight staple-lines, but the tip of the J and afferent limb both to the left of midline. Intraoperatively she was found to have an unintentionally 180-degree twisting of her pouch with the mesentery anteriorly. After redo IPAA, she had no further SBOs at 2 months. Patient 3 was a 33-year-old female with severe pouch dysfunction. Preoperative imaging was unrevealing, and preoperative endoscopy showed spiraling of the lower half of her pouch. 3D reconstruction revealed a 360-degree spiraling of the lower half of her pouch. 3D reconstruction was consistent with TPS which was confirmed at time of redo IPAA. Conclusion(s): Three-dimensional segmentation of ileoanal pouch staple-line morphology is highly feasible using readily available technology. In our practice, this has proven to be an extremely useful, “go to” radiologic adjunct which may be used to successfully diagnose occult mechanical pouch complications requiring redo pouch surgery. Further study, to characterize and validate, with comparison to normal pouches, is ongoing of what we have observed to be a clinical breakthrough to aid in the diagnosis of twisted pouch syndrome.
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