Observation Time Research Articles

Encoding of object location in a scrolling display.

There are two main characteristics of visual information processing when viewing an image by scrolling on a small screen: viewing the image sequentially, section by section, owing to the limited visible area, and moving the image to view the desired section of the image. In this study, we investigated the effects of these characteristics on the encoding of object location. The participants were required to observe an image containing 10 objects under three viewing conditions without a time limit and to recall the location of the target object. The viewing conditions were a scrolling condition, a moving-window condition in which a fixed image was viewed by moving the window, and a no-window condition in which the entire image was viewed without a window. The results showed that although the recall accuracy did not differ among the conditions, the observation time increased in the order of scrolling, moving-window, and no-window conditions. These results indicate that in a scrolling view, the object location can be encoded with the same accuracy as that in a full view; however, more time is required for encoding. This finding suggests that viewing the image sequentially and moving the image degrade the encoding of object location.

Abstract MP20: Leveraging Electronic Health Records to Assess Neighborhood Advantages and Risk of Cardiovascular Outcomes Among Hypertensive Patients

Introduction: Hypertension disproportionately impacts socially disadvantaged groups in the U.S. with increasing prevalence and suboptimal control rates. Our study aims to examine the association between neighborhood-level social vulnerability and hypertension outcomes using electronic health record (EHR) data from a large regional health system. Methods: We conducted a retrospective analysis of EHR data from the Sentara Health System, covering the period from January 1st, 2010, to December 31st, 2022. We assigned a Social Vulnerability Index (SVI) based on the residential census tract of each patient and established a longitudinal cohort of patients who consistently utilized healthcare services. To be included in the study, patients were required to have a minimum of five years of observational time and to have healthcare visits in at least 50% of the observed years. The study focused on patients diagnosed with hypertension—either through a hypertension diagnosis, a blood pressure measurement exceeding 140/90, or antihypertensive medication prescriptions. We utilized multivariate Cox Proportional Hazards models to analyze the associations of SVI with cardiovascular outcomes and blood pressure control (<140/90 mmHg). Results: The longitudinal cohort consisted of 55,060 patients, with an average age of 54 years (Interquartile range: 42-65), 30.0% of whom were Black adults and 60.0% were females. Compared to patients residing in the most advantaged neighborhoods (quartile 1 of SVI), those in more disadvantaged neighborhoods (quartiles 2, 3, and 4) had hazard ratios for composite cardiovascular endpoint (myocardial infarction, heart failure, and stroke) of 1.22 (95% CI, 1.19-1.25), 1.40 (95% CI, 1.37-1.44), and 1.64 (95% CI, 1.60-1.68), respectively, after adjustment for age and sex. Additionally, blood pressure control was significantly lower in higher SVI quartiles, with control rates in quartiles 1 through 4 at 78.4%, 76.5%, 75.2%, and 72.8%, respectively (P<0.001). Among the SVI themes, socioeconomic status (theme 1) and housing type and transportation (theme 4) were associated with the highest hazard ratios for cardiovascular outcomes. Conclusions: Neighborhood-level social vulnerability is significantly associated with worse hypertension control and adverse cardiovascular outcomes. Health systems can employ tailored interventions targeting high-risk neighborhoods to reduce disparities and enhance health outcomes for vulnerable populations.

199. YOUNGER AGE AS AN INDEPENDENT FACTOR FOR SUBSEQUENT HEAD AND NECK CANCER AFTER CURATIVE ESOPHAGECTOMY FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Abstract Background Post-operative survival of esophageal cancer patients has improved with advances in technology and treatment modalities. However, squamous cell carcinoma often affects the esophagus together with the head and neck regions, with second primary head and neck cancer (SPHNC) adversely influencing the patients’ quality of life. Therefore, patients with esophageal squamous cell carcinoma (ESCC) should be carefully followed up post-operatively. This study evaluated the risk of developing SPHNCs after an esophagectomy for ESCC. Methods Patients with ESCC who underwent curative esophagectomy from January 2008 to December 2017 from two tertiary medical centers, Taipei Veteran General Hospital and Kaohsiung Veteran General Hospital, were retrospectively reviewed. SPHNC development was documented according to anatomic region and the cumulative incidence rate and risk factors were analyzed. Results The median observation time of the 435 patients included in our study was 48.5 months [interquartile range (IQR) 16.7–92.4 months]. Among the ESCC patients after curative esophagectomy, younger age <50 [hazard ratio (HR) 4.13, 95% CI: 2.53–6.75, p < 0.001) was the only independent factor for developing SPHNCs in the multivariable analysis. The cumulative incidence rate of SPHNCs of patients aged < 50 years old was 14.3%, 22.1%, and 34.2% after 3, 5, and 10 years, respectively. Conclusion There was a high risk of secondary cancer after ESCC in the upper aerodigestive tract, especially the head and neck regions, therefore active surveillance is strongly recommended, especially in younger patients.

Small dop of comonomer, giant shift of dynamics: α-methyl-regulated viscoelasticity of poly(methacrylamide) hydrogels

α-Methyl groups play significant roles in the regulation of water molecules within both small molecular systems and bio-macromolecular systems. Systematically studying the influence of α-methyl on the dynamics of water molecules within hydrogel systems is therefore worthwhile. In this study, we prepared a series of hydrogen-bonded (H-bonded) hydrogels with varying densities of α-methyl groups by copolymerizing methacrylamide (MAm) with its α-methyl-absent analogue, acrylamide (Am). Introducing a small amount of Am (≤6 mol%) into the polymer chain resulted in significant shifts in the viscoelasticity of the hydrogels. The hydrogels exhibit a “time-temperature-α-methyl equivalence”, meaning that introduction of α-methyl-absent monomer has effects similar to elevating temperature and prolonging observation time on the dynamic properties. Based on low-field nuclear magnetic resonance spectroscopy and Raman scattering, a “hydrophilic defects-assisted H-bonds dissociation” mechanism is proposed, depicting that the α-methyl-absent monomer can disturb the rearrangement of water molecules surrounding the polymer chain and accelerate chain dissociation. These findings enabled the copolymer hydrogels with functions such as fast self-healing and tunable interface adhesion.

Visual field loss and falls requiring hospitalisation: results from the eFOVID study.

Visual fields are important for postural stability and ability to manoeuvre around objects. Examine the association between visual field loss and falls requiring hospitalisation in adults aged 50 +. Older adults aged 50+ with and without visual field loss were identified using a fields database obtained from a cross-section of ophthalmologists' practices in Western Australia (WA). Data were linked to the Hospital Morbidity Data Collection and WA Hospital Mortality System to identify participants who experienced falls-related hospitalisations between 1990 and 2019. A generalised linear negative binomial regression model examined the association between falls requiring hospitalisation for those with and without field loss, based on the better eye mean deviation (mild: -2 to -6dB, moderate: -6.01dB to -12dB, severe < -12.01dB) in the most contemporaneous visual field test (3years prior or if not available, 2years after the fall), after adjusting for potential confounders. A total of 31 021 unique individuals of whom 6054 (19.5%) experienced 11 818 falls requiring hospitalisation during a median observation time of 14.1years. Only mean deviation index of <-12.01dB (severe) was significantly associated with an increased rate of falls requiring hospitalisations by 14% (adjusted IRR 1.14, 95% CI 1.0-1.25) compared with no field loss, after adjusting for potential confounders. Other factors included age, with those aged 80+ having an increased rate (IRR 29.16, 95% CI 21.39-39.84), other comorbid conditions (IRR 1.49, 95% CI 1.38-1.60) and diabetes (IRR 1.25, 95% CI 1.14-1.37). Previous cataract surgery was associated with a decreased rate of falls that required hospitalisations by 13% (IRR 0.87, 95% CI 0.81-0.95) compared with those who did not have cataract surgery. The findings highlight the importance of continuous clinical monitoring of visual field loss and injury prevention strategies for older adults with visual field loss.

Prognostic Impact of Postoperative Recurrence in Patients With Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.

Mutations in the epidermal growth factor receptor (EGFR) gene are the most common targetable gene alterations in non-small cell lung cancer (NSCLC). In Japan, approximately 40% of patients who undergo surgical resection for non-squamous NSCLC have EGFR mutations. However, no long-term studies have been conducted including a large number of EGFR-positive NSCLC patients with postoperative recurrence (PR). We conducted a retrospective observational study of the data of EGFR-positive NSCLC patients with PR who had undergone surgery at the Shizuoka Cancer Center between October 2002 and November 2017. We evaluated post-recurrence overall survival (PRS) and postoperative overall survival (POS) using the Kaplan-Meier method and identify any associations between the clinical variables at recurrence and PRS using univariate and multivariate analysis. We enrolled 162 patients. The median observation time for PRS was 4.95 years (range, 0.82-13.25) and POS was 5.81 years (range, 2.84-16.71). The median PRS was 5.17 years (95% confidence interval [CI], 3.90-5.61) and POS was 7.07 years (95% CI, 5.88-8.01). Univariate analysis identified male sex (median PRS: 3.32 vs. 5.39 years; p < 0.05), bone metastasis (median PRS: 2.43 vs. 5.33 years; p < 0.05), and central nervous system (CNS) metastasis (median PRS: 3.05 vs. 5.39 years; p < 0.05) and multivariate analysis identified bone metastasis (hazard ratio [HR], 2.01; 95% CI, 1.23-3.28; p < 0.05) and CNS metastasis (HR, 1.84; 95% CI, 1.14-2.98; p < 0.05) as poor prognostic factors. The pattern of recurrence (oligo vs. non-oligo recurrence) was not a prognostic factor. Logistic regression analysis revealed the association between sex and the presence bone/CNS metastasis at recurrence. Our data may help visualize future prospects and determine the timing of osimertinib initiation. New treatment strategies need to be developed for patients with bone/CNS metastasis at the first recurrence.

Recovery rate from conduction disorders in patients with permanent pacemaker implantation after transcatheter aortic valve implantation

BackgroundsPermanent pacemaker implantation (PPMI) is one of the greatest disadvantages of transcatheter aortic valve implantation (TAVI). To seek the predictors and clinical impacts of PPMI and investigate the recovery rate...

Electrosynthesis of ferrate from iron waste and seawater salts as Antibacterials for water pollutant treatment

The synthesis of ferrate from waste iron and seawater salt as antibacterial pollutants for Staphylococcus aureus and Escherichia coli in water treatment has been successfully carried out. The synthesis phases comprised the preparation of NaOCl from saltwater, Fe(OH)3 synthesis from iron waste, and the electrosynthesis of ferrate. The successful synthesis was confirmed by XRD at 30.05°, 36.87°, 40.51°, and 75.30° as Na2FeO4 (JCPDS file: 890169), the functional groups of FeO42- at 779 and 879 cm−1 in the FTIR spectrum. Moreover, it was also confirmed by the dominance of Fe and O element content in XRF and SEM-EDX, as well as the stability and ability to produce hydroxide radicals in Fluorescence analysis. Furthermore, tests of the antibacterial effectiveness were carried out with variations in doses, time observation, and method variations (agar well, disc-diffusion, and turbidimetry) using comparison variables positive control (ampicillin) and negative control (distilled water). The test results showed antibacterial ability with the inhibitory zone category “very strong” and “strong” with 100 % inhibition against E. coli bacteria 5.954 x 108 CFU/mL and 4.723 x 108 CFU/mL S. aureus. This ability increases with the dose of ferrate addition and decreases with the observation time of inactivation. Bacterial inactivation occurs through oxidation and coagulation adsorption by reactive oxygen species (ROS). E. coli is more sensitive than S. aureus due to its thinner membrane structure, allowing more manageable penetration. This research is expected to overcome the problem of iron waste while turning it into something useful as an antibacterial treatment of pollutants in the aquatic environment.

Abstract P442: Impact of arterial stiffness on the blood pressure lowering effect of the dual endothelin antagonist aprocitentan in patients with resistant hypertension

Background: The phase-3 PRECISION study demonstrated the efficacy of aprocitentan to lower both office and ambulatory blood pressure (BP) in patients with resistant hypertension. Increased arterial stiffness has been associated with less favorable responses to pharmacologic BP lowering therapies. In this post-hoc analysis, we investigated the impact of arterial stiffness, assessed by the ambulatory arterial stiffness index (AASI), on the BP lowering effect of aprocitentan. Methods: The study included a 4-week double blind period (aprocitentan 12.5 mg, 25 mg, or placebo) and a 32-week single blind period (aprocitentan 25 mg). A total of 730 patients with resistant hypertension were randomized and 633 had available ambulatory BP monitoring (ABPM) results at baseline. The AASI was calculated from ABPM data as 1 minus the regression slope of diastolic on systolic BP. The patient population was dichotomized into two groups according to the baseline median AASI. Results: Patients with higher baseline AASI (≥0.54) tended to be older (63±11 versus 60±10) and to have a higher 24-hour ambulatory systolic BP (140±14 versus 135±14 mmHg) than patients with lower AASI (&lt;0.54). These patients with higher baseline AASI were also more likely to have chronic kidney disease stage 3-4 corresponding to an estimated glomerular filtration rate in the 15 to 60 mL/min/1.73 m 2 range (27% versus 18%). The BP lowering effect of aprocitentan at Week 4 was similar for both the patients with stiffer vasculature who have a higher baseline AASI (≥0.54) and for those with a lower AASI (&lt;0.54) (Table 1). No relevant change in AASI was reported with aprocitentan treatment at Week 4 (end of the double-blind period) or Week 36 (end of the single-blind period). Conclusion: Aprocitentan is an effective BP lowering therapy across the arterial stiffness continuum observed in patients with resistant hypertension. Longer observation times are needed to fully assess the impact of treatment on this structural and functional parameter.

Transient Electromagnetic Field Response Analysis Considering Dam Boundary Conditions

Abstract The transient electromagnetic (TEM) method has outstanding advantages in detecting depth and response information and can be used to detect anomalies hidden deep inside dams. However, the current data analysis method based on geological exploration is inapplicable to the interpretation of dam detection data, the main reason being the lack of consideration of the influence of dam boundary conditions on the diffusion of the TEM field. In this work, by establishing a numerical model of a dam for TEM detection, the effects of the dam slope ratio, upstream water body, overburden, and other dam boundary conditions on the TEM field were studied. The results showed that the slope ratio made the propagating TEM field to exhibit a constraining behavior, and a negative deviation could be seen in the attenuation curve, indicating a false high-resistance anomaly. The upstream water body distorted the diffusion of the electromagnetic field, and the low-resistance covering layer caused a low-retardation retention phenomenon in the magnetic field, leading to a positive deviation in the attenuation curve, indicating a false low-resistance anomaly. The influence of the boundary conditions was present throughout the entire observation window in which the detection was performed, and the sensitivity of the magnetic field to these boundary conditions was significantly higher than that of the change rate of the magnetic field. With the increase in the observation time, the main influencing factors were the slope ratio, overburden layer, and upstream water body.

Prognostic factor of patients with short bowel syndrome due to nonCrohn disease: A single institution observational study.

Short bowel syndrome (SBS) is a severely disabling and potentially life-threatening condition. Survival data for patients with SBS are limited. This study aimed to investigate prognostic factors in patients with SBS undergoing surgery. We reviewed the medical records of 27 consecutive patients with SBS who were treated at our hospital between January 2018 and December 2022. SBS was defined as a remaining small bowel length <200 cm, excluding patients with Crohn disease. Of the 27 patients identified, 17 were males and 10 were females, with a median age of 77 (46-90) years and a total observation time of 137 (2-1628) days. All patients underwent surgery and received parenteral nutrition (PN) and follow-up in our hospital. Superior mesenteric artery stenosis (44.4%) and nonocclusive mesenteric ischemia (25.9%) most commonly caused SBS. The median residual small bowel length and postoperative hospital stay were 50 (5-150) cm and 48 (2-104) days, respectively. Jejunostomy was performed in 17 (62.9%) patients, and 4 (14.8%) patients were weaned off their PN. Death occurred in 14 (51.8%), and the median survival time was 209 days. The survival outcome was compared between the survival (n = 13) and the death groups (n = 14). Jejunostomy and PN rates were significantly higher in the death group (P < .01, P = .03, respectively). SBS is associated with significantly higher mortality rates. Jejunostomy and long PN duration are significantly associated with death in patients with SBS.

Delayed kernels for longitudinal survival analysis and dynamic prediction.

Predicting patient survival probabilities based on observed covariates is an important assessment in clinical practice. These patient-specific covariates are often measured over multiple follow-up appointments. It is then of interest to predict survival based on the history of these longitudinal measurements, and to update predictions as more observations become available. The standard approaches to these so-called 'dynamic prediction' assessments are joint models and landmark analysis. Joint models involve high-dimensional parameterizations, and their computational complexity often prohibits including multiple longitudinal covariates. Landmark analysis is simpler, but discards a proportion of the available data at each 'landmark time'. In this work, we propose a 'delayed kernel' approach to dynamic prediction that sits somewhere in between the two standard methods in terms of complexity. By conditioning hazard rates directly on the covariate measurements over the observation time frame, we define a model that takes into account the full history of covariate measurements but is more practical and parsimonious than joint modelling. Time-dependent association kernels describe the impact of covariate changes at earlier times on the patient's hazard rate at later times. Under the constraints that our model (a) reduces to the standard Cox model for time-independent covariates, and (b) contains the instantaneous Cox model as a special case, we derive two natural kernel parameterizations. Upon application to three clinical data sets, we find that the predictive accuracy of the delayed kernel approach is comparable to that of the two existing standard methods.

Regression of Chiari malformation type 2 following early postnatal meningomyelocele repair-a retrospective observation from an institutional series of patients.

Spontaneous regression of Chiari malformation type 2 (CM2) is observed rarely, as CM2 is associated with meningomyelocele (MMC) that issurgically repaired either pre- or early postnatally. While the radiological regression of CM2 occurs frequently following prenatal repair of MMC, it has been reported in only a few studies after postnatal repair. From the consecutive series of children with postnatally repaired MMC, we reviewed the clinical and radiological data regarding CM2, particularly its regression either spontaneously or following CSF diversion. Eighteen children underwent postnatal repair of MMC between February 2011 and April 2023. CM2 was present in 16 (89%), and hydrocephalus in 15 children (83%), requiring shunting in 14 of them. During the mean clinical observation time (from birth to April 2023) of 59 ± 51months, three children with CM2 (19%) underwent 1-2 foramen magnum decompressions (FMD), five children (28%) 1-4 surgical untethering procedures and 13 children with shunted hydrocephalus (93%) 1-5shunt revisions. Out of sixteen children with CM2, we observed regression of CM2 on MRI in only one case (6%) during the mean radiological follow-up (from birth to the last MRI taken) of 49 ± 51months. In our experience, spontaneous regression of CM2 in children with postnatally repaired MMC occurs quite rarely. Pathophysiological mechanisms behind the development of CM2 in children with MMC remain unclear, but our observation supports the hypothesis of an association between the downward displacement of the hindbrain and the low intraspinal pressure secondary to CSF leakage in children born with MMC.

Surface water dynamics of Lake Chad Basin (Sahelian Africa) based on daily temporal resolution Earth observation time series

ABSTRACT Water availability is vital for the sustenance of livelihoods in the Lake Chad Basin. However, the daily and seasonal dynamics of open water bodies are not well understood. This study aims to (1) analyze the daily and seasonal dynamics of water bodies, (2) estimate changes in surface water area extent including trends and change points, and (3) assess the connection between surface water extent and seasonal rainfall variation. To achieve this, we used the Global WaterPack and ERA5-Land daily aggregated datasets. We employed time series decomposition, trends analysis, and temporal lag correlation in our analysis. The results showed strong seasonal patterns of natural lakes compared to reservoirs/dams. Between 2003 and 2022, Lake Chad averaged 2,475.64 km2. The Northern pool of Lake Chad exhibited significant fluctuations, remaining below 600 km² between 2005 and 2012, from 2016 to 2019), with less than 350 km2 lasting only for a few days annually. The Southern pool averaged between 2,200 and 2,400 km2, except during drought years (2006–2007), specifically between the days of the year to approximately 66, and days 301–365/6. In Lake Fitri, the yearly maximum and minimum water extents were observed between days 1–59 and 305–365/6, and between days 60 and 304, respectively.

Unruptured intracranial aneurysm volume change patterns and association with age, sex, location in vascular tree, and common risk factors: a single-centre retrospective study.

Unruptured intracranial aneurysms pose a significant clinical and decision-making dilemma. Increase in dome size is one of the crucial indications for treatment. Almost no data exists as to how aneurysms change in size over time. 102 patients (76 women) who had a total of 501 CT examinations were included in the study. Inclusion criteria were: at least three CT angiography studies, an observation period of at least three years, or bleeding during the follow-up period. In each study, the volume of each aneurysm was measured at least four times by two experienced neuroradiologists with the use of dedicated tools. Collected data was used to obtain numerical volume change models for each aneurysm. 149 aneurysms were analysed in the study (118 in women) No significant differences in location, size or age of observation were detected between men and women. Median follow-up was 5.64 years (IQR 4.17-7.71) and total aneurysm observation time amounted to 964.59 years. There were 57 branching zone aneurysms (women 46), 44 sidewall aneurysms (women 36), 20 anterior communicating artery aneurysms (women 16), 20 posterior communicating artery aneurysms (women 13), and eight posterior circulation aneurysms (women 7). 78 (52%) aneurysms remained stable (women 59), 24 (16.6%) increased their volume (women 20), and five (3.4%) decreased (women 4). In 42 (28%) cases, we observed non-uniform routes of volume changes over surveillance (women 35). In the last group, analysing the whole period of follow-up, 29 (69%) did not change volume (women 24), 11 (26%) grew (women 10), and two decreased in size (4.8%, women 1). Bifurcation zone aneurysms, lower aspect ratio, lower patient age, and higher initial volume were associated with an increased risk of aneurysm growth. Posterior circulation aneurysms presented the lowest rate of volume increase. A substantial amount of followed up aneurysms could change volume in a non-uniform way, and an increase in volume may not lead to aneurysm rupture.

The influence of the location of arable land incorporating its roughness on the optimal time when the land reaches its mean diurnal blue-sky albedo value

This work is a supplement the article “Influence of arable land location incorporating its roughness on blue-sky albedo variation” [J Quant Spectrosc Radiat Transf. 296 (2023) 108,440]. It quantifies the influence of the location (expressed by latitude) of bare arable land on a global scale and its roughness on the optimal time (To) of land observation with acceptable errors to determine its mean diurnal blue-sky albedo (αd). The article also discusses how the risk of making these errors changes with the change in land latitude. The study focuses on the influence of the location of one soil unit, Cambisol, common to all latitudes in both hemispheres. This is the same unit whose albedo variation was analyzed in the supplementary article mentioned above.

Cerium oxide for L-band Q-switched pulse laser generation

Cerium oxide (CeO2), a rare earth metal oxide belonging to the lanthanide group is a mature engineered nanoparticle that has been developed for various industry applications. The nanoparticle features defects in its lattice structure, which is highly advantageous for bandgap tuning, and is acclaimed for its least cytotoxicity among other metal oxides. In this work, CeO2 is employed as a saturable absorber (CeO2-SA) in the generation of an L-band Q-switched erbium-doped fiber laser. Q-switching was attained at 33.33 mW pump power threshold with a central wavelength of 1600.512 nm. Within 33.33 mW to 153.20 mW pump power range, the Q-switched laser obtained pulse repetition rates between 11.00 to 34.48 kHz, and pulse widths between 39.0 to 12.0 µs, with a high maximum pulse energy of 410 nJ. The Q-switched fiber laser remained stable over a 45-minute observation time at 153.20 mW pump power. The room temperature and direct mechanical deposition fabrication technique of the CeO2-SA in this work demonstrates the extreme simplicity and low cost of the device, which would reduce the overall cost and facilitate a wider technology adoption of pulse laser systems.

Accuracy of MSBase criteria to diagnose secondary progressive multiple sclerosis in large German real-world patient cohort

Background and ObjectivesAccurate diagnosis of secondary progression in multiple sclerosis (MS) remains a challenge since standardized criteria are missing. In 2016, the MSBase registry presented an algorithm that enabled the diagnosis of secondary progressive multiple sclerosis (SPMS) more than three years earlier compared to diagnosis by neurologists. This work aimed to test whether this approach is equally effective in a real-world cohort of MS patients. MethodsThis longitudinal retrospective study analyzed clinical data of outpatients with MS recorded until October 2020 in the NeuroTransData registry, a Germany-wide network of 153 certified neurologists. Patient data had been captured in time during clinical visits employing a defined standardized clinical data set in the webbased NeuroTransData patient management platform DESTINY®. The time between the diagnosis of relapsing-remitting multiple sclerosis (RRMS) to SPMS onset was compared with one determined using MSBase criteria (MSBC). Group 1 consisted of patients diagnosed with SPMS during the observation period, whereas group 2 included RRMS patients who did not convert to SPMS during the observation period. ResultsOf 21,281 patients with MS included in our registry, 194 and 9506 patients were allocated to groups 1 and 2, respectively. 10.3% of patients with RRMS were diagnosed with SPMS simultaneously, whereas 60.8% were diagnosed with SPMS at least 3 months earlier by treating neurologists compared to the MSBC. In group 1, the MSBC showed a low sensitivity of 32.0% and an accuracy of 61.4% but a high specificity of 89.6%. In group 2, the MSBC identified 7.8% of patients with SPMS at some point during the observation time. Moreover, test-retest variability remains a challenge since 29.4% of patients diagnosed with SPMS by treating physicians did not fulfil the MSBC at a later point in time. DiscussionThese results are inconsistent with earlier SPMS diagnosis using the MSBC compared to clinical diagnosis by treating physicians. Therefore, there remains a need for an operational, structured, and validated approach to SPMS diagnosis.

Survival and complication rates of tooth- and implant-supported restorations after an observation period up to 36 years.

Tooth- and implant-supported fixed dental prostheses are well-documented and aesthetic treatment alternatives, and after a comprehensive periodontal treatment, a protocol with a good long-term prognosis if the maintenance program is strictly followed. To reexamine a pre-existing patient cohort in order to obtain estimated long-term survival and complication outcomes of fixed dental prostheses. For this study, patients treated with fixed dental prostheses between 1978 and 2002 were reexamined between 2019 and 2020. The restorations were divided in single crowns and fixed dental prostheses supported by teeth (TSC, FPTDP) and implants (ISC, FPIDP). Survival and complication rates were obtained. Kaplan-Meier functions were used to model complication probabilities, and average hazard ratios of different strata were compared using weighted Cox regression. The mean observation time of 40 patients and 223 reconstructions was 20.3 (±9.7, 1.2-36.2) years. The estimated survival rates were 84% (CI: 77%-92%) for TSC, 63% (CI: 51%-79%) for FPTDP, 87% (CI: 71%-100%) for ISC, and 64% (CI: 34%-100%) for FPIDP after 25 years. Biological complications included carious lesions (10.6%), periodontitis (7.9%), and peri-implantitis (6.8%). Technical complications included chipping (20.2%) and loss of retention (10.8%). Biological complications lead to abutment loss in more than two-thirds of cases, regardless of the type of abutment (tooth or implant). Technical complications are less associated with abutment loss than biological complications.

A new approach to drug intravenous compatibility research: the case of obstetric parenteral drugs

ObjectivesThe product information and literature does not provide confirmation of compatibility for co-administration of all commonly used drug pairs in obstetrics. However, there is a need for co-administration of these...