Periodontal diseases are multifactorial infectious diseases that are caused by pathogenic bacteria that harbour subgingival niches that initiates tissue destruction with the elevation of certain inflammatory mediators. Although there are many systemic and local factors that play an important role in progression of this disease. Psychosocial stress is one of the modifiable factor that influences both systemic and periodontal health. As we all know stress is the modifiable risk factors in number of chronic diseases like chronic periodontics in which stress response not only alters immune function but also causes dysbiosis of oral biofilm formation by expression of more pathogenic gene and taxa composition acting via several neuroendocrine mechanisms and thereby modulating the course and progression of the periodontal diseases. Although there are several biomarkers of stress present in saliva and blood, due to difficulty in assessment of stress in terms of amount and duration in patients, it serves as the major hindrance to assess and manage the deleterious effect of stress on periodontal health. Keywords: Acute stress, Chronic Periodontal disease, Chronic stress, Stress