A 71-year-old female patient, totally edentulous, presented an asymptomatic lesion in the right buccal mucosa, close to the mandibular branch. Clinically the lesion showed a pedunculated nodule with a smooth surface, normal coloring, softened consistency, measuring approximately 2cm x 2cm. The patient reported a slow growth, with a 4-year evolution. No ulcerations were observed in the region. According to these characteristics, the clinical diagnostic hypotheses were inflammatory fibrous hyperplasia, fibroma, or lipoma. Therefore, the tumor was excised under local anesthesia, and the specimen was submitted to histopathological analysis. Microscopically, we observed a nodular limited lesion with dispersed mature adipocyte proliferation in a dense collagenous fibrous stroma, and lined with hyperplastic and hyperkeratotic squamous epithelium. Given these characteristics, the lesion was diagnosed as fibrolipoma, a histopathological variant of lipoma that is rare in the buccal mucosa. The treatment was concluded with surgical excision and, currently, the patient has shown no recurrence. A 71-year-old female patient, totally edentulous, presented an asymptomatic lesion in the right buccal mucosa, close to the mandibular branch. Clinically the lesion showed a pedunculated nodule with a smooth surface, normal coloring, softened consistency, measuring approximately 2cm x 2cm. The patient reported a slow growth, with a 4-year evolution. No ulcerations were observed in the region. According to these characteristics, the clinical diagnostic hypotheses were inflammatory fibrous hyperplasia, fibroma, or lipoma. Therefore, the tumor was excised under local anesthesia, and the specimen was submitted to histopathological analysis. Microscopically, we observed a nodular limited lesion with dispersed mature adipocyte proliferation in a dense collagenous fibrous stroma, and lined with hyperplastic and hyperkeratotic squamous epithelium. Given these characteristics, the lesion was diagnosed as fibrolipoma, a histopathological variant of lipoma that is rare in the buccal mucosa. The treatment was concluded with surgical excision and, currently, the patient has shown no recurrence.
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