In order to weaken the ground vibration caused by mechanical equipment, a vibration isolation platform of nonlinear vibration isolation system is proposed. The influence of flexible foundation and nonlinear isolator parameters on the performance of nonlinear vibration isolation platform is studied. By optimizing the nonlinear parameters of the vibration isolation platform, the vibration response of equipment vibration is effectively blocked. The research results show that the structural parameters such as stiffness and damping of the nonlinear vibration isolation system affect the vibration mode of the vibration isolation platform, thus affecting the vibration response of the whole system. Applying the nonlinear vibration isolation system to the project, the impact of the vibration of the refiner on the vibration of the floor is greatly reduced. It shows that this method can be used to reduce the foundation vibration caused by the equipment, improve the operation status of the equipment, and increase the safety factor of the building.