Stable isotope measurement of in vivo nitric oxide production in health and disease: an updated systematic review and meta-analysis.

Single-pore silica nanotherapeutic platform with pH-Responsive NO release for osteoporosis repair.

The role of nitric oxide in skin inflammation and the pathogenesis of psoriasis.

Bidirectional coupling of neuronal Ca2+ and nitric oxide signals visualized by a dual biosensor.

Maize (Zea mays L.) is one of the major grain crops worldwide that is particularly vulnerable to waterlogging (WL) stress. Glutathione (GSH) and nitric oxide (NO) are known to protect plants from a variety of abiotic stresses; however, their potential for improving WL tolerance in maize remains unexplored. The present study examined the impact of exogenously applied GSH and NO on maize plants exposed to WL-stress. Our findings revealed that GSH + NO-treated waterlogged maize plants grew better and produced more biomass than only WL-stressed plants. The improved performance of GSH + NO-sprayed WL-stressed maize seedlings was supported by the increased root dry and fresh weight, shoot length, shoot dry and fresh weight, chlorophyll a, chlorophyll b, and carotenoid content. Exogenous GSH and NO treatments significantly enhanced the amounts of leaf proline, leaf soluble sugars, and total protein in maize seedlings, suggesting adaptive metabolic reprogramming under stress. The increased malondialdehyde (MDA) levels and accumulation of hydrogen peroxide (H2O2) in maize leaves and roots revealed that WL caused significant oxidative damage. Exogenous GSH, NO individually, and combinedly significantly decreased total H2O2 and MDA contents in both leaves and roots. Exogenous GSH and NO reduced oxidative stress by increasing peroxidase activity, ascorbic acid, and anthocyanin content in maize leaf and root tissues. Our findings emphasize the possible relevance of GSH and NO, simultaneously and individually, in enhancing adaptive mechanisms in maize seedlings for reducing WL-induced damage. Although the GSH + NO-mediated approach shows promise for mitigating WL-stress in maize under controlled conditions, further field-based investigations are required to validate its practical applicability.

Nitric oxide (NO) plays a central role in wound healing, by regulating vascular homeostasis, inflammation, and antimicrobial effects. However, chronic diabetic wounds are difficult to heal due to the hyperglycemic microenvironment, which reduces endogenous NO production. Therefore, developing intelligent dressings capable of spatiotemporally programmed NO delivery holds great promise in promoting diabetic wound healing. Herein, we engineered an environmentally activatable hydrogel that enabled on-demand NO release for diabetic wound healing. The CS-SNAP hydrogel was achieved by covalent grafting of NO donor (S-nitroso-N-acetylpenicillamine, SNAP) onto the matrix of carboxymethyl chitosan methacryloyl (CMCSMA), and by subsequent fast photopolymerization during only 10 s. The CS-SNAP hydrogel enabled sustained release of NO over 300 min by simply modulating ambient light and temperature. When applied to diabetic wounds, not only did the CS-SNAP hydrogel exhibit effective antibacterial activity, but it also showed good angiogenic ability and promoted M1-to-M2 polarization of macrophages. Together, this environmentally activatable platform demonstrates great potential to shorten the inflammatory phase of diabetic wounds, prevent bacterial colonization, and accelerates diabetic wound healing.

Sensitive and specific methodology for detection of labile NO-ferroheme complexes in vitro and in blood.

Hypoxia-activated dual donors of H2S and NO alleviate myocardial injury in coronary heart disease via synergistic mechanisms.

Isolation, structural re-elucidation of two active prenylated flavonoids from Morus alba L. twigs responsible for anti-inflammatory effects: an in vitro and in silico approach.

A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds.

Gut microbiota-derived isoxanthohumol metabolite, 8-prenylnaringenin, mitigates endothelial dysfunction in Angiotensin II-induced hypertension through G protein-coupled estrogen receptor-mediated eNOS activation.

A synthetic gene circuit to convert biochemical signals to electrical signal in engineered sensory bacteria for electrochemical biosensing.

Cissatriterpenoids D-L, nine undescribed polyhydroxylated oleanane triterpenoids from Cissampelos pareira var. hirsuta.

Auroranes A-G: Polyoxygenated cyclohex(a/e)ne diterpenes from Kaempferia aurora and their anti-inflammatory activity via inhibition of nitric oxide production.

A novel macrophage membrane-camouflaged ultra-small copper sulfide and photothermal-responsive nitric oxide donor nanocomposites for enhanced synergistic antitumor therapy.

S-nitrosylation of Dexras1 attenuates fear memory generalization in the infralimbic cortex.

α-Glucosidase inhibitory and anti-inflammatory activities of components from Tinospora sinensis.

Cascade ROS-modulating Au/Cu nanozyme hydrogel with nitric oxide release ability for accelerated diabetic foot ulcer healing.

Effects of cyanobacterial metabolites and their mixtures on biomarkers of oxidative stress in RTgill-W1 cells.

Nitrogen Species Modulate Macrophage ER Stress to Preserve Alveolar Bone: A Translational Adjunct for Periodontal Care.