Reports have emanated from a number of regions in the world indicating that various ethnic groups are intolerant to lactose in milk. We accomplished lactose tolerance tests on four major tribal groups in Nigeria: Yoruba, Ibo, Fulani, and Hausa. The Yoruba and Ibo live in an area where there never was cattle-raising and, until recently, no milk was taken after weaning. The Hausa and Fulani live in the north of Nigeria where cattle-rising and ingestion of milk and milk-products are traditional. The data indicate that 99% of the Yoruba and 96% of the Ibo after the age of 1½ to 3 years malabsorb lactose, whereas only 64% of the Hausa and Fulani show malabsorption. But normadic Fulani, who are migratory cattlemen, show only 20% malabsorption. We also found that when white Semites were compared with Anglo-Saxons, the Semites were incapable of absorbing lactose in contrast to the Anglo-Saxons. Individuals with lactose malabsorption showed no difficulty in their ability to hydrolyze sucrose. Since no other mammal, so far examined, is able to hydrolyze lactose efficiently after weaning, we contend that malabsorption of lactose after two years of age is genetically normal in man and that the individuals who are capable of hydrolyzing lactoze in adult life are carrying a mutation derived from natural selection. In regions where malabsorption in adults is prevalent, lactose-free milk should be given to children so as to avoid diarrhea related to lactose intolerance.
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