Abstract The recent growing focus on higher packaging densities, better performance, multiple functions, and smaller feature sizes in consumer electronic products has stimulated greater development of three dimensional integrated circuits (3D ICs). However, due to serious Joule heating in the 3D IC packages, a thermal gradient must be induced when dissipating the heat. The thermal gradient would affect the growth of intermetallic compounds (IMCs) and further impact the reliability of devices. To investigate the influence of thermal gradient on interfacial reactions of Ni 3 Sn 4 IMCs, we have employed heat sink and heat source devices to establish a temperature gradient across the eutectic Sn2.5Ag alloys/Ni thin films systems at 145 °C. After applying a temperature gradient of 3.8 °C across the alloys for 771 h, the significant Ni consumption at the hot end was observed. Additionally, the growth of Ni 3 Sn 4 at hot end was hindered, whereas the growth of Ni 3 Sn 4 at cold side was accelerated. We propose that this abnormal Ni 3 Sn 4 growth at cold side is mainly attributed to the thermal gradient driven Ni moving toward the cold end. The molar heat of transport of Ni in Sn was calculated to be +0.58 kJ/mole.