Newborn Blood Pressure Research Articles

Артериальная гипертензия среди детей и подростков как прогностический фактор риска. Проблемы диагностики

An analysis of modern studies has shown that arterial hypertension, detected in childhood, is one of the main risk factors for both cardiovascular diseases and the progression of renal failure in subsequent age periods, which indicates the importance of early diagnosis, treatment and prevention of this condition among children and children. teenagers. The increase in the prevalence of hypertension among children and the associated health risks actualize the issues of the level, methods, techniques and frequency of blood pressure screening, differentiation of primary and secondary hypertension for successful treatment and control of the disease, as well as the development of methods for analyzing multiple factors for accurate diagnosis and prediction of spread. arterial hypertension. Of greatest research interest are the issues of accurate measurement of blood pressure during routine medical examinations of children, including invasive or noninvasive methods for measuring blood pressure in newborns, the availability of proven equipment and specialists in pediatric hypertension, and the interpretation of blood pressure measurements.

Prevalence of Renal Hypertension In Apparently Healthy Term Newborns.

Introduction: Neonatal hypertension (HT) is an emerging challenge for neonatologists and pediatricians around the world. The prevalence of renal causes of neonatal hypertension due to congenital renal anomalies and malformations including obstructive uropathy and cystic kidney disease is not well estimated up till now. Early diagnosis of congenital renal anomalies is the corner stone of good prognosis and better outcome. Aim of the study: To determine the prevalence of neonatal renal hypertension in apparently healthy term neonates discharged in the first 48 h of life from two university hospitals. Methods: Two thousand apparently healthy appropriate for gestational age (AGA) term newborns had blood pressure (BP) measurements using the oscillometric technique All results of blood pressure were compared to estimated blood pressure values in percentile curves generated by Dionne et al. Results: There were 29 of 2000 (1.45%) screened newborns diagnosed as having systemic hypertension, our study showed that renal anomalies were the main causes of neonatal systemic hypertension. It represent (93.1 %) of total causes in our study, [with pelviureteric junction (PUJ) Obstruction (31%), polycystic kidney (24.1%), nephrocalcinosis (13.7 %), unilateral renal dysplasia (10.3%), renal hypoplasia (3.4%), unilateral multi cystic kidney (3.4%)].The remaining cases (6.9%) were due to aortic coarctation. No endocrinal cases was diagnosed in our study. Conclusion: This study showed that renal anomalies were the most common causes of neonatal systemic hypertension in apparently healthy term newborns. Beside that this study provided normative BP values for healthy full term AGA newborns in the first 48h of life. These values can be used in the evaluation of BP in newborns.

Ambient Particle Components and Newborn Blood Pressure in Project Viva.

BackgroundBoth elemental metals and particulate air pollution have been reported to influence adult blood pressure (BP). The aim of this study is to examine which elemental components of particle mass with diameter ≤2.5 μm (PM2.5) are responsible for previously reported associations between PM2.5 and neonatal BP.Methods and ResultsWe studied 1131 mother‐infant pairs in Project Viva, a Boston‐area prebirth cohort. We measured systolic BP (SBP) and diastolic BP (DBP) at a mean age of 30 hours. We calculated average exposures during the 2 to 7 days before birth for the PM2.5 components—aluminum, arsenic, bromine, sulfur, copper, iron, zinc, nickel, vanadium, titanium, magnesium, potassium, silicon, sodium, chlorine, calcium, and lead—measured at the Harvard supersite. Adjusting for covariates and PM2.5, we applied regression models to examine associations between PM2.5 components and median SBP and DBP, and used variable selection methods to select which components were more strongly associated with each BP outcome. We found consistent results with higher nickel associated with significantly higher SBP and DBP, and higher zinc associated with lower SBP and DBP. For an interquartile range increase in the log Z score (1.4) of nickel, we found a 1.78 mm Hg (95% CI, 0.72–2.84) increase in SBP and a 1.30 (95% CI, 0.54–2.06) increase in DBP. Increased zinc (interquartile range log Z score 1.2) was associated with decreased SBP (−1.29 mm Hg; 95% CI, −2.09 to −0.50) and DBP (−0.85 mm Hg; 95% CI: −1.42 to −0.29).ConclusionsOur findings suggest that prenatal exposures to particulate matter components, and particularly nickel, may increase newborn BP.

Higher Neonatal Blood Pressure in Association with Air Pollution Exposure during the Last Weeks of Pregnancy: an ENVIRONAGE birth cohort study

TPS 742: Adverse birth outcomes 1, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Background: Elevated blood pressure (BP) in early life may lead to cardiovascular morbidity and mortality in adulthood. Air pollution exposure has been associated with increased BP in adults and children. The contribution of in utero air pollution exposure, however, has been rarely assessed. We investigated the association between newborn BP and prenatal air pollution, traffic and land use indicators. Methods: We used data from 427 mother-newborn pairs from the ENVIRONAGE birth cohort. Daily maternal residential air pollutant exposures during pregnancy, including particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM2.5) and ≤ 10 µm (PM10), nitrogen dioxide (NO2), and black carbon (BC), were modelled using a high-resolution spatial-temporal model. The association between newborn BP and air pollution during the last 15 weeks of pregnancy was assessed using distributed lag models. Results: Each 5 μg/m3 increment in prenatal PM2.5 exposure was associated with a 2.4 mm Hg (95%CI, 0.5 to 4.2) higher systolic and a 1.8 mm Hg (0.2 to 3.5) higher diastolic BP at birth. Overall (15-week) estimates for PM10 were similar but those for NO2 and BC did not reach significance. Associations between newborn BP and exposures during the last 4 to 5 weeks of pregnancy were significant for all pollutants. An IQR (20.3%) increment in percentage residential greenness in a 5 km radius was associated with a 1.2 mmHg (-2.5 to 0.1, p = 0.07) lower systolic and a 1.2 mm Hg (-2.4 to 0.0, p = 0.05) lower diastolic BP. An IQR (4.1%) increment in percentage industrial area in a 5 km radius was associated with a 1.0 mm Hg (0.1 to 2.0) higher diastolic BP. Residential traffic indicators (distance to major roads and distance-weighted traffic density) did not significantly associate with newborn BP. Conclusions: Prenatal air pollution exposure may induce BP elevations from birth onwards.

Neonatal blood pressure in association with prenatal air pollution exposure, traffic, and land use indicators: An ENVIRONAGE birth cohort study

Elevated blood pressure (BP) in early life may lead to cardiovascular morbidity and mortality in later life. Air pollution exposure has been associated with increased BP in adults and children, but the contribution of prenatal air pollution exposure has rarely been assessed. In addition, we are not aware of any study on neonatal BP and maternal residential traffic and land use indicators during pregnancy. We investigated the association between newborn BP and prenatal air pollution, traffic and land use indicators, using data from 427 term (gestational age > 36 weeks) births from the ENVIRONAGE birth cohort. Newborn BP was measured using an automated device within 4 days after birth. Daily maternal residential air pollutants during pregnancy, including particulate matter with an aerodynamic diameter ≤ 2.5 μm (PM2.5) and ≤10 μm (PM10), black carbon (BC), and nitrogen dioxide (NO2), were modelled using a high-resolution spatial-temporal model. The association between newborn BP and air pollution during the last 15 weeks of pregnancy was assessed using distributed lag models. Each 5 μg/m3 increment in prenatal PM2.5 exposure was associated with a 2.4 mm Hg (95% CI, 0.5 to 4.2) higher systolic and a 1.8 mm Hg (95% CI, 0.2 to 3.5) higher diastolic BP at birth. Overall estimates for PM10 were similar but those for NO2 and BC did not reach significance. Associations between newborn BP and exposures during the last 4 to 5 weeks of pregnancy were significant for all pollutants. An IQR (20.3%) increment in percentage residential greenness in a 5 km radius was associated with a 1.2 mm Hg (95% CI, −2.5 to 0.1; p = 0.07) lower systolic and a 1.2 mm Hg (95% CI, −2.4 to −0.0; p = 0.05) lower diastolic BP. An IQR (4.1%) increment in percentage industrial area in a 5 km radius was associated with a 1.0 mm Hg (95% CI, 0.1 to 1.9; p = 0.03) higher diastolic BP. Residential traffic indicators did not significantly associate with newborn BP. Prenatal air pollution exposure, greenness, and industrial area at maternal residence may affect offspring BP from birth onwards.

Should first blood pressure measurement be performed in the newborn?

Abstract Dilated cardiomyopathy is the most common form of cardiomyopathy and the main cause of cardiac transplantation in children and in adults. Infants and children have a wider spectrum of etiologies, hampering their identification. The most frequent initial manifestation of dilated cardiomyopathy is symptomatic heart failure during exercise or at rest (although many patients are asymptomatic). Some causes are potentially reversible, therefore the investigation should be carefully planned and immediately performed after diagnosis. In most children no cause is identified, which limits the targeted therapeutic approach and therefore the effectiveness of the treatment. The authors present a case of dilated cardiomyopathy secondary to renovascular hypertension diagnosed in an infant with 3.5 month-old, highlighting the etiological investigation, treatment and evolution. The authors present this case emphasising the fact that the arterial hypertension diagnose in infants is not always easy, questioning the current recommendations relating to an initial evaluation on blood pressure. We postulate that the assessment of blood pressure in newborns can detect early renovascular hypertension (and even other cardiovascular diseases) and help prevent the development of deleterious effects, including fatal episodes.

Prenatal exposure to ambient PM components and newborn blood pressure

Introduction: Air pollution exposure has been associated with increased blood pressure (BP) in adults. Previously, we found that higher exposures to particle mass (PM2.5) and black carbon in the third trimester of pregnancy were associated with higher newborn BP. We examined associations of antenatal exposure to ambient PM2.5 components with newborn systolic blood pressure (SBP). Methods: We studied 1,131 mother-infant pairs in Project Viva, a Boston-area pre-birth cohort. We measured SBP at a mean age of 30 hours (SD:18) with a Dynamap. We calculated average exposures by trimester and during the 7 to 90 days before birth for a selected group of PM2.5 components: S, Cu, Fe, Zn, Ni, V, Ti, Mg, K, Si, Na, Cl, Ca, Br, Sr, Pb, and Mn. Other elements were excluded either because the analytical measurement was judged to be unreliable or the element had a large proportion of the measurements below the method detection limit. We used mixed effects models to examine associations between PM components and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socio-economic position, 3rd trimester BP, and time trend. Estimates represent differences in SBP for the 75th vs. 25th percentile (IQR) of each element. Results: Higher mean S, K, Cu, Ni, Zn, Br, Sr, Pb exposures between the first and the third trimester were associated with higher SBP. An increase (IQR: 0.0006 ng/m3) in the mean 90-day of Pb was associated with 1.06 mmHg (95% CI: 0.45 to 1.66) higher SBP; the result was stable after additionally adjusting for PM2.5. Each 0.0042 ng/m3 increase in mean 90-day Zn was associated with 1.1 mmHg (95% CI: 0.06 to 2.15) higher in SBP. Future work will include multi-metal models and assessment of BP associations with component mixtures. Conclusions: These initial findings suggest that prenatal exposures to PM components, many of which have road dust sources, may influence newborn SBP.

Association of genetic variation in the natriuretic peptide system and left ventricular mass and blood pressure in newborns.

The natriuretic peptides play a key role in the modulation of left ventricular mass (LVM) and blood pressure (BP). We hypothesised that NPPA (natriuretic peptide precursor A gene), NPPB (natriuretic peptide precursor B gene), and NPPC (natriuretic peptide precursor C gene) are candidate genes possibly involved in the development or modulation of LVM at early life. To assess the relationship between NPPA, NPPB, and NPPC gene polymorphisms with LVM and BP in newborns. A total of 206 healthy newborns were studied by two-dimensional M-mode echocardiography. The polymorphisms NPPA rs5065, NPPB rs198389, and NPPC rs5268 were characterised. Newborns carrying the C allele of the NPPB polymorphism had significantly lower LVM/body surface area (BSA) and LVM/body weight (BW) values when compared with newborns' homozygotes for the T allele (41.76 g/m2 vs. 48.31 g/m2, p adjusted = 0.044 and 2.78 g/kg vs. 3.26 g/kg, p adjusted = 0.031, respectively). An association was observed between NPPA genotype and systolic BP, diastolic BP, and mean arterial pressure ≥ 90th percentile (p = 0.029, p = 0.0048, p = 0.004, respectively). Also an association was observed for systolic BP ≥ 90th percentile for NPPB (p = 0.016). The present study shows that the NPPB gene polymorphism is associated with modulation of LVM in newborns. The NPPA and NPPB gene polymorphisms are associated with BP.

Prenatal air pollution exposure and newborn blood pressure.

BackgroundAir pollution exposure has been associated with increased blood pressure in adults.Objective:We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).Methods:We studied 1,131 mother–infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child’s birth weight; mother’s age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.Results:Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residential BC). In contrast, O3 was negatively associated with SBP (e.g., –2.3 mmHg; 95% CI: –4.4, –0.2 for a 13.5-ppb increase during the 90 days before birth).Conclusions:Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.Citation:van Rossem L, Rifas-Shiman SL, Melly SJ, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz JD, Mittleman MA, Oken E, Gillman MW, Koutrakis P, Gold DR. 2015. Prenatal air pollution exposure and newborn blood pressure. Environ Health Perspect 123:353–359; http://dx.doi.org/10.1289/ehp.1307419

Preeclampsia: effect on newborn blood pressure in the 3 days following preterm birth: a cohort study.

Maternal hypertension and preeclampsia are associated with greater risk of hypertension in childhood, and cardiovascular events in adulthood. However, whether preeclampsia affects blood pressure (BP) in the newborn period is unclear. Previous neonatal studies were based on small sample sizes, very low birth weight or gestational age or limited duration (h). To delineate hemodynamic repercussions of maternal preeclampsia on preterm infants (gestational ages ⩾29 weeks) with/without intrauterine growth restriction (IUGR) in the first 3 postnatal days, we conducted a single-centre retrospective cohort study of singleton births at 29-35 weeks of gestation in Montreal, Canada, from 2008 to 2011. Data were obtained from medical charts. Exclusion criteria included congenital anomalies, infections, pre-pregnancy maternal hypertension and gestational diabetes. IUGR was defined as birth weight <10th percentile. Of the 338 eligible neonates, 230 were included: 75 preeclampsia-IUGR, 72 preeclampsia-only and 83 controls. The preeclampsia-IUGR group had longer gestations than the preeclampsia-only or control groups (32.4±1.8 vs. 31.3±1.6 vs. 31.7±1.6 weeks, respectively; P<0.001). Mean BPs increased over the first 3 days for all newborns (P<0.001). Infants with preeclampsia-associated IUGR had the highest systolic and diastolic BPs, even after adjustment for birth weight, and preeclampsia-only the next highest. Systolic BP progression showed significant differences between groups (P<0.05). We conclude that impact of preeclampsia on children blood pressure was manifest within days of birth, over and above coexisting IUGR. Long-term cardiovascular follow-up and targeted preventive strategies are advised for this underrecognized high-risk population.

Prenatal Exposure to Air Pollution and Newborn Blood Pressure

Background: Air pollution is associated with blood pressure (BP) in adults. However, little is known about its influence on newborns, whose mothers may be exposed to pollution during gestation, a c...

Common Genetic Variants of theBMP4,BMPR1A,BMPR1B, andACVR1Genes, Left Ventricular Mass, and Other Parameters of the Heart in Newborns

The members of the family of bone morphogenetic proteins (BMPs) are important regulators in cardiac development. The present study was designed to evaluate the effect of common genetic variants of BMP-4 and its receptors BMPR1A, BMPR1B, and ACVR1 on left ventricular mass (LVM) and other parameters of the heart and blood pressure in newborns. The study included 210 healthy newborns. Two-dimensional M-mode echocardiography was used to assess LVM between days 3 and 4 after birth. Polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism technique. We found lack of associations between LVM, values of blood pressure, and the BMP4, BMPR1A, BMPR1B, and ACVR1 genotypes. A significant association was observed between the 455C allele of BMP4 and increased left ventricular internal diameter systolic (p=0.004) and between 1650T allele of BMPR1B and lower left atrium diameter (p=0.038). Presence of the 455C allele of BMP4 and the 8474T allele of ACVR1 gene was significantly associated with decreased left ventricular ejection fraction (LVEF) (p=0.0004 and p=0.046, respectively). The 455C allele of BMP4 and the 8474T allele of ACVR1 may play a role as significant predictors for decreased LVEF in newborns.

Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns

Objective. The 1936G AKAP10 allele is associated with increased adult basal heart rate (HR) and decreased variability, markers of low cholinergic/vagus sensitivity associated with hypertension. Blood pressure (BP) values in newborns are important measurable markers of cardiovascular risk later in life. The question was whether decreased vagal function-related 1936A > G AKAP10 is associated with newborn BP. Study design. 114 healthy Polish newborns born after 37th gestational week to healthy women with uncomplicated pregnancies. At birth, newborn cord blood obtained for isolation of genomic DNA. BP and HR measured on days 1 and 3 after delivery. Results. Diastolic BP on day 3 and absolute and relative differences between diastolic BP values, as well as between mean BP values on day 3 and on day 1 after birth, in carriers of 1936G AKAP10 allele, were significantly higher as compared with wild-type homozygotes. Conclusion. Results demonstrate possible association between 1936G AKAP10 variant and BP in Polish newborns.

Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

BackgroundHypertension is an increasing health issue in sub-Saharan Africa where malaria remains common in pregnancy. We established a birth cohort in Nigeria to evaluate the early impact of maternal malaria on newborn blood pressure (BP).MethodsAnthropometric measurements, BP, blood films for malaria parasites and haematocrit were obtained in 436 mother-baby pairs. Women were grouped to distinguish between the timing of malaria parasitaemia as ‘No Malaria’, ‘Malaria during pregnancy only’ or ‘Malaria at delivery’, and parasite density as low (<1000 parasites/µl of blood) and high (≥1000/µl).ResultsPrevalence of maternal malaria parasitaemia was 48%, associated with younger maternal age (p<0.001), being primigravid (p = 0.022), lower haematocrit (p = 0.028). High parasite density through pregnancy had the largest effect on mean birth indices so that weight, length, head and mid-upper arm circumferences were smaller by 300 g, 1.1 cm, 0.7 cm and 0.4 cm respectively compared with ‘No malaria’ (all p≤0.005). In babies of mothers who had ‘malaria at delivery’, their SBPs adjusted for other confounders were lower respectively by 4.3 and 5.7 mmHg/kg compared with ‘malaria during pregnancy only’ or ‘none’. In contrast the mean newborn systolic (SBP) and diastolic BPs (DBP) adjusted for birth weight were higher by 1.7 and 1.4 mmHg/kg respectively in babies whose mothers had high compared with low parasitaemia.ConclusionsAs expected, prenatal malarial exposure had a significant impact on fetal growth rates. Malaria at delivery was associated with the lowest newborn BPs while malaria through pregnancy, which may attenuate growth of the vascular network, generated higher newborn BPs adjusted for size. These neonatal findings have potential implications for cardiovascular health in sub-Saharan Africa.

Comparison of noninvasive techniques to measure blood pressure in newborns

To compare blood pressure measurements in newborn infants using the flush method, pulse oximetry and oscillometry according to Doppler findings. Noninvasive blood pressure measurements were made using three techniques (flush method, pulse oximetry and oscillometry) in three groups of newborns: 15 normal term infants, 16 stable preterm infants, and 14 critically ill infants. All measurements were video recorded, edited separately, coded and analyzed independently by three neonatologists. Fifty-seven measurements were made using each method. The flush method and pulse oximetry had a better correlation with Doppler findings than oscillometry (correlation coefficients: 0.89, 0.85, 0.71; p < 0.01). The difference between measurement means, their standard deviations and the 95% confidence intervals when compared with Doppler findings were: -5.2 ± 7.9 (-21.1:10.7) mmHg for the flush method; 0.4 ± 8.9 (-17.5:18.2) mmHg for pulse oximetry; and 6.4 ± 16.1 (-25.8:8.6) mmHg for oscillometry. The flush method had a better agreement with Doppler findings for the diagnosis of hypotension than oximetry and oscillometry. The flush method and pulse oximetry seem to be useful techniques to measure systolic blood pressure in newborn infants; oscillometry had the poorest agreement with Doppler findings to detect hypotension.

Maternal Age and Other Predictors of Newborn Blood Pressure

Maternal Age and Other Predictors of Newborn Blood Pressure

Maternal age and other predictors of newborn blood pressure

Objective To investigate perinatal predictors of newborn blood pressure. Study design Among 1059 mothers and their newborn infants participating in Project Viva, a US cohort study of pregnant women and their offspring, we obtained five systolic blood pressure readings on a single occasion in the first few days of life. Using multivariate linear regression models, we examined the extent to which maternal age and other pre- and perinatal factors predicted newborn blood pressure level. Results Mean (SD) maternal age was 32.0 (5.2) years, and mean (SD) newborn systolic blood pressure was 72.6 (9.0) mm Hg. A multivariate model showed that for each 5-year increase in maternal age, newborn systolic blood pressure was 0.8 mm Hg higher (95% CI, 0.2, 1.4). In addition to maternal age, independent predictors of newborn blood pressure included maternal third trimester blood pressure (0.9 mm Hg [95% CI, 0.2, 1.6] for each increment in maternal blood pressure); infant age at which we measured blood pressure (2.4 mm Hg [95% CI 1.7, 3.0] for each additional day of life); and birth weight (2.9 mm Hg [95% CI, 1.6, 4.2] per kg). Conclusions Higher maternal age, maternal blood pressure, and birth weight were associated with higher newborn systolic blood pressure. Whereas blood pressure later in childhood predicts adult hypertension and its consequences, newborn blood pressure may represent different phenomena, such as pre- and perinatal influences on cardiac structure and function.

Predictors of blood pressure in newborns

Predictors of blood pressure in newborns

Budding tastes: Higher blood pressure in newborns links to salt preference

Science NewsVolume 162, Issue 7 p. 101-102 This Week Budding tastes: Higher blood pressure in newborns links to salt preference Nathan Seppa, Nathan SeppaSearch for more papers by this author Nathan Seppa, Nathan SeppaSearch for more papers by this author First published: 02 July 2009 https://doi.org/10.2307/4013789AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume162, Issue717 August 2002Pages 101-102 RelatedInformation

Maternal age and newborn blood pressure

0018 Background. Blood pressure (bp) level after birth may reflect the fetal cardiovascular environment, but few data exist on newborn bp. Methods. We report findings from a new cohort of pregnant women and their offspring, Project Viva. Enrollment as of September, 2000, is 1338 pregnant women (of a target 6000), and 581 have delivered. Data collected include maternal dietary, sociodemographic, economic, psychological, lifestyle, and clinical variables; and infant bp, pulse rate, length, weight, and circumferences measured during the first 2 days of life. We averaged 5 systolic bp readings taken with a Dinamap automated bp recorder. This abstract is limited to the first 260 measured newborns (131 girls and 129 boys) and partial maternal data. Results. The highest newborn systolic bp was in children of the oldest mothers, and the lowest in the maternal age group 20-24 years ( Table). Multivariate adjustment for infant birth weight and sex and for maternal body mass index, pregnancy weight gain, 3 rd trimester bp, and number of pregnancies did not attenuate the differences. For example, adjusted mean newborn systolic bp was 10.8 (95% CI 2.4, 19.2) mmHg higher among children of 40-44 y.o. than 20-24 y.o. mothers. Variables minimally or not related to newborn systolic bp included birth weight and length, pulse rate, head, chest, and abdominal circumferences, gestational age, and maternal body mass index, weight gain, and systolic bp. Conclusions. Higher maternal age was associated with higher newborn systolic bp. Whereas bp later in childhood predicts adult hypertension and its consequences, newborn bp may represent different phenomena, such as pre- and peri-natal influences on cardiac structure and function. Studies of newborn bp may shed new light on effects of the fetal environment on lifelong cardiovascular health. Table 1.