Introduction: Idiopathic gastroparesis (IG) refers to a symptomatic patient from delayed gastric emptying with no detectable primary underlying abnormality. This may represent the most common form of gastroparesis. Few studies have evaluated the effect of Helicobacter pylori (Hp) eradication on symptoms and gastric emptying (GE). Methods: Prospective uncontrolled study, patients >18 y, which met criteria for IG, confirmed by gastric emptying scintigraphy for 4 h (GES) and had documented Hp by Endoscopy. Before and after the Eradication treatment (ET) the patients filled the Gastroparesis Cardinal Symptom Index (GCSI), a validated instrument for measuring symptoms of gastroparesis, It queries 9 symptoms of which the patients assess the severity using a 0-5 Likert scale. Patients taking prokinetics or other drugs that affect gastric motility were asked to stop it. ET was amoxicillin 1gm PO BID for 10 days, clarithromycin 500mg PO BID for 10 days and esomeprazole 40mg. 8 weeks after ET, upper endoscopy and GES were performed. Results: 32 patients, mean age (44±16 y) female (93%). 97% of patients received complete ET; 1 patient withdrew because of intolerance, 2 patients showed minor side effects. ET was effective in 76.7%. The mean GE T ½ pretreatment was (147±20.2 mins); after ET 83.3% of GES were normal, with a mean GE T ½ (97±24.6 mins); the improvement in the mean GE T ½ was statistically significant with a difference of 53.7 mins (95% CI 39.7-67.6; p < 0.00001). The mean GCSI pretreatment was (2.66±1.09) and after ET (1.22±0.98); the improvement in the mean GCSI was 1.44 points, this difference was statistically significant (95% CI 1.12-1.84; p < 0.00001). The number of positive cases with Hp after ET is so small it does not allow comparison with negative patients Conclusion: The aim of this study was to explore the change in symptoms and GE with a new line of treatment in patients with IG. This study has several strengths as are its prospective nature, using a validated scale that has been used in several studies of gastroparesis, objective measurement of GES using a standardized protocol. Most patients in the study had improvement in symptoms of gastroparesis and values of GE. The lack of a control group prevents us from establishing a categorical conclusion, however it opens a new hypothesis of treatment in patients with IG and Hp infection that should be explored through RCTs.