Neurobiology Of Aging Research Articles

Hypothesis on the Regulation of Cytosol Calcium Concentration and the Aging Brain

This commentary proposes that neurobiology of aging must look beyond the issue of age related changes in calcium concentrations within the cytosol. The more important question is what causes these changes. Studies of structure, function, and dynamics of membranes may begin to give a better clue about underlying mechanisms of these changes.

The Neurobiology of Aging: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders . Papers from a symposium, Houston, Oct. 1980. S. J. Enna, T. Samorajski, and Bernard Beer, Eds. Raven, New York, 1981. xiv, 278 pp., illus. $32. Aging Series, vol. 17.

The Neurobiology of Aging: <i>Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders</i> . Papers from a symposium, Houston, Oct. 1980. S. J. Enna, T. Samorajski, and Bernard Beer, Eds. Raven, New York, 1981. xiv, 278 pp., illus. $32. Aging Series, vol. 17.

The blood-brain barrier in renovascular hypertension.

HomeStrokeVol. 13, No. 2The blood-brain barrier in renovascular hypertension. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBThe blood-brain barrier in renovascular hypertension. S M Mueller and F C Luft S M MuellerS M Mueller Search for more papers by this author and F C LuftF C Luft Search for more papers by this author Originally published1 Mar 1982https://doi.org/10.1161/01.STR.13.2.229Stroke. 1982;13:229–234 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Ménard B, Chazalviel L, Roussel S, Bernaudin M and Touzani O (2017) Two-kidney one-clip is a pertinent approach to integrate arterial hypertension in animal models of stroke: Serial magnetic resonance imaging studies of brain lesions before and during cerebral ischemia, Journal of Cerebral Blood Flow & Metabolism, 10.1177/0271678X17715813, 38:10, (1769-1780), Online publication date: 1-Oct-2018. Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K and Kalaria R (2017) Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion, Journal of Neuroinflammation, 10.1186/s12974-017-0850-5, 14:1, Online publication date: 1-Dec-2017. Marrazzo* G, Barbagallo* I, Galvano F, Malaguarnera M, Gazzolo D, Frigiola A, D’Orazio N and Li Volti G (2014) Role of Dietary and Endogenous Antioxidants in Diabetes, Critical Reviews in Food Science and Nutrition, 10.1080/10408398.2011.644874, 54:12, (1599-1616), Online publication date: 2-Dec-2014. Mooradian A (2007) Diabetes and the Consequences for the Blood-Brain Barrier Blood-Brain Barriers, 10.1002/9783527611225.ch26, (649-669) Kamei J, Hirano S, Miyata S, Saitoh A and Onodera K (2005) Effects of First- and Second-Generation Histamine-H1-Receptor Antagonists on the Pentobarbital-Induced Loss of the Righting Reflex in Streptozotocin-Induced Diabetic Mice, Journal of Pharmacological Sciences, 10.1254/jphs.FP0040832, 97:2, (266-272), . Al-Sarraf H and Philip L (2003) Effect of hypertension on the integrity of blood brain and blood CSF barriers, cerebral blood flow and CSF secretion in the rat, Brain Research, 10.1016/S0006-8993(03)02632-5, 975:1-2, (179-188), Online publication date: 1-Jun-2003. Sparks D (1999) Vascular-Related and Mediated Alterations in Alzheimer’s Disease Cerebral Cortex, 10.1007/978-1-4615-4885-0_20, (733-772), . Mooradian A (1997) Central nervous system complications of diabetes mellitus — a perspective from the blood–brain barrier, Brain Research Reviews, 10.1016/S0165-0173(97)00003-9, 23:3, (210-218), Online publication date: 1-Apr-1997. Wallin A and Blennow K (2016) Heterogeneity of Vascular Dementia: Mechanisms and Subgroups, Journal of Geriatric Psychiatry and Neurology, 10.1177/089198879300600307, 6:3, (177-188), Online publication date: 1-Jul-1993. Shaver S, Wall K, Wainman D and Gross P (1992) Regional quantitative permeability of blood-brain barrier lesions in rats with chronic renal hypertension, Brain Research, 10.1016/0006-8993(92)90747-W, 579:1, (99-106), Online publication date: 1-May-1992. Edmunds M and Walls J (2007) Pathogenesis of Seizures During Recombinant Human Erythropoietin Therapy, Seminars in Dialysis, 10.1111/j.1525-139X.1991.tb00080.x, 4:3, (163-167) Werber A and Fitch-Burke M (1990) Pial venous pressure and acute hypertensive disruption of the blood-brain barrier in spontaneous and renal hypertension, Brain Research, 10.1016/0006-8993(90)90601-7, 515:1-2, (235-240), Online publication date: 1-May-1990. Johansson B (1989) Hypertension and the Blood-Brain Barrier Implications of the Blood-Brain Barrier and Its Manipulation, 10.1007/978-1-4615-7255-8_10, (389-410), . Ritter S, Dinh T, Stone S and Ross N (1988) Cerebroventricular dilation in spontaneously hypertensive rats (SHRs) is not attenuated by reduction of blood pressure, Brain Research, 10.1016/0006-8993(88)91574-0, 450:1-2, (354-359), Online publication date: 1-May-1988. WERBER A and FITCH M (1988) Susceptibility of the Blood-Brain Barrier to Acute Hypertensive Disruption in Four Models of Hypertension, Annals of the New York Academy of Sciences, 10.1111/j.1749-6632.1988.tb51453.x, 529:1 Fourth Colloq, (178-180), Online publication date: 1-Jun-1988. Mooradian A (1988) Effect of aging on the blood-brain barrier, Neurobiology of Aging, 10.1016/S0197-4580(88)80013-7, 9, (31-39), Online publication date: 1-Jan-1988. Werber A and Fitch-Burke M (1988) Effect of chronic hypertension on acute hypertensive disruption of the blood-brain barrier in rats., Hypertension, 12:6, (549-555), Online publication date: 1-Dec-1988.Tamaki K, Sadoshima S and Heistad D (1984) Increased susceptibility to osmotic disruption of the blood-brain barrier in chronic hypertension., Hypertension, 6:5, (633-638), Online publication date: 1-Sep-1984. Busija D and Heistad D (1984) Factors involved in the physiological regulation of the cerebral circulation Reviews of Physiology, Biochemistry and Pharmacology, Volume 86, 10.1007/BFb0027696, (161-211), . March 1982Vol 13, Issue 2 Advertisement Article InformationMetrics Copyright © 1982 by American Heart Associationhttps://doi.org/10.1161/01.STR.13.2.229 Originally publishedMarch 1, 1982 PDF download Advertisement

Sympathetic nerves protect against blood-brain barrier disruption in the spontaneously hypertensive rat.

SUMMARY The cerebral vessels of spontaneously hypertensive rats (SHR) are reported to have an in­ creased luminal size and decreased wall thickness after chronic sympathetic denervation. In order to evaluate a possible physiological significance of this observation, we studied blood-brain barrier protein transfer in two month old SHR and their normotensive controls, Wistar-Kyoto (WKY), during profound vasodilation stimuli one month after a unilateral superior cervical ganglionectomy. Our hypothesis was that during acute vaso­ dilation, protein transfer, which is dependent on vessel tension (tension = pressure X radius/wall thickness), would be greater in the vasculature of the chronically denervated (De) than in contralateral innervated hemi­ sphere (In). Vasodilation was induced with acute hypertension (norepinephrine) and seizures (bicucilline). Immediately prior, the cervical trunk to the innervated hemisphere was sectioned to prevent acute sympathetic neuronal effects. Protein transfer was assessed qualitatively with Evans blue dye and quantitatively with radio­ iodinated albumin. Successful chronic denervation was demonstrated by the absence of histofluorescence in De. Evans blue dye staining of SHR (n = 3) cerebral hemispheres was greater in De than in In. Radioiodinated albumin protein transfer was elevated in SHR De compared to In in each of eight animals studied (De-In = 0.16 ± 0.04%*, *p < 0.01); WKY (n = 8) De protein transfer was not different from In (De-In = 0.07 ± 0.05%). These results suggest that the trophic influence of sympathetic nerves on SHR cerebral vessels con­ tributes to protection of the blood-brain barrier during hypertension and seizures.

Neurobiology of aging

Neurobiology of aging

Neurobiology of Aging: Experimental and Clinical Research

Neurobiology of Aging: Experimental and Clinical Research

Neurobiology of aging

Neurobiology of aging

Neurobiology of aging: Experimental and clinical research

Neurobiology of aging: Experimental and clinical research

Neurobiology of Aging: Experimental and Clinical Research

Neurobiology of Aging: Experimental and Clinical Research

Neurobiology of aging

Neurobiology of aging