The purpose of this paper is to deeply study the quantitative model of network security situation assessment and establish a quantitative model of network security situation assessment based on intelligent immune. First, we introduce the related theory of network security situation awareness, grasp the algorithm framework of intelligent immune and the relevant knowledge of grey prediction model. On this basis, we design the quantitative process of network security situation assessment and the evolutionary process of intelligent immune detector, and finally realize the quantitative evaluation hierarchical structure and frame model of network security situation based on intelligent immunity.