You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research (II)1 Apr 2013106 INCREASED SERUM ADIPOKINE LEVELS IN PATIENTS WITH OVERACTIVE BLADDER SUGGESTS INFLAMMATION IS INVOLVED IN PATHOGENESIS OF BLADDER DYSFUNCTION Yuan-Hong Jiang, Cheng-Ling Lee, Jia-Fong Jhang, Hsin-Tzu Liu, and Hann-Chorng Kuo Yuan-Hong JiangYuan-Hong Jiang Hualien, Taiwan More articles by this author , Cheng-Ling LeeCheng-Ling Lee Hualien, Taiwan More articles by this author , Jia-Fong JhangJia-Fong Jhang Hualien, Taiwan More articles by this author , Hsin-Tzu LiuHsin-Tzu Liu Hualien, Taiwan More articles by this author , and Hann-Chorng KuoHann-Chorng Kuo Hualien, Taiwan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1485AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent studies have shown that urinary proteins such as nerve growth factor (NGF), brain-derived neurotrophic factor levels increase in patients with overactive bladder (OAB). Histological study in the bladder tissues also showed that signs of chronic inflammation exist in the bladder wall. OAB could be a subtype of neurogenic inflammation. This study investigated the serum adipokine levels in patients with OAB. METHODS Thirty-one consecutive patients with OAB-dry (n=16) or OAB-wet (n=15) were prospectively enrolled in this study, a group of 28 normal subjects (non-OAB) served as control. Blood (5-10 μL) was withdrawn from each subject. Blood samples were allowed to clot on ice and centrifuged in a swinging bucket rotor at 4°C, 3000 rpm for 15 min. The supernatant serum was carefully collected and stored at -80°C until the ELISA testing was performed. Concentrations of the serum adipokines including hepatic growth factor (HGF), interleulin IL-1β, IL-6, IL-8, tumor necrosis factor TNF-α, NGF, monocyte chemotactic protein MCP-1, Insulin and leptin were quantified by using a bead-based human serum adipokine panel B kit (Millipore, Billerica, MA, USA). The Milliplex MAP based on the Luminex xMAP technology by Millipore (Billerica, MA, USA). Data were analyzed by using LX 200?platforms (Millipore, Billerica, MA, USA). R2 of the standard curve is 1. RESULTS The serum concentrations of HGF, IL-1β, IL6, IL8, TNF-α in OAB-dry and OAB-wet patients were significantly higher than the controls. There was no significant difference between OAB-dry and OAB-wet (Table). However, serum NGF level was significantly higher in OAB-wet, but not OAB-dry, than control. The MCP-1 levels, on the other hand, were significantly higher in OAB-dry, but not OAB-wet, than controls. Limitation of the study is the non-parallel age between control and OAB groups. CONCLUSIONS Both OAB-dry and OAB-wet patients showed increased serum adipokine levels than the controls, suggesting chronic inflammation of the bladder involving both peripheral and central mechanisms. The difference of serum NGF and MCP-1 levels between OAB dry and OAB wet and controls might be due to changes in the bladder afferent nervous condition and inflammation causing different symptoms. Table. The serum adipokines expressions among the controls, OAB-dry, and OAB-wet Control (n=28) OAB-wet (n=15) OAB-dry (n=16) Control v OAB-wet; Control v OAB-dry; OAB-wet v OAB-dry Age 32.4±8.2 (22∼55) 65.8±10.8 (49∼86) 65.1±9.6 (48∼82) P=0.000**; P=0.000*; P=0.922 Gender F:17 M:11 F:5 M:10 F:9 M:7 HGF (pg/mL) 104.5±60.3 (4.25∼267.39) 207.8±112.4 (50.11∼399.04) 214.9±97.6 (67.63∼430.57) P=0.003; P=0.000; P=0.830 IL-1β (pg/mL) 2.13±3.24 (0.00∼13.74) 5.23±3.30 (0.00∼10.00) 7.19±2.75 (3.86∼15.37) P=0.002; P=0.000; P=0.175 IL-6 (pg/mL) 0.83±1.03 (0.00∼3.67) 3.50±5.23 (0.65∼21.82) 2.05±2.80 (0.65∼12.11) P=0.000; P=0.006; P=0.093 IL-8 (pg/mL) 1.43±1.02 (0.00∼4.09) 4.35±3.68 (1.38∼16.58) 3.98±1.99 (1.66∼8.65) P=0.000; P=0.000; P=0.800 TNF-α (pg/mL) 0.89±0.81 (0.00∼4.64) 4.69±4.18 (0.65∼12.30) 5.24±5.98 (0.62∼23.11) P=0.000; P=0.000; P=0.861 NGF (pg/mL) 2.79±1.19 (1.00∼5.85) 3.72±2.30 (2.20∼11.60) 3.10±1.58 (2.20∼8.97) P=0.026; P=0.233; P=0.119 MCP-1 (pg/mL) 106.9±36.8 (36.91∼196.08) 136.2±52.1 (48.58∼234.16) 153.9±79.6 (60.54∼401.63) P=0.085; P=0.026; P=0.654 Insulin (pg/mL) 828±518.9 (73.7∼2154.4) 723.7±108.0 (282.69∼1808.34) 713.3±669.6 (73.67∼2152.59) P=0.575; P=0.175; P=0.281 Leptin (pg/mL) 6513±4477 (229.8∼17337) 7402.6±8283.8 (472.66∼26122.12) 11821±12309 (523.04∼51014.8) P=0.610; P=0.150; P=0.140 Data are expressed as Mean ± standard deviation © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e42-e43 Peer Review Report Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yuan-Hong Jiang Hualien, Taiwan More articles by this author Cheng-Ling Lee Hualien, Taiwan More articles by this author Jia-Fong Jhang Hualien, Taiwan More articles by this author Hsin-Tzu Liu Hualien, Taiwan More articles by this author Hann-Chorng Kuo Hualien, Taiwan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...