Negligible Harm Research Articles

Environmental Just Wars: Jus ad Bellum and the Natural Environment

ABSTRACTWar is bad for the environment, yet the environmental ramifications of warfare have not been widely addressed by just war theorists and revisionist philosophers of war. The law and legal scholars have paid more attention to protecting nature during armed conflict. But because the law focuses invariably on rules mitigating the conduct of hostilities rather than on objective justice of cause, environmental jus ad bellum has been explored even less extensively than environmental ethics in war. Setting out with the presumption against the use of force and its exceptions, this article considers whether environmental harm can trigger a new justification for war, at whose behest, and what might be a proportionate response to aggressive or negligent harm to nature. Force is clearly justified against military attacks. Where environmental harm is not caused by military aggression, proportionality points towards a response short of war. Full‐scale warfare will likely be counterproductive in protecting nature. This is less true if war is fought by drones destroying specific targets, or by cyber‐war, or by alternatives (or supplements) to war such as boycotts, ‘lawfare’, and ‘information/media warfare’. Responding in ways that minimize harm to nature also helps demonstrate ‘right intention’.

Exploration of Phage-Agrochemical Interaction Based on a Novel Potent Phage LPRS20-Targeting Ralstonia solanacearum.

Phage therapy has the potential to alleviate plant bacterial wilt. However, the knowledge gap concerning the phage-agrochemical interaction impedes the broader application of phages in agriculture. This study characterized a phage isolate and investigated its interactions with agrochemicals. A novel species within the Ampunavirus genus was proposed, serving phage LPRS20 as a type phage with a broad lytic range and significant antibacterial activity against Ralstonia solanacearum strains infecting tobacco, chili, or tomato. Sensory evaluation of the morphology of tobacco leaves suggested that phage application resulted in negligible harm to plants. Investigations into phage-agrochemical interactions revealed synergisms when LPRS20 was delivered 4 h before thiodiazole-copper as well as LPRS20 in combination with low-concentration berberine. Overall, our findings reveal that phage LPRS20 represents a novel, effective, and eco-friendly biocontrol agent against tobacco bacterial wilt in vivo and in vitro and contributes to the potential integration of phages and agrochemicals for controlling soil-borne pathogens.

Ecotoxicity of bromate and human health risks resulting from wastewater treatment units' effluents associated with some key physicochemical parameters in two hotspots connected to the Egyptian Mediterranean Sea

This study is the first of its kind in terms of focusing on the seasonal monitoring of bromine species (bromide− and bromate) and some of the main physicochemical parameters in the surface water of stations inside and in front of the El Noubareya and El-Umum drains that flow directly or indirectly to the Egyptian Mediterranean coast at A (El Noubareya Drain) and B (El-Mex Bay) sites. Among the bromine species, bromate (BrO3−) is a disinfection byproduct considered by many international agencies to have a potential carcinogenic effect in humans and is also known to be ecologically toxic to aquatic organisms. Drain water samples collected from the studied sites A and B had a bromide/chlorinity ratio (3.85E-03 - 6.25E-03 and 3.27E-03 - 6.97E-03, respectively) significantly higher than the typical value for open seawater (3.50E-03), showing significant dilution with wastewater at drain stations in the investigated sites. The source and origin of bromine species and the major ions studied associated with the wastewater units were identified and tracked by calculating the ion/chlorinity ratio and multivariate analysis. The total hazard quotient (THQ) for bromate intake and dermal exposure in children, females, and males demonstrates negligible harm to human health. The toxic unit (TU) and the sum of toxic units (STU) values of the three trophic levels in the surface water for the two sites under investigation yielded approximately comparable values for risk quotient (RQ) and mixture risk characterization ratios (RCRmix(MEC/PNEC)), indicating that invertebrates are more sensitive to bromate dangers than fish and algae. The study highlights the importance of conducting large-scale laboratory tests on the effluents resulting from wastewater treatment units, including bromide levels, to prevent the formation of dangerous side compounds such as bromate, which may have negative effects on populations and may lead to the toxicity of trophic levels in ecosystems.

Threat of heavy metal pollutants and parasites to freshwater fish with special reference to their risk of cancer to humans in Egypt

Understanding how pollution and parasite infection work together to stress their hosts' health raises the possibility of a danger to aquatic life and humans. This study examined two freshwater fish species, Clarias gariepinus, and Oreochromis niloticus, at El-Abbasa Fish farm in Sharkia Governorate of Egypt. to determine their heavy metal content, parasite frequency, and potential health risks. Parasitological investigations revealed higher parasite prevalence in C. gariepinus, with trematodes being the most prevalent. Histopathological examinations displayed severe alterations in infected fish, including gill necrosis, intestinal damage, liver degeneration, and muscle necrosis. Moreover, heavy metal analysis. Heavy metals levels in water, Fe, Zn, Pb, Cu, As, and Cd levels were 0.95 ± 0.04, 0.75 ± 0.03, 0.14 ± 0.02, 0.09 ± 0.01, 0.07 ± 0.01, and 0.03 ± 0.01 mg/L, respectively. Sediment samples showed Cd as the lowest (2.38 ± 0.94 μg/g dry wt. basis) and Fe as the highest (241.01 ± 6.39 mg/kg dry wt. basis). The sequence of heavy metal concentrations in both water and sediment was Fe > Zn > Pb > Cu > As > Cd. Significant differences were found among metals in water and sediment (p < 0.05). Heavy metal concentrations in fish tissues followed the order liver > muscles > gills > intestine Iron was the most abundant, while cadmium was the lowest is the order in which bio-accumulation factors (BAF) between water and fish tissues followed a descending order: BAF-Liver < BAF-Gills < BAF-Intestine < BAF-Muscles. The sequence of heavy metal accumulation in tissues was BAF-Fe > BAF-Pb > BAF-Cd > BAF-As > BAF-Cu > BAF-Zn, indicating varying degrees of accumulation across different metals and tissues and bio-sedimentation (BSF) of metals in fish tissues are the order of heavy metal concentration within tissues was BSF-Cd > BSF-As > BSF-Fe > BSF-Zn > BSF-Cu > BSF-Pb. Additionally, data were recoded to reflect histological changes in several fish organs. The estimated daily intake of heavy metals (EDI-HMs) was far lower than the permissible tolerated daily intake (PTDI) limits, which were set by international authorities at 70 kg of body weight. As the hazard index value is below 1, the THQ and HI associated with the consumption muscle of fish demonstrate negligible non-carcinogenic harm to residents' health. Contrarily, As, and Cd pose a cancer threat for kids and adults who eat muscular fish, and it needs to be viewed as a warning sign from the perspective of data indices and human health.

Environmental Ethics of War: Jus ad Bellum, Jus in Bello, and the Natural Environment

The conduct of hostilities is very bad for the environment, yet relatively little attention has been focused on environmental military ethics by just war theorists and revisionist philosophers of war. Contemporary ecological concerns pose significant challenges to jus in bello. I begin by briefly surveying existing literature on environmental justice during wartime. While these jus in bello environmental issues have been addressed only sparsely by just war theorists, environmental jus ad bellum has rarely been tackled within JWT or the morality of war. In line with the theme of this special issue, I focus my discussion of war and the natural environment primarily on the jus ad bellum level. I set out with the presumption against the use of force, and its possible exceptions. The principal question raised is whether environmental harm can trigger a new justification for war. Beyond just cause, I consider what might be a proportionate response to “environmental aggression,” or negligent harm to nature. The use of force is clearly justified in response to military attacks, against the natural environment or otherwise. Where harm to nature or its inhabitants are not caused by military aggression, just war theory criteria point in favor of responding via measures short of war. Finally, I suggest that responding by means that are not themselves harmful to nature serves to fulfill the further jus ad bellum criterion of “right intention.”

If negligence is intentionality’s cousin, recklessness is it’s sibling: Differentiating negligence and recklessness from accidents and intentional harm

Previous research has examined lay conceptualizations of intentionality and negligence. This work has shown that intentionality is attributed when several key mental states are perceived as simultaneously present (i.e., knowledge, desire, awareness, and intent), suggesting an actor was trying to bring about an outcome by acting in a particular way. Following this, research has shown that attributions of negligence—a judgment that is applied when a person’s actions unintentionally lead to material or physical harm—rely on beliefs that similar mental states are present (e.g., knowledge and awareness), but when intent to harm is absent. Yet, no in-depth investigations into recklessness and its relation to negligence and intentionality have been reported, despite recklessness being theorized as occupying a conceptual space between negligent and intentional harm. Across four studies (N = 2,092), the current research begins filling this gap. Results show that folk conceptualizations of recklessness are associated with similar (e.g., knowledge) but distinct (e.g., uncaring desire, disregard of risk) mental states from those of intentionality and negligence. In addition, the current studies also demonstrate how negativity in evaluations respectively track a full continuum of harm judgments running from accidents through negligence to recklessness and intentional harm. Moreover, the current work shows how evaluations of recklessness are situated between negligent and intentional harm, with negligence situated between accidents (i.e., where harm was not caused by an actor’s actions) and recklessness, with each concept sharing some features (but not others) with both adjacent concepts. Implications for social and legal psychology are discussed.

Construction of charge-switchable and pH-sensitive carboxymethyl chitosan/Zn2+/heterocycle nanocomposite for the treatment of phytopathogens in agriculture

Bacterial and fungal infections have resulted in serious crop diseases, posing severe threats to food security. There is an urgent need to develop innovative antibacterial strategies to manage microbial infections. Herein, we fabricated a novel charge-switchable nanocomposite demonstrating pH-responsive infiltration into an acidic biofilm for heterocycles synergistic Zn2+ eradication of the Gram-negative bacteria (E. coli), Gram-positive bacteria (S. aureus) and fungi (R. Solani) biofilm with negligible harm to normal tissues. Originally, by stabilizing the Zn2+/heterocycles nanocomposite with the pH-sensitive functional carboxymethyl chitosan (DA-CMCS) via a facile aqueous one pot flash nanoprecipitation (FNP), the nanocomposite DA-CMCS@Zn2+@heterocycles was finely prepared. Due to the amide group of DA-CMCS was sensitive to pH variations and could be rapidly hydrolyzed, the DA-CMCS@Zn2+@heterocycles nanocomposite shows perfect surface charge change from negative charge at healthy pH (7.4) to positive charge at acidic biofilm pH (5.5). Thus, the nanocomposite with nano-scale size and positive charge are favorable for enhanced strong adherence to the negatively charged surfaces of microorganisms against plant disease. The present research contributes a prospective idea to the development of charge-switchable heterocycles/metal nanocomposites for effective inhibition microbial infections, showing a great potential of application in the modern agricultural industry.

4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells

ABSTRACT Multidrug resistance (MDR) is considered as a major obstacle in achieving an effective treatment of breast cancer. Paclitaxel has been used to treat cancers of the cervical, breast, ovarian and brain but MDR limits its therapeutic potential. Phytochemicals have received much interest in recent decades especially in combination approaches to tackle MDR due to their negligible harm to healthy cells and synergistic potential. Considering this notion, the present study aimed at investigating the synergistic activity of 4-MTBITC and PTX against a panel of breast cancer cells. Our results revealed that the combination had a significant antiproliferative activity against T-47D cells. Mechanistic studies revealed that 4-MTBITC and PTX also promoted the production of reactive oxygen species (ROS) and reduced mitochondrial membrane potential. In the presence of 4-MTBITC- PTX, T-47D cells were found to be arrested in the G2/M phase which also confirmed the enhancement of late apoptotic cell population in the flow cytometer analysis. In western blot experiment, the combination had a significant decrease in Bcl-xl protein level, whereas a higher level of p53, cleaved caspase-3, and cleaved caspase-9 proteins compared to individual treatment in T-47D cells. The RT-qPCR analysis also showed that the combination had significant upregulation in the gene expression of p53, cytochrome-c, Apaf-1 and downregulation in the expression of Bcl-2 gene in T-47D cells. Hence, all the results showed that a combination of 4-MTBITC-PTX significantly enhanced the apoptosis pathway in the T-47D cell line which indicates its clinical application for the treatment of breast cancer. Abbreviations: Apaf-1: Apoptotic protease activating factor 1; AO/EB: Acridine orange/ethidium bromide; Bcl-2: B-cell lymphoma 2; CI: Combination Index; Cyt-c: Cytochrome c; CO2: Carbon dioxide; DCFH-DA 2,7-Dichloroflourescein diacetate; DMEM: Dulbecco’s modified Eagle’s medium; ELISA: Enzyme-linked immunosorbent assay; EA: Early apoptosis; EDTA: Ethylenediaminetetraacetic acid; L929: Normal mouse fibroblast cells; LA: Late apoptosis; L: Live; 4-MTBITC: 4-methylthiobutyl isothiocyanate; MCF-7: Human breast cancer cells; MDA-MB-231: Human triple negative breast cancer cells; MMP: Mitochondria membrane potential; MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide; NCCS: National Centre for Cell Science; N: Necrotic; PTX Paclitaxel; PVDF: Polyvinylidene fluoride; PAGE: Polyacrylamide gel electrophoresis; PBS: Phosphate-buffered saline; RPMI-1640: Roswell Park Memorial Institute Medium- 1640; RT-qPCR: Quantitative real-time polymerase chain reaction; ROS: Reactive oxygen species; Rh-123: Rhodamine123; g Relative centrifugal force; SDS: Sodium dodecyl sulphate; SEM: Scanning electron microscopy; T-47D: Human estrogen positive breast cancer cells; WB: Western blotting.

Preclinical evaluation of modified carbon nanohorns and their complexation with insulin.

The current study emphasizes the minimal toxicity observed in vitro and in vivo for carbon nanohorns (CNHs) modified with third generation polyamidoamine (PAMAM) dendrimers. Initially, we investigated the interactions between CNH-PAMAM and lipid bilayers, which were utilized as representative models of cellular membranes for the evaluation of their toxicity in vitro. We found that the majority of those interactions occur between the modified CNHs and the polar groups of phospholipids, meaning that CNH-PAMAM does not incorporate into the lipid chains, and thus, disruption of the lipid bilayer structure is avoided. This outcome is a very important observation for further evaluation of CNH-PAPAM in cell lines and in animal models. Next, we demonstrated the potential of CNH-PAMAM for complexation with insulin, as a proof of concept for its employment as a delivery platform. Importantly, our study provides comprehensive evidence of low toxicity for CNH-PAMAM both in vitro and in vivo. The assessment of cellular toxicity revealed that the modified CNHs exhibited minimal toxicity, with concentrations of 151 μg mL-1 and 349 μg mL-1, showing negligible harm to EO771 cells and mouse embryonic fibroblasts (MEFs), respectively. Moreover, the histological analysis of the mouse livers demonstrated no evidence of tissue necrosis and inflammation, or any visible signs of severe toxicity. These findings collectively indicate the safe profile of CNH-PAMAM and further contribute to the growing body of knowledge on the safe and efficient utilization of CNH-based nanomaterials in drug and protein delivery applications.

Characterization and assessment of potential risks of titanium dioxide nanoparticles isolated from gummy candies

Nanomaterials in food emerge in an endless stream; thus, the safety evaluation of nanomaterials in food is essential. In this study, titanium dioxide nanoparticles (TiO2-NPs) were extracted from five different gummy candies. The nanoparticles were comprehensively characterized using scanning electron microscopy, energy spectrum analysis, Fourier-transform infrared spectroscopy, and X-ray diffraction. The safety of TiO2 was evaluated using a simulated gastrointestinal system. Cell viability was determined using a Cell-Counting Kit-8 assay, and reactive oxygen species levels were measured to examine the cytotoxicity of TiO2 in GES-1 and Caco-2 cells. The effects of direct TiO2-NP exposure in animals were assessed by determining the body weight, organ coefficients, and tissue histopathology of mice. The energy-dispersive spectroscopy results demonstrated TiO2 present as separated nanoparticles. These negatively charged particles had a particle size of 180–300 nm and mostly comprised anatase crystals. TiO2 showed significantly more agglomeration during the gastric digestion phase relative to the oral and intestinal tracts with an increased particle size. The cytotoxicity of the nanoparticles increased with digestion time, leading to an insignificant increase in the intracellular ROS levels. Animal experiments revealed a significant increase in the five organ coefficients after TiO2-NP compared with those of the control group. Collectively, the results of this study suggest that organ damage caused by nanoparticles in food could be discerned from the tissue histopathology. The content and distribution of Ti in the experimental group could be detected by energy dispersive X-ray spectroscopy and inductively coupled plasma mass spectrometry, although this value was very small. These results suggest that daily intake of gummy candies has negligible harm to bodily function.

Transparency, Values and Trust in Science

Current debates over inductive risk and the role(s) of values in science have largely revolved around the question of the moral responsibilities of scientists: Do scientists have the duty to consider the potential non-epistemic consequences of theories they advocate and, if yes, what (or whose) values should be taken into account in decision-making? The paper discusses two different – though potentially complementary – responses to this question: a) H. Douglas’s view that scientists should avoid causing reckless or negligent harm to others as a result of the decisions they make and b) K. Elliott’s Multiple Goals Criterion. Drawing from the case of potential coronavirus transmission by sharing the Holy Communion that recently divided Greek society and medical experts, it shows the tensions emerging between autonomy and the moral responsibilities of scientists, when the boundaries of science are blurred and the epistemic goal of truth is inconsistent with (or succumbs to) alternative goals. It argues that the balance attempted between scientific principles and religious beliefs was unattainable and concludes that the need to distinguish between epistemic and non-epistemic values (and contexts or truths), which is traditionally related to the ideal of value free science, should be reconsidered and even prioritized among the responsibilities of scientists.

Should the Food and Drug Administration Limit Placebo-Controlled Trials?

Should the Food and Drug Administration Limit Placebo-Controlled Trials?

Civil liability for medical error

The article is devoted to the research of the grounds for bringing a medical worker to civil liability for a mistake made during the provision of medical care (services) to a patient.The structural elements of insurance risk are considered in the contract of civil liability insurance of health care institutions, where the mistake made by a medical worker during the provision of medical care (services) to a patient is a source of insurance risk, an event that causes negative health consequences or the patient’s life and, accordingly, is subject to insurance coverage in the above insurance contract.It has been proven that medical malpractice, as a basis for payment of insurance indemnity by the insurer to the victim, is characterized by unsuccessful processes that are clearly associated with adverse consequences for the health or life of the patient in connection with the latter’s medical care. In this case, this error is such only in the presence of inconsistency of actual decision, actions (inaction) of the nurse to the established standards of medical care in each case, provided there are no grounds for reasonable for establishing the validity of the deviation of the medical worker from the established standards of medical care must find its own clear regulations of medical care must find its own clear regulations to avoid unjustified reference to him as a basis for exemption from legal liability of the perpetrator. The concept of medical error is clarified, which is proposed to mean the negligent infliction of harm to the life or health of a patient during the performance of his professional duties, in the absence of adequate (necessary and sufficient) application of special knowledge and skills, as well justified risk in each case. It is assumed that the justification of the risk, as a condition for the release of a medical worker from liability, should be established by the court on the basis of a forensic examination. It has been established that medical error is characterized by negligent harm to the health or life of a patient by a healthcare professional, and therefore intent, as one of the forms of guilt in civil law, excludes error as such; only fault in the form of negligence is the basis for insurance indemnity. Carelessness in these legal relations is manifested in the form of careless attitude of the medical worker to the potential risk or his negligence in relation to the latter.

Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box-Behnken Design.

In the current study, nitrofurazone- (NFZ) and lidocaine-loaded (LD) silica microspheres were fabricated to address pathological indications of skin infections. The microspheres were prepared by the sol–gel method applying the Box–Behnken design and evaluated for size distribution, morphology, zeta potential, physico-chemical compatibility, XRD, thermogravimetric analysis, antibacterial and cytotoxicity activities. The comparative in vitro drug release study of microspheres revealed a 30% release of NFZ and 33% of LD after 8 h. The microspheres showed 81% percentage yield (PY) and 71.9% entrapment efficiency. XRD patterns confirmed the entrapment of NFZ–LD in silica microspheres with a significant reduction in crystallinity of the drugs. Thermal and FTIR studies proved the absence of any profound interactions of the formulation ingredients. The smooth spherical microspheres had a −28 mV zeta potential and a 10–100 µm size distribution. In vitro antibacterial activities of the NFZ–LD microspheres showed an increased zone of inhibition compared to pure drug suspensions. The in vivo efficacy tested on rabbits showed a comparatively rapid wound healing with complete lack of skin irritation impact. The cytotoxicity studies revealed more acceptability of silica microspheres with negligible harm to cells. The study suggests that the NFZ- and LD-loaded silica microspheres would be an ideal system for accelerating and promoting rapid healing of various acute and chronic wounds.

Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China.

In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal‐derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight sulfonamides, nine fluoroquinolones, four tetracyclines, and five macrolides) were screened in 88 meat samples (cattle muscles and sheep muscles, kidneys, and livers) obtained from southern Xinjiang. The antibiotics were screened via the clean‐up step based on solid‐phase extraction and determined through ultraperformance liquid chromatography–tandem mass spectrometry. Moreover, their risk to human health was analyzed. Overall, 16 antibiotics were detected with a total detection rate of 95.46%. The percentage of noncompliant samples was 28.41% with an exceedance maximum residue limit of 1.14%. The illegal use rate of the antibiotic norfloxacin was 27.27%. The estimated daily exposure doses of all compounds in adults were <102.218 ng/kg bw/day even after applying the worst‐case scenario approach. This result demonstrated that the antibiotic residues in the tested samples imposed negligible harm to people's health and had an acceptable level of food safety risk. However, the high detection frequencies found in this work indicated that the risk of antibiotic residues could not be ignored given the cumulative risk of antibiotics, particularly the emergence of bacterial resistance, to the human body. The need for effective strategies and publicity for the judicious use of antibiotics to safeguard residents’ health is immediate.

Pharmacologic and Non-Pharmacologic Dyspnea Management in Advanced Cancer Patients.

As there is a high propensity for patients with advanced malignancy to experience refractory dyspnea, it is necessary for physicians to be well-versed in the management of these patients' dyspneic symptoms. For symptomatic treatment of cancer patients with dyspnea, both pharmacologic and non-pharmacologic methods should be considered. The main source of pharmacologic symptom management for dyspnea is oral and parenteral opioids; benzodiazepines and corticosteroids may serve as helpful adjuncts alongside opioid treatments. However, oxygen administration and nebulized loop diuretics have not been shown to clinically benefit dyspneic cancer patients. Applying non-pharmacologic dyspnea management methods may be valuable palliative therapies for advanced cancer patients, as they provide benefit with negligible harm to the patient. Advantageous and minimally harmful non-pharmacologic dyspnea therapies include facial airflow, acupuncture and/or acupressure, breathing exercises, cognitive behavioral therapy, music therapy, and spiritual interventions. Thus, it is vital that physicians are prepared to provide symptomatic care for dyspnea in advanced cancer patients as to minimize suffering in this patient population during definitive cancer treatments or hospice care.

Medico-Legal Analysis of General Surgery Cases in Greece: A 48 Year Study.

IntroductionSurgery can be dangerous not only for patients, but it also carries a risk for the surgeon in case of medical error, which can affect their future medical career. The purpose of our research is to assess the current situation regarding medical liability in General Surgery in Greece, the reasons for the allegations of medical malpractice as well as the relationship between these issues and the court results.MethodsPublished court decisions of criminal, civil, administrative and disciplinary content were searched in legal information banks, between year 1973 and 2020. Court decisions were analyzed by an expert, a specialist general surgeon and an anesthesiologist, for the causes of death and the correctness of the court decision in collaboration with the lawyers of the investigation.Results 588 court decisions were retrieved, out if which 103 (17.751%) criminal (n = 81), or civil and administrative decisions (n ​​= 22) for surgeons. Out of a total of 81 first and second instance criminal cases and appellate court decisions of the Supreme Court, 27 cases concerned negligent homicide, 16 cases concerned negligent bodily harm and seven were acquittals. Out of 22 civil cases decisions, awarding or not awarding compensation, three cases concerned negligent homicide, seven bodily harm and two were acquittals. 11 cases of negligent homicide concerned laparoscopic and bariatric surgical procedures.ConclusionsLaparoscopic surgery represents one of the most important surgical developments in the last 30 years. However, they represent a great proportion of the cases concerning medical malpractice in the greek legal system. It is important to have a national center for reporting misdiagnosis and complications and a medical liability system that will facilitate improved diagnosis, learning from diagnostic errors and delays in diagnosis, in order to avoid similar cases of malpractice in the future.

Bioactive glasses and glass-ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives.

Bioactive glasses and glass-ceramics are well-proven potential biomaterials for bone-tissue engineering applications because of their compositional flexibility. Many research groups have been focused to explore the utility of bioactive glass–ceramics beyond bone engineering to hyperthermia treatment of cancer. Hyperthermia refers to raising the temperature of tumor close to 44°C at which malignant cells perish with negligible harm to normal cells. Hyperthermia can be employed by many means such as by ultrasonic waves, electromagnetic waves, infrared radiations, alternating magnetic fields, etc. Magnetic bioactive glass–ceramics are advantageous over other potential candidates for thermoseeds such as nanofluids, superparamagnetic nanoparticles because they can bond not only to the natural bone but also with soft tissues in few cases, which helps regenerating the affected part due to its bioactive nature. Strict restrictions on clinical settings (< ) force the research activities to be more focused on material characteristics to raise the implant temperature to required ranges. Lots of efforts have been made in past years to tackle these challenges and design best-suited glass–ceramics for hyperthermia treatment. This review aims to provide essential information on the concept of hyperthermia treatment of cancer and recent developments in the field of bioactive glass–ceramics for cancer treatment. The advantages and disadvantages of magnetic glass–ceramics over other potential thermoseed materials are highlighted. In this field, the major challenges are to develop magnetic glasses, which have fast and bulk crystallization with optimized magnetic phases with lower Curie and Neel temperatures.

Corrosion Mechanisms of High-Mn Twinning-Induced Plasticity (TWIP) Steels: A Critical Review

Twinning-induced plasticity (TWIP) steels have higher strength and ductility than conventional steels. Deformation mechanisms producing twins that prevent gliding and stacking of dislocations cause a higher ductility than that of steel grades with the same strength. TWIP steels are considered to be within the new generation of advanced high-strength steels (AHSS). However, some aspects, such as the corrosion resistance and performance in service of TWIP steel materials, need more research. Application of TWIP steels in the automotive industry requires a proper investigation of corrosion behavior and corrosion mechanisms, which would indicate the optimum degree of protection and the possible decrease in costs. In general, Fe−Mn-based TWIP steel alloys can passivate in oxidizing acid, neutral, and basic solutions, however they cannot passivate in reducing acid or active chloride solutions. TWIP steels have become as a potential material of interest for automotive applications due to their effectiveness, impact resistance, and negligible harm to the environment. The mechanical and corrosion performance of TWIP steels is subjected to the manufacturing and processing steps, like forging and casting, elemental composition, and thermo-mechanical treatment. Corrosion of TWIP steels caused by both intrinsic and extrinsic factors has posed a serious problem for their use. Passivity breakdown caused by pitting, and galvanic corrosion due to phase segregation are widely described and their critical mechanisms examined. Numerous studies have been performed to study corrosion behavior and passivation of TWIP steel. Despite the large number of articles on corrosion, few comprehensive reports have been published on this topic. The current trend for development of corrosion resistance TWIP steel is thoroughly studied and represented, showing the key mechanisms and factors influencing corrosion processes, and its consequences on TWIP steel. In addition, suggestions for future works and gaps in the literature are considered.

Исторические зигзаги юридической ответственности врача

The article is devoted to studying the history of the issue of legal liability of doctors. It is noted that in Russia over the past 300 years, the legal regulation of doctors’ liability for negligent harm has undergone a number of multidirectional changes: first, the legalization of sanctions on the talion principle (XVII– XVIII centuries), then actual decriminalization (mid-XIX century), and then the transition to the practice of criminal prosecution on a general grounds (beginning of XX century).