A fundamental aspect of eye care and the long-term prevention of vision loss for patientswith diabetesmellitus involves the identification of specific retinal pathologies and the subsequent determination of the severity of diabetic retinopathy. Traditionally, this has been accomplished through individualized assessments by experienced eye care professionals, preferably following pupillary dilation. However, given that it is estimated that there will be more than half a billionpersonswithdiabetesby2030,necessitatingnearly2000 eye examinations per minute just to evaluate those in need once every year, this approach to retinal evaluation is unlikely to be sustainable by health care systems globally. Furthermore, despite multiple national and international initiatives to increase access andpromote awareness regarding the need for eye examinations for all persons with diabetes, only approximately 18% to 60% of persons undergo examinations that attain the recommended ocular examination guidelines. Progress, however, is possible. One of the success stories in the fight against complications due to diabetic retinopathy comes from the UK National Health Service in England andWales, which reports that, for the first time in 5 decades, diabetic retinopathy is no longer the leading cause of blindness in the working age population.1 A large part of this success appears to be due to their introduction of a nationwide telemedicine program for diabetic retinopathy and to improved glycemic control. Similar studies2-4 across multiple countries and populations have demonstrated that the prevalence of blindness and visual impairment among patients with diabetes is lowest among populations with programs that provide retinal evaluations for all patients with diabetes. Largely achieved using telemedicine programs for diabetic retinopathy, the implementation of retinal evaluations for all patients with diabetes has been shown to reduce the incidence of blindness among patients with diabetes by as much as 95%.3 In this issue of JAMA Ophthalmology, Mansberger and colleagues5 report on the long-termeffectiveness of telemedicine comparedwith traditional eye examinations for diabetic retinopathy by an eye care professional. This study,5 with up to5yearsof follow-up, reports that telemedicine increased the percentage of diabetic retinopathy examinations, with diabetic retinopathyseverity remaininggenerally stable, thussupporting theuseof telemedicine to screen fordiabetic retinopathy and monitor for disease worsening over a long period in the primary care setting. This and the other studies cited suggest that a telemedicine approach for diabetic retinopathy evaluation can effectively increase the rates of eye examinations, thereby potentially reducing the rates of blindness and vision loss in thediabetic population.However,Daskivich and Mangione6 caution readers that the devilwill be in the details whenitcomestoprimarycare–basedscreeningfordiabetic retinopathy. Indeed, to ensure that the benefits of telemedicine are fully realized in the real world, there is a need for standardized image capture; validated methods for image evaluation and reporting; definedquality control andquality assurance metrics; and secure data transmission, storage, and retrieval. Toaid this endeavor, theAmericanTelemedicineAssociationhaspublished the secondeditionof thepractice recommendations forocular telehealthprograms fordiabetic retinopathy that discusses eachof these critical aspects indetail.7 Given the ever more firmly established benefit of telemedicineprogramsfordiabetic retinopathy,ouremphasismust now shift toward optimizing approaches that improve efficiency, maximize beneficial long-term outcomes, and promote sustainability. Keys to success are the ongoing efforts to develop accepted recommendations on quality control, qualityassurance, referralguidelines, andstandards forpatientcare and safety. Furthermore, as the electronicmedical record becomes more universally integrated within telemedicine programs, evaluationof longitudinal clinical datamayprovide information relevant to care recommendations that may not otherwise be readily discovered.8 The retinal imaging device remains a technological cornerstone of any telemedicine program for diabetic retinopathy. Retinal imaging devices must meet current recommendations of image resolution (20 pixels per degree with a resolution of at least 10-15 μm) andmust be validated against Early Treatment Diabetic Retinopathy Study standard 7-field photography in determining the ability to identify and determine diabetic retinopathy severity. The importance of image quality is highlighted in the study by Mansberger and colleagues,5 who reported that the rate of ungradable images was approximately 3%to 11% fordiabetic retinopathyand 13% to 22% for diabetic macular edema across the different time intervals. These ungradable images prompted traditional eye examinations (as opposed to telemedicine examinations) for approximately 19%to26%ofpersons.Becauseungradable images necessitate a traditional examination, 1 in 4 or 5 patients would require a referral, limiting the cost-effectiveness of any telemedicineprogram.Furthermore,supplemental imagingapproachesmaybeofconsiderablebenefit.Forexample, the rates of ungradable images for diabetic macular edema are almost always higher than the rates of ungradable images for retinopathy, suggesting that the supplemental use of optical coherence tomography or a combined optical coherence tomographic/photographic modality might improve community outreach programs. Given recent progress in the care of personswithdiabetic retinopathy, the futureadvancementof teleRelated article Telemedicine and Eye Examinations for Diabetic Retinopathy Invited Commentary
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