Cadmium (Cd) toxicity is one of the most severe environmental threats inhibiting crop growth and productivity. Strategies to mitigate the adverse effects of Cd stress on plants are under scrutiny. Nano silicon dioxide (nSiO2) is an emerging material and could protect plants against abiotic stress. Can nSiO2 alleviate Cd toxicity in barley, and the possible mechanisms are poorly understood. A hydroponic experiment was conducted to study the mitigation effects of nSiO2 on Cd toxicity in barley seedlings. The results showed that the application of nSiO2 (5, 10, 20, and 40mg/L) increased barley plant growth and chlorophyll and protein content, improving photosynthesis, compared with Cd-treated alone. Specifically, 5-40mg/L nSiO2 addition increased net photosynthetic rate (Pn) by 17.1, 38.0, 30.3, and - 9.7%, respectively, relative to the Cd treatment alone. Furthermore, exogenous nSiO2 reduced Cd concentration and balanced mineral nutrient uptake. The application of 5-40mg/L nSiO2 decreased Cd concentration in barley leaves by 17.5, 25.4, 16.7, and 5.8%, respectively, relative to the Cd treatment alone. Moreover, exogenous nSiO2 lowered malondialdehyde (MDA) content by 13.6-35.0% in roots, and by 13.5-27.2% in leaves, respectively, compared with Cd-treated alone. Besides, nSiO2 altered antioxidant enzyme activities and alleviated detrimental effects on Cd-treated plants, attaining maximal values at 10mg/L nSiO2. These findings revealed that exogenous nSiO2 application may be a viable option for addressing Cd toxicity of barley plants.