Multi-parameter Quality Research Articles

БАГАТОКРИТЕРІАЛЬНА МОДЕЛЬ ЯКІСНОЇ ОЦІНКИ ТА ВИБОРУ СУЧАСНИХ ІМПУЛЬСНИХ РЕФЛЕКТОМЕТРІВ

A multicriteria model of qualitative assessment and selection of modern time-domain reflectometers is proposed in the article. The purpose of this study is to accelerate the procedure of determining the best model of the reflectometer from the appropriate company by creating a criterial equation based on modeling and visualization of multi-parameter quality criteria. A relational model of a set of modern time-domain reflectometers with structured data of technical and economic indicators has been developed. Conditional dimensional criteria for determining values based on dimension theory have been compiled. A multicriteria model of qualitative assessment of modern time-domain reflectometers in dimensionless coordinates has been constructed. A comparative analysis to determine the best model of the reflectometer of a certain company by parameters has been performed. To solve this problem, a set of modern time-domain reflectometers with structured data of technical and economic parameters in the form of a relational model is defined. It is proposed to use dimensional theory, physical modeling and to create conditional quality criteria based on the heuristic method. Comparative analysis shows that Megger company is the best in terms of dimensional criteria. The histogram compares technical and economic indicators of time-domain reflectometers of this company. As can be seen from the comparison of technical and economic indicators of Megger time-domain reflectometers, Megger Teleflex VX model, which has the best range and accuracy is the best one. The developed model allows to accelerate the design process and select the way to improve and ensure high quality for devices of this type.

Nanofluidic device for continuous multiparameter quality assurance of biologics.

Process analytical technology (PAT) is critical for the manufacture of high-quality biologics as it enables continuous, real-time and on-line/at-line monitoring during biomanufacturing processes. The conventional analytical tools currently used have many restrictions to realizing the PAT of current and future biomanufacturing. Here we describe a nanofluidic device for the continuous monitoring of biologics' purity and bioactivity with high sensitivity, resolution and speed. Periodic and angled nanofilter arrays served as the molecular sieve structures to conduct a continuous size-based analysis of biologics. A multiparameter quality monitoring of three separate commercial biologic samples within 50 minutes has been demonstrated, with 20 µl of sample consumption, inclusive of dead volume in the reservoirs. Additionally, a proof-of-concept prototype system, which integrates an on-line sample-preparation system and the nanofluidic device, was demonstrated for at-line monitoring. Thus, the system is ideal for on-site monitoring, and the real-time quality assurance of biologics throughout the biomanufacturing processes.

Bioengineering a human plasma-based epidermal substitute with efficient grafting capacity and high content in clonogenic cells.

Cultured epithelial autografts (CEAs) produced from a small, healthy skin biopsy represent a lifesaving surgical technique in cases of full-thickness skin burn covering >50% of total body surface area. CEAs also present numerous drawbacks, among them the use of animal proteins and cells, the high fragility of keratinocyte sheets, and the immaturity of the dermal-epidermal junction, leading to heavy cosmetic and functional sequelae. To overcome these weaknesses, we developed a human plasma-based epidermal substitute (hPBES) for epidermal coverage in cases of massive burn, as an alternative to traditional CEA, and set up critical quality controls for preclinical and clinical studies. In this study, phenotypical analyses in conjunction with functional assays (clonal analysis, long-term culture, or in vivo graft) showed that our new substitute fulfills the biological requirements for epidermal regeneration. hPBES keratinocytes showed high potential for cell proliferation and subsequent differentiation similar to healthy skin compared with a well-known reference material, as ascertained by a combination of quality controls. This work highlights the importance of integrating relevant multiparameter quality controls into the bioengineering of new skin substitutes before they reach clinical development. This work involves the development of a new bioengineered epidermal substitute with pertinent functional quality controls. The novelty of this work is based on this quality approach.

Perioperative Steroids for Peritumoral Intracranial Edema

There has been a renewed interest in the recent literature regarding the proposed benefits of systemic steroids in the perioperative period. Among these benefits are the relief of postoperative pain, the decrease in postoperative nausea, and a higher overall multiparameter quality of recovery. Perioperative steroids, however, are not without their potential drawbacks, including decreased immune function, hyperglycemia, and impaired wound healing. The use of perioperative steroids for brain tumor treatment and resection has been a component of therapy for approximately 50 years, owing primarily to their well-described, although poorly understood, effect in minimizing vasogenic peritumoral edema, and therefore intracranial pressure. This review seeks to highlight the history, mechanisms, therapeutic efficacy, and side effects of steroid use for brain tumors in the perioperative period.