BACKGROUND AND AIM: Extramedullary Plasmacytomas (EMP) are rare tumors accounting for 0.4% of all head and neck malignancies. The patients ranged from 34 to 76 years, there was a marked preponderance of males. Chronic, non-painful swelling of the posterior portion of mandible with is the commonest symptom. Monoclonal immunoglobulin was initially detected in 42% of the evaluated patients. The majority of patients were treated with radiation therapy. 17% of the patients progressed to multiple myeloma within 1 year. A 60 yr old male, chronic tobacco sniffer presented with swelling posterior end mandible. Radiography revealed a multilocular radiolucent lesion in the mandibular posterior region. Bone marrow aspiration revealed a plasma cell infiltrate of less than 3% of all nucleated cells. Microscopically the tumour shows mature, immature, typical, atypical, binucleate plasma cells in sheets. A histological diagnosis of plasmacytoma was made. CONCLUSION: We report a case of extramedullary plasmacytoma ( EMP ) of the mandible in a 60 year old male, who was a chronic tobacco sniffer. The case demonstrates the multidisciplinary approach required for the optimal diagnosis and management of such tumors and proposes chronic irritation as one of the INTRODUCTION: Extramedullary Plasmacytomas (EMP) are rare tumors accounting for 0.4% of all head and neck malignancies. Review of the literature disclosed the following characteristics regarding the clinical course and prognosis. The patients ages ranged from 34 to 76 years, with a mean of 53 years; there was a marked preponderance of males. The site of predilection was the posterior portion of the mandible. The common symptom was a non-painful swelling of the mandible of long duration, and radiological features were non-specific. Monoclonal immunoglobulin was initially detected in 42% of the evaluated patients. The majority of patients were treated with radiation therapy with a mean dose of 48Gy with or without surgery. The period of follow-up ranged from 4 months to 12 years, and 17% of the patients progressed to multiple myeloma within 1 year. A plasmacytoma is a discrete, solitary mass of neoplastic monoclonal plasma cells in either bone or soft tissue (extramedullary).Solitary plasmacytomas can be divided into 2 groups according to location: