Dear Editor, Castelman’s disease (CD), angiofollicular, or giant lymph node hyperplasia results in abnormal proliferation of B lymphocytes and plasma cells in lymphoid tissues. There are clinically two types of the disease as localized and multicentric. While CD are divided to hyaline-vascular and plasma cell types, plasmablastic type is also described, according to histopathological features. Hyaline-vascular type is detected in 90% and 3–10% of the patients with localized and multicentric CD, respectively. However plasma cell type is seen in 10% and 80–90% of the patients with localized and multicentric CD, respectively. Plasmablastic type is usually multicentric and associated with human herpes virus-8 (HHV-8) infections. Several disorders may be seen in especially multicentric type and plasma cell variant CD. However, Crohn’s disease was reported in only one case with CD in literature. This case was multicentric and plasma cell type of CD. Here we report both hyaline-vascular type of CD and Crohn’s disease in the same patient. In case, a 66-year-old female suffering from fatigue, abdominal pain, loss of body weight of 10 kg, and watery diarrhea without blood and mucus for 3 months was hospitalized. Her history included hypertension for 10 years, cholecystectomy, total abdominal hysterectomy, and bilateral salpingoopherectomy 15 years ago. On physical examination, a blood pressure 150/70 mmHg, pulse rate of 116/min, and temperature of 37.5°C were recorded. Dullness on percussion of lower zones of bilateral chest was detected and lung sounds were not heard on lower zones of lung auscultation. A 2-cm liver was palpated. Other findings were operation scars in abdomen and (+++) pretibial edema. Laboratory values were: hemoglobin level 8.2 g/dl, white blood cell count 5.8×10/μl, platelet count 512×10/μl, and erythrocyte sedimentation rate 45 mm/h. Iron parameters were normal except of decrease of serum iron 6 μg/dl and iron saturation 9%. Biochemical values were normal except total protein 4.2 g/dl and albumin 1.8 g/dl. C-reactive protein (CRP) increased to 23 mg/dl. Polyclonal gammopathy was found on protein electrophoresis. Viral markers such as hepatitis-B surface antigen, human immune deficiency virus (HIV), and antibody to hepatitis-C virus were negative. PPD was negative. Thyroid function tests and urine analysis were normal. While blood was detected on stool examination, fat was negative. At the upper gastrointestinal system endoscopy, polyp appearance in size 5 mm in cardia and erythematous gastritis in antrum were seen. Helicobacter pylori were not detected with rapid urease test. Rectosigmoidoscopy was normal. Colonoscopy could not be performed because the patient did not accept. The pathological examination revealed hyperplastic polyp and pangastritis. There was bilateral pleural effusion on chest X-ray and spiral computed tomography of thorax. When pleural effusion was examined, it was benign and transudate. Hepatomegaly, peritoneal fluid, thickness in the wall of small intestine, and multiple mesenteric lymph nodes were found on spiral computed tomography of abdomen. Protein-losing enteropathy was excluded using Tec99m dextrane scintigraphy. Diagnostic laporotomy was performed on the patient. After the pathological examination, Int J Colorectal Dis (2009) 24:123–124 DOI 10.1007/s00384-008-0545-6