Single transient exposure to low-frequency low-intensity electrical stimulation produces ketamine-like effects in human iPSC-derived dopaminergic neurons via Ca2+-dependent BDNF and mTOR signaling.

RNF130 inhibits the proliferation, migration and invasion of osteosarcoma through DAB1 mediated suppression of the PI3K/AKT signaling pathway.

GP73 inhibition alleviates hepatic fibrosis by suppressing TGF-β/mTOR signaling pathways.

Ethyl acetate fraction of Chaidangbo prescription (EAFC) improves hippocampal neural plasticity in CUMS mice: involving glucocorticoid receptors and Akt-related signaling pathway.

Rougan Granules ameliorates liver fibrosis through autophagy regulation: Insights from HPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation.

Anmei decoction alleviates myocardial injury in sleep-deprived rats by PI3K/Akt/mTOR/HIF-1 pathway.

Gut microbiome and metabolic responses of adult zebrafish (Danio rerio) to the co-exposure of polyethylene microplastics and levofloxacin.

mTORC1-mediated inhibition of AMBRA1/PINK1/Parkin-dependent mitophagy contributes to renal podocyte injury in trichloroethylene-sensitized mice.

Cell-penetrating TIPE2 peptide effectively suppresses tumor migration and progression via targeting RAC1.

Multi-omics analysis reveals that Rabdosia rubescens aqueous extract inhibits esophageal squamous cell carcinoma by targeting the PI3K/AKT/mTOR pathway.

EXOC6B promotes cilial elongation via autophagy-dependent protein turnover.

Dietary geroprotective peptides: structural determinants, AI-driven discovery, and synthetic biology production for healthy ageing.

SPG11 models reveal lysosomal calcium regulation of neural progenitor proliferation.

Effects of butylated hydroxytoluene (BHT) on taste compounds in Ruditapes philippinarum: Taste evaluation and metabolic interference mechanisms.

Ferulic acid potentiation of two natural iridoids induced PACAP signaling extended the antidepressant effects.

Quercetin attenuates LTA-induced tight junction disruption in mammary epithelial cells by modulating autophagy via the AMPK/mTOR pathway.

PMEPA1 promotes mTOR inhibitor resistance in triple-negative breast cancer: Targeting the TGF-β/PMEPA1 axis as a therapeutic strategy to overcome resistance.

Partial replacement of fish meal with Chlorella meal improved flesh quality without compromising growth and health condition in largemouth bass (Micropterus salmoides)

Alogliptin attenuates diabetes-associated cognitive impairment in rats via HMGB1/RAGE/TLR4-NFκB pathway modulation.

Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation.