A phylogeny of the family Lacertidae was derived from mtDNA gene sequence data. Seventeen species, representing 16 currently recognized genera and subgenera, were included in the analysis. A total of 954 bp was obtained and aligned from 12S and 16S partial gene sequences. A preferred tree was selected based on weighted parsimony and functional ingroup and outgroup analyses. Decay analysis, bootstrapping, and permutation tail probability were used to evaluate support for the recovered nodes. The genusGallotiawas resolved as the basal taxon and the sister group of all remaining lacertids.Takydromusbranched off next. All African lacertids grouped together and formed a monophyletic clade with the Eurasian generaEremiasandOphisops.The remaining Eurasian lacertids sequentially branched off near the base of the tree in a “comb-like” fashion. The basal position ofGallotiaand the monophyly of African lacertids are consistent with previous hypotheses. The European-origin hypothesis of lacertids is favored, and the distribution of lacertids in Africa is likely a Miocene dispersal event. Most of the extant European lacertids probably arose after the Eocene. The classification of the family needs to be revised.