Objectives: To evaluate applicability of Tanaka and Johnston (T&J) and Moyer’s mixed dentition prediction methods and formulate regression equations for predicting mesiodistal widths of unerupted canines and premolars in Mysore population. Dental casts of 400 Mysore subjects aged 16-23years were used. Mesiodistal dimensions of mandibular permanent incisors, maxillary and mandibular permanent canines, first and second premolars were measured using a digital calliper calibrated to 0.01mm. Actual teeth measurements were then statistically compared with predicted values derived from T&J’s equations and Moyers probability tables at 75th percentile. T&J prediction equations overestimated mesiodistal widths of permanent canines and premolars in both arches. Moyers 75th percentile also overestimated actual measurements except for maxillary arch in female subjects. Percentage of overestimation was more for T&J prediction method than Moyers. Regression equations and probability tables derived for tooth size prediction for Mysore population would be more accurate when applied locally.