Movement Rules Research Articles

Preliminary Result of Phase 1 Trial of Orelabrutinib in Combination with Rituximab, Methotrexate, and Dexamethasone in Patients with Newly Diagnosed Primary CNS Lymphoma Implementing Bayesian Design for Dose-Seeking

Background: Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal subtype of diffuse large B-cell lymphoma (DLBCL). High-dose methotrexate (HD-MTX)-based regimen is the first-line treatment of PCNSL, with or without the anti-CD20 antibody rituximab, remaining to be suboptimal due to unstable response and short effective remission time. Genetic alterations often occur in the chronic active B-cell receptor signaling featured by MYD88 and CD79B which mediate the response to BTK inhibition (BTKi) in PCNSL. Orelabrutinib is a novel, potent, highly selective BTK inhibitor with a high CSF concentration. This study aims to investigate optimal combination dose of Orelabrutinib in combination with Rituximab, Methotrexate, and Dexamethasone (ORMD) as well as safety and efficacy of the regimen. Methods: This was a phase 1, investigator-initiated, dose-escalation study of ORMD, being conducted at Huashan Hospital, Fudan University (ClinicalTrials.gov identifier: NCT05036577). It was planned to enroll 12-15 patients with newly diagnosed PCNSL to the regimen of orelabrutinib and MTX combined with the fixed dose of rituximab(R) and dexamethasone(D). Eligible patients must have histopathologically confirmed PCNSL-DLBCL by biopsy of brain lesions and be aged 18-75 years with adequate organ functions. Patients were treated for 6-8 cycles of induction therapy with 21 days per cycle, receiving rituximab (375mg/m2 on day 1), dexamethasone (10-15mg on d1-d4), MTX (d2, 3.5g/m2 or 5g/m2), and orelabrutinib (once daily, after MTX clearance, 150mg/d, or 200mg/d), followed by orelabrutinib maintenance up to one year among CR/CRu patients. The primary objective was to determine the maximum tolerated dose (MTD) of the combination of orelabrutinib and MTX with R and D and investigate the safety and tolerability of this regimen using Bayesian Optimal Interval (BOIN) waterfall design to determine rule of dose escalation and movement among dose combination matrix to identify MTD contour. DLT was defined by the occurrence of severe toxicities during the first cycle: any grade 4 hematologic toxicity, grade 3 febrile neutropenia and grade 3 thrombocytopenia with hemorrhage, or any grade 3 non-hematologic toxicity that failed to respond to supportive therapy and possibly related to orelabrutinib and/or MTX (assessed according to NCI CTCAE V5.0). The secondary objectives included ORR/CR(u) and PFS/OS. Baseline tissue/CSF samples and sequential CSF/plasma samples were collected for targeted NGS and pharmacokinetics evaluation as exploratory objectives. Results: Eight patients were enrolled from October 2021 to June 2022 as the preliminary analysis set. The median age was 62 year (range: 43-73) and six patients were male. All the patients with histologically confirmed DLBCL (6 non-GCB subtypes and 2 GCB subtypes) had completed at least one cycle of ORMD treatment and were evaluable for DLT. The median cycle of ORMD was one (range: 1-7). No DLT occurred among first three patients in cohort 1 (Orelabrutinib: 150mg/MTX: 3.5g/m2) and dose escalation was allowed to cohort 2 (Orelabrutinib: 200mg/MTX: 3.5g/m2). In cohort 2, 5 patients were dosed in total, and Gr 3 lung infection was observed in patient #4 during cycle 1, was deemed as a DLT. Another four patients were enrolled in the same cohort according to BOIN design algorithm and no DLT was identified, allowing to escalate to cohort 3 (Orelabrutinib:200mg/MTX:5g/m2). No Gr 4 AE had been observed. The most common adverse events were lymphopenia (Gr 3 in 4 case) and hyperglycemia (Gr 3 in 1 case). No atrial fibrillation, hypertension, or bleeding was observed by the cut-off date. The study is ongoing. Further results will be updated as data becomes mature. Conclusions: ORMD regimen preliminarily demonstrated predictable and manageable safety profile in newly diagnosed PCNSL patients with 200mg/d orelabrutinib and 3.5g/m2 MTX to date. MTD contour not reached and further evaluation continues. Longer follow-up is needed regarding efficacy, biomarker, and more safety data Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal

FEATURES OF CUSTOMS CONTROL OF TRANSBOUNDARY MOVEMENT OF RARE SPECIES OF ANIMALS PROTECTED BY THE INTERNATIONAL CITES CONVENTION

The article discusses the features of control and supervision activities carried out by customs authorities in cases of transboundary movement of rare species of animals protected by the CITES Convention, details the procedure and rules for the transboundary movement of these objects. The CITES Convention is characterized as a special international act that ensures the conservation of biodiversity in the context of foreign trade in protected species of wild fauna.

Highway Vehicles’ Overtaking Classification

Abstract Highway users can apprehension to certain subjects with utilizing of Vehicular Ad-hoc Networks (VANET) applications if the rules for safe overtaking movement are violated to make the lane change maneuver between vehicles on the highway road. In our research, we suggest an algorithm for semi-automated vehicles S-AV compliant lane change to emphasize rules for safe overtaking between vehicles on the highway. The proposed algorithm technique classify the safe overtaking into major categories and critically analyzed them depending on various classes of lane change movements between vehicles interrelated to road condition based on different performance criteria; this technique will add awareness to drivers traveling on highway to increasing the comfort and safety of driving. Finally, we have conclude and suggest research issues associated to Vehicular Ad-hoc Networks to investigate and ensure the real-time decision of safe overtaking between vehicles on the highway, which is important research task to motivate researchers to connect the semi-automated vehicles with driver face emotion detection and increase driving safety.

Pedestrian emergency evacuation model based on risk field under attack event

In recent years, stabbings have occurred frequently around the world, often causing serious casualties and property losses. Therefore, using evacuation model to simulate and analyze this type of attack mode is of great significance to personnel safety and social stability. However, in the simulation process, the lack of interaction rules between pedestrians and attackers will seriously reduce the accuracy and credibility of the simulation result. Herein, this article focuses on the pedestrian evacuation under stabbings, we proposed a risk field model for pedestrian movement, its formula referred to the continuous point-source diffusion equation in unbounded space. The influence of the surrounding environment on pedestrian movement was considered comprehensively to set the direction of the force exerted by the attacker, pedestrian movement rules and exit selection mechanism were introduced in details. At the same time, we discuss two different attack strategies for attackers, and carried out virtual reality experiments to analyze the experimenter’s attack modes and compare them with the two pure strategies. Multiple simulations are conducted on the basis of the model to explore the physical significance of model parameters and the influence of attack mode and location on evacuation, and to explore the mechanism of pedestrians’ selection of exits under the condition of multiple exits. At the end of this paper, the simulation results are summarized and suggestions for evacuation under emergencies are provided, which may be helpful to the simulation of pedestrian evacuation under emergencies in the future.

Numerical Study on Cubic Particle Solid–Liquid Two-Phase Flow in Multistage Pump

To investigate the movement characteristics of cubic particles in a pump, a deep-sea mining lift model pump with a specific speed of 94 is used as the research object in this study. The discrete element method is coupled with the computational fluid dynamics method to simulate the solid–liquid two-phase flow of cubic particles with different densities in the pump while the effect of particle shape on the solid–liquid two-phase flow in the pump is considered. Results show that the cubic particle movement rules for the same flow component are the same. The cubic particle density imposes a more significant effect on the number of particles in the low-velocity zone than in other zones. The number of particles in the low-velocity zone increases with the increase of density. The cubic particle velocity gradient in the impeller decreases as the particle density increases, and the particles exhibit unsatisfactory following performance in the fluid. As the density increases, the collision exhibited by the cubic particles is primarily particle-to-particle collisions, (i.e., more than 37%), and the collision rate between the cubic particles and first-stage guide vane decreases significantly. Compared with cubic particles, spherical particles are likely to obstruct the flow channel in the guide vane. The collision exhibited by the spherical particles in the pump is primarily particle-to-guide vane collision, and the collision rate between the spherical particles decreases by 15.92%.

THE ART OF POSTAL AS A MEANS OF COMMUNICATION (MAIL ART)

In recent years, increasingly popular postal art movement in our country has managed to attract attention with its adventure, nostalgia and philosophy. Postal art is an artwork that offers excerpts from life. It often carries the traces of the postal organization; with all the damage and stains it receives on the route before been reached to the recipient’s hands. Sometimes even with the handwriting additions of officers who will never be recognized. Postal art as an art movement which can be sent to desired recipient and location demonstrate a resistance against whom supporting the idea of that art is only for certain groups. Moreover, it publicizes the art by actually letting regular people who does not have artistic identities produce art. In order to fully comprehend the art of mail, evaluating only the artistic dimension of the work is insufficient. Moreover, before considering postal art as an art movement it is necessary to consider it as a way of communication. In communication with the art of mail, the basic elements of the communication process should be examined. Because some of the standards and rules that arise in the communication channel restrict and guide the freedom of this art movement. During the circulation of this art movement, local and international postal rules are applied in Turkey, which is a member of the Universal Postal Union organization. What are the communication processes of postal art in our country? In this research, answer to that question was sought and the communicative processes of the postal art were interpreted according to the local literature due to topicality. The study is restricted by the experience (problems and examples) of Öğr. Gör. Kevser AKTAŞ KURUÇAY who is lecturing for many years in postal services program. This study reveals the importance of postal art and the requirements of PTT for the art of mail.

Design of College Scheduling Algorithm Based on Improved Genetic Ant Colony Hybrid Optimization

With the gradual expansion of college scale, the professional categories in colleges and universities are becoming more and more complete, and the volume of courses is becoming more and more huge. In the meantime, the number of students is growing by leaps and bounds, and the teaching resources are subject to more and more complicated teaching tasks. The workload and the difficulty of scheduling in teaching management are also on the rise year by year. This paper proposes a design of a college scheduling algorithm based on an improved genetic ant colony hybrid optimization algorithm. Firstly, the fitness-enhanced elimination law is proposed to improve the selection process of traditional genetic algorithms. Subsequently, the gene infection crossover method is proposed to ensure the increase of the average fitness value in the evolutionary process. Next, the unnecessary replication operation in the traditional genetic algorithm is removed to enhance the operation speed of the algorithm. Finally, the parallel mechanism of fuzzy adaptive is introduced to improve the convergence and stability of the algorithm. For the ant colony optimization algorithm, a nonuniform pheromone distribution is used according to the position of the current raster relative to the starting point, which makes the initial pheromone concentration of the dominant raster higher and avoids blind search by ants. The ant movement rules are redefined by the directional neighborhood expansion strategy to further shorten the path. The experimental results indicate that the hybrid optimization algorithm outperforms other algorithms in terms of performance in terms of scheduling success and scheduling time, and it can be applied in practical scheduling because of the high quality of courses schedule.

An evacuation simulation model of pedestrian flow using Bayesian Nash equilibrium and a Multi-Agent System

Abstract. The shortage of experimental data for individual behaviours has hampered systematic research on pedestrian behaviours and the refined development of evidence informed rules for pedestrian movement in simulation models. This research proposes an evacuation simulation model of pedestrian flow based on Bayesian Nash Equilibrium (BNE) and Multi-Agent System (MAS). In this paper, BNE was used to augment the logics of pedestrian decision-making processes in an evacuation MAS simulation and to improve evacuating agents’ movement and behaviours. A detailed introduction of the construction process and implementation details for the initial model as well as the visualization of experiment results are provided in this paper. Limitations and several potential future research directions are also identified.

Dynamic deorbit of small-sized space debris in near-Earth orbit in view of space-based pulse laser

The objective of this work is to address active deorbit of small-sized space debris in the near-Earth orbit by a space-based pulse laser. A dynamic deorbit model based on perigee altitude was established during space-based laser pulse irradiating the debris. The effects of orbital eccentricity, perigee altitude, true anomaly, and action distance of the debris with the number of pulse lasers and laser powers were obtained. Furthermore, the whole deceleration process of the debris removal irradiated by a pulse laser was intuitively described, and the evolution rules of the debris movement in the whole stage of active deorbit were also demonstrated. As a result, the three-dimensional visualization scene of the debris movement and the complete period evolution images of the debris deorbit were displayed. Finally, the results of numerical computations were consistent with the outcomes of visual simulations based on the given conditions. That is, when the laser power was 500 kW and the number of pulses was 965, the purpose of debris deorbit was completed by four laser irradiations, and the semimajor axis and eccentricity of the debris reached were 9915.4 km and 0.338 at the moment. These results can provide an important reference for the integrated research on space-based pulse laser active removal and clearance evaluation of small-sized space debris.

L v. B and Feminist Identity: Examining Lesbians’ Bi-Negativity and Bisexuals’ Lesbian Negativity Using Norm-Centered Stigma Theory

Historically, there has been a schism between lesbian and bisexual women that was largely embedded in the rigid rules of the 1970s lesbian feminist movement. Yet while the overt separatist tactics of lesbian feminism that once excluded bisexual women have largely faded away, the current study demonstrates continued evidence of fractures between L (lesbian) v. (B) bisexual women using data from a sample of U.S. adults aged 18-64 stratified by U.S. census categories of age, gender, race/ethnicity and census region collected from online panelists (lesbian women, n = 346; bisexual women, n = 358) and a partial test of Norm-Centered Stigma Theory (NCST) with an emphasis on feminist identity. Specifically, lesbian women’s negativity toward bisexual women (looking at measures of authenticity, unfaithfulness, and hypersexuality) is more pronounced than bisexual women’s negativity toward lesbian women; however, the findings demonstrate that today’s negativity toward bisexual women may not be embedded in feminism as it once was. In addition, the results suggest that feminism may mean something different to bisexual women in comparison to lesbian women (which perhaps may be related to differences in investments in queer activism). Overall, by using NCST’s theoretical framework that focuses on the intersecting roles of sexuality, gender, and feminist identity to investigate lesbian women’s stigma toward bisexual women and bisexual women’s stigma toward lesbian women, this research offers insight into working toward the ultimate goal of ameliorating these schisms.

A Novel Denoise Method of Acoustic Signal from Train Bearings Based on Resampling Technique and Improved Crazy Climber Algorithm

The wayside acoustic defective bearing detector system (TADS) is located on both sides of the railway, so that the acoustic signals recorded by the microphone not only include the sound from the train bearings but also include it from the other disturbance sources. The heavy noise and multisource acoustic signals would badly reduce the reliability and accuracy of the detection result of the TADS. In order to extract the useful information from the recorded signal exactly and efficiently, a novel denoising method based on the Short-time Fourier transform (STFT) and improved Crazy Climber algorithm was improved in this paper. Firstly, the STFT was performed on the recorded acoustic signals in order to obtain the time-frequency distribution matrix. Based on the original algorithm, the novel movement rule and the fitting process of the ridge lines were presented which could extract the time-frequency ridge lines of the acoustic signal accurately and rapidly. In this way, the important information from the train bearings could be divided from the heavy noise and other signals. Finally, the simulation and experimental verifications were carried out, and the denoising method based on the STFT and improved Crazy Climber algorithm has proved to be effective in extracting ridge lines of the time-frequency distribution matrix and dividing the useful information form the recorded acoustic signals.

Analysis of eye movements of workers in safe and unsafe behaviors using a video-based method

Analyzing eye movements of workers in safe and unsafe behaviors can reduce accidents. With a video-based method, the angular velocity of gaze direction (AVGD) represents micro-movements in gaze and angular velocity in saccade is used to analyze eye movements. A similar behavior simulation experiment is designed to collect operation videos, and an eye movement information extraction and processing framework is constructed to quantify and analyze eye movements. The results show that: the root mean square and movement frequency of AVGD can be used to recognize unsafe behavior; in operations with attention target fixation, compared with safe behavior, workers in unsafe behavior have higher angular velocity, movement frequency and turn frequency of eye movements; and in operations with attention target change, eye movement rules of workers in safe and unsafe behaviors depend on operation types. The results can provide features for unsafe behavior recognition and theoretical bases for safety training.

High-temperature area migration characteristics of loose coal spontaneous combustion based on experimental scale of semi-enclosed experimental system

According to the actual combustion characteristics of loose coal, and in view of the advantages and disadvantages of the existing research equipment for the high-temperature area, a simulated experimental device for the development of coal fire was designed and fabricated. The coal sample of Mengcun coal mine in Xianyang, Shaanxi Province China as the research object, the device was used to simulate the combustion of loose coal, and the distribution and movement of high-temperature area during the combustion were studied. The temperature change of the high-temperature area was obtained from normal temperature to ignition. The results showed that during combustion, the temperature rose first with the increase of time and then decreased. When the temperature reached 309.5 °C, the coal sample started to combustion. In addition, the temperature decreased to the ambient temperature after 600 h. The high-temperature area of the selected coal sample was concentrated in the middle part and the back part of the furnace, which was for the poor thermal conductivity, water evaporation of coal intrinsic quality. Moreover, the temperature decreases in turn during the downward propagation of the high-temperature area in the depth. And its decline to the limit oxygen concentration (1%∼3%) is similar to reaching the combustion point temperature. Due to the influence of water content, pore and oxygen concentration, the movement of oxygen concentration and high temperature areas are mainly moved to the position and crack direction near the wind direction of coal-like combustion, showing nonlinear movement rules.

Soil water-salt control and yield improvement under the effect of compound control in saline soil of the Yellow River Delta, China

Soil salinization and water shortage restrict the utilization of saline soil resources in the Yellow River Delta, China (YRD). As such, soil water and salt management are two methods for the saline soil reclamation in this area. In this study, a two-year field experiment was conducted to investigate the effects of compound control on the rules of water and salt movement in salt-affected field, and their effect on cotton yield, which were combined by plastic film mulch and buried wood fibre layer (FM+BL). Hydrus-2D was used to analyse their spatial and temporal change. Results showed that soil water at different observation positions were maintained above 0.15 cm3 cm−3 under film mulch, which was higher than that in bare ground (BG), and the closer to the topsoil the greater difference between FM+BL and BG, especially in 2020. FM+BL controlled soil water stress and improved water use efficiency during the whole growing season both in 2019 and 2020. FM+BL invariably and significantly controlled the salt content of the upper 60 cm depth, which was lower than 2.00 g kg−1 during the whole growing season. Furthermore, soil salt contents under film mulch in the upper 30 cm depths were significantly reduced for the high soil water contents. Thus, soil salt content of 0–60 cm layer responded to the heavy rainfall events positively, soil salinity decreased as a whole along with the process of rainfall under the effect of FM+BL. FM+BL has a significant effect on crop growth and yield improvement, the average yields were 1163.7 and 1301.7 kg ka−1 in 2019 and 2020, respectively. Therefore, FM+BL could be an efficient way for soil water conservation, salt accumulation interruption and cotton yield increasing in the YRD.

Mobility policy as pandemic policy. The Schengen regime in the Corona crisis.

During the Corona-pandemic, restricting mobility became an important means of pandemic policy. Within the European Union, this resulted in stress for the Schengen area. The essay deals with the question of how the Schengen system coped with pandemic policy and argues that the exceptions from the basic rule of free movement provided the Schengen system with the flexibility necessary to survive the pandemic. Elaborating on this thesis, the paper explores some important changes the EU-borders are likely to undergo due to the pandemic.

I Like This Analysis, but I Don’t Think Every Linguist Will: Syntactic NOT-Transportation, VP Ellipsis and VP Pronominalisation

In this article I consider some recent objections raised against the syntactic treatment of negation in English multiclausal structures, in particular what has been called NEG-raising. I argue that the objections based on pronominalisation and ellipsis presented in the recent literature do pose a problem for syntactic accounts of the mechanisms of so-called NOT-transportation that rely on a rule of leftwards movement, as is customary in generative grammar. However, there is an alternative syntactic treatment that assumes that negation originates as a higher predicate and is subject to a rule of lowering. I show that a syntactic theory of NOT-transportation is tenable and accounts for the problematic data if NEG-raising is replaced, in the analysis of the cases considered here, by a rule of NEG-lowering.

Emergence of adaptive global movement from a subjective inference about local resource distribution

In animal foraging, the optimal search strategy in an unknown environment varies depending on the context, such as the resource density and season. When food is distributed sparsely and uniformly, superdiffusive walks outperform normal-diffusive walks. However, superdiffusive walks are no longer advantageous when random walkers forage in resource-rich environments. It is not currently clear whether a relationship exists between an agent's use of local information to make subjective inferences about global food distribution and the optimal random walk strategy. Therefore, I investigated how flexible exploration is achieved if an agent alters its directional rule based on the local resource distribution. In the proposed model, the agent, a Brownian-like walker, estimates whether an abundant or sparse area is nearby using local resource patterns and then makes a decision by altering its movement rules. I show that the agent can behave like a non-Brownian walker if it interacts with a prey distribution. The agent can adaptively switch between diffusive properties depending on the resource density. This leads to a more effective resource-searching performance than a simple random-walk model. These results demonstrate that optimal searching is a context-dependent process.

Numerical Simulation Study of the Strata Movement Rule of Deep Mining with the Super-Thick and Weak Cementation Overburden: A Case Study in China

As the national energy strategy is to mine westward, the deep coal resources under the super-thick and weak cementation overburden in the western mining area will play a critical role in China’s sustainable economic growth. The super-thick and weak cementation overburden has weaker lithology, thicker strata, no large joints, bedding development, and better integrity. Therefore, its movement rule is inevitably different from that of the weak overburden and the middle hard overburden in Central China and Eastern China. However, lack of studies on the movement of the super-thick and weak cementation overburden has led to severe constraints for the large-scale exploitation of coal resources under the super-thick and weak cementation overburden in the western mining area. This study explored the surface movement rule and the influence of overburden characteristics on strata movement with field measurement and numerical simulation. The findings indicate that the surface reaches full mining and the subsidence coefficient is about 0.9 when D1 (width in the dip direction) and D3 (length in the strike direction) are 3 times H0 (the mean mining depth) or more. The strike mining degree has a certain influence on the surface movement law, the maximum difference of the surface subsidence coefficient is 0.35, and the maximum difference of the horizontal movement coefficient is 0.05. In addition, the control effect of the Zhidan group sandstone is stronger. Thus, its first breaking results in surface sinking in a fractured manner when D1 is about 1.3 times H0 and D3 is 3 times H0 or more. The above results can provide reference for the safe mining and control of the super-thick weak cementation overburden.

Research on Roof Fracture Characteristics of Gob-Side Entry Retaining with Roof Cutting and Non-pillar Mining in Thick Coal Seam, China

Based on the S1201-2 large height mining in the 2–2 coal seam of Ningtiaota colliery with on-site microseismic measurement, physical simulation and theoretical analysis methods, this paper explores the rule of roof movement in thick coal seams with roof cutting and non-pillar (hereinafter referred to as RCN-P) mining, so as to obtain scientific and effective theoretical basis for entry support and to summarize the regional structural characteristics and dynamic periodic fracture characteristics. As can be seen from microseismic events, the entry roof is featured by "two zones and one line" along the horizontal direction, namely, the crack generation area, the roof movement area. Additionally, and the obvious lateral breaking of the entry roof on the coal wall is a typical feature of the thick coal seam with RCN-P mining. The roof is vertically divided into "three zones", the crack generation area, the roof movement area and the crack development area. The roof cutting activity mainly affects the overburden activity within the basic roof height range, which is also the roof movement area. In addition, the distribution frequency and the intensity of microseismic events indicate the roof periodic breaking characteristics. The "breaking pressure relief,” “advanced crack development,” and “the limit breaking state” of roof breaking corresponds to the initial, middle, and final stage of breaking in the periodic weighting process, respectively. Compared with the normal mining, the RCN-P mining reduces the periodic weighting length and increases the pressure strength. As is shown in the physical simulation experiment, the basic roof and the cutting control layer in the "regional structural characteristics" constitute the “large” and “small” structures with RCN-P mining. The basic roof key layer is the core to control the stability of the strata, and the breaking process from the cantilever beam to the short masonry beam of the roof-cutting control layer is the main cause of the entry stress. Correspondingly, the basic structure model of “short masonry-hinged” roof was proposed and the calculation method of support was established for the entry with RCN-P mining in thick coal seam, providing a research foundation for scientific and effective rock formation control.

RangeShifter 2.0: an extended and enhanced platform for modelling spatial eco‐evolutionary dynamics and species' responses to environmental changes

Process‐based models are becoming increasingly used tools for understanding how species are likely to respond to environmental changes and to potential management options. RangeShifter is one such modelling platform, which has been used to address a range of questions including identifying effective reintroduction strategies, understanding patterns of range expansion and assessing population viability of species across complex landscapes. Here we introduce a new version, RangeShifter 2.0, which incorporates important new functionality. It is now possible to simulate dynamics over user‐specified, temporally changing landscapes. Additionally, we integrated a new genetic module, notably introducing an explicit genetic modelling architecture, which allows for simulation of neutral and adaptive genetic processes. Furthermore, emigration, transfer and settlement traits can now all evolve, allowing for sophisticated simulation of the evolution of dispersal. We illustrate the potential application of RangeShifter 2.0's new functionality by two examples. The first illustrates the range expansion of a virtual species across a dynamically changing UK landscape. The second demonstrates how the software can be used to explore the concept of evolving connectivity in response to land‐use modification, by examining how movement rules come under selection over landscapes of different structure and composition. RangeShifter 2.0 is built using object‐oriented C++ providing computationally efficient simulation of complex individual‐based, eco‐evolutionary models. The code has been redeveloped to enable use across operating systems, including on high performance computing clusters, and the Windows graphical user interface has been enhanced. RangeShifter 2.0 will facilitate the development of in‐silico assessments of how species will respond to environmental changes and to potential management options for conserving or controlling them. By making the code available open source, we hope to inspire further collaborations and extensions by the ecological community.