Because wear-resistant is one of the demanded properties of tires used for motor cars due to the growing demand for resource saving, industrial developments toward such a direction have been attempted. However, attrition of rubber has not been fully elucidated yet. In this study, we have performed large scale coarse-grained molecular dynamics simulations of rubber to analyze the fracture that occurs inside the rubber from molecular level. In our model, the polymer molecules were represented by the coarse-grained beads-spring model. The filler particles were represented as clusters of beads, and their dispersion was reconstructed from the three-dimensional transmission electron microscope images of actual rubber. We added the coupling agent between polymers and particles to see the effect of interface modification. To reasonably accommodate the particle dispersion, we construct the large simulation box containing more than 130 million beads. After the sufficient equilibration, instantaneous stretch toward one direction was applied, whereas the box dimension for the other directions was fixed. During the relaxation process, dynamics of void formation was observed. As a result, we have found that a specific coupling agent can suppress the void formation at the interface. Owing to the result, we have developed the new tire product with high wear-resistance.