Monophosphoric Acid Research Articles

Bimodal Magneto‐Luminescent Response of Lanthanide Metallopolymers for Distinguishing of Phosphates in Aqueous Solutions

AbstractLinear N‐substituted polyacrylamides bearing tricarboxylic moieties pendant to the backbone are synthesized, and coordinative binding approach is developed to convert them into Gd3+/Eu3+‐metallopolymers. Inner‐sphere coordination of the lanthanide ions with the pendant chelating moieties, together with their outer‐sphere stabilization by the randomly coiled backbone, are the reasons for peculiar water proton relaxation and luminescence properties of the metallopolymers obtained. Indeed, for Gd3+‐metallopolymer, the values of longitudinal and transverse relaxivity (r1 and r2) are 50 and 60 mm−1·s−1, respectively, while for the Eu3+‐counterpart, Eu3+‐centered luminescence is significantly raised compared to Eu3+ aquaions. Coil‐like conformation of the metallopolymer molecules undergoes a swelling at pH values above 5.0 as evidenced by transmission electron microscopy TEM and dynamic light scattering (DLS) data, which is followed by the changes in the Eu3+‐centered luminescence and r1(2)‐values of Gd3+/Eu3+‐metallopolymers. The phosphates additives (adenosine monophosphoric acid (AMP), adenosine diphosphoric acid (ADP), HPO42− and adenosine triphosphoric acid (ATP) induce well detectable changes in both water proton relaxation and luminescence of Gd3+/Eu3+‐metallopolymers. The luminescent changes distinguish AMP from the other phosphates, while the changes in water proton relaxation are greater for HPO42− and ATP compared to AMP and ADP. This study explains this by interplay of the effects associated with the formation of ternary phosphate‐lanthanide‐polymer complexes and stripping of lanthanide ions from the polymer molecules.

Postharvest quality and metabolism changes of daylily flower buds treated with hydrogen sulfide during storage

Daylily flower buds are a good source of nutrients and contain lots of bioactive compounds, but they are subject to deterioration after harvest, which limits the taste and consumer satisfaction. Hydrogen sulfide (H2S) has been regarded as an important gaseous signaling molecule, which could prolong postharvest freshness of fruits and vegetables. The present study aims to investigate the effects of H2S on postharvest quality and metabolism changes of daylily flower buds during storage. The results showed that 3.2 mM NaHS (H2S donor) effectively inhibited weight loss, blooming and decay of daylily during storage. H2S application markedly reduced the accumulation of malondialdehyde and H2O2. H2S treatment also delayed the loss of total protein and antioxidant glutathione, and maintained the activities of antioxidant enzymes superoxide dismutase and catalase at higher level compared to control group. Widely targeted metabolomics identified various differentially accumulated metabolites (DAMs) during storage and with H2S treatment of daylily. These DAMs largely distributed in the classes of amino acids, organic acids, sugars and alcohols, terpenoids. A special focus was given to 303 common DAMs between the comparison of CK0 vs. CK6 and CK6 vs. T6, of which the DAMs were mainly enriched in the KEGG pathways of monobactam biosynthesis, pyrimidine metabolism, glycine, serine and threonine metabolism, arginine biosynthesis, pentose and glucuronate interconversions. Four DAMs including Cytidine 5′-Monophosphate, Fumaric Acid, Hydroxypyruvic Acid, 2′-Deoxycytidine-5′-Monophosphoric Acid exhibited great downregulation during storage, and H2S treatment dramatically recovered their relative contents. This study indicated that H2S treatment offers the potential to preserve the quality of daylily flower buds and extend their postharvest life.

Multifunctional Organocatalysts - Singly-Linked and Macrocyclic Bisphosphoric Acids for Asymmetric Phase-Transfer and Brønsted-Acid Catalysis.

The linking of phosphoric acids via covalent or mechanical bonds has proven to be a successful strategy for the design of novel organocatalysts. Here, we present the first systematic investigation of singly-linked and macrocyclic bisphosphoric acids, including their synthesis and their application in phase-transfer and Brønsted acid catalysis. We found that the novel bisphosphoric acids show dramatically increased enantioselectivities in comparison to their monophosphoric acid analogues. However, the nature, length and number of linkers has a profound influence on the enantioselectivities. In the asymmetric dearomative fluorination via phase-transfer catalysis, bisphosphoric acids with a single, rigid bisalkyne-linker give the best results with moderate to good enantiomeric excesses. In contrast, bisphosphoric acids with flexible linkers give excellent enantioselectivities in the transfer-hydrogenation of quinolines via cooperative Brønsted acid catalysis. In the latter case, sufficiently long linkers are needed for high stereoselectivities, as found experimentally and supported by DFT calculations.

Pertraction of Vanadium(V) from Dilute Acidic Media by an Emulsion Liquid Membrane Containing a Commercial Extractant

AbstractEmulsion liquid membrane (ELM) pertraction of VV ions from dilute acidic solution by using a mixture of di(2‐ethylhexyl)phosphoric acid (D2EHPA) and mono(2‐ethylhexyl)phosphoric acid (M2EHPA) was studied. First, solvent extraction of VV from an aqueous medium was performed, and the optimum feed pH and extractant concentration were obtained. Tributyl phosphate was used as modifier to increase membrane stability and decrease membrane swelling. The effects of diluent type, extractant concentration of the emulsifier concentration, stripping reagent concentration (sulfuric acid), organic phase/stripping phase volume ratio, emulsification time and speed, feed initial pH, agitation speed, temperature, and contact time on VV extraction efficiency and ELM stability were considered.

Scandium recovery from ion-adsorption rare earth concentrate with HEHEHP as extractant

An excellent extraction selectivity towards Sc over other REEs in 4 mol/L HCl solution was achieved with the separation factor βSc/REEs over 8000 by 2-ethylhexyl phosphoric acid mono 2-ethylhexyl ester (HEHEHP) and the extraction equilibrium can be obtained within 20 min. The extracted Sc can be stripped using 5 mol/L NaOH solution as eluent at 363 K with the stripping rate of 92.1% obtained. The extraction mechanism was clearly elucidated by slope analysis, saturation extraction, IR, and NMR analysis. It was revealed that the extraction of Sc in 4 mol/L HCl solution is still dominated by cation exchange process between P—O—H and Sc, and coordination process between P=O and Sc, with 6 molecules of extractant as dimer participating in the process. Finally, a flowsheet for the recovery of Sc from ion-adsorption rare earth elements (REEs) concentrate was proposed and proved in lab-scale experiment.

Experimental and Theoretical Study on Sm/Eu-Gd Extraction by P204 and [A336][P204

Extraction of rare earth using ionic liquid as extractant become an alternative practice to replace the common volatile organic solvents in recent years. In general, the work to extract rare earth element, require a large number of extraction stage, and different extractant used resulted in different number of extraction needed. Therefore an analysis on the theoretical number of stages is necessary prior to laboratory work. This study was designed to compare between the number of extraction stages required by 2-ethylhexyl phosphoric acid mono 2-the ester (P204), a common rare earth extractant with a bifunctional ionic liquid, and [A336][P204] in a counter-current extraction process for the separation of Sm in Sm-Eu-Gd mixed solution. The value of the separation factor (β) of both extractants, was obtained from the experimental work, while other process parameters were calculated using the counter-current theory developed by Xu Guangxian. Extraction of Sm using [A336] [P204] was optimum in 3.0 M of nitric acid, with organic to aqueous (O/A) ratio of 4:1, while the optimum condition for P204 was when the medium was 2.0 M of hydrochloric acid and 7:3 of O/A ratio. The β value for the optimized condition for P204 was lower compared to the condition for [A336][P204] at β:1.93 and β:2.81, respectively. To derive an optimum extraction condition to calculate the number of extraction stage, target purity and recovery ratio were set to 99.9% and 90%, respectively, for both extractants. As a result, [A336][P204] was able to reduce the number of extraction stage by 5 compared to P204. The result indicated that [A336][P204] is preferable over P204 from the viewpoint of economic efficiency.

Comparison of optimal solvent extraction stages between P204 and [A336][P204] for the separation of europium and gadolinium

This study was designed to compare between the number of extraction stages required by 2-ethylhexyl phosphoric acid mono 2-ethylhexyl ester P204 and ionic liquid-based system of [A336][P204] in a cascade counter-current extraction process for the separation of europium (Eu) and gadolinium (Gd). Eu and Gd were chosen for this study as these metals are among the strenuous due to low availability in nature and small separation factor. The value of the separation factor (β) of both extractants, was obtained from the experimental work, while other process parameters were calculated using the counter-current model developed by Xu Guangxian. Extraction of Eu using [A336][P204] was found optimum at 3.5 M of nitric acid, with organic to aqueous (O/A) ratio of 9:1, while the optimum condition for P204 was determined at 3.0 M of hydrochloric acid and 9:1 of O/A ratio. The optimized β value for P204 was identified lower (β:2.38) compared to the condition for [A336][P204] (β:3.44). In order to obtain the optimal number of separation stages, the target purity and recovery rates were set to 99.9% and 90% respectively for both extractants. From the Xu model, the results show that [A336][P204] extractant requires at a minimum of four and two extraction and scrubbing stages respectively for maintaining the desired outputs. Meanwhile, P204 extractant needs to develop at least eight extraction stages as well as five scrubbing stages to produce the same production capacity. This finding generally suggests that [A336][P204] is favorable over P204 for the separation of europium and gadolinium particularly from the viewpoint of economic interest.

Indicators of energy metabolism in pigs when feeding various iron compounds

Intensive pig breeding is usually aimed at increasing the growth of young pigs, reducing feed costs by 1 kg of live weight gain, balancing diets with the content of the main nutrients. In order to obtain high-quality pig production, it is necessary to make corrections of rations in pigs of different technological groups using mineral feed additives that take into account not only the physiological needs of minerals of the corresponding age groups and classes of pigs but also the biogeochemical zone or the province where the farms are located in which feed is grown, as well as the conditions that accompany the emergence of the deficit. However, the use of these substances should not adversely affect the quality of products, its cost. These substances include iron preparations. Carbohydrates are the main source of energy for the life of the organism. They get into the blood from the digestive tract in the form of monosaccharide – glucose. When it comes from the intestines into the bloodstream, glucose passes through the portal vein to the liver, where it becomes a glycogen. The activities of practically all organs without exception are more or less dependent on the content of carbohydrates in the blood streaming into them. Glucose is a universal energy source. As expended, glucose stores in the blood are replenished and, thus, its relatively stable content in the plasma is provided. The transformation of glucose in the tissues occurs both with the participation of oxygen, and without it, by glycolysis. Glycogen under the influence of the enzyme phosphorylase is split into glucose and phosphoric acid. Glucose, as a source of energy, is necessary for all tissues of the body, especially its great importance for the functions of the muscular and nervous systems. The results of our studies indicate that the glucose content in the experimental pigs' blood was lower by an average of 4.7% (P < 0.05) – the first group; 6.4% (P < 0.02) was the second group and 8.2% (P < 0.01) was the third group compared to the control animals. Decrease in glucose (within the limits of physiological fluctuations) is associated with more intensive use of the body tissues as an energy source. The activation of energy processes and increase of an additional background of phosphates in the body due to the action of chelating iron compounds is evidenced by the observed increase in the activity of alkaline phosphatase in pigs in experimental groups. The enzyme mentioned catalyzes the cleavage of the phosphate group from the organic monophosphoric acid orthophosphoric acid, and is responsible for the absorption of phosphorus from animal rations. The activity of LF was significantly higher with respect to control in the blood of experimental animals throughout the study period at 1.2; 1.5 and 1.6 times. The higher activity of alkaline phosphatase in the blood of pigs in experimental groups is also explained by the increase of phosphorylation processes due to the better absorption of phosphorus from the feed by the organism due to the action of iron chelate compounds.

Molecular Design of a Chiral Brønsted Acid with Two Different Acidic Sites: Regio-, Diastereo-, and Enantioselective Hetero-Diels-Alder Reaction of Azopyridinecarboxylate with Amidodienes Catalyzed by Chiral Carboxylic Acid-Monophosphoric Acid.

A chiral Brønsted acid containing two different acidic sites, chiral carboxylic acid-monophosphoric acid 1a, was designed to be a new and effective concept in catalytic asymmetric hetero-Diels-Alder reactions of azopyridinecarboxylate with amidodienes. The multipoint hydrogen-bonding interactions among the carboxylic acid, monophosphoric acid, azopyridinecarboxylate, and amidodiene achieved high catalytic and chiral efficiency, producing substituted 1,2,3,6-tetrahydropyridazines with excellent stereocontrol in a single step. This constitutes the first example of regio-, diastereo-, and enantioselective azo-hetero-Diels-Alder reactions by chiral Brønsted acid catalysis.

Perfluorinated Aryls in the Design of Chiral Brønsted Acid Catalysts: Catalysis of Enantioselective [4 + 2] Cycloadditions and Ene Reactions of Imines with Alkenes by Chiral Mono-Phosphoric Acids with Perfluoroaryls

Perfluorinated aryl-incorporating chiral monophosphoric acids were used for highly stereoselective reactions of N-acyl and N-acyloxy aldimines with styrenes. Their electronic and steric profiles were established in comparison with those of phenyl, binaphthyl, and partially fluorinated aryls. The [4 + 2] cycloaddition reactions of N-benzoyl aldimines with alkenes proceeded with excellent diastereo- and enantioselectivities in the presence of the perfluorophenyl-incorporating chiral monophosphoric acid catalysts 1a and 1c. The stereoselective elaboration of polysubstituted cycloadducts to amines is described. The imino–ene reactions of N-Fmoc imines with alkenes have been successfully developed in a three-component manner. This process uses aldehydes, 9-fluorenylmethyl carbamate, and alkenes in the presence of a chiral monophosphoric acid catalyst, 2a, possessing an F10binaphthyl skeleton.

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.

The glutamate metabotropic receptor 5 (mGluR5) and the adenosine A2A receptor (A2A R) represent major non-dopaminergic therapeutic targets in Parkinson's disease (PD) to improve motor symptoms and slow down/revert disease progression. The 6-hydroxydopamine rat model of PD was used to determine/compare the neuroprotective and behavioral impacts of single and combined administration of one mGluR5 antagonist, 2-methyl-6-(phenylethynyl)pyridine (MPEP), and two A2A R antagonists, (E)-phosphoric acid mono-[3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl] (MSX-3) and 8-ethoxy-9-ethyladenine (ANR 94). Chronic treatment with MPEP or MSX-3 alone, but not with ANR 94, reduced the toxin-induced loss of dopaminergic neurons in the substantia nigra pars compacta. Combining MSX-3 and MPEP further improved the neuroprotective effect of either antagonists. At the behavioral level, ANR 94 and MSX-3 given alone significantly potentiated L-DOPA-induced turning behavior. Combination of either A2A R antagonists with MPEP synergistically increased L-DOPA-induced turning. This effect was dose-dependent and required subthreshold drug concentration, which per se had no motor stimulating effect. Our findings suggest that co-treatment with A2A R and mGluR5 antagonists provides better therapeutic benefits than those produced by either drug alone. Our study sheds some light on the efficacy and advantages of combined non-dopaminergic PD treatment using low drug concentration and establishes the basis for in-depth studies to identify optimal doses at which these drugs reach highest efficacy. Combined treatment with low concentrations of known adenosine A2A receptor (A2A R) and metabotropic glutamate receptor (mGluR5) antagonists results in a therapeutic benefit and provides better results than those produced by either drug given alone, both in terms of motor performance and neuroprotection. Future trials should involve careful optimization of drug combinations and concentrations that may avoid the emergence of debilitating side effects and slow-down/revert disease progression.

Synthetic Method for 2,2'-Disubstituted Fluorinated Binaphthyl Derivatives and Application as Chiral Source in Design of Chiral Mono-Phosphoric Acid Catalyst.

A practical synthetic method for 2,2'-disubstituted fluorinated binaphthyl derivatives was achieved using magnesium bis(2,2,6,6-tetramethylpiperamide) [Mg(TMP)(2)], prepared from LiTMP (2 equiv) and MgBr(2) (1 equiv), which allows for access to a variety of fluorinated binaphthyl compounds. The utility of the fluorinated binaphthyl backbone was evaluated in F10 BINOL derived chiral mono-phosphoric acid (R)- as the chiral Brønsted acid catalyst. The catalyst (R)- performs exceptionally well in the catalytic enantioselective imino-ene reaction, demonstrating the potential of a fluorinated binaphthyl framework.

Thermodynamics and kinetics of thorium extraction from sulfuric acid medium by HEH(EHP)

Solvent extraction of Th(IV) using 2-ethylhexyl phosphoric acid mono 2-ethylhexyl ester (HEH(EHP)) in kerosene from sulfuric acid medium was studied by investigating the dependence of thorium extraction on aqueous acidity and HEH(EHP) concentration. The extraction mechanism was also determined by slope analysis. Th(IV) extraction kinetics was investigated using a constant interfacial cell with a laminar flow, and the data were analyzed based on the principle of pseudo first-order reaction. Some parameters' effect on the mass transfer, including the effect of temperature, Th(IV) concentration, HEH(EHP) concentration and pH was studied, and the rate equation for thorium extraction was obtained through slope analysis. Based on the high activation energy (Ea=45.8kJmol−1), the extraction regime was defined to be an interfacial chemical reaction control. In addition, a mass transfer model with a rate-control step was proposed and it was consistent with the experimental results.

Functional PEG-PAMAM-tetraphosphonate capped NaLnF₄ nanoparticles and their colloidal stability in phosphate buffer.

Developing surface coatings for NaLnF4 nanoparticles (NPs) that provide long-term stability in solutions containing competitive ions such as phosphate remains challenging. An amine-functional polyamidoamine tetraphosphonate (NH2-PAMAM-4P) as a multidentate ligand for these NPs has been synthesized and characterized as a ligand for the surface of NaGdF4 and NaTbF4 nanoparticles. A two-step ligand exchange protocol was developed for introduction of the NH2-PAMAM-4P ligand on oleate-capped NaLnF4 NPs. The NPs were first treated with methoxy-poly(ethylene glycol)-monophosphoric acid (Mn = 750) in tetrahydrofuran. The mPEG750-OPO3-capped NPs were stable colloidal solutions in water, where they could be ligand-exchanged with NH2-PAMAM-4P. The surface amine groups on the NPs were available for derivatization to attach methoxy-PEG (Mn = 2000) and biotin-terminated PEG (Mn = 2000) chains. The surface coverage of ligands on the NPs was examined by thermal gravimetric analysis, and by a HABA analysis for biotin-containing NPs. Colloidal stability of the NPs was examined by dynamic light scattering. NaGdF4 and NaTbF4 NPs capped with mPEG2000–PAMAM-4P showed colloidal stability in DI water and in phosphate buffer (10 mM, pH 7.4). A direct comparison with NaTbF4 NPs capped with a mPEG2000-lysine-based tetradentate ligand that we reported previously (Langmuir2012, 28, 12861−1287022906305) showed that both ligands provided long-term stability in phosphate buffer, but that the lysine-based ligand provided better stability in phosphate-buffered saline.

Kinetics of rare earth pre-loading with 2-ethylhexyl phosphoric acid mono 2-ethylhexyl ester [HEH(EHP)] using rare earth carbonates

A new environment friendly approach for rare earth separation has been developed in this paper. The approach used rare earth carbonates to control the equilibrium acidity during the rare earth loading with HEH(EHP) in chloride system. The kinetics of rare earth pre-loading by the approach was investigated. High rare earth loading of 0.17molL−1 and fast kinetics with about 5min for equilibrium were achieved, which is suitable to the application of conventional rare earth separation process. The approach is free from environmental pollution because no saponification reagent is introduced.

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. The present experiments focused on the effects of the pro-inflammatory cytokine interleukin 1-beta (IL-1β) on effort-related choice behavior. Rats were tested on a concurrent fixed ratio 5 lever pressing/chow feeding choice procedure, which assesses the tendency of rats to work for a preferred food (high carbohydrate pellets) in the presence of a concurrently available but less preferred substitute (laboratory chow). IL-1β (1.0-4.0 μg/kg IP) shifted choice behavior, significantly decreasing lever pressing and increasing intake of the freely available chow. The second experiment assessed the ability of the adenosine A2A antagonist (E)-phosphoric acid mono-[3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl] propyl] ester disodium salt (MSX-3) to reverse the behavioral effects of IL-1β. MSX-3 attenuated the effort-related impairments produced by IL-1β, increasing lever pressing and also decreasing chow intake. In the same dose range that shifted effort-related choice behavior, IL-1β did not alter food intake or preference in parallel free-feeding choice studies, indicating that these low doses were not generally suppressing appetite or altering preference for the high carbohydrate pellets. In addition, IL-1β did not affect core body temperature. These results indicate that IL-1β can reduce the tendency to work for food, even at low doses that do not produce a general sickness, malaise, or loss of appetite. This research has implications for the involvement of cytokines in motivational symptoms such as anergia and fatigue.

Palladium-catalyzed ortho-alkenylation of aryl hydrogen phosphates using a new mono-phosphoric acid directing group

A highly efficient Pd-catalyzed ortho-alkenylation is reported using a mono-phosphoric acid-directing group for the first time. This phosphoric acid-directing group is successfully utilized for the synthesis of various alkenylated products and offers a new approach to transition-metal-catalyzed C-H activation.

Preparation and Properties of Phosphate-Fluorocarbon Acrylate Anticorrosion Emulsion

Phosphate-fluorocarbon acrylate anticorrosion emulsion was successfully synthesized with hexafluorobutyl methacrylate(HFMA), methyl methacrylate(MMA), butyl acrylate(BA), α-methacrylic acid(MAA) as copolymerization monomer and monophosphoric acid allyloxy nonylphenoxy poly(ethyleneoxy)(10) ether(ANPEO10-P1) as phosphate reactive emulsifier. The surface properties and anticorrosion properties were tested by scanning electron microscope and energy dispersive spectroscopy (SEM-EDS), contact angle (CA), water absorption, electrochemical impedance spectroscopy (EIS), flash-rust resistant and adhesion, respectively. The structure and morphology of emulsion and copolymer were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM) and particle size analysis. The anticorrosion mechanism of acrylate emulsion containing fluorine atom and phosphate group was discussed. The results showed that fluorine component migrated to the film-air interface during film formation and then led to the CA and water resistance of the films increased. The reactive emulsifier used in copolymerization improved water resistance of emulsion film again, and then benefited the corrosion resistance. The adhesion and flash-rust resistant were improved rapidly because of the introducing of phosphate group which could form phosphate film on mild steel. The results of EIS showed that the emulsion had good anticorrosion properties with the synergistic of fluorine atom and phosphate group.

Solvent extraction of bismuth with 2-ethylhexylphosphonic acid mono-(2-ethylhexyl) ester and 2,2′-bipyridyl

In the present work, the solvent extraction of bismuth with mixtures of acidic phosphorus extractants, di(2-ethylhexyl) phosphoric acid (D2EHPA) and 2-ethylhexylphosphonic acid mono-(2-ethylhexyl) ester (HEHEHP), with some other extractants was investigated including sec-octylphenoxyacetic acid (CA12), sec-nonylphenoxy acetic acid (CA100), 8-hydroxyquinoline (HQ), and 2,2′-bipyridyl (bipy). The extraction effects from nitric acid medium were studied in detail. Results showed that all other mixing systems except HEHEHP+bipy did not have synergistic effects on bismuth. The methods of slope and constant mole were employed to study the extraction of bismuth in HEHEHP+bipy system. Thermodynamic functions and stripping behaviors were also investigated.

Synthesis of arsenic graft adsorbents in pilot scale

Synthesis of arsenic (As) adsorbents in pilot scale was carried out with a synthesizing apparatus by radiation-induced graft polymerization of 2-hydroxyethyl methacrylate phosphoric acid monomer (PA), which consists of phosphoric acid mono- (50%) and di- (50%) ethyl methacrylate esters onto a nonwoven cotton fabric (NCF), and following chemical modification by contact with a zirconium (Zr) solution. The apparatus which was equipped with reaction tanks, a washing tank and a pump can produce up to 0.3m×14m size of the As(V) adsorbent in one reaction. A degree of grafting of 150% was obtained at an irradiation dose of 20kGy with 5% of PA solution mixed with deionized water for 1h at 40°C. Finally, after Zr(IV) was loaded onto a NCF with 5mmol/L of Zr(IV) solution, the graft adsorbent for the removal of As(V) was achieved in pilot-scale. The adsorbent which was synthesized in pilot scale was evaluated in batch mode adsorption with 1ppm (mg/l) of As(V) solution for 2h at room temperature. As a result, the adsorption capacity for As(V) was 0.02mmol/g-adsorbent.