Moderna Research Articles

1932. Antibody Response to SARS-CoV-2 Vaccination in US Veterans Living with HIV

Abstract Background COVID-19 (C-19) vaccines have demonstrated effectiveness in reducing SARS-CoV-2 related morbidity/mortality. The duration of protection in the general population is showing a waning immunity over time. Variable antibody responses to C-19 vaccines have been shown in persons living with HIV. We followed the anti-SARS-CoV-2 receptor biding domain (RBD) antibody titers, after 2 and 3 (booster) C-19 vaccinations, in US Veterans living with HIV (USVLH). Methods Retrospective chart review of USVLH who had received C-19 vaccinations at Northport VAMC. Testing was done with the © Beckman Coulter enzyme immunoassay measuring total IgG antibody to the RBD, a critical target of neutralizing antibodies within the spike protein encoded in the mRNA vaccines. Titers were drawn after the 2nd and 3rd doses C-19 vaccines in variable timing. Demographic data, CD4+ T cell counts nadir and current, HIV viral load, comorbid conditions were reviewed. Results We analyzed the SARS CoV-2 RBD IgG titers in 50 vaccinated USVLH. The median age is 65 years (range 36-75). 50% were Black, Caucasian 40%, Hispanic 10%. Risk factor for HIV infection, Heterosexual 52%, IVDU 18%, MSM 26%, needle stick 2%, blood transfusion 2%. The median CD4 nadir was 200/µL (5- 600), median current CD4 656 (174-1529). All USVLH were on HAART, 92% on INSTI-based therapy. 45 had undetectable HIV viral load (< 20), 5 had viremia from 22 to 563 copies. Medical conditions: diabetes 30%, CAD 18%, HTN 60%, COPD 8%, HLD 66%, smokers 18%. Six USV had C-19 prior to vaccination, and six had C-19 after vaccination with median 102 days (90-148) from last vaccine dose. Vaccines given: Janssen in 3 USVLH: Moderna (MOD)- 2 doses: 4; MOD-3 doses:5; Pfizer (PFZ)-2: 6; PFZ-3: 32. IgG titers decrease with time after 2nd vaccine dose and increase after booster dose. IgG titers checked after 2nd dose median days 120 (11-392) {titers: median 4.63 S/CO [0.17 – 53.66]}, 91 days (5-181) after 3rd dose {titers: median 16.22 [1.15-73.92]}. Titers were higher in MOD-2 vs. PFZ-2, median 25.7 vs. 4.63, P: 0.039, MOD-3 vs. PFZ-3 33.89 vs. 15.5, P: 0.117. No death due to C-19 was seen. SARS-CoV-2 RBD IgG titers in US Veterans living with HIV after 2nd dose of COVID vaccine. COVID-19 VACCINATED IN US VETERANS LIVING WITH HIV N=50 Conclusion In a cohort of USVLH, well controlled on HAART, C-19 vaccinations produced a serologic response that decayed over time and increased after booster dose. MOD vaccine may have achieved higher titers than PFZ. Disclosures All Authors: No reported disclosures.

Moderna strikes new vaccine deals with Lonza and Thermo Fisher

Moderna strikes new vaccine deals with Lonza and Thermo Fisher

Allergic Reactions to COVID-19 mRNA Vaccines

The small size of the phase 3 clinical trials of the Moderna and Pfizer-BioNTech COVID-19 mRNA vaccines limited the ability to define the incidence and

Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination.

Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination.

Allergic Reactions to the Pfizer-BioNTech and Moderna COVID-19 Vaccines: Early Reports

An initial CDC report detailed adverse reactions (including anaphylaxis) during the first 10 days of administration of the Pfizer-BioNTech COVID-19

Our Latest COVID-19 Coverage

Dear readers,This week, NEJM Journal Watch covered COVID-19–related topics including bamlanivimab in the outpatient setting, trends in COVID-19

The Moderna COVID-19 Vaccine: Noteworthy Efficacy to Date

One week after the FDA granted an emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 mRNA vaccine (BNT162b2; NEJM JW Infect Dis Dec 15

Developing awareness of interference errors in translation. An English-Spanish pilot study in popular science and audiovisual transcripts

The use of astronomy discourse in the form of written and web/audiovisual texts has been gaining ground in undergraduate courses of specialized translation. These materials have been used at the University of Leon for the last four years during the last semester of the degree Filologia Moderna: Ingles , as part of the course Traduccion ingles -espanol II , basically geared towards awareness raising of translation problems and solutions available. The aim of this paper is twofold: a) to show the main differences between the language of astronomy in different genres (Stolze 2009; Byrne 2012; Tessuto, Bait 2017) in English and in audiovisual texts (Diaz Cintas, Remael 2007; Chaume 2012) in English and Spanish and b) to show which linguistic areas are more problematic for undergraduate students, e.g. types of technical dialects, nominalization chains, metaphoric language, among others (Rabadan 1991; Shuttleworth 2014). We will use two small comparable subcorpora of written research articles and popular science, and an audiovisual corpus of popular science in order to identify a) similarities and differences at different levels and b) a hierarchy of relevance. Our taxonomy will include linguistic, cultural, genre-based, and semiotic problems and their linguistic manifestations. We will also use an En-Es parallel corpus (Gutierrez Lanza 2011) which will include the originals mentioned above and the translations made by undergraduate students during this period. They will be compared with a “standard” target text in order to identify which features are more problematic in English-Spanish transfer. The results will be collated both statistically and qualitatively so as to produce a tagset of errors to be applied to learners’ corpora. The procedure is replicable for other domains, genres, and language pairs. These corpus-based data En-Es will be used to produce language pair focused training materials (Lopez-Rodriguez, Tercedor-Sanchez 2008; Rabadan 2010).

Pfizer, Moderna ready vaccine manufacturing networks

Pfizer, Moderna ready vaccine manufacturing networks

Fever, aches from Pfizer, Moderna jabs aren’t dangerous but may be intense for some

Fever, aches from Pfizer, Moderna jabs aren’t dangerous but may be intense for some

Donato Decumbertino and Gianserio Strafella from Copertino. Painters of the Maniera moderna in the Kingdom of Naples, in a net of Patronage

Donato Decumbertino and Gianserio Strafella from Copertino. Painters of the Maniera moderna in the Kingdom of Naples, in a net of Patronage

Chemistry Teachers’ Awareness, Understanding, and Confidence toward Computational Tools for Molecular Visualization

Recent advances in cheminformatics and bioinformatics research have generated software and computational tools for molecular modeling and visualization that can be incorporated to improve chemistry teaching and learning in high school. Nevertheless, there have never been any study simultaneously reporting chemistry teachers’ awareness, understanding, and confidence toward contemporary computer-aided molecular modeling and visualization tools. This study examined 32 high school chemistry teachers’ knowledge, understanding and confidence toward nine new computational programs on molecular modeling and visualization namely ChemDraw, HyperChem, UCSF Chimera, Marvin Sketch, PsiPred, MBC (PS2), Rampage, Vienna RNA Package and Mode RNA following two days of professional workshop-based training. After completing the training and assessments, the teachers showed an enhancement in awareness, understanding, and confidence toward those nine computational programs. Intensive activities consisting of theoretical lectures, hands-on practices, assignments, and case study presentations seem to provide valuable resources to the increase in teachers’ knowledge, understanding, and skill that incorporates computational technology. Hence, the impact of this research pointed toward the value of teachers’ professional development that creates a platform to reduce the barriers of access, resources, knowledge, and skills. This study is expected to help improving teachers’ awareness, understanding, and confidence necessarily required for further implementation of available technology for instructional purposes.Â

Origen del Movimiento Mexicano para la Escuela Moderna: una lucha polí­tica-pedagógica en la década de 1980

Este artí­culo busca describir quiénes fueron los fundadores de la agrupación freinetiana de docentes denominada Movimiento Mexicano para la Escuela Moderna (MMEM) y cómo se originó el grupo en la Ciudad de México en la década de 1980, así­ como ofrecer una interpretación del escenario histórico-polí­tico involucrado en su nacimiento. Desde una perspectiva cualitativa y mediante procedimientos metodológicos de la historia oral se encontró que los iniciadores del movimiento fueron jóvenes profesores de educación primaria egresados de la Escuela Nacional de Maestros, hijos de padres obreros, comerciantes o maestros, quienes llegaron a trabajar a escuelas públicas en zonas marginadas del Distrito Federal. Inmersos en el escenario de la lucha polí­tica-sindical magisterial de la década, los maestros se agruparon para reaccionar ante una preconcepción de escuela tradicional así­ como para enfrentar al grupo gremial Vanguardia Revolucionaria.

Moderna raises cash, invests in manufacturing

Moderna raises cash, invests in manufacturing

Vertex and Moderna pursue mRNA for CF

Vertex and Moderna pursue mRNA for CF

Moderna wins more backing from Merck

Moderna wins more backing from Merck

AstraZeneca Places US$240 M Bet on Moderna Therapeutics’ mRNA Technology

AstraZeneca has signed an option-based deal with start-up Moderna Therapeutics to discover, develop and commercialise up to 40 messenger RNA therapeutics™ for the treatment of serious cardiovascular, metabolic and renal diseases as well as cancer. Moderna will receive US$240 M upfront, which ranks as one of the largest initial payments ever disclosed for a discovery or preclinical-stage partnering deal. News of the collaboration came on the same day that AstraZeneca outlined a new strategy to revive growth that involves a significant overhaul of its R&D operations.

Nos reíamos como locas, como locas, como locas… La catástrofe eufórica en Yo era una chica moderna de César Aira.

Cesar Aira’s Yo era una chica moderna can be read as a metaphorical reconstruction of the social dynamics surrounding the argentine socio-economical crisis culminated at the end of 2001. The national catastrophe is portrayed with an euphoric tone that draws ironically on a literary tradition accustomed to associating popular advance with the monster figure and to focalizing the narrative through his violent point of view, thus communicating a sadistic glee in the very act of destruction. Nevertheless, the euphoria permeating the discourse can be also seen in the perspective of a new alliance between artists and lower classes emerging from the civil society’s spontaneous reaction to the crisis, specifically from a series of collective actions promoting horizontality, participation and solidarity between social groups. Aira’s novel seems to celebrate this unusual sensibility, especially in the literary field, where innovative practices began to diffuse as an answer to the new social demands.

Left Ventricular Relaxation

Left ventricular (LV) relaxation is an energy-dependent process and susceptible to disruption by various disease statuses. For assessment of LV relaxation, not only invasive methods but also noninvasive methods have been developed, such as digitized M mode echocardiogram, RNA, RVG, DTI, and cardiac cine CT or MRI. Recently, new techniques were developed to measure myocardial rotational movement, such as 2-dimensional STI, VVI, and harmonic phase-tagged MRI.

Geology and petrography of paleoproterozoic granitoid rocks from Uatumã- Anauá Domain, central region of Guyana Shield, southeastern Roraima, Brazil

Regional mapping carried out in the Uatuma-Anaua Domain (UAD), Guyana Shield, southeastern Roraima (Brazil), has showed widespread calc-alkaline granitic to alkaline magmatism and local peraluminous granites. These granitoid rocks are distributed into several magmatic associations with different Paleoproterozoic (1.97-1.89 Ga) ages, structural and geochemical affinities. In this paper, detailed mapping and petrographic studies have distinguished two main subdomains in UAD. In the northern UAD, the Martins Pereira I-type, calc-alkaline granitoid rocks and Serra Dourada S-type granite (1.97-1.96 Ga) are deformed and affected by NE-SW and E-W shear zones. Basement inliers (2.03 Ga) crop out to the northeastern part of this area, and are formed by rocks from metavolcano-sedimentary sequence (Cauarane Group) and TTG-like calc-alkaline association (Anaua Complex). Younger and undeformed (with local discrete NE-SW shear zones) Igarape Azul and Caroebe granites (I-type, calc-alkaline Agua Branca suite) crop out in the southern UAD. A-type granites such as Moderna (1.81 Ga) and Mapuera (1.87 Ga) plutons, cross cut both areas of UAD. Gold mineralization is observed in the Martins Pereira granitoid rocks (northern UAD), alluvial columbite-tantalite is related to the Igarape Azul granitoid rocks (southern UAD), and amethyst is associated to pegmatites of the Moderna A-type granites.