ML-based Approaches Research Articles

Automated Characterization of Catalytically Active Inclusion Body Production in Biotechnological Screening Systems.

We here propose an automated pipeline for the microscopy image-based characterization of catalytically active inclusion bodies (CatIBs), which includes a fully automatic experimental high-throughput workflow combined with a hybrid approach for multi-object microbial cell segmentation. For automated microscopy, a CatIB producer strain was cultivated in a microbioreactor from which samples were injected into a flow chamber. The flow chamber was fixed under a microscope and an integrated camera took a series of images per sample. To explore heterogeneity of CatIB development during the cultivation and track the size and quantity of CatIBs over time, a hybrid image processing pipeline approach was developed, which combines an ML-based detection of in-focus cells with model-based segmentation. The experimental setup in combination with an automated image analysis unlocks high-throughput screening of CatIB production, saving time and resources. Biotechnological relevance- CatIBs have wide application in synthetic chemistry and biocatalysis, but also could have future biomedical applications such as therapeutics. The proposed hybrid automatic image processing pipeline can be adjusted to treat comparable biological microorganisms, where fully data-driven ML-based segmentation approaches are not feasible due to the lack of training data. Our work is the first step towards image- based bioprocess control.

A DDoS attack detection and countermeasure scheme based on DWT and auto-encoder neural network for SDN

Software Defined Networking provides new functionalities to easily manage, configure, and optimize network resources by introducing a clear separation between the control entity and the forwarding devices. Such functionalities also help network operators detect and mitigate the security attacks to the network and provide better security level when compared to the traditional networks. However, some security threats, particularly distributed denial of service (DDoS) attacks, keep their effectiveness in degrading the availability of the networks even if the networking paradigm have changed. Existing DDoS attack detection approaches for SDN are mainly based on statistical (threshold-based) and Machine Learning-based (ML) approaches. Considering the dynamic characteristics of the network traffic, finding a dynamic threshold is somehow problematic. On the other hand, finding an appropriate feature that can discriminate DDoS attack from normal traffic is challenging for ML-based approaches. Therefore, to address the aforementioned issues, in this work, we propose a DDoS attack detection and countermeasure scheme based on discrete wavelet transform (DWT) and auto-encoder neural network for SDN. The proposed scheme extracts statistical features from the wavelet transform to be processed by an auto-encoder neural network to detect samples of DDoS attack traffic. Later, to reduce the computational burden imposed by the neural network model, the average hit rate in the flow table of the switches is used to activate the DDoS detection of the scheme. We also provide a detailed performance analysis by considering the computational cost complexity of the algorithms proposed in scheme and the evaluation of the successful detection rate with simulations. Our experimental results show that the proposed scheme achieves high detection rate against DNS amplification, Network Time Protocol and TCP SYN flood attacks with a remarkably low false alarm rate.

LlamaTune

Tuning a database system to achieve optimal performance on a given workload is a long-standing problem in the database community. A number of recent works have leveraged ML-based approaches to guide the sampling of large parameter spaces (hundreds of tuning knobs) in search for high performance configurations. Looking at Microsoft production services operating millions of databases, sample efficiency emerged as a crucial requirement to use tuners on diverse workloads. This motivates our investigation in LlamaTune, a tuner design that leverages domain knowledge to improve the sample efficiency of existing optimizers. LlamaTune employs an automated dimensionality reduction technique based on randomized projections, a biased-sampling approach to handle special values for certain knobs, and knob values bucketization, to reduce the size of the search space. LlamaTune compares favorably with the state-of-the-art optimizers across a diverse set of workloads. It identifies the best performing configurations with up to 11X fewer workload runs, and reaching up to 21% higher throughput. We also show that benefits from LlamaTune generalize across both BO-based and RL-based optimizers, as well as different DBMS versions. While the journey to perform database tuning at cloud-scale remains long, LlamaTune goes a long way in making automatic DBMS tuning practical at scale.

BioAutoML: automated feature engineering and metalearning to predict noncoding RNAs in bacteria.

Recent technological advances have led to an exponential expansion of biological sequence data and extraction of meaningful information through Machine Learning (ML) algorithms. This knowledge has improved the understanding of mechanisms related to several fatal diseases, e.g. Cancer and coronavirus disease 2019, helping to develop innovative solutions, such as CRISPR-based gene editing, coronavirus vaccine and precision medicine. These advances benefit our society and economy, directly impacting people’s lives in various areas, such as health care, drug discovery, forensic analysis and food processing. Nevertheless, ML-based approaches to biological data require representative, quantitative and informative features. Many ML algorithms can handle only numerical data, and therefore sequences need to be translated into a numerical feature vector. This process, known as feature extraction, is a fundamental step for developing high-quality ML-based models in bioinformatics, by allowing the feature engineering stage, with design and selection of suitable features. Feature engineering, ML algorithm selection and hyperparameter tuning are often manual and time-consuming processes, requiring extensive domain knowledge. To deal with this problem, we present a new package: BioAutoML. BioAutoML automatically runs an end-to-end ML pipeline, extracting numerical and informative features from biological sequence databases, using the MathFeature package, and automating the feature selection, ML algorithm(s) recommendation and tuning of the selected algorithm(s) hyperparameters, using Automated ML (AutoML). BioAutoML has two components, divided into four modules: (1) automated feature engineering (feature extraction and selection modules) and (2) Metalearning (algorithm recommendation and hyper-parameter tuning modules). We experimentally evaluate BioAutoML in two different scenarios: (i) prediction of the three main classes of noncoding RNAs (ncRNAs) and (ii) prediction of the eight categories of ncRNAs in bacteria, including housekeeping and regulatory types. To assess BioAutoML predictive performance, it is experimentally compared with two other AutoML tools (RECIPE and TPOT). According to the experimental results, BioAutoML can accelerate new studies, reducing the cost of feature engineering processing and either keeping or improving predictive performance. BioAutoML is freely available at https://github.com/Bonidia/BioAutoML.

A Machine Learning Framework towards Bank Telemarketing Prediction

The use of machine learning (ML) methods has been widely discussed for over a decade. The search for the optimal model is still a challenge that researchers seek to address. Despite advances in current work that surpass the limitations of previous ones, research still faces new challenges in every field. For the automatic targeting of customers in a banking telemarketing campaign, the use of ML-based approaches in previous work has not been able to show transparency in the processing of heterogeneous data, achieve optimal performance or use minimal resources. In this paper, we introduce a class membership-based (CMB) classifier which is a transparent approach well adapted to heterogeneous data that exploits nominal variables in the decision function. These dummy variables are often either suppressed or coded in an arbitrary way in most works without really evaluating their impact on the final performance of the models. In many cases, their coding either favours or disfavours the learning model performance without necessarily reflecting reality, which leads to over-fitting or decreased performance. In this work, we applied the CMB approach to data from a bank telemarketing campaign to build an optimal model for predicting potential customers before launching a campaign. The results obtained suggest that the CMB approach can predict the success of future prospecting more accurately than previous work. Furthermore, in addition to its better performance in terms of accuracy (97.3%), the model also gives a very close score for the AUC (95.9%), showing its stability, which would be very unfavourable to over-fitting.

Verifying Machine Learning conclusions for securing Low Inertia systems

Machine Learning (ML) for real-time Dynamic Security Assessment (DSA) promises a probabilistic approach to secure lower safety margins and costs. However, future systems with a high share of renewables have low inertia and converter-interfaced devices resulting in faster dynamics. Past research on ML-based DSA used high inertia systems to study ‘the best’ ML data, features, and models building upon each other’s work for decades. Seldom has ML-based research for DSA questioned whether the underlying assumptions for (and the conclusions of) these studies are still valid for low inertia systems. This work studies exemplary changes in assumptions (and conclusions) for ML-based DSA when moving from High Inertia (HI) to Low Inertia (LI) systems. The dynamical system of the LI system is brought in perspective with the most typical ML-based approaches, which are organised in sequential steps. The steps consider the generation of the training database, the data pre-processing and feature selection, the model training and validation. This work analyses each step individually for the changed assumptions in the dynamical LI system, and subsequently, a case study provides the evidence that considering a LI system to identify the ‘best’ ML approaches is important. The case studies on IEEE 14 and 68 bus systems confirm that LI systems must be optimised for security (otherwise, they result in 80% less security than HI systems). The key findings, however, are that using ML makes significantly more sense in LI systems than in HI systems as the LI dynamics are in shorter timescales (and the advantage of ML is to predict security in milliseconds) and that secure/insecure operations can be separated more straightforwardly in LI systems as ML increases the accuracy by up-to 40% towards close to 100% when using neural networks. • A dynamic model for low inertia power systems. • Impact analysis of the newly introduced low-inertia dynamics on ML-based real-time dynamic security assessment. • Case studies on the IEEE 14 and 68 bus system to compare the performance of ML-based approaches in high and low inertia systems. • High performance of ML-based security in low inertia systems.

234-OR: Noninvasive Hypoglycemia Detection during Real Car Driving Using In-Vehicle Data

Aim: To develop a non-invasive machine learning (ML) approach to detect hypoglycemia during real car driving based on driving (CAN) , and eye and head motion (EHM) data. Methods: We logged CAN and EHM data in 21 subjects with type 1 diabetes (18 male, 41 ± yrs, A1c 6.8 ± 0.7 % [51 ± 7 mmol/mol]) during driving in eu- (EU) and hypoglycemia (< 3.0 mmol/L, HYPO) . Participants drove in a car (Volkswagen Touran) supervised by a driving instructor on a closed test-track. Using CAN and EHM data, we built ML models to predict the probability of the driver being in HYPO. To make our approach applicable to different generations of cars, we present 3 ML models: first, a model combining CAN+EHM, representing the modern car with integrated camera. Second, a CAN model using driving data only, since modern cars are not generally equipped with EHM tracking. Third, anticipating that autonomous driving will limit the role of CAN data in the future, we tested a model solely based on EHM. Results: Mean BG in EU and HYPO was 6.3 ± 0.8 mmol/L and 2.5 ± 0.5 mmol/L (p< 0.001) , respectively. The model CAN+EHM achieved an area under the receiver operating characteristic curve of 0.88 ± 0.05, sensitivity of 0.70 ± 0.30, and specificity of 0.83 ± 0.in detecting HYPO. Further results are in Fig. 1. Conclusion: We propose ML-based approaches to non-invasively detect HYPO from driver behavior, applicable to contemporary cars and anticipating developments in automotive technology. Disclosure V.Lehmann: None. E.Fleisch: None. T.Kowatsch: Advisory Panel; Pathmate Technologies AG, Research Support; CSS Insurance, Stock/Shareholder; Pathmate Technologies AG. S.N.Lagger: None. M.Laimer: None. F.Wortmann: None. C.Stettler: None. T.Zueger: None. M.Maritsch: None. M.Notter: None. S.Schallmoser: None. C.Bérubé: None. C.Albrecht: None. M.Kraus: None. S.Feuerriegel: None. Funding Swiss National Science Foundation (SNF CRSII5_183569) , Swiss Diabetes Foundation, Diabetes Center Berne, Automobile Club Switzerland (ACS) , Federal Department of Defence, Civil Protection and Sport (DDPS) and Department of Research of the University Hospital Berne

Important Features Selection and Classification of Adult and Child from Handwriting Using Machine Learning Methods

The classification of different age groups, such as adult and child, based on handwriting is very important due to its various applications in many different fields. In forensics, handwriting classification helps investigators focus on a certain category of writers. This paper aimed to propose a machine-learning (ML)-based approach for automatically classifying people as adults or children based on their handwritten data. This study utilized two types of handwritten databases: handwritten text and handwritten pattern, which were collected using a pen tablet. The handwritten text database had 57 subjects (adult: 26 vs. child: 31). Each subject (adult or child) wrote the same 30 words using Japanese hiragana characters. The handwritten pattern database had 81 subjects (adult: 42 and child: 39). Each subject (adult or child) drew four different lines as zigzag lines (trace condition and predict condition), and periodic lines (trace condition and predict condition) and repeated these line tasks three times. Handwriting classification of adult and child is performed in three steps: (i) feature extraction; (ii) feature selection; and (iii) classification. We extracted 30 features from both handwritten text and handwritten pattern datasets. The most efficient features were selected using sequential forward floating selection (SFFS) method and the optimal parameters were selected. Then two ML-based approaches, namely, support vector machine (SVM) and random forest (RF) were applied to classify adult and child. Our findings showed that RF produced up to 93.5% accuracy for handwritten text and 89.8% accuracy for handwritten pattern databases. We hope that this study will provide the evidence of the possibility of classifying adult and child based on handwriting text and handwriting pattern data.

Prediction of QcrB Inhibition as a Measure of Antitubercular Activity with Machine Learning Protocols.

It has always been a challenge to develop interventional therapies for Mycobacterium tuberculosis. Over the years, several attempts at developing such therapies have hit a dead-end owing to rapid mutation rates of the tubercular bacilli and their ability to lay dormant for years. Recently, cytochrome bcc complex (QcrB) has shown some promise as a novel target against the tubercular bacilli, with Q203 being the first molecule acting on this target. In this paper, we report the deployment of several ML-based approaches to design molecules against QcrB. Machine learning (ML) models were developed based on a data set of 350 molecules using three different sets of molecular features, i.e., MACCS keys, ECFP6 fingerprints, and Mordred descriptors. Each feature set was trained on eight ML classifier algorithms and optimized to classify molecules accurately. The support vector machine-based classifier using the ECFP6 feature set was found to be the best classifier in this study. Further, screening of the known imidazopyridine amide inhibitors demonstrated that the model correctly classified the most potent molecules as actives, hence validating the model for future applications.

Machine Learning-Based Research for COVID-19 Detection, Diagnosis, and Prediction: A Survey.

The year 2020 experienced an unprecedented pandemic called COVID-19, which impacted the whole world. The absence of treatment has motivated research in all fields to deal with it. In Computer Science, contributions mainly include the development of methods for the diagnosis, detection, and prediction of COVID-19 cases. Data science and Machine Learning (ML) are the most widely used techniques in this area. This paper presents an overview of more than 160 ML-based approaches developed to combat COVID-19. They come from various sources like Elsevier, Springer, ArXiv, MedRxiv, and IEEE Xplore. They are analyzed and classified into two categories: Supervised Learning-based approaches and Deep Learning-based ones. In each category, the employed ML algorithm is specified and a number of used parameters is given. The parameters set for each of the algorithms are gathered in different tables. They include the type of the addressed problem (detection, diagnosis, or detection), the type of the analyzed data (Text data, X-ray images, CT images, Time series, Clinical data,...) and the evaluated metrics (accuracy, precision, sensitivity, specificity, F1-Score, and AUC). The study discusses the collected information and provides a number of statistics drawing a picture about the state of the art. Results show that Deep Learning is used in 79% of cases where 65% of them are based on the Convolutional Neural Network (CNN) and 17% use Specialized CNN. On his side, supervised learning is found in only 16% of the reviewed approaches and only Random Forest, Support Vector Machine (SVM) and Regression algorithms are employed.

P261 Early and accurate diagnosis of patients with axial spondyloarthritis using machine learning: a predictive analysis from electronic health records in the United Kingdom

Abstract Background/Aims On average, there is a delay of 6.7 years between symptom onset and diagnosis of axial spondyloarthritis (axSpA). Since traditional approaches to improving early axSpA identification have had limited success, predictive automated analyses using patient records may help alleviate the burden on healthcare providers. We report results from a machine learning (ML) algorithm developed with UK electronic health records (EHRs) Clinical Practice Research Datalink (CPRD) data to estimate the probability or likelihood of a patient being diagnosed with axSpA based on prior clinical indicators and patient history. Methods Primary care UK EHR data - CPRD GOLD was used to identify patients with axSpA and healthy controls (HC). Patients aged ≥18 years with first diagnosis date of axSpA within the identification period (01-Jan-2005 to 31-Dec-2018) and fulfilling CPRD research acceptability criteria were included. Data pertaining to clinical presentation, consultation, referral, test, and therapy history were extracted for individual patients prior to diagnosis of axSpA. A total of 5,090 patients with axSpA satisfied the acceptability criteria. HC were randomly sampled to create a subset of one unique HC matched to each patient with axSpA, resulting in 5,089 HC. ML usable features derived from the total population (patients with axSpA and HC) numbered 820. After using a further exclusion criterion for the patients with axSpA and HC who had ≥1 of 820 usable features, the final dataset included 7,813 patients (3,902 with axSpA and 3,911 HC). This combined dataset was randomly split (67:33) into a train (n = 5237) and a test (n = 2576) dataset. A random forest (RF) model was trained on the train dataset. Cross-validation was performed for hyper-parameter tuning of the RF classifier. Once the model was trained, accuracy, precision, and F-1 scores were obtained with the test dataset. Results The RF-based algorithm resulted in a high level of accuracy (88.12%), with precision of 0.95 for patients with axSpA and 0.83 for HC. The RF algorithm identified 89 best clinical predictors (out of 820 used as inputs) that differentiated between patient and HC such as: total number of tests, total number of referrals, first age of consultation, first symptom age, and number of low back pain symptoms. The model sensitivity was 0.75 and positive predictive value was 80.88%. The model specificity was 0.96 and negative predictive value was 82.56%. Conclusion The ML algorithm demonstrated a high level of accuracy and precision in the identification of possible cases of axSpA, which may be useful in reducing the delay in diagnosis. Previous studies have successfully demonstrated automated cohort identification of axSpA in large datasets, with only a few using ML-based approaches for diagnosis from patient medical history. While our model supports previous work in axSpA, it needs further validation in routine clinical practice (exploration ongoing). Disclosure R. Sengupta: Honoraria; AbbVie, Biogen, Celgene, Lilly, MSD, Novartis, Roche, UCB. Grants/research support; AbbVie, Celgene, Novartis, UCB. S. Narasimham: Shareholder/stock ownership; Novartis. Other; Employee of Novartis. B.S. Mato: Shareholder/stock ownership; Novartis. Other; Employee of Novartis. M. Meglic: Other; Employee of Novartis. C. Perella: Other; Employee of Novartis. P. Pamies: Other; Employee of Novartis. P. Emery: Consultancies; AbbVie, Astra-Zeneca, BMS, Boehringer Ingelheim, Celltrion, Gilead, Janssen, MSD, Lilly, Novartis, Pfizer, Roche, Samsung, UCB. Grants/research support; AbbVie, BMS, Lilly, Novartis, Pfizer, Roche, Samsung.

Machine learning-based discrimination of indoor pollutants using an oxide gas sensor array: High endurance against ambient humidity and temperature

Machine learning (ML) methodologies were applied to detect and discriminate five indoor volatile organic compounds (VOCs) such as benzene, xylene, toluene, formaldehyde, and ethanol using a sensor array constructed of five In2O3-based semiconducting metal oxide (SMO) gas sensors. The sensor array was evaluated using principal component analysis (PCA) and neural network-based classification in terms of the gas sensor data type/amount, neural network algorithms, sensor combinations, and environmental factors. The PCA analyses indicated the limitations on the discrimination of VOCs under temperature- and/or humidity-interfered gas sensing environments. Gas detection/discrimination could be improved significantly by using three supervised algorithms, i.e., artificial neural networks (ANNs), deep neural networks (DNNs), and 1-dimensional convolutional neural networks (1D CNNs). The neural network algorithm prediction based on the entire gas sensing/purge transient data outperforms deep learning-assisted predictions based on partial gas sensing transients. Compared to 1D CNNs, DNNs are more appropriate in terms of training/validation/test datasets. The effects due to humidity variation are more significant than those due to temperature fluctuation. A 2-sensor mode combination can be exploited to replace the 5-sensor operation in ML-based applications. The indoor pollutants can be successfully discriminated even under the variation of ambient humidity and temperature by ML-based approaches.

Detections of IoT Attacks via Machine Learning-Based Approaches with Cooja

Once hardware becomes "intelligent", it is vulnerable to threats. Therefore, IoT ecosystems are susceptible to a variety of attacks and are considered challenging due to heterogeneity and dynamic ecosystem. In this study, we proposed a method for detecting IoT attacks that are based on ML-based approaches that release the final decision to detect IoT attacks. However, we have implemented three attacks as a sample in the IoT via Contiki OS to generate a real dataset of IoT-based features containing a mix of data from malicious nodes and normal nodes in the IoT network to be utilized in the ML-based models. As a result, the multiclass random decision forest ML-based model achieved 98.9% overall accuracy in detecting IoT attacks for the real novel dataset compared to the decision tree jungle, decision forest tree regression, and boosted decision tree regression, which achieved 87.7%, 93.2%, and 87.1%, respectively. Thus, the decision tree-based approach efficiently manipulates and analyzes the KoÜ-6LoWPAN-IoT dataset, generated via the Cooja simulator, to detect inconsistent behavior and classify malicious activities.

An Exploration of the Potential of Machine Learning Tools for Media Analysis to Support Sense-Making Processes in Foresight

In view of the many discussions about uncertainty regarding the further development of the coronavirus disease 2019 (COVID-19) pandemic and its effects on the economy and society, we observed that the crisis led to an increased presence of individual researchers and experts making forward-looking statements on the impacts of the COVID-19 pandemic or stating trends in mass media publications. From a strategic foresight research perspective, there is a need to further analyse an increase of future-oriented expert statements in public media in a context of high uncertainty like the impacts of the COVID-19 pandemic and related crises. Given the increasing amount of media texts available for web-based scanning and text analysis, Machine Learning (ML) is a promising approach for text analysis of big data, which also raises high expectations in the field of foresight, particularly in the context of scoping and scanning activities for weak signal detection and text analysis for sense-making processes. In this study, we apply a natural language processing (NLP)-based ML approach to analyse a large corpus of news articles from web sources to explore the potential of applied ML to support sense-making in the field of foresight, specifically for the analysis of future-related statements or predictive statements in media. The results underline the potential of ML approaches as a heuristic tool to support sense-making in foresight processes and research, particularly by pre-structuring large datasets (e.g., news articles around a particular topic of public debate). The ML can provide additional insights for actor analysis associated with a specific topic of public debate from a large data corpus. At the same time, our results show that ML models are limited in their ability to provide solid evidence and that they can also lead to fallacies. Therefore, an ML can only be considered as a heuristic tool supporting specific steps in a sense-making process and development of further research questions, as well as encouraging reflection on the application of ML-based approaches in foresight.

Machine learning methods for prediction of cancer driver genes: a survey paper.

Identifying the genes and mutations that drive the emergence of tumors is a critical step to improving our understanding of cancer and identifying new directions for disease diagnosis and treatment. Despite the large volume of genomics data, the precise detection of driver mutations and their carrying genes, known as cancer driver genes, from the millions of possible somatic mutations remains a challenge. Computational methods play an increasingly important role in discovering genomic patterns associated with cancer drivers and developing predictive models to identify these elements. Machine learning (ML), including deep learning, has been the engine behind many of these efforts and provides excellent opportunities for tackling remaining gaps in the field. Thus, this survey aims to perform a comprehensive analysis of ML-based computational approaches to identify cancer driver mutations and genes, providing an integrated, panoramic view of the broad data and algorithmic landscape within this scientific problem. We discuss how the interactions among data types and ML algorithms have been explored in previous solutions and outline current analytical limitations that deserve further attention from the scientific community. We hope that by helping readers become more familiar with significant developments in the field brought by ML, we may inspire new researchers to address open problems and advance our knowledge towards cancer driver discovery.

A Brief Review of Machine Learning-Based Bioactive Compound Research

Bioactive compounds are often used as initial substances for many therapeutic agents. In recent years, both theoretical and practical innovations in hardware-assisted and fast-evolving machine learning (ML) have made it possible to identify desired bioactive compounds in chemical spaces, such as those in natural products (NPs). This review introduces how machine learning approaches can be used for the identification and evaluation of bioactive compounds. It also provides an overview of recent research trends in machine learning-based prediction and the evaluation of bioactive compounds by listing real-world examples along with various input data. In addition, several ML-based approaches to identify specific bioactive compounds for cardiovascular and metabolic diseases are described. Overall, these approaches are important for the discovery of novel bioactive compounds and provide new insights into the machine learning basis for various traditional applications of bioactive compound-related research.

Machine learning-based modeling in food processing applications: State of the art.

Food processing is a complex, multifaceted problem that requires substantial human interaction to optimize the various process parameters to minimize energy consumption and ensure better-quality products. The development of a machine learning (ML)-based approach to food processing applications is an exciting and innovative idea for optimizing process parameters and process kinetics to reduce energy consumption, processing time, and ensure better-quality products; however, developing such a novel approach requires significant scientific effort. This paper presents and evaluates ML-based approaches to various food processing operations such as drying, frying, baking, canning, extrusion, encapsulation, and fermentation to predict process kinetics. A step-by-step procedure to develop an ML-based model and its practical implementation is presented. The key challenges of neural network training and testing algorithms and their limitations are discussed to assist readers in selecting algorithms for solving problems specific to food processing. In addition, this paper presents the potential and challenges of applying ML-based techniques to hybrid food processing operations. The potential of physics-informed ML modeling techniques for food processing applications and their strategies is also discussed. It is expected that the potential information of this paper will be valuable in advancing the ML-based technology for food processing applications.

Seismic performance assessment of corroded RC columns based on data-driven machine-learning approach

Corrosion of steel reinforcements is a major factor that will adversely affect the seismic performance of the reinforced concrete (RC) columns. This paper investigates the application of machine learning (ML)-based approach for seismic failure mode and maximum bearing capacity prediction for corroded RC columns. A comprehensive database consisting of 180 cyclic tests of corroded RC columns are collected. Six ML algorithms including three single learning methods (k-Nearest neighbors, Decision tree, Artificial neural network) and three ensemble learning methods (Random forest, AdaBoost, CatBoost) are selected to develop the predictive model. The performance of the six models are evaluated and the application of ML-based approaches for life-cycle seismic performance assessment of RC column is demonstrated with a case-study column. The results show that the Random forest and CatBoost models have the best performance for seismic failure mode prediction with an accuracy of 89%. The best model for bearing capacity prediction is the CatBoost model which has a R2 of 0.92, and the CatBoost model is superior to the traditional mechanism-based code models for bearing capacity prediction. The ML-based models can conveniently predict the seismic failure mode and bearing capacity of RC columns in its life-cycle context without complicated numerical simulations or theoretical calculations.

Advances in and the Applicability of Machine Learning-Based Screening and Early Detection Approaches for Cancer: A Primer.

Simple SummaryNon-communicable diseases in general, and cancer in particular, contribute greatly to the global burden of disease. Although significant advances have been made to address this burden, cancer is still among the top drivers of mortality, second only to cardiovascular diseases. Consensus has been established that a key factor to reduce the burden of disease from cancer is to improve screening for and the early detection of such conditions. To date, however, most approaches in this field relied on established screening methods, such as a clinical examination, radiographic imaging, tissue staining or biochemical markers. Yet, with the advances of information technology, new data-driven screening and diagnostic tools have been developed. This article provides a brief overview of the theoretical foundations of these data-driven approaches, highlights the promising use cases and underscores the challenges and limitations that come with the introduction of these approaches to the clinical field.Despite the efforts of the past decades, cancer is still among the key drivers of global mortality. To increase the detection rates, screening programs and other efforts to improve early detection were initiated to cover the populations at a particular risk for developing a specific malignant condition. These diagnostic approaches have, so far, mostly relied on conventional diagnostic methods and have made little use of the vast amounts of clinical and diagnostic data that are routinely being collected along the diagnostic pathway. Practitioners have lacked the tools to handle this ever-increasing flood of data. Only recently, the clinical field has opened up more for the opportunities that come with the systematic utilisation of high-dimensional computational data analysis. We aim to introduce the reader to the theoretical background of machine learning (ML) and elaborate on the established and potential use cases of ML algorithms in screening and early detection. Furthermore, we assess and comment on the relevant challenges and misconceptions of the applicability of ML-based diagnostic approaches. Lastly, we emphasise the need for a clear regulatory framework to responsibly introduce ML-based diagnostics in clinical practice and routine care.

Aggregate-based Training Phase for ML-based Cardinality Estimation

Cardinality estimation is a fundamental task in database query processing and optimization. As shown in recent papers, machine learning (ML)-based approaches may deliver more accurate cardinality estimations than traditional approaches. However, a lot of training queries have to be executed during the model training phase to learn a data-dependent ML model making it very time-consuming. Many of those training or example queries use the same base data, have the same query structure, and only differ in their selective predicates. To speed up the model training phase, our core idea is to determine a predicate-independent pre-aggregation of the base data and to execute the example queries over this pre-aggregated data. Based on this idea, we present a specific aggregate-based training phase for ML-based cardinality estimation approaches in this paper. As we are going to show with different workloads in our evaluation, we are able to achieve an average speedup of 90 with our aggregate-based training phase and thus outperform indexes.