Based upon two overlapped, body-unfitted meshes, a type of unified-field monolithic fictitious domain-finite element method (UFMFD-FEM) is developed in this paper for moving interface problems of dynamic fluid-structure interactions (FSI), which is accompanied with high-contrast physical coefficients across the interface and with contacting collisions between the structure and fluidic channel wall in the immersed FSI case. In particular, the proposed novel numerical method consists of a monolithic, stabilized mixed finite element method within the frame of fictitious domain/immersed boundary method (FD/IBM) for generic fluid-structure-contact interaction (FSCI) problems in the Eulerian–updated Lagrangian description, while involving the no-slip type of interface conditions on the fluid-structure interface, and the repulsive contact force/stress on the structural surface when the immersed structure contacts the fluidic channel wall. The developed UFMFD-FEM for FSI/FSCI problems can deal with the structural motion with large rotational and translational displacements and/or large deformation in an accurate and efficient fashion, which is first validated by two benchmark FSI problems and one FSCI model problem, then by experimental results of a realistic FSCI scenario – the microfluidic deterministic lateral displacement (DLD) problem that is applied to isolate circulating tumor cells (CTCs) from blood cells in the blood fluid through a cascaded filter DLD microchip in practice, where a particulate fluid with the pillar obstacles effect in the fluidic channel, i.e., the effects of fluid-structure interaction and structure collision, play significant roles to sort particles (cells) of different sizes with tilted pillar arrays. The developed unified-field, monolithic fictitious domain-based mixed finite element method can be seamlessly extended to more sophisticated, high dimensional FSCI problems with contacting collisions between the moving elastic structure and fluidic channel wall.
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