The influence of mindfulness therapy on NSSI and serum proBDNF in adolescents with depressive episode of depressive episode of bipolar disorder.

Patients with psoriasis often experience emotional distress, which may be alleviated through psychological interventions. To evaluate online Mindfulness-Based Cognitive Therapy (MBCT) as an adjuvant treatment for psoriasis, focusing on severity of lesion, anxiety, depression, quality of life, and itching. This randomized trial enrolled 109 patients with psoriasis assigned to either treatment as usual (TAU) or TAU plus MBCT, which included 8 weekly online sessions. Primary outcomes included Psoriasis Area and Severity Index (PASI), Self-Rating Anxiety/Depression Scale (SAS/SDS), and Dermatology Life Quality Index (DLQI). Itching was a secondary outcome measured by Visual Analogue Scale (VAS). Assessments were conducted at baseline, 4, 8, and 12 weeks. Treatment effects were analyzed with mixed linear models. A total of 109 patients were randomized 1:1 to MBCT + TAU (n = 53) or TAU (n = 56). Significant group × time interactions favoring MBCT + TAU were observed for PASI (F = 3.746, P = .013, d = 0.331), SDS (F = 3.205, P = .025, d = 0.269), DLQI (F = 3.130, P = .028, d = 0.309), and VAS (F = 3.126, P = .028, d = 0.295). No significant between-group difference was found for anxiety. Single-center. Adjunctive online MBCT led to improvements in psoriasis severity, depression, DLQI and itching, suggesting its potential to enhance comprehensive psoriasis management.

Healthy aging as Black adults, in it together (HABIT): Protocol for a comparative effectiveness trial to address comorbid chronic pain and early cognitive decline among older, community-based Black adults.

Implementation and effectiveness of Mindfulness-Based Cognitive Therapy for mild depression in primary care: Protocol for a stepped-wedge cluster RCT

Older Black adults experience disproportionately high rates of chronic pain (CP) and depression, yet inequities in access, recognition, and culturally resonant treatment persist. Mindfulness-based cognitive therapy (MBCT) is an evidence-based group intervention for depression with emerging promise for CP. However, adaptations for older Black adults with comorbid CP-depression remain underexplored. Guided by cultural intervention adaptation and community engagement principles, we conducted four Community Engagement Studios with 20 older Black adults in Boston (ages 51-84), all reporting CP (≥ 3months) and mild to moderate depressive symptoms (PHQ-9 ≥ 15). Participants reviewed MBCT content and reflected on cultural relevance, barriers, and facilitators. Through thematic analysis of recorded transcripts, we identified themes pertaining to their perceptions of MBCT. Three themes emerged: (1) nuanced acceptance of mindfulness practices when adapted to faith, physical limitations, and language; (2) importance of instructors who are grounded in respect and shared cultural context; and (3) preference for flexible, sustainable delivery (community-based, hybrid options, shorter sessions). Our findings highlight MBCT's feasibility for older Black adults with the CP-depression comorbidity when adapted for cultural resonance, accessibility, and sustainability. Results will directly inform our adaptation of MBCT for the CP-depression comorbidity among older Black adults.

Psychological intervention for postpartum depression: A systematic review and network meta-analysis.

Introduction: Appendectomy is a relatively safe surgical procedure. One important aspect of this stage is maintaining the patient's mental stability, especially before administering anesthesia. However, anesthesia often causes anxiety in patients. Mindfulness-based cognitive therapy has been shown to significantly improve quality of life by minimizing anxiety. Objective: This study analyzed the effect of Mindfulness-based cognitive therapy (MCT) in reducing pre-anesthetic anxiety in appendectomy patients. Methods: This study used a case study design with a nursing care process approach. The subjects in this case study were two patients who met the inclusion criteria. The instrument used was an observation sheet according to the Indonesian Society for Anesthesia and Clinical Trials (SLKI). Results: The results of the case study showed that both patients experienced pre-anesthetic anxiety. After receiving Mindfulness-based cognitive therapy, pre-anesthetic anxiety decreased. Conclusion: This case study demonstrated that pre-anesthetic anxiety decreased after Mindfulness-based cognitive therapy.

Pediatric surgical nursing is characterized by high clinical acuity, emotional intensity, and significant occupational stressors that contribute to burnout, compassion fatigue, and workforce challenges. Mindfulness-based interventions (MBIs), including Mindfulness-Based Stress Reduction, Mindfulness-Based Cognitive Therapy, and Acceptance and Commitment Therapy, have demonstrated effectiveness in reducing stress, anxiety, depression, and burnout across healthcare settings. Grounded in Lazarus and Folkman's Transactional Model of Stress and Coping and aligned with Jean Watson's Theory of Human Caring, mindfulness supports resilience, emotional regulation, and holistic, person-centered care. Evidence synthesized in this literature review indicates that MBIs improve psychological well-being among nurses, enhancing coping and resilience, and may reduce secondary traumatic stress. Additionally, mindfulness interventions have demonstrated benefits for pediatric patients and family members, including reductions in anxiety and pain. Although the research specific to pediatric settings is limited, the implementation of abbreviated MBIs shows promise for feasibility in inpatient environments. Future research should evaluate long-term outcomes and organizational impact. Expanding implementation of MBIs within pediatric surgical nursing may support clinician well-being, family-centered care, and improved healthcare outcomes.

Neuropathic pain is a debilitating late effect among cancer survivors. This scoping review aims to provide an overview of pharmacological, psychological, and exercise interventions for neuropathic pain among cancer survivors and to identify further relevant research areas. Patient/material and methods: PubMed, PsychInfo, and EMBASE were systematically searched for studies published from January 2004 to January 2026 and abstract and full text screening was carried out. The target population was cancer survivors who had completed primary treatment and have no active disease. Neuropathic pain was defined as a) a mean pain intensity the last week/month of ≥ 3 at a numerical rating scale (0 = no pain, 10 = worst pain), and b) symptoms of neuropathy, or c) neuropathic pain diagnosed by an experienced neurologist. Of the 956 systematic reviews/guidelines and 604 original studies identified, 11 pharmacological, two psychological and three studies on exercise were eligible. Most of the studies included patients with breast cancer. Duloxetine was effective in reducing neuropathic pain from painful chemotherapy-induced neuropathy and gabapentin + concomitant morphine compared to morphine alone reduced neuropathic pain in cancer survivors with neuropathic pain due to radiation therapy, and surgery. Mindfulness-based cognitive behavioral therapy showed no effect after correction for multiple comparisons. Exercise interventions were useful in both reducing neuropathic pain as well as neuropathic symptoms. This scoping review found evidence for pharmacological treatment of neuropathic pain in cancer survivors, could not make any conclusion on psychological treatment, and exercise interventions show promising effects. Further research on interdisciplinary treatment of neuropathic pain among cancer survivors is needed.

Breast cancer surgery and corresponding treatments have significant residual effects on survivors of breast cancer in China. Body image distress and stigma are persistent challenges that negatively affect their quality of life. Accessible, sustainable, and cost-effective support remains scarce. This study aimed to evaluate the effectiveness and cost-effectiveness of an app-based mindfulness breast care (MBC) program in addressing body image distress and stigma for survivors of breast cancer. We carried out a randomized controlled trial in 2 university-affiliated hospitals in China. Survivors of breast cancer who had completed primary treatments and had mobile phone internet access were recruited and randomly assigned at a 1:1 ratio to the intervention (3-month MBC program plus routine care) or the control group (routine care alone). Under the conceptualization of mindfulness-based cognitive therapy, the MBC program was developed, including three modules: (1) Library, (2) Mindfulness Yoga, and (3) Mindfulness Practices. The primary outcomes measured were body image distress and stigma, and secondary outcomes included sleep quality, social support, and quality of life (physical and mental well-being). Assessments were conducted at baseline, 3 months (T1), and 6 months (T2). Multiple imputation was used to handle missing data and generalized estimating equations were fitted to evaluate the effectiveness. The incremental cost per quality-adjusted life year (QALY) gained was used to measure cost-effectiveness. A total of 192 survivors of breast cancer participated in the baseline assessment, with 155 completing the 2 follow-up surveys. The median total usage duration was 199.60 (IQR 70.90-451.31; mean 360.59, SD 511.72) minutes, and total login frequency was 39.50 (IQR 19.00-86.50; mean 57.02, SD 50.26) times. The reduction in body image distress at T2 (adjusted mean difference -1.91; 95% CI -3.40 to -0.42; P=.01; d=-0.31), the reduction in stigma at T1 (adjusted mean difference -5.83; 95% CI -8.46 to -3.20; P<.001; d=-0.61) and T2 (adjusted mean difference -7.79; 95% CI -10.62 to -4.97; P<.001; d=-0.82), and the improvement in mental well-being at T1 (adjusted mean difference 4.44; 95% CI 1.70 to 7.18; P=.002; d=0.43) were statistically significantly greater in the intervention group compared with the control group. No statistically significant group differences were observed regarding sleep quality, social support, and physical well-being. The cost-effectiveness analysis showed that the intervention group gained more QALYs than the control group at T2 (adjusted mean difference 0.008; 95% CI 0.004 to 0.016; P=.01). The incremental cost per QALY gained at T2 was US $19,431.25, indicating a 57% probability that the MBC program is a cost-effective intervention at a threshold of US $37,530, three times the 2023 gross domestic product per capita of China. An app-based MBC program was effective and potentially cost-effective and had the promise to be scalable for clinical practice. Chinese Clinical Trial Registry ChiCTR2200059952; https://www.chictr.org.cn/showproj.html?proj=167247.

This study investigates the adjunctive effects of mindfulness-based cognitive therapy (MBCT) combined with escitalopram hydrobromide on cognitive function and emotional well-being in older adults with treatment-resistant depression (TRD). We hypothesized that this combined approach would lead to greater enhancements in cognitive abilities and overall well-being compared to escitalopram hydrobromide alone in this vulnerable population. A total of 230 older adults with TRD and cognitive impairment were randomly assigned into two groups: an experimental group receiving MBCT plus escitalopram (n = 115) and a control group receiving escitalopram alone (n = 115). Cognitive function, depression severity, and quality of life were assessed at baseline, 6 weeks, and 12 weeks using the Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAM-D), and General Quality of Life Index-74 (GQOLI-74). The experimental group demonstrated significant improvements in cognitive function (MoCA scores) and quality of life (GQOLI-74 scores) compared to the control group at both 6 and 12 weeks (p < 0.05). Additionally, depression severity (HAM-D scores) was significantly reduced in the experimental group (p < 0.05). The combined therapy also resulted in higher rates of significant and effective treatment outcomes, with fewer cases of average or ineffective responses (p < 0.05). The integration of MBCT with escitalopram hydrobromide significantly enhances cognitive function, reduces depressive symptoms, and improves quality of life in older adults with TRD. Clinicians should consider incorporating mindfulness-based interventions alongside pharmacological treatments for older adults with TRD. The trial was retrospectively registered with ClinicalTrials. gov (Identifier: NCT07077291).

Abstract Objectives This review examined why personal mindfulness practice is regarded as foundational for teachers delivering mindfulness-based interventions (MBIs), particularly Mindfulness-Based Cognitive Therapy (MBCT) and Mindfulness-Based Stress Reduction (MBSR). Although professional standards mandate sustained personal practice, empirical findings linking teacher competence or embodiment to participant outcomes remain inconsistent. The review aimed to synthesise evidence examining relationships between personal practice, embodiment, teaching competence, and participant outcomes. Method A systematic search of PsycINFO, MEDLINE, PubMed, Web of Science, and CINAHL was conducted for studies published between 2010 and 2025. Eligible studies examined teacher-related variables within MBCT or MBSR. Quantitative, qualitative, mixed-methods studies, and professional guidelines were included. Data were synthesised using a narrative synthesis approach due to the heterogeneity of designs, measures, and outcomes. Results Seventy-two publications met inclusion criteria. Quantitative studies reported mixed associations between assessed teacher competence and clinical outcomes. In contrast, qualitative studies consistently emphasised teacher embodiment, relational presence, and authenticity as central to participant experience. Mixed-methods and training studies suggested improvements in teacher interoceptive awareness and emotional regulation following extended training, although links to participant outcomes remained unclear. Conclusions While direct associations between teacher competence and symptom change remain inconsistent, converging evidence supports prioritising personal practice as foundational for cultivating embodiment and relational presence. These qualities appear central to ethical and effective teaching and warrant continued emphasis in mindfulness teacher training and future research. Preregistration This study is not preregistered.

Depression is a major contributor to global disability, yet symptom reduction alone does not exhaust the clinical problem of meaning, self-interpretation, and cultural fit in treatment [1][2]. This article develops a conceptual review of how Zhuangzi's philosophy may inform integrative psychotherapy for depression. Through close reading of recurrent Zhuangzi themes and a focused synthesis of literature on cognitive therapy, mindfulness-based cognitive therapy, Acceptance and Commitment Therapy, Morita Therapy, and cultural psychiatry, the paper identifies three clinically relevant constructs: decentering from rigid self-identification, acceptance of change and limited control, and reconstruction of value beyond instrumental achievement. The analysis argues that Zhuangzi should not be treated as a stand-alone treatment or as an empirical substitute for evidence-based care. Rather, it can function as a culturally resonant interpretive framework, especially in contexts where patients struggle with rumination, perfectionism, and performance-contingent self-worth. The paper concludes by outlining a cautious agenda for theoretically grounded and culturally responsive integration.

Mindfulness-based interventions are widely used, yet concerns about potential negative effects-particularly those related to mindfulness meditation practice-have gained increasing attention. Individuals with difficult-to-treat depression (DTD) represent a population of particular relevance due to heightened vulnerability, but comparative evidence on clinically relevant negative outcomes of mindfulness-based cognitive therapy (MBCT) versus established alternative psychotherapies in this group is lacking. This protocol describes a systematic review and individual participant data (IPD) network meta-analysis to assess and compare the incidence of clinically relevant negative outcomes associated with MBCT and the cognitive behavioural analysis system of psychotherapy (CBASP), an established individual psychotherapy for DTD. Randomised controlled trials of MBCT and CBASP for adults with DTD were identified through systematic searches of major databases. Eligible studies must compare MBCT or CBASP (alone or with treatment as usual) to each other or to control groups. The primary outcome is clinically significant deterioration, defined as a ≥6-point increase on the Patient Health Questionnaire-9 or equivalent. Secondary outcomes are suicidality and treatment dropout. IPD will be requested from trial investigators; aggregate data will be used when IPD is unavailable. One-stage random-effects IPD network meta-analyses will be conducted to integrate direct and indirect evidence and to examine participant-level moderators of deterioration. Adverse events reported in the included trials will be summarised descriptively at the study level. No local ethical review was required following consultation with the Swedish Ethical Review Authority. Primary trial investigators obtained local ethical approval and will share pseudonymised IPD. Findings will inform clinical decision-making and guideline development by strengthening the evidence base on potential negative effects of MBCT and CBASP in adults with DTD, including identification of subgroups at increased risk. Results will be disseminated through peer-reviewed publication and accessible summaries for relevant stakeholders. CRD42022332039.

Background: Mindfulness-based cognitive therapy (MBCT), a therapeutic method that combines cognitive behavioral therapy (CBT) techniques and mindful meditation teachings, has been highly efficacious in remission maintenance for depressive symptoms and is currently recommended for remission maintenance of depression. Objective: The MBCT quality improvement study sought to implement an evidence-based MBCT-guided self-education program to maintain remission of depressive symptoms, improve quality of life, and reduce disability. Results: Comparing the Patient Health Questionnaire-9 (PHQ-9), Sheehan Disability Scale (SDS), and World Health Organization Well-Being Questionnaire-5 (WHO-5) surveys from both the treatment-as-usual and MBCT groups, there is a notable improvement in scores in the MBCT group. Within 8 weeks, the intervention group mean PHQ-9 scores reflected a 41% decline in depression; the WHO-5 scores reflected a 56.06% increase in quality of life, and the group mean SDS scores reflected a 66.67% improvement in function. Conclusions: This evidence-based MBCT self-education program, through a quality improvement implementation, decreased incidence of relapse in depressive symptoms by maintaining stable mood, maintaining functional ability, and maintaining or improving quality of life of the participants. Implications for Nursing: Combining MBCT techniques with self-education offers evidence-based practice education, autonomy, and self-efficacy for those who struggle with recurrent depression and lack of access to quality mental health care.

Traumatic amputations are common traumatic injuries that require digital replantation to restore the form, function, and sensation of the hand. The post-surgical survival of replanted digits is influenced by multiple factors, including psychological factors such as posttraumatic stress disorder (PTSD), anxiety, and depression. Mindfulness-based cognitive therapy (MBCT) is considered a potential intervention to address such emotional distress. Traditionally, MBCT involves an 8-week face-to-face group format. Due to feasibility concerns regarding implementation and patient adherence, this study proposes a modified 4-week online version, referred to as brief online MBCT (eMBCT). This study is a two-arm randomized controlled clinical trial. The control group will receive standard postoperative nursing care, while the intervention group will receive the eMBCT for 4weeks. The primary outcome measure is PTSD symptom severity, assessed using the Stanford Acute Stress Reaction Questionnaire (SASRQ). Secondary outcomes include the Connor-Davidson Resilience Scale (CD-RISC), the General Self-Efficacy Scale (GSES), the EuroQol Five-Dimensional Health Scale (EQ-5D), and postoperative recovery status. This study aims to investigate the effects of a brief eMBCT program on PTSD symptoms, psychological resilience, self-efficacy, and clinical outcomes-specifically the incidence of vascular crisis and hand function recovery-in patients undergoing digital replantation. ChiCTR2500101285 [Chinese Clinical Trial Registry; registered on 23 April 2025].

Objective: To assess the level of depersonalization among critical care nurses prior to the implementation of the MBCT, to evaluate the effect of mindfulness-based cognitive therapy as a psychological intervention to manage depersonalization among critical care nurses. Study Design: A quasi-experimental studyPlace and Duration of Study: This study was conducted at the Critical Care Units of Al-Hussein Medical City and Imam Al-Hassan Al-Mujtaba Teaching Hospital, in Karbala, Iraq from 7th June 2024 to 13th November 2024. Methods: This study was conducted involving 88 critical care nurses. Both male and female nurses with at least one year of experience in critical care units who voluntarily agreed to participate. Owing to the specialized nature of critical care units, participants in the study group were assigned to sessions comprising 2 to 5 individuals each. Participants were randomly assigned to either an intervention (n=43) or a control group (n=45). The intervention group participated in an eight-week mindfulness-based cognitive therapy program, while the control group continued with their routine work schedule. Both groups completed the depersonalization subscale of the Maslach Burnout Inventory prior to and following the intervention. Results: Both groups had high depersonalization at baseline (p=0.196). Post-intervention, the experimental group declined from 10.6 to 4.86 (54.1% reduction; p&lt;0.001, d=1.38), while the control group remained unchanged significantly from 11.7 to 10.9; p=0.432, d=0.02). Between-group differences were significant (p&lt;0.001, d=1.57). Improvements were greatest among male nurses, those with insufficient income, and those employed in both government and private hospitals. Conclusion: Mindfulness-based cognitive therapy is an effective intervention for reducing high levels of depersonalization among critical care nurses, suggesting its potential as a valuable psychological support strategy in high-stress healthcare environments.

Efficacy and mechanisms of internet-delivered mindfulness-based cognitive therapy for Adjustment Disorder: A randomized controlled trial.

Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on Depression and Anxiety in Older Adults: A Systematic Review and Meta-Analysis.

Autonomic indices of negative emotion regulation predict treatment response in opioid-treated chronic low back pain.