Min Of Near-infrared Irradiation Research Articles

Rational approach to design gold nanoparticles for photothermal therapy: the effect of gold salt on physicochemical, optical and biological properties

Among the unique characteristics associated to gold nanoparticles (AuNPs) in biomedicine, their ability to convert light energy into heat opens ventures for improved cancer therapeutic options, such as photothermal therapy (PTT). PTT relies on the local hyperthermia of tumor cells upon irradiation with light beams, and the association of AuNPs with radiation within the near infrared (NIR) range constitutes an advantageous strategy to potentially improve PTT efficacy. Herein, it was explored the effect of the gold salt on the AuNPs’ physicochemical and optical properties. Mostly spherical-like negatively charged AuNPs with variable sizes and absorbance spectra were obtained. In addition, photothermal features were assessed using in vitro phantom models. The best formulation showed the ability to increase their temperature in aqueous solution up to 19 °C when irradiated with a NIR laser for 20 min. Moreover, scanning transmission electron microscopy confirmed the rearrangement of the gold atoms in a face-centered cubic structure, which further allowed to calculate the photothermal conversion efficiency upon combination of theoretical and experimental data. AuNPs also showed local retention after being locally administered in in vivo models. These last results obtained by computerized tomography allow to consider these AuNPs as promising elements for a PTT system. Moreover, AuNPs showed high potential for PTT by resulting in in vitro cancer cells’ viability reductions superior to 70 % once combine with 5 min of NIR irradiation.

Multifunctional magnetic composite nanomaterial for Colorimetric-SERS Dual-Mode detection and photothermal sterilization of Vibrio parahaemolyticus

In this study, a colorimetric and SERS dual-mode detection and photothermal sterilization method targeting Vibrio parahaemolyticus (V. parahaemolyticus) was proposed by preparing a multifunctional composite magnetic material (Fe3O4@MOF(Fe-Cu)-GNS-MBA-Apt) and integrating it with magnetophoretic chromatography technology. The composite magnetic material modified with aptamer demonstrated specific capture of V. parahaemolyticus in food matrices through magnetic separation. The dual-mode quantitative detection of V. parahaemolyticus was achieved by combining magnetophoretic chromatography for the separation of free materials and bacteria-material complexes and the peroxidase-like activity and SERS effect of the composite material. Under optimized conditions, the dual-mode sensor exhibited detection limits of 9 cfu·mL−1 (101 ––105 cfu·mL−1) in the colorimetric modality and 7 cfu·mL−1 (101 ––105 cfu·mL−1) in the SERS modality. Furthermore, the photothermal properties of the material allowed for the sterilization of bacteria in the detection solution within 4 min of near-infrared irradiation. Moreover, the developed method, based on the multifunctional materials, characterized by its rapid, sensitive, and efficient, was successfully applied to fresh shrimp samples, thus validating its potential for rapid pathogen diagnosis and contributing to the establishment of a safety control system of food and environmental detection process.

NIR-Triggered SrSnO3 -photosynthesized nanocatalyst: A potent anticancer agent against triple negative breast cancer cells

The major systemic therapeutic option for Triple Negative Breast Cancer (TNBC) is chemotherapy. TNBC often responds well to chemo, however, chemotherapy carries toxic adverse effects and content-limited interventional efficiency. Thereby, a drug-free treatment paradigm is imperative, in which synthetic polymers spontaneously display efficient anticancer efficacy without the use of conventional chemotherapeutic agents. Aiming at the goal to treat TNBC, SrSnO3 nanoparticles were devised as a nanocatalyst to accomplish near infrared (NIR) photocatalytic production of oxidative holes for achieving hole therapy. An inexpensive sol-gel method was employed in this study to synthesize SrSnO3 nanoparticle using strontium chloride hexahydrate and stannous chloride dihydrate. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) analyses were used to characterize the synthesized SrSnO3 nanoparticles while Density Functional Theory (DFT) was used to study the nanoparticle at atomistic level and the band gap was calculated to be 1.84 eV using Perdew−Burke−Ernzerhof (PBE) functionals. The anticancer effect of SrSnO3 nanoparticle was tested against TNBC cell line MDA-MB-231 at different concentration (10–50 μg/mL) with near infrared (NIR) irradiation while cells without any treatment or treatment with only SrSnO3 or NIR served as controls. Under NIR irradiation, the IC50 value was found to be 40 μg/mL achieving 50% cell death with augmented release of reactive oxygen species (ROS) over time. Reduced and oxidized glutathione (GSH and GSSG, respectively) serve as cellular redox buffers and protect cells from ROS mediated damage. Nearly 18.6% reduced glutathione (GSH) was found to be consumed with 5 min of NIR irradiation that was augmented to 66.5% of GSH when exposure time was increased to 10 min suggesting a prooxidant mediated death of cancer cell line. The results suggested SrSnO3 nanoparticle is a potent photocatalyst when triggered by NIR and can enable highly effective and biosafe hole-mediated treatment for TNBC.

A Multilayered Mesoporous Gold Nanoarchitecture for Ultraeffective Near-Infrared Light-Controlled Chemo/Photothermal Therapy for Cancer Guided by SERS Imaging.

Surface-enhanced Raman scattering (SERS) imaging has emerged as a promising tool for guided cancer diagnosis and synergistic therapies, such as combined chemotherapy and photothermal therapy (chemo-PTT). Yet, existing therapeutic agents often suffer from low SERS sensitivity, insufficient photothermal conversion, or/and limited drug loading capacity. Herein,a multifunctional theragnostic nanoplatform consisting of mesoporous silica-coated gold nanostar with a cyclic Arg-Gly-Asp (RGD)-coated gold nanocluster shell (named RGD-pAS@AuNC) is reported that exhibits multiple "hot spots" for pronouncedly enhanced SERS signals and improved near-infrared (NIR)-induced photothermal conversion efficiency (85.5%), with a large capacity for high doxorubicin (DOX) loading efficiency (34.1%, named RGD/DOX-pAS@AuNC) and effective NIR-triggered DOX release. This nanoplatform shows excellent performance in xenograft tumor model of HeLa cell targeting, negligible cytotoxicity, and good stability both in vitro and in vivo. By SERS imaging, the optimal temporal distribution of injected RGD/DOX-pAS@AuNCs at the tumor site is identified for NIR-triggered local chemo-PTT toward the tumor, achieving ultraeffective therapy in tumor cells and tumor-bearing mouse model with 5min of NIR irradiation (0.5Wcm-2 ). This work offers a promising approach to employing SERS imaging for effective noninvasive tumor treatment by on-site triggered chemo-PTT.

Ag functionalized SnS2 with enhanced photothermal activity for safe and efficient wound disinfection.

Severe bacterial infections have brought an urgent threat to our daily life, and photothermal therapy (PTT) has acted as an effective method to kill bacteria. Herein we decorated Ag on the surface of SnS2 (Ag@SnS2), which has outstanding photothermal conversion capability and good biocompatibility. The decoration of Ag on SnS2 improved the absorption of near-infrared (NIR) light in comparison to SnS2, resulting in a temperature increase of 50 °C after 5 min of NIR light irradiation (1.9 W cm-2) and a photothermal conversion efficiency of 31.3%. Ag@SnS2 exhibits almost 100% growth inhibition of E. coli and S. aureus bacteria due to hyperthermia, with a concentration larger than 0.5 mg mL-1 and 5 min of NIR irradiation. Meanwhile, SEM images of treated bacterial cells showed the attachment of Ag@SnS2 on the cell surface and obvious cellular membrane destruction. Ag@SnS2 can also accelerate in vivo wound healing through PTT-induced bacterial disinfection. Therefore, Ag@SnS2 exhibits great potential for photothermal antibacterial application and wound disinfection.

Remote and efficient infrared induced self-healable stretchable substrate for wearable electronics

Flexible and wearable electronics as candidates for the next-generation electric devices have attracted wide attention and been actively investigated recently. A remote, fast and efficient self-healable stretchable polyurethane nanocomposite for the substrate of flexible wearable electronics is reported in this paper. Carbon nanotubes (CNTs) were embedded in a self-healing polyurethane based on disulfide bonds. The tensile strength at break of the composites was improved significantly from 1.01 MPa to 3.64 MPa when the content of CNTs was 5 wt%. The elongation at break decreased as the addition of CNTs, but still remained at the high level above 300%, indicating the composites had enough flexibility for stretchable wearable electronics. The damages of the composites could be healed by near-infrared (NIR) irradiation remotely and quickly due to the photothermal effect of CNTs. The healing efficiencies were over 80% after 1 min of NIR irradiation. The nanocomposites exhibited volume resistivity values in the range of 1.31 × 105 to 1.65 × 105 Ω cm as a result of the incorporation of CNTs which could meet the requirements for electrostatic charge dissipation (ESD) materials requiring conductivities in the range of 105 to 109 Ω cm. The conductivity of the broken electric circuit fabricated by silver paste drop-cast on the composite strip was completely recovered after 1 min of NIR irradiation. These results demonstrate that the nanocomposites in this work can be used as substrates of electrical devices, especially for flexible wearable electronics. The electrical devices can be healed by remote NIR irradiation quickly and precisely.

Near-infrared triggered antibacterial nanocomposite membrane containing upconversion nanoparticles

Many conventional bactericidal materials exhibit antibacterial activities by releasing biocides, which potentially trigger antibiotic resistance and cause environmental concerns. In the present work, we reported the development of antibacterial nanocomposite membrane containing upconversion nanoparticles (UCNPs) by electrospinning. The nanocomposite membrane itself was not bactericidal but exhibits strongly antimicrobial performance on demand as activated by near-infrared (NIR) light. Upon just 5 min of NIR irradiation, the UCNPs in the nanocomposite membrane could trigger the release of reactive oxygen species (ROS) from photosensitizers, which could kill both Gram-positive Staphylococcus aureus (94.5%) and Gram-negative Escherichia coli (93.2%) rapidly. Moreover, the bactericidal activity could be effectively maintained for at least four cycles. In addition, the nanocomposite membrane showed no adverse effects on the mammalian cells, as verified by a cytotoxicity assay. This work provided a new strategy in designing novel antibacterial materials that might be potentially applied in infection-resistant and wound healing.

Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 s. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

Gold Nanoparticles-Decorated Silicon Nanowires as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Cells Destruction

Near-infrared (NIR) hyperthermia agents are of current interest because they hold great promise as highly efficacious tools for cancer photothermal therapy. Although various agents have been reported, a practical NIR hyperthermia agent is yet unavailable. Here, we present the first demonstration that silicon nanomaterials-based NIR hyperthermia agent, that is, gold nanoparticles-decorated silicon nanowires (AuNPs@SiNWs), is capable of high-efficiency destruction of cancer cells. AuNPs@SiNWs are found to possess strong optical absorbance in the NIR spectral window, producing sufficient heat under NIR irradiation. AuNPs@SiNWs are explored as novel NIR hyperthermia agents for photothermal ablation of tumor cells. In particular, three different cancer cells treated with AuNPs@SiNWs were completely destructed within 3 min of NIR irradiation, demonstrating the exciting potential of AuNPs@SiNWs for NIR hyperthermia agents.