INTRODUCTION: The epidemiology of functional gastroduodenal disorders (FGDs) has been recently studied in the Rome IV Global Study. The prevalence of functional dyspepsia varied significantly across countries, such as 10.1% in the USA vs. 6.6% in Mexico (Sperber et al. 2020). The global study did not sufficiently explore the prevalence among specific sub-populations within those countries, such as those residing on the US-Mexico border, a population composed primarily of Hispanics with high rates of acculturation. The aim of this study was to characterize the prevalence of FGDs in this unique population. METHODS: This cross-sectional study recruited subjects from various community centers throughout El Paso, Texas—a city on the US-Mexico border, from 2019 to 2020. Validated paper-based English or Spanish versions of the Rome IV Questionnaire were used according to subjects' preference. Those with a history of peptic ulcer disease, gastrointestinal cancer, celiac disease, or inflammatory bowel disease were excluded. Subjects’ perception of their health status was rated as: poor, fair, good, very good, and excellent. Collected data is presented as prevalence (95% confidence interval (CI)) and compared using Chi-square test/Fisher's exact test. RESULTS: A total of 216 adult subjects (54.6% female; 66.2% Hispanic) completed the questionnaire. After excluding the patients with history of organic gastrointestinal disorders, 197 subjects were included in the study. The overall prevalence of FGDs was 6% (95% CI: 3%–10%) and they were more prevalent in females than in males (7.4% vs. 4.5%, P < 0.05). The most common FGDs were functional dyspepsia and rumination syndrome, both observed in 2.5% (0.8%–6%); followed by belching disorders in 2% (0.6%–5%). Chronic nausea and vomiting syndrome and cyclic vomiting syndrome were detected in 1.5% (0.3%–4%) and 1% (0.1%–4%), respectively. More subjects with FGDs rated their health status as poor/fair compared to those without FGDs (50% vs. 12.4%, P < 0.001). CONCLUSION: In this study on the US-Mexico border, we found that FGDs were relatively common. The prevalence of functional dyspepsia was lower than the worldwide prevalence, including that of the US and Mexico. The prevalence of belching disorders and vomiting disorders were statistically similar to the worldwide prevalence. In our population, the prevalence of rumination syndrome was similar to functional dyspepsia.
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