Phillyrea latifolia L. is widely used as astringent, diuretic and hypoglycaemic in Mediterranean traditional medicine. This work focused on the biological properties (antioxidant and enzyme inhibitory) of P. latifolia L. leaves extracts, obtained by different solvents (ethyl acetate, methanol and aqueous). The amount of phenolics and flavonoids in P. latifolia L. extracts was also assessed by spectrophotometric methods. The methanol extract showed the highest total flavonoid content (68.07 mg RE g-1). The ethyl acetate extract exhibited stronger DPPH radical scavenging activity (190.71 mg TE g-1). The best CUPRAC activity was shown by the methanol extract (609.38 mg TE g-1). The aqueous extract (14.83 mg EDTA g-1) displayed the highest activity in metal chelating assay. Results showed that ethyl acetate extract indicated the highest activity in enzyme inhibition tests. Considering the obtained data, P. latifolia L. has potential to be used as sources of natural antioxidant and enzyme inhibitor.