Molecular signature of early obesity-associated insulin resistance: Adipocyte-derived extracellular vesicle proteins reveal stage-specific candidates for metabolic dysfunction.

Treatment approaches for alcohol use disorder with metabolic dysfunction.

Association between self-reported behavioral habits and their respective behavioral risk factors in individuals with metabolic syndrome.

Breast cancer risk varies across metabolic obesity phenotypes, but its associations with premenopausal status and carcinoma in situ remain unclear. The objective of this study was to investigate breast cancer risk across metabolic obesity phenotypes before and after menopause. For this retrospective cohort study, the authors used data from the Korean National Health Insurance Service, including 2,156,798 women who underwent health screening in 2009 (883,250 premenopausal and 1,273,548 postmenopausal). Metabolic obesity phenotypes were classified by the presence or absence of obesity and metabolic syndrome: metabolically healthy obesity, metabolically unhealthy normal weight, and metabolically unhealthy obesity, with metabolically healthy normal weight as the reference category. Breast cancer risk was estimated by using multivariable-adjusted Cox proportional hazards models. Over a mean follow-up period of 11.94 years, 17,052 premenopausal and 18,870 postmenopausal women developed breast cancer. Before menopause, no significant associations were identified except for a reduced risk of carcinoma in situ among women with metabolically healthy obesity (adjusted hazard ratio, 0.80; 95% confidence interval [CI], 0.74-0.87) and metabolically unhealthy obesity (adjusted hazard ratio, 0.84; 95% CI, 0.74-0.95). After menopause, metabolically healthy obesity, metabolically unhealthy normal weight, and metabolically unhealthy obesity were associated with increased breast cancer risk (adjusted hazard ratio: 1.20 [95% CI, 1.15-1.25], 1.11 [95% CI, 1.06-1.15], and 1.40 [95% CI, 1.35-1.45], respectively). After menopause, obesity was associated with elevated breast cancer risk, which was further increased by metabolic syndrome. In contrast, no elevated risk was observed before menopause. The current findings highlight differences in breast cancer risk by menopausal status across metabolic obesity phenotypes, emphasizing the need for targeted prevention strategies and further research into underlying mechanisms.

Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction.

Effect of the PPARG rs1801282 polymorphism on weight reduction and metabolic syndrome outcomes in obese individuals undergoing a partial meal replacement hypocaloric diet.

Dietary and exercise interventions improve cognition and alter hippocampal transcriptomics in a mouse model of the metabolic syndrome.

The hidden impact of intrauterine growth restriction in the pathogenesis of metabolic syndrome: Functional and structural alterations in rat visceral adipose tissue.

Energy expenditure and physical activity responses to football for health training in adults with metabolic syndrome: a randomized clinical trial

Characterizing the link between stunting and metabolic syndrome in developing nations.

The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions.

Indole-3-propionic acid function through PXR and AhR, molecular signaling pathways, and antitoxic role in underlying diseases.

Network pharmacology-guided systems biology reveals β-Sitosterol's multi-target role in reversing 7-ketocholesterol-induced oxidative and inflammatory stress.

Metals exposure, biological aging and metabolic syndrome: exploring the associations and mediation effects.

The work presents the educational contributions to the prevention of metabolic syndrome in the Education program. Biology. Actions are examined that, from the degree training, can be implemented from the different disciplines that are studied in the degree, for this a review of the scientific literature that is related to the topic and that has been published in the last five years was carried out. years. The review made it possible to recommend different educational content activities aimed at prevention and that, in light of the social role of the professional in training, for whom the proposal is directed, focuses on the impact that future Biology teachers should exercise in their teaching work. in Basic Secondary School. The frank exchange with students on the basis of experiential contributions, which emanate, to a large extent, from their interpersonal relationships is present in an important part of the interventions proposed. Although undergraduate educational activity offers ample potential to induce various coping actions based on the referential knowledge of the traits that manifest in metabolic syndrome, it is no less true that a motivation inducing the active search for knowledge, on the part of students, for the purposes of inducing and strengthening appropriate attitudes of self-care of health with a preventive nature and that at the same time radiates towards their contexts of family and professional action.

Type D personality and metabolic syndrome severity jointly predict 2-year MACE after acute coronary syndrome: A prospective cohort study.

Time-restricted feeding in adult mice improves mood-related behaviors in a sex-dependent manner.

Piper longum ameliorates obesity by regulating gut microbiota and promoting adipose thermogenesis.

Altered PCSK9 plasma levels after preeclampsia in the PERLA-Brazil study.

Enhancing cardiac serine biosynthesis mitigates the progression of dilated cardiomyopathy in mice.