Meta-analytic Study Research Articles

Global incidence of non-alcoholic fatty liver disease: A systematic review and meta-analysis of 63 studies and 1,201,807 persons

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. We aimed to estimate the pooled global NAFLD incidence. We performed a systematic review and meta-analysis of cohort studies of adults without NAFLD at baseline to evaluate the global incidence of ultrasound-diagnosed NAFLD. A total of 63 eligible studies (1,201,807 persons) were analyzed. Studies were from Mainland China/Hong Kong (n= 26), South Korea (n= 22), Japan (n= 14), other (n= 2, Sri Lanka, Israel); 63.8% were clinical center studies; median study year 2000 to 2016; 87% were good quality. Among the 1,201,807 persons at risk, 242,568 persons developed NAFLD, with an incidence rate of 4,612.8 (95% CI 3,931.5-5,294.2) per 100,000 person-years and no statistically significant differences by study sample size (p=0.90) or study setting (p=0.055). Males had higher incidence vs. females (5,943.8 vs. 3,671.7, p=0.0013). Both the obese (vs. non-obese) and the overweight/obese groups (vs. normal weight) were about threefold more likely to develop NAFLD (8,669.6 vs. 2,963.9 and 8,416.6 vs. 3,358.2, respectively) (both p <0.0001). Smokers had higher incidence than non-smokers (8,043.2 vs. 4,689.7, p=0.046). By meta-regression, adjusting for study year, study setting, and study location, study period of 2010 or after and study setting were associated with increased incidence (p=0.010 and p=0.055, respectively). By country, China had a higher NAFLD incidence compared to non-China regions (p=0.012) and Japan a lower incidence compared to non-Japan regions (p=0.005). NAFLD incidence is increasing with a current estimate of 4,613 new cases per 100,000 person-years. Males and overweight/obese individuals had significantly higher incidence rates compared to females and those of normal weight. Public health interventions for prevention of NAFLD are needed with a special emphasis on males, overweight/obese individuals, and higher risk regions. Non-alcoholic fatty liver disease (NAFLD) affects approximately 30% of people worldwide and appears to be increasing, but data to estimate the incidence rate are limited. In this meta-analytic study of over 1.2 million people, we estimated an incidence rate of NAFLD of 46.13 per 1,000 person-years with significant differences by sex, BMI, geography, and time-period. As treatment options for NAFLD remain limited, prevention of NAFLD should remain the focus of public health strategies. Studies such as these can help policy makers in determining which and whether their interventions are impactful.

Abstract 2202: Role of FadA secreting Fusobacterium nucleatum in initiation and progression of colorectal cancer

Abstract Colorectal cancer (CRC) is a global disease with poor prognosis. There is an alarming increase in incidence of CRC in younger patients along with well recognized racial disparities. Recent data implicate a role of microbiome in initiation and progression of CRC. Fusobacterium nucleatum (Fn), an oral opportunistic pathogen, has emerged as one of the common pathogens associated with CRC. Fn transformation from commensal to pathogen requires expression of amyloid-like FadA adhesin that plays a key role in its attachment to the colonic mucosal cells resulting in inflammatory, oncogenic, and metastatic changes. CRC initiates as polyps that go on to invade the mucosal layers and metastasize. This study analyzed the significance of Fn as a biomarker in CRC as well as to understand the etiology and metastasis of CRC. Deidentified and delinked formalin fixed paraffin embedded tissue sections from cancerous, precancerous and non-cancerous colorectal biopsies were analyzed for Fn presence and markers in epithelial to mesenchymal transition (EMT) in CRC through immunofluorescence. EMT was studied through biomarkers such as E-cadherin, which is an epithelial cell surface protein, vimentin as an intracellular filament protein normally expressed in mesenchymal cells, and N-cadherin, a cell adhesion molecule that is shown to express aberrantly in some solid tumor cells undergoing EMT. As expected, E-cadherin was abundantly expressed on the surface of epithelial cells while vimentin was found in the stromal cells in the non-cancerous tissue sections. Interestingly, the E-cadherin expression was lower in the cancerous tissue and some cancerous specimens also exhibited the vimentin positive foci within epithelial cells signifying partial EMT. N-cadherin expression was not observed in any of the specimens. The presence of Fn as analyzed through the FadA staining correlated with decline in the E-cadherin expression in some cancer specimens. To further analyze the significance of Fn, a meta-analytic study was conducted from 20 studies that indicated a significant presence of Fn not only in CRC tissues but also in fecal specimens from patients with CRC. A whole genome sequencing analysis corroborated with the abundance of Fn in CRC tissue specimens. These data suggest that analysis for Fn presence offers an attractive opportunity for intervention and targeted treatment for chemo resistant tumors. EMT analysis provides an additional corroboration in early detection of cancer progression which is pivotal in successful treatment of CRC. Citation Format: Angela Huang, Anjana Saxena, Mintoo Patel. Role of FadA secreting Fusobacterium nucleatum in initiation and progression of colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2202.

Is There a Relationship Between Vitamin D Level and Iron Deficiency Anemia in Children?

Iron deficiency anemia (IDA) is the most common type of anemia in children and a major cause of morbidity and mortality. VitaminD deficiency (VDD) is a growing public health issue that has been connected to several chronic diseases, such as osteoporosis,cancer, and metabolic syndrome. Recently, in a meta-analytic study conducted on both children and adults, it was clearly shownthat there is a relationship between VDD and the risk of anemia. In this study, we wanted to review the prevalence of vitamin Dinsufficiency in children with IDA. We conducted a retrospective review of patient records from January 2017 to December 2019 toidentify individuals aged 4 months to 18 years who had been diagnosed with IDA. Demographic data, dietary patterns, nutritionalsupplements, Vitamin D levels, and laboratory tests were recorded. Two hundred thirty girls and 198 boys were enrolled in thestudy, bringing the total number of patients to 428. The patients had a mean age of 7.24±5.1 months. The distribution of femalegender according to vitamin D groups (normal, insufficient, deficient) was 85, 103, and 42, respectively; the male gender is 78,89, and 31, respectively (p=0.745). No statistically significant difference was found between nutrition categories and vitamin Dgroups in different age groups (p=0.293; p=0.238; p=0.396). No statistically significant difference was found between continuousquantitative variables such as age, hemoglobin, and ferritin and vitamin D groups in different age groups (p=0.885; p=0.168;p=0.728). There was no significant association observed between the severity of anemia and VDD in children with IDA in our study.In the diagnosis of IDA, it may be useful to look at vitamin D levels by considering the time of admission. Further studies are neededfor the association between vitamin D levels and IDA.

Planned Home Birth as a Safe Alternative to Hospital Birth for Low-Risk Women: A Systematic Review

Home birth is a widely practised norm among women in most developing countries. Studies continue to evaluate the safety of planned home birth (PHB) for low-risk women in high-income countries. However, such studies are scarce in Africa and other developing countries. The study examined PHB as a safe alternative to planned hospital birth for low-risk women. An electronic search was carried out on databases such as Medline database, Cochrane, Google Scholar, PubMed, and CINAHL to identify studies published in English from January 2007 to December 2017. A Meta-analytic study, systematic reviews, and observational (prospective and retrospective) studies were included in the literature reviews. The studies were analyzed using descriptive and narrative synthesis. The strength and or limitations of each study were assessed. Sixteen eligible articles were finally reviewed. PHB is equally safe in terms of complication (especially postpartum haemorrhage) compared to planned hospital birth. PHB would have a similar outcome in reducing maternal death for low-risk women if compared with planned hospital birth. Although neonatal asphyxia is mixed across studies, PHB is associated with a similarly low rate of neonatal intensive care unit admission. It was also indicated that there was no increase in neonatal mortality for PHB, especially for parous women. PHB compared to the hospital is associated with a similar low risk of maternal complications, maternal deaths, newborn complications, and newborn deaths, especially for parous women. Therefore, PHB is a safe alternative to hospital birth for low-risk women. While studies that are more recent are required to evaluate its feasibility and safety in developing countries, PHB (if properly attended) may reduce maternal and newborn complications and death associated with unplanned home births.

Level 4 Triple-P Positive Parenting Program and the Interaction of Parent-child With Special Needs: A Meta-analytic Study in Iran

Background: Since positive parenting program (Triple-P) is one of the ways to improve parent-child interaction, conducting a meta-analysis will help determine its effect size. This study aimed to use meta-analysis to examine the effect of level 4 Triple-P on parent-child interaction with special needs in Iran. Methods: The current study is a meta-analysis review study. Before analyzing the effect size of the mean differences, the PRISMA (preferred reporting items for systematic reviews and meta-analyses) method was used to investigate the decision tree model. Then, the effect size of Triple-P was investigated using the meta-analysis method. Twelve studies (out of the 37) were collected with the keywords “Triple-P” and “parent-child interaction” from Google Scholar, IranDoc, IranMedex, Magiran, and SID according to the inclusion and exclusion criteria. They were conducted in Iran during 2012-2021 and were analyzed through meta-analysis. The inclusion criteria of the articles included written in Persian, having a control group, being interventional, and using original data. The exclusion criteria included duplicate articles and non-compliance with the title with Triple-P level 4. The study instrument was a meta-analysis checklist. Funnel plot, fail-safe number, and Cochran Q test were used to assess the publication bias, expected confidence, and effect size heterogeneity, respectively. The obtained data were analyzed by comprehensive meta-analysis (CMA) software. Results: Findings showed that the effect size of the mean difference rate of level 4 Triple-P on parent-child interaction was 0.59 (P&lt;0.0001), which is medium according to the Cohen table. Fisher’s z indicated a low standard error and no publication bias. The value of the Q test is significant, and the effect sizes are heterogeneous (P&lt;0.0001). Conclusion: Given the moderate impact of level 4 Triple-P, this method of parenting program can play an important role in improving the interaction of parent-child with special needs.

Network capabilities and firm performance: a meta-analytical study

PurposeThis study aims to perform a meta-analysis about network capabilities (NCs) and how they influence firm performance. Previous studies present distinct results regarding this relationship due to samples, cultural and contextual differences.Design/methodology/approachThe authors conducted a meta-analysis of 33 papers published between 2008 and 2019.FindingsThe results contribute to theory and practice by (1) synthesizing previous research, testing the relationship between NCs and firm performance; (2) confirming the influence of entrepreneurial orientation on NCs; (3) showing how contextual variables affect the relationship between NCs and firm performance; (4) suggesting that NCs moderate the relationship between entrepreneurial orientation and firm performance.Practical implicationsFurthermore, the authors also offer managerial implications. Firms should consider investing in developing NCs to foster performance. Moreover, the contextual variables we investigated show that firms in specific contexts may experience a higher relevance of their NCs for firm performance.Originality/valueThis meta-analysis contributes to the management literature by offering a set of empirical generalizations, including relationship direct, mediation and moderation effects about network capabilities.

Triple-A supply chain and firm performance relationship: a meta-analysis

ABSTRACT The triple-A supply chain (SC) is characterised as agile, adaptable, and aligned that help firms achieve competitive advantage in the business environment, but few studies have examined their impact on firm performance. This meta-analysis provides a generalised overview of this relationship, based on the extant empirical evidence. Via a systematic literature review, 63 peer-reviewed quantitative empirical studies were carefully identified with 63 usable effect sizes. This meta-analytic study confirms that triple-A SC is positively associated with firm performance, including in the areas of aggregate, business, and operational performance. The findings reveal that each dimension of triple-A SC (agility, adaptability, and alignment) contributes to overall firm performance. Moreover, performance measurement, industry type, and economic region moderate the relationship between triple-A SC and firm performance. Significant implications can be drawn for business managers or practitioners by displaying how to build a triple SC to improve firm performance.

Desconexión Moral y Delincuencia en Población Penitenciaria Adulta: una Revisión Metaanalítica

Research on moral disengagement associated with adult criminal profiles is recent a recent issue and, therefore, has been less evaluated. This meta-analytic study aims to determine the strength of the relationship between moral disengagement and crime in the adult prison population. The results showed a moderate relationship between moral disengagement and crime, with an effect size of r = .26 (p .001). The analysis of moderating variables (i.e., type of offence, gender, age, and instrument measuring moral disengagement) do not show statistically significant results in this association. Finally, it is concluded that moral disengagement is a risk factor for criminal behaviour commission, and future lines of research are proposed.

Análise de indícios de aspectos característicos e constitutivos do trabalho colaborativo de um grupo de professores que ensinam matemática

O presente artigo tem por objetivo identificar e analisar indícios de aspectos característicos e constitutivos do trabalho colaborativo de um grupo de professores que ensinam matemática. O grupo elegido constituiu-se a partir de um projeto desenvolvido no âmbito do Programa Observatório da Educação (Obeduc) e desenvolveu atividades no período de junho de 2013 a junho de 2017. Para atingir o objetivo proposto, realizamos um estudo meta-analítico focalizando em pesquisas que investigaram o grupo em questão. Assim, foram consideradas duas teses de doutorado e três dissertações de mestrado. As categorias de análise elencadas foram: indícios de voluntariedade, identidade e espontaneidade; indícios de liderança compartilhada e corresponsabilidade; e indícios de apoio, respeito mútuo e reciprocidade de aprendizagem. Concluímos que, considerando a perspectiva longitudinal do grupo, foi possível evidenciar a mobilização de diferentes aprendizagens, ancoradas no apoio e respeito mútuo entre os membros.

Relationship between the Use of Video Terminals and Dry Eye Symptoms during the COVID-19 Pandemic: Assessments Based on a Meta-Analytical Approach

Purpose: The objective of this meta-analytical study is to consider the impact of the use of VDTs on the onset and/or worsening of the signs and symptoms of dry eye during the COVID-19 pandemic, but also to offer the best solutions to perform the various tasks in daily life in order to safeguard vision, with the aim of promoting a lifestyle that allows you to work and perform different activities more safely and efficiently. Patients should be encouraged to follow proper planning of visits. Methods: Scientific articles chosen by the following inclusion criteria were analyzed: 1) Type of study (Primary); 2) Population (patients suffering from dry eye); 3) Study period (all studies carried out in the period between January 2020 and January 2022); 4) Result variables (correlation between increased use of VDTs during the pandemic and worsening of the symptoms of dry eye syndrome; correlation between autoimmune mechanism from Covid- 19 and etiology of dry eye); 5) Language (English). Results: The results of the various cross-sectional studies, obtained thanks to the administration of an online and anonymous questionnaire, have found a correlation between excessive use of VDTs and the onset of complications related to dry eye syndrome. The results suggest that in university students there is a higher incidence of problems related to dry eyes following the many hours spent in front of a screen to follow the lessons that were proposed to them remotely during the lockdown following the COVID-19 pandemic. Dry eye is the most commonly diagnosed pathology among eye disorders during the lockdown, as people spent much more time locked in the house, even 20-24h in the first months of lockdown in 2020. Conclusions: In conclusion, the analysis of the data shows a correlation between prolonged use of VDTs (exacerbated during the COVID-19 era) and the onset or worsening of dry eye syndrome.

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease.

Although people with human leukocyte antigens (HLA) DQ2 and/or DQ8 are more likely to develop celiac disease (CD), the condition cannot be fully explained by this genetic predisposition alone. Multiple, as yet unidentified, factors contribute to the genesis of CD, including genetics, the environment, and the immune system. In order to provide insight into a prospective possibility and an expanded screening technique, we aim to undertake a comprehensive and meta-analytical study of the assessment and distribution of HLA class II (HLA-DQ2/DQ8) in adult CD patients. A systematic review was conducted using an electronic search of databases (PubMed, Google Scholar, Embase, and Direct Science) from January 2004 to February 2022. DQ2/DQ2 homozygotes have the highest risk of developing CD. DQ2/DQ8 typing is an effective test to exclude CD from the differential diagnosis of a patient with CD symptoms. Although other non-HLA genes have been associated with CD, they are rarely considered at diagnosis because they account for only a small proportion of the heritability of CD. This finding, together with the information gathered previously, may be useful in considering widely available and economically feasible screening options for celiac disease in young people.

Attitudinal and motivational effects of out-of-school learning activities on students: A meta-analysis

This meta-analytic review study examined the effects of out-of-school learning (OSL) activities on student attitude and motivation by combining the results of experimental studies conducted between 1990 and 2020. Out of the 1272 studies identified through the literature search, the study selected 46 studies that yielded 47 effect sizes. The effect sizes were combined under a random-effects model to obtain a mean effect for each meta-analysis. The results suggested that OSL practices exert a moderate effect on student attitude (g = 0.525, 95% CI [0.353, 0.704]) and motivation (g = 0.675, 95% CI [0.389, 0.961]), through considerable heterogeneity. Further analysis showed that geographical locations and intervention group size in studies on attitude and geographical locations, OSL structure, and publication year in studies on motivation significantly contributed to effect size variability. Some limitations include publication bias in the metaanalysis on attitude and the few studies on motivation included in the analysis.

A Meta-Analysis on Adjustment Difficulties in Siblings of Children with and without Autism Spectrum Disorder

This meta-analytic study aimed to examine how the presence of Autism Spectrum Disorder (ASD) in a child affects their sibling(s)’s social, emotional, and behavioral adjustment. Many studies have investigated how the presence of ASD in a child affects their sibling(s) in social, emotional, and behavioral adjustment, but their results are mixed. Moreover, the previous reviews did not address the personal characteristics that account for the differences in siblings’ adjustment. This review focused on examining the three primary domains of adjustment and the moderating factors of their adjustment by applying a new meta-analytic approach of structural equation modeling (SEM) to provide a reliable statistical synthesis of effect sizes observed in existing individual studies. A total of 120 effect sizes – standardized differences between siblings of children with ASD and siblings of typically developing (TD) children—were calculated from 24 studies. The results revealed that siblings of children with ASD experienced more adjustment difficulties than siblings of TD children in all three domains. Furthermore, this study found that adjustment difficulties were more likely to be alleviated when siblings were older, female, and/or older than their sibling(s) with ASD. The findings provide important implications for support systems that can help siblings of children with ASD learn practical coping skills, develop a strong bond with family, and share their experiences with others in the community. Future research is needed to clarify other potential covariates that affect adjustment in siblings of children with ASD.

TMS for peripartum depression: a meta-analytical study to explore a functional DLPFC target

TMS for peripartum depression: a meta-analytical study to explore a functional DLPFC target

Logotherapy is effective in increasing self-esteem, but caution is needed: A meta-analytic study

Individuals with positive self-esteem recognize their personal qualities. They feel comfortable, optimistic, and confident about themselves. Conversely, individuals with negative self-esteem tend to experience poor quality of life. This study examines the effectiveness of logotherapy in increasing self-esteem. We conducted a meta-analysis by collecting and reviewing 14 research articles on logotherapy and self-esteem. We analyzed the data from the selected articles based on the number of participants (N), the average value (M), and the standard deviation (SD). The meta-analysis showed that logotherapy is a recommended and effective intervention to increase self-esteem. Keywords: logotherapy, meta-analysis, self-esteem

A meta-analytical study on the role of religiosity on purchase intention in the theory of planned behavior

PurposeReligion plays a crucial role as a sociocultural factor to assess consumer behavior. Stemming from the above, this study aims to analyze the impact of religion and ethnic concern on the purchase intention (PI) of consumers based on the theory of planned behavior.Design/methodology/approachThe research method adopted for this study includes a meta-analysis of the extant literature for the past 20 years focusing on the relationship between religiosity and PI. Data of 24 values from 23 studies were used to assess the impact of religiosity on the PI of consumers.FindingsThe findings of this study indicate that religiosity has a strong impact on the PI of consumers. Further, this study identifies that location, sample size and product category play a vital role as moderators toward the relationship between religiosity and PI. This study identifies critical and pertinent implications for brands as they reach out to religious and cultural groups across various geographies, in the context of identifying target markets and adapting marketing strategies.Originality/valueThis study acts in response to the consistent call for research to focus on religion-related variables and fills the gap calling for empirical research into religiosity and its impact on PIs. This study makes notable theoretical, managerial and methodological contributions to the field.

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18–72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18–73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen’s d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.

Do informant-reported subjective cognitive complaints predict progression to mild cognitive impairment and dementia better than self-reported complaints in old adults? A meta-analytical study.

Subjective cognitive complaints (SCCs) are considered a risk factor for objective cognitive decline and conversion to dementia. The aim of this study was to determine whether self-reported or informant-reported SCCs best predict progression to mild cognitive impairment (MCI) and/or dementia. We reviewed prospective longitudinal studies of Cognitively Unimpaired (CU) older adults with self-reported and informant-reported SCCs at baseline, assessed by questions or questionnaires that considered the transition to MCI and/or dementia. A random-effects meta-analysis was performed to obtain pooled estimates and 95% CIs. Both self-reported and informant-reported SCCs are associated with an elevated risk of transition from CU to MCI and/or dementia. The association appears stronger and more robust for informant-reported data [1.38, with a 95% CI of 1.16 -1.64, p<0.001] than for self-reported data [1.27 (95% CI 1.06 - 1.534, p=0.011]. Our results suggest that corroborated information from one informant could provide important details for distinguishing between normal aging and clinical states.

A meta-analytic validation study of the Shirom-Melamed burnout measure: Examining variable relationships from a job demands-resources perspective.

Job-related burnout has become a central construct in occupational health psychology. Given the considerable emphasis on burnout in both basic research and organizational initiatives, affirming the validity of inferences from commonly used measures is imperative to explore this phenomenon. The Shirom-Melamed burnout measure (SMBM) is well grounded with strong theoretical roots stemming from conservation of resources theory to assess exhaustion across physical, cognitive, and emotional subscales. However, despite its strong theoretical foundation and consistent use to measure burnout across various disciplines, there have been no meta-analytic validation efforts of the SMBM. The goal of the present meta-analysis is to fill this gap and provide a comprehensive evaluation of the SMBM using 564 effect sizes retrieved from 100 samples (N = 53,484). Results revealed that the three subscales of physical fatigue, cognitive weariness, and emotional exhaustion all displayed strong intercorrelations and that the SMBM was stable over time, as suggested by high test-retest estimates. Relationships with demographic controls, such as age, sex, and hours worked, were low in magnitude or nonsignificant. Following a job demands-resources perspective, we examined the nomological network of the SMBM, finding strong support for associations with job and personal predictors, motivational covariates, and job and personal outcomes. These findings, inferring the construct validity of the SMBM, hold implications for future research and practice, including support for its use in organizational research and applied settings. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Rhetoric, Policy, and Medicine: An Analysis of the Effects of COVID-19 on Florida Policymaking

As with most institutions in the United States, healthcare is subject to its own unique set of issues, the largest of which pertain to the quality of and access to medical care. These issues were initially spawned at the federal level and currently still exist on a national scale; however, due to the political structure of the U.S., statewide governments have a large hand in the control and dispersal of medical care. With the onset of the COVID-19 pandemic, greater emphasis has been placed on the installment of public health measures like Coronavirus testing, mask-wearing, and vaccination, as a response to the shortcomings of clinical care; a result of this public health emphasis is a heightened need for governmental regulation of healthcare at a statewide level. This meta-analytical study aims to assess the role of political rhetoric in regulating healthcare amid COVID-19, specifically within the state of Florida. Applying a rhetorical lens to the politico-medical intersection has yielded four overarching means of general healthcare regulation: legislation, executive order, speech, and action. These four political extensions of rhetoric have each played a role in managing the health and livelihood of Florida residents throughout the COVID-19 public health crisis, and the assessment of these extensions has immediate implications with regard to understanding the issues of the U.S. healthcare system in other states, and on a federal level. Beyond this, analyzing the role of rhetoric in the politico-medical relationship may also help improve and understand the conditions of both institutions in many contexts.