To conduct an overview of systematic reviews of RCTs assessing the effects of perinatal/neonatal interventions in reducing IVH among preterm infants. PUBMED, EMBASE, Cochrane database for systematic reviews, and systematic review repositories were searched for meta-analyses of RCTs involving preterm infants or women at high risk of preterm birth and reporting on IVH. Metaumbrella package of R software was used to pool outcome data for each intervention. Quality of the systematic reviews were assessed using AMSTAR 2 tool. Certainty of evidence (COE) was reported using GRADE recommendations. A total of 148 systematic reviews (110 Cochrane vs 38 non-Cochrane) were included. Postnatal interventions were reported in 118 reviews. Severe IVH was reported in 100/148 reviews that included 39483 infants and 20400 antenatal women. 78% (n=116) of the reviews were rated high or moderate quality on AMSTAR -2 assessment. Antenatal corticosteroids and magnesium sulphate for imminent preterm birth, volume targeted ventilation, early rescue surfactant administration through thin catheter, prophylactic indomethacin significantly reduced the rates of severe IVH (moderate COE). Use of respiratory function monitors and heated humidified respiratory gases in the delivery room and early prophylactic erythropoietin supplementation for preterm infants may reduce the rates of severe IVH (Very Low COE). Antenatal steroids and magnesium sulphate administration and early neonatal lung protective strategies reduce the rates of IVH in preterm neonates. Adequately powered RCTs evaluating IVH care bundles with long-term follow up are required.

Epidemiology and genomic features of MERS coronavirus in Africa: a systematic and meta-analysis review.

Maternal and paternal smoking during pregnancy and the risk of ADHD in offspring: An umbrella review of systematic reviews and meta-analyses.

Facial expression recognition in older adults with depression: a meta-analytic review.

Unravelling the obesity paradox in cancer: An umbrella review of protective associations and evidence credibility across 13 malignancies.

Unpacking sleep and mental health disparities across childhood and adolescence: A meta-analytic and systematic review.

This systematic review and meta-analysis aimed to evaluate the efficacy of narrow compared to wide surgical excision margins in the treatment of cutaneous malignant melanomas (MM) with Breslow thickness greater than 2 mm. All prior meta-analyses included studies analyzing patients with a variety of Breslow indexes. There is no prior meta-analysis analyzing the survival of the subgroup of MM patients with MMs > 2 mm in Breslow thickness. Hence, the aim of the present meta-analysis and systematic review was to examine the survival of the subgroup of MM patients with MMs > 2mm in Breslow thickness. We followed the Cochrane Handbook for Systematic Reviews of Interventions and reported our findings in accordance with PRISMA guidelines. We included randomized controlled trials (RCTs) that compared narrow (1-2 cm) versus wide (3-4 cm) surgical excision margins for cutaneous melanomas thicker than 2 mm. Studies on non-cutaneous melanomas, observational studies, and non-randomized trials were excluded. Ten-year mortality rate and overall survival were the primary outcomes. Our searches were conducted in EMBASE and PUBMED databases. Three RCTs were included, with a total of 2,304 randomized patients. This meta-analysis showed no significant difference in 10-year all-cause mortality between narrow (2 cm) and wide (4 cm) margins (risk difference: 3.3%, 95% CI: -1.7% to 8.2%, p=0.202). Similarly, there was no significant difference in overall survival between narrow (1-2 cm) and wide (3-4 cm) margins (hazard ratio: 1.09, 95% CI: 0.974-1.214, p=0.3). Heterogeneity was low and non-significant. This meta-analysis supports the non-inferiority of narrow (1-2 cm) surgical margins compared to wide (3-4 cm) margins for localized cutaneous melanomas with Breslow thickness greater than 2 mm. These findings suggest that narrow margins could be considered in surgical practice, although a 1 cm margin may be inadequate based on the results of individual studies. Further RCTs focusing on patients with localized MM thicker than 2 mm and taking into account modern adjuvant therapies and sentinel lymph node biopsies are recommended to refine surgical guidelines.

Active conservative interventions for obstructive sleep apnea: An umbrella review and meta-meta-analysis of systematic reviews.

Psychological capital for hospitality management: A multi-level meta-analytic review

Intellectual achievement and cognitive functioning in children and adolescents with ADHD-affected siblings: A systematic literature review and meta-analysis.

Investigating the therapeutic impact of platelet-rich plasma on knee, hip, and traumatic osteoarthritis: a meta-analysis and systematic review.

Antifungal prophylaxis among critically ill COVID-19 patients: a meta-analysis and systematic review.

The effect of glucagon-like peptide 1 (GLP-1) receptor agonists on cognition: A systematic review of systematic reviews and meta-analyses.

Hepatocellular carcinoma (HCC) is a highly lethal form of cancer with a global mortality rate that is unparalleled among malignant tumours. The photothermal effect exhibited by nanoparticles offers a novel approach for the treatment of HCC. To perform a systematic review and meta-analysis on the therapeutic effects of nanoparticles on hepatocellular carcinoma (HCC) under the photothermal effect. We conducted a comprehensive literature search across four major databases (PubMed, Embase, Web of Science, and Scopus) and performed bibliometric analysis to demonstrate the remarkable therapeutic efficacy of photothermal effect-driven nanoparticles in hepatocellular carcinoma (HCC) treatment within the near-infrared (NIR) biological tissue optical window (wavelength range: 650-1350nm). The study selection, quality assessment, and data extraction were rigorously performed according to standardized protocols, with particular emphasis on key parameters including control group descriptions, sample sizes of control and experimental groups, tumor volume and weight, as well as therapeutic outcome measures. Sensitivity analysis and bias assessment were implemented, ultimately yielding research conclusions with high reliability. A total of 36 studies were included, all of which were assessed as high-quality studies. Based on the data of tumor volume and mass, Meta-analysis and sensitivity analysis revealed the significant therapeutic effect of photothermal effect-driven nanoparticles in the treatment of HCC, with a high degree of stability in general. In terms of tumor volume, 34 data sets were obtained from 31 studies, with a WMD of -0.95, a 95% confidence interval of (-1.10, -0.80), an I² value of 98.3%, and a p-value of less than 0.001, indicating that photothermal effect-driven nanoparticles have significant efficacy in reducing tumor volume. Regarding tumor mass, 25 studies provided 29 data sets, with a WMD of -0.90, a 95% confidence interval of (-1.03, -0.77), an I² value of 99.0%, and a p-value of less than 0.001. Sensitivity analysis revealed that excluding the data from Dun et al. (2022) significantly influenced the overall effect sizes for both tumor volume (WMD = -3.49) and tumor mass (WMD = -3.98). Funnel plot analysis indicated good symmetry for tumor volume data, suggesting no significant publication bias, whereas asymmetry was observed for tumor mass data, implying potential bias from small-sample studies. Photothermal effect-driven nanoparticles exhibit positive therapeutic effects in HCC, primarily manifested in the reduction of tumor volume and mass, offering new ideas and strategies for the treatment of advanced hepatocellular carcinoma.

BackgroundThe relationship between dairy consumption and breast cancer remains controversial, with studies reporting protective, neutral, and adverse associations.ObjectivesTo synthesize current evidence on the association between dairy consumption and breast cancer risk through a systematic review.MethodsWe conducted a systematic review of observational studies and meta-analyses published between 2015 and 2025 using PubMed, Scopus, and Cochrane Library. Data extraction followed PRISMA guidelines, focusing on study design, population, dairy type, intake levels, and outcomes.ResultsEleven eligible studies were included, involving over 2 million participants across diverse populations. Yogurt and low-fat dairy were generally associated with reduced breast cancer risk, while high-fat milk and processed cheese showed trends toward increased risk. Subgroup analyses revealed differences by estrogen receptor (ER) status and menopausal stage.ConclusionsThe impact of dairy on breast cancer risk varies by product type and patient characteristics. Further research is needed to delineate these relationships and inform dietary recommendations.

Objective This study systematically evaluates the effects of diverse exercise and combined interventions on patients with bipolar disorder (BD), identifies optimal intervention parameters through subgroup analyses, explores dose–response relationships, and delivers evidence-based support for exercise interventions in this population. Methods Randomized controlled trials (RCTs) examining exercise interventions for BD patients were retrieved from domestic and international databases. Literature screening and data extraction adhered to standard criteria. Study quality was assessed via the Cochrane Risk of Bias Tool 2.0. Meta-analyses were conducted in RevMan 5.4, while subgroup analyses (stratified by intervention type, duration, frequency, and age) and dose-response analyses were performed in Stata 15. The Benjamini-Hochberg method was used to apply false discovery rate (FDR) correction, controlling false positive risks in multiple comparisons (statistical significance was defined as corrected P < 0.05). Results Exercise interventions significantly improved depression, anxiety, and mania symptoms and health questionnaire outcomes in BD patients (all corrected P < 0.05). No significant improvements were observed in quality of life questionnaire scores or systolic blood pressure (all corrected P > 0.05). For diastolic blood pressure, the pooled effect lacked statistical significance (SMD = −0.113, 95% CI: −0.665–0.439, P = 0.688), with only one individual study showing significant improvement after correction (corrected P = 0.0224). Subgroup analyses revealed the following: Exercise combined with psychological or mindfulness training improved all three symptoms (depression, anxiety, mania; all corrected P < 0.05), whereas exercise alone improved only mania (corrected P < 0.05). Interventions lasting ≤ 12 and >12 weeks both improved depression, anxiety, and mania (all corrected P < 0.05). Exercise performed ≤ 2 sessions/week improved only anxiety (corrected P < 0.05), while >2 sessions/week improved only depression and mania (all corrected P < 0.05). Single sessions lasting ≤ 60 and >60 min both improved mania (all corrected P < 0.05), but only sessions >60 min improved anxiety (corrected P < 0.05). Patients aged ≤ 40 and >40 years both derived benefits (all corrected P < 0.05). Dose-response analyses indicated that anxiety and depression scores were lowest with two exercise sessions per week ( P < 0.01). Conclusion Exercise interventions significantly improve depression, anxiety, and mania symptoms as well as health questionnaire outcomes in BD patients, with exercise combined with psychotherapy or mindfulness training producing superior effects. Improvements in diastolic blood pressure warrant cautious interpretation, as they are supported by only one study. The recommended protocol consists of exercise combined with psychotherapy or mindfulness training, with a duration of ≥12 weeks, 2–3 sessions/week, and single-session length ≤ 90 min; this protocol exerts a positive impact on patients' emotional symptoms. Future RCTs with larger samples and longer follow-up periods are needed to further validate these findings. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD420251032877 , identifier: CRD420251032877.

Unpacking Leader Bottom-Line Mentality (BLM) in Organizations: A Meta-analytic Review of Its Drivers, Consequences, Mechanisms, and Boundary Conditions

Academic resilience has become a central construct in secondary education research because it speaks directly to a persistent educational dilemma: why some adolescents sustain achievement and positive school functioning despite adversity while others with comparable risk exposure do not. This review synthesizess empirical evidence on whether academic resilience predicts school success in secondary education and clarifies how definitional and measurement choices shape conclusions. Drawing on recent meta-analytic and systematic review evidence alongside large-scale international assessment research and school-based studies, the review shows that academic resilience is consistently associated with indicators of school success, but the strength and interpretability of this relationship vary markedly across operationalizations. In correlational syntheses, resilience-related protective factors exhibit statistically reliable but typically small links with achievement outcomes, suggesting predictive relevance but also indicating that resilience is not a standalone remedy for structural disadvantage. Evidence from large-scale assessments highlights the role of school climate, instructional quality, and cultural-contextual protective factors in differentiating resilient from non-resilient adolescents. At the same time, research warns that “resilience” is often defined partly by academic performance itself, complicating causal claims about prediction. The review proposes an integrative account that treats academic resilience as a dynamic capacity expressed through self-regulation, perceived competence, and supportive relationships, and it outlines implications for identification, measurement, and intervention in secondary schooling. A defensible conclusion is that academic resilience can be predictive of school success when assessed as a capacity independent of achievement and when examined in designs that account for prior performance and contextual conditions. For secondary schooling, the practical promise of the construct lies in combining student-focused supports with school-level conditions that make resilient adaptation possible.

Network Meta-Analysis and Umbrella Review: Complementary, Not Competing, Tools of Evidence Synthesis

This study analyzed recent advances in third-wave psychotherapies applied to mental disorders. An integrative review of systematic reviews and meta-analyses published between 2022 and 2025 in indexed scientific literature was conducted. The findings indicate that Acceptance and Commitment Therapy, Dialectical Behavior Therapy, Behavioral Activation, Functional Analytic Psychotherapy, and Integrative Behavioral Couple Therapy show differential evidence depending on disorder and therapeutic process. It is concluded that process-based and transdiagnostic approaches constitute a relevant contribution to clinical mental health practice.