Intensity Of Menstrual Pain Research Articles

Efektivitas Air Rebusan Jahe Merah terhadap Intensitas Nyeri Haid

The menstrual cycle lasts an average of 28 days. During menstruation some young women will feel menstrual pain, or in medical language called dysmenorrhea which is caused by uterine muscle spasms. The purpose of this study was to determine the effectiveness of red ginger boiled water on menstrual pain in female students at the Health Polytechnic of Palangka Raya. This research method uses Pre-experimental research with One Group Control Pretest-Posttest Design study. The population of this research is female students at Poltekkes Palangka Raya and the sample size is 73 respondents with the sampling technique used is purposive sampling. The statistical test used in this study was the Wilcoxon test. The results of the statistical test showed the value of Z = -7.047, which means that giving red ginger drink 7.047 times can help reduce the intensity of pain during menstruation. Statistical test results obtained a p value of 0.001 (p <0.05) meaning that there is an effect of red ginger boiled water on decreasing the intensity of menstrual pain. There is an effect of red ginger boiled water on decreasing the intensity of menstrual pain.

Efficacy of Physiotherapy Treatment in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.

Primary dysmenorrhea (PD) refers to painful cramps before and/or during menstruation. There is a need for emphasis on alternative methods of conservative treatment, so as to reduce the dependence on drugs for alleviating the symptoms. The aim was to find out the effectiveness of some physiotherapy techniques in the treatment of PD. A systematic review and meta-analysis was conducted according to PRISMA standards. The descriptors were “dysmenorrhea”, “physical the-rapy”, “physiotherapy”, and “manual therapy”. The search was performed in five databases: Scopus, PubMed, PEDro, Web of Science, and Medline, in February 2021. The inclusion criteria were randomized controlled trials over the last six years. Articles not related to the treatment of PD or using pharmacology as the main treatment were excluded. Nine articles met the objectives and criteria, with a total of 692 participants. The most used scale to measure pain was the VAS (visual analogue scale). The main techniques were isometric exercises, massage therapy, yoga, electrotherapy, connective tissue manipulation, stretching, kinesio tape, progressive relaxation exercises and aerobic dance. Meta-analysis shows benefits of physiotherapy treatment for pain relief compared with no intervention or placebo (MD: −1.13, 95% CI: −1.61 to −0.64, I2: 88%). The current low-quality evidence suggests that physiotherapy may provide a clinically significant reduction in menstrual pain intensity. Given the overall health benefits of physiotherapy and the low risk of side effects reported, women may consider using it, either alone or in conjunction with other therapeutic modalities.

Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk.

Menstrual pain has been associated with increased ovarian cancer risk, presumably through increased inflammation, which is known to play a critical role in ovarian carcinogenesis. Analgesic medications are frequently used to treat menstrual pain, some of which lower ovarian cancer risk. In this study, we examined the association between analgesic use for menstrual pain during the premenopausal period and ovarian cancer risk among women with history of menstrual pain. We used data from the New England Case-Control Study, including 1,187 epithelial ovarian cancer cases and 1,225 population-based controls enrolled between 1998 and 2008 with detailed information on analgesic use for their menstrual pain. We used unconditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between analgesic use (i.e., aspirin, ibuprofen, acetaminophen) for menstrual pain and ovarian cancer risk. We further conducted a stratified analysis by intensity of menstrual pain (mild/moderate, severe). Among women with menstrual pain during their 20s and 30s, ever use of analgesics for menstrual pain was not significantly associated with ovarian cancer risk. However, among women with severe menstrual pain, ever use of aspirin or acetaminophen for menstrual pain was inversely associated with risk (OR, 0.41; 95% CI, 0.18-0.94 and OR, 0.43; 95% CI, 0.21-0.88 compared with never users, respectively). No significant association was observed between analgesic use and ovarian cancer risk among women with mild/moderate menstrual pain (P interaction ≤ 0.03). Our results suggest that use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer. PREVENTION RELEVANCE: This study investigates whether analgesic use specifically for menstrual pain during the premenopausal period influences ovarian cancer risk. Our results suggest use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer among women with severe menstrual pain.

Systematic Literature Review: The Effectiveness of giving Cinnamon (Cinnamon) on Reducing the Intensity of Menstrual Pain (Dysmenorrhea)

Every woman experiences menstruation, which is the process of releasing blood, mucus, and cell debris from the dissertation of the uterine mucosa by removing the endometrium (desquamation) periodically and cyclically. It begins about 14 days after ovulation. Sometimes menstruation causes pain (primary dysmenorrhea) during menstruation. Primary dysmenorrhea can be reduced with natural ingredients, one of which is cinnamon, which has the main compounds cinnamaldehyde and eugenol as anti-inflammatory and antispasmodic. This study aimed to determine the effectiveness of cinnamon in reducing the intensity of menstrual pain (dysmenorrhea). The method used Systematic Literature Review or SLR to analyze articles from some databases The results showed that eight from ten studies were researched with the intervention group (cinnamon) and two journals were descriptive studies. Eight cinnamon intervention groups, three used pills, two used aromatherapy massage, one used cinnamon tea, one used cinnamon extract, and one did not explain the method. All journals show that cinnamon is effective for reducing the intensity of dysmenorrhea.

Upaya Integrasi Penanganan Nyeri Haid dengan Abdominal Stretching pada Remaja Puteri di Pesantren Baitul Ulum El-Musawwa, Serang, Banten

Menstrual pain or dysmenorrhea is a problem that is often faced by teenagers during menstruation. Dysmenorrhea occurs due to an imbalance of the hormone progesterone which causes uterine contractions and stimulate the pain response of each individual. Based on the underlying pathophysiology, there are two types of dysmenorrhea, namely primary dysmenorrhea and secondary dysmenorrhea, primary dysmenorrhea occurs in women of childbearing age in the form of pain in the lower abdomen so that it can disrupt their quality of life. Dysmenorrhea often interferes with teenagers' productivity and influences coping abilities. The purpose was to evaluate the abdominal stretching on the intensity of menstrual pain (dysmenorrhea) in teenagers. This public service is a test pre-test of pain menstrual by using Visual Analogue Scale, demonstration-re-demonstration abdominal stretching, and evaluate pain scale of dysmenorrhea. From 26 participants founding that the level of menstrual pain at middle is 69.23%, lower is 30.77%, there are no severe pain levels. After abdominal stretching reduce the pain become 100% at lower pain and there are no moderate and severe pain levels. The Abdominal stretching exercise is recommended to be another alternative for reducing dysmenorrhea in teenagers that is easy, economic, safe and without side effects

PENGARUH TERAPI AKUPRESUR TERHADAP INTENSITAS NYERI HHAID (DISMENORE) PADA MAHASISWA KEBIDANAN INSTITUT KESEHATAN MITRA BUNDA 2020

The period of menarche in Indonesia has reached 60-70% who experience dysmenorrhea and cause women to be unable to carry out activities and reduce women's quality of life. This study aims to describe the effect of acupressure therapy on the intensity of menstrual pain. This type of quantitative research is a quasi-experimental design with a one group pretest-posttest approach with sampling using a purposive sampling technique using 100 respondents from April 20 to June 21 2020. The data was obtained from a questionnaire and processed using the Wilcoxon test. The results showed the overall data of the variable dysmenorrhea pre test - post test in the intervention group Asymp value. The significance is 0.000 <0.05, while the control group has Asymp value. The significance is 1,000 > 0.05, so it can be concluded that the results of the analysis of changes in the pain scale pre-test - post-test in the intervention group showed a significant change between the pre-test and post-test pain scales. It can be seen from the measurement results of the Mean Rank pain scale before therapy is 0.00 and Mean Rank after therapy is 25.50 which means there is a decrease in the intensity of menstrual pain. Based on the results of the research above, adolescents need to add information and understanding through various mass media to equip themselves in dealing with complementary menstrual pain

Effectiveness and Safety of CGRP-mAbs in Menstrual-Related Migraine: A Real-World Experience.

IntroductionMigraine shows a significantly higher prevalence in women, especially during reproductive age when menstrual-related hormonal fluctuations represent the most common migraine trigger. Indeed, over 50% of patients report a higher occurrence of migraine attacks during the perimenstrual window. Menstrual migraine attacks are consistently referred to as more disabling, less responsive to symptomatic treatments, longer in duration, and more prone to relapse than non-menstrual migraine attacks. Evidence strongly suggests that estrogen fluctuations are involved in migraine attacks worsening during the perimenstrual window through several mechanisms directly or indirectly involving the CGRP pathway. We aimed to evaluate whether mAbs blocking CGRP-ligand or receptor (CGRP-mAbs) could represent an effective and safe preventive treatment for menstrual migraine attacks in patients with menstrual-related migraine (MRM) with previous treatment failures.MethodsForty patients with MRM with at least three previous treatment failures received monthly CGRP-mAbs. At the baseline and after six CGRP-mAbs administrations, patients underwent to extensive interviews to assess frequency, duration, intensity, and responsiveness to painkiller intake of migraine attacks occurring during the perimenstrual window.ResultsAfter six administrations of CGRP-mAbs we observed a reduction of median menstrual migraine frequency (from 5 to 2 days per month), pain intensity (from 8/10 to 6/10), and attacks duration (from 24 to 8 h) (p < 0.001). Nevertheless, a significant increase in the percentage of responding to migraine painkillers was observed from 42.5% at baseline to 95% at T1 (p < 0.001).ConclusionsCGRP-mAbs could represent a safe and effective preventive therapeutic strategy able to reduce the disabling burden of menstrual migraine attack frequency, duration, intensity, and significantly improve the response to painkillers. These findings could be related to and further indirectly prove the greater influence of CGRP-mediated mechanisms in the pathophysiology of menstrual migraine attacks.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40122-021-00273-w.

Comparison of Physical Activity, Quality of Life and Menstrual Symptoms by Menstrual Pain Intensity in Turkish Women with Primary Dysmenorrhea

Objective: The aim of this study was to compare physical activity, quality of life, and menstrual symptoms by pain intensity in Turkish women with primary dysmenorrhea.&#x0D; &#x0D; Method: Women with primary dysmenorrhea (n = 333) were divided into mild, moderate and severe-pain groups based on pain intensity. Physical and demographic characteristics of the participants were recorded. Pain intensity by Visual Analogue Scale, physical activity level by International Physical Activity Questionnaire-7 (IPAQ-7), quality of life by Short Form-36 (SF-36) were assessed. The presence of menstrual symptoms was recorded. &#x0D; &#x0D; Result: Physical functioning, bodily pain, vitality, role limitations due to emotional and physical problems scores of SF-36 in the severe-pain group were lower than in the mild-pain group (p &lt; 0.05). Physical functioning and bodily pain scores of SF-36 in the moderate-pain group were lower than in the mild-pain group (p &lt; 0.05). Role limitations due to emotional problems and bodily pain scores of SF-36 in the moderate-pain group were higher than in the severe-pain group (p &lt; 0.05). IPAQ-7 scores did not show difference among three groups (p &gt; 0.05). Severe-pain group had a greater number of menstrual symptoms than other groups (p &lt; 0.05). &#x0D; &#x0D; Conclusion: In this study, there was no difference between physical activity level and menstrual pain intensities in Turkish women with primary dysmenorrhea. In addition, the higher menstrual pain intensity was associated with lower quality of life and higher frequency of menstrual symptoms. Therefore, these parameters should be taken into account for assessment and treatment of primary dysmenorrhea.

Effect of Reflexology Therapy On Decreased Intensity of Menstrual Pain

Pharmacological treatment of menstrual pain relief and non-pharmacological treatment such as reflexology, reflexology massage can be done on the feet and hands so that these points provide a spontaneous relaxation stimulation when massaged so that pain is not felt. Purpose The purpose of this study was to determine the effect of giving reflexology therapy on reducing the intensity of menstrual pain in undergraduate nursing study program students at Panrita Husada College of Health Sciences, Bulukumba. Methods This study used a pre-experimental design with a one-group pretest-posttest design approach. The sample of this study was 41 respondents who were taken using the non-probability sampling method with the consecutive sampling technique. The experimental group received reflexology therapy once with a duration of 20 minutes. Analysis of the data in this study using the Wilcoxon test statistic. The results of the analysis used the Wilcoxon test statistical test with a level of confidence (α = 0.05). Based on the results of this test, the value of ρ = 0,000 was obtained, thus ρ &lt;α (0,000 &lt;0.05), so there was an effect of giving reflexology therapy on reducing the intensity of menstrual pain in undergraduate nursing study program students at Stikes Panrita Husada Bulukumba. The conclusion of this study is a Researchers suggest that the results of this study can provide information for people in the surrounding environment, families, and young women about how to deal with menstrual pain without consuming pharmacological drugs but in a non-pharmacological way, namely by using reflexology techniques.

Menstrual Pain and Elasticity of Uterine Cervix.

Menstrual pain is consequent to intense uterine contraction aimed to expel menstrual flow through downstream uterine cervix. Herein it was evaluated whether characteristics of uterine cervix are associated with intensity of menstrual pain. Ultrasound elastography was used to analyze cervix elasticity of 75 consecutive outpatient women. Elasticity was related to intensity of menstrual pain defined by a Visual Analogue Scale (VAS). Four regions of interest (ROI) were considered: internal uterine orifice (IUO), anterior (ACC) and posterior cervical (PCC) compartment and middle cervical canal (MCC). Tissue elasticity, evaluated by color score (from 0.5 = blue/violet (low elasticity) to 3.0 = red (high elasticity), and percent tissue deformation was analyzed. Elasticity of IUO was lower (p = 0.0001) than that of MCC or ACC, and it was negatively related (R2 = 0.428; p = 0.0001) to menstrual VAS (CR −2.17; 95%CI −3.80, −0.54; p = 0.01). Presence of adenomyosis (CR 3.24; 95% CI 1.94, 4.54; p = 0.0001) and cervix tenderness at clinical examination (CR 2.74; 95% CI 1.29, 4.20; p = 0.0004), were also independently related to menstrual VAS. At post hoc analysis, women with vs. without menstrual pain had lower IUO elasticity, expressed as color score (0.72 ± 0.40 vs. 0.92 ± 0.42; p = 0.059), lower percent tissue deformation at IUO (0.09 ± 0.05 vs. 0.13 ± 0.08; p = 0.025), a higher prevalence of cervical tenderness at bimanual examination (36.2% vs. 9.5%; p = 0.022) and a higher prevalence of adenomyosis (46.5% vs. 19.9%; p = 0.04). These preliminary data indicate that IUO elasticity is associated with the presence and the intensity of menstrual pain. Mechanisms determining IUO elasticity are useful to be explored.

Efektivitas Akupresur dan Minuman Jahe terhadap Pengurangan Intensitas Nyeri Haid/Dismenore Pada Remaja Putri

Half of the women in Indonesia experience menstrual pain / dysmenorrhoea, 54.89%, experience various disorders including abdominal pain, cramps and back pain. The purpose of this study was to determine the effectiveness of acupressure, ginger drink and the difference in giving acupressure and ginger drink to reducing the intensity of menstrual pain / dysmenorrhea in young women at SMK Swasta PAB 5 Klambir Lima 2020. The design of this study used a quasi-experimental pre and post test with a sample of 30 students who were divided into two groups. Each group was given acupressure and ginger drink in the morning and evening during menstruation from day one to day two. Respondents were assessed for pain before and after the intervention was given. The results of the Shapiro-Wilk normality test contained Sig data (p &lt;0.05). The Wilcoxon test has a p-value of 0.002 (p &lt;0.05), which means that acupressure is effective in reducing the intensity of menstrual pain / dysmenorrhea, there is a p-value of 0.001 (p &lt;0.05) which means that ginger is effective against reducing pain intensity. menstruation / dysmenorrhea, there is a p-value of 0.034 (p &lt;0.05), which means that there is a difference in the effectiveness of acupressure and ginger drink in reducing the intensity of menstrual pain / dysmenorrhea. There is an effectiveness of giving acupressure, ginger drink, and there is a difference in giving acupressure and ginger drink on the intensity of menstrual pain / dysmenorrhea on young women. It is hoped that the school will provide ginger drinks and acupressure measures to young women who experience menstrual pain / dysmenorrhea so that they can participate in learning activities at school.

Reducing Visual Descriptor Scale (VDS) in Dysminorrhea on Adolescence by Giving Wood Secang Boiled Water (Caesalpinia Sappan L) in Megarezky University

Dysmenorrhea is the pain experienced during menstruation that causes women to experience varying degrees of cramps. It presents as discomfort, while others suffer pain that can stop daily activities for some women. Therefore, to reduce the use of drugs, herbal methods are used, boiled water for the wood secang, so that side effects can minimize for the body. This research aims to analyze the reduction of Visual Descriptor Scale (VDS) of adolescence with dysmenorrhea in Makassar. This research lasted for one year with several stages, including the first stage; identify research samples based on criteria. The second stage, making informed consent and choice of respondents. The third stage, using a Quasi-Experimental design with a pretest and post-test approach in one treatment group, namely adolescents with dysmenorrhea, measured VDS before giving the boiled water for secang wood and after giving it. The fifth stage, assessing the decrease of VDS before and after treatment. This study indicated that the average intensity of the respondents' menstrual pain before giving the boiled water of secang wood was 4.5, where the lowest menstrual pain intensity was two. The highest was 8, while after giving secang wood boiled water was 3.0, where the pain intensity was the lowest menstrual period was 0, and the highest was 6. The Paired T-Test results obtained a p-value of 0.000 &lt;0.05 so that the boiled water of secang wood affects reducing pain intensity in young females.

PENGARUH PEMBERIAN MINUMAN KUNYIT ASAM TERHADAP INTENSITAS NYERI MENSTRUASI PADA REMAJA PUTRI

Menstruation is a natural and natural event, but in reality many women experience menstrual problems, including menstrual pain or dysmenorrhoea. Nonpharmacological menstrual pain management can be done by giving turmeric acid extract. This study aims to determine the effect of giving turmeric acid extract on the intensity of menstrual pain in adolescent girls in State High School 1 Serdang Bedagai Regency in 2020. The research method is quantitative. This type of research is a quasi-experimental design with one-group pretest-posttest design. The study population was 150 class X and XI students of State High School 1 Serdang Bedagai Regency as many as 150 people. The sample selection using purposive sampling as many as 36 people. The results of the study using Wilcoxon sign rank test showed p-value of 0,000 &lt;0.05. The conclusion is there are differences before and after giving turmeric acid drink to the intensity of menstrual pain (dysmenorrhea). It is expected that schools can provide information to students about the use of turmeric acid as a non-pharmacological treatment in reducing menstrual pain.

The Effect of Slow Stroke Back Massage on Primary Dysmenorrhea: Levels of Beta-Endorphin, Interleukin-6, Tumor Necrosis Factor-α, and Pain Intensity

Objectives: Dysmenorrhea is one of several gynecological issues that occur among women of reproductive age. In addition, it appears as pain that forms in the pelvis or lower abdomen and spreads to the back and thighs. The peripheral blood among women with dysmenorrhea increases the synthesis and the concentration of oxytocin, F2α prostaglandin hormone, vasopressin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα). In this regard, this study aimed to determine the effect of slow-stroke back massage (SSBM) on the levels of β-endorphins, IL-6, TNF-α, and menstrual pain intensity (MPI). Materials and Methods: Based on the aim of the study, the posttest only quasi-experimental method with the control group design approach, pretest-posttest control group approach, and purposive sampling techniques were applied for sample selection. The samples were divided into SSBM and control groups each containing 20 subjects. The numeric rating scale (NRS), β-endorphin, IL-6, and TNFα levels were measured using the indirect enzyme-linked immunosorbent assay. Then, data were analyzed by paired sample t test and independent-samples t test with α ≤ 0.05. Results: The results revealed that SSBM had an effect on the intensity of menstrual pain (P&lt;0.05), and differences were found between β-endorphin levels, IL-6, TNFα, and MPI among SSBM and control (P&lt;0.05) groups. Accordingly, SSBM can stimulate releasing β-endorphin levels and reducing pro-inflammatory cytokines (IL-6 and TNFα). Conclusions: In general, SSBM is a nonpharmacological action that is effective in primary dysmenorrhea.

Abnormal white matter microstructure along the thalamus fiber pathways in women with primary dysmenorrhea.

Primary dysmenorrhea (PDM) is a cyclic menstrual pain in the absence of pelvic anomalies, and women with PDM have an increased sensitivity to pain than the internal and external areas associated with menstrual pain. However, the brain abnormality in the ascending pain pathways in dysmenorrhea remains largely unclear. As the thalamus plays a significant role in transmission of nociceptive input, we examined whether white matter microstructure of the thalamus-related fiber tracts obtained by DTI in women with PDM (n= 47) differs from healthy controls. A novel tractography atlas-based analysis method that detects tract integrity and altered microstructural properties along selected fibers was employed. The fiber bundles of interest contained the thalamus- primary somatosensory cortex (SI), thalamus- dorsal anterior cingulate cortex (dACC)/supplementary motor area (SMA), thalamus-insula, and thalamus-ACC. As compared with controls, abnormal white matter microstructures were found along the thalamus-related white matter fiber tracts. Additionally, the intensity of menstrual pain was significantly associated with diffusion measures of thalamus-SI fiber connections. Our study suggested that the thalamus-related pain processing pathways had altered white matter integrity that persisted beyond the time of menstruation, and the white matter microstructure of the thalamus-SI pathways was closely related to menstrual pain in the intensity by women with PDM.

The Effect of Religious Music Therapy on the Intensity of Menstrual Pain in Teenage Girls in Daarul Muttaqien II Islamic Boarding School Tangerangngerang

Adolescence is a transition from childhood to adulthood which includes biological, psychological and social changes. During menstruation there will be problems or complaints such as dysmenorrhea. Meanwhile, menstrual pain (dysmenorrhea) is a physical disorder that is very prominent in women who are experiencing menstruation in the form of pain in the stomach. This study aims to determine the effect of religious music on the intensity of menstrual pain in class X adolescents at the Daarul Muttaqien II Modern Islamic boarding school, Tangerang. The research design used was a quasy-experiment with a pre and post-test design without control (self-control). Collecting data using the NRS observation sheet and pain measurement that has been tested for validity and reliability. The sample consisted of 35 respondents who were taken by consecutive sampling technique. This study showed that 68.6% of respondents had mild pain, while 31.4% of respondents had no pain. The results of the Wilcoxon statistical test showed that there were significant differences in the level of knowledge before and after religious music therapy with a value of p = 0.001 (p &lt;0.05). This research is expected to be developed in further research and can be used as a reference by increasing the number of samples and variables as a comparison.Keywords: Effect of Music Therapy, Menstrual Pain

The Role of Zinc in Selected Female Reproductive System Disorders.

Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

Management of Primary Dysmenorrhea among University Students in the South of Spain and Family Influence.

The present study analyses the management of primary dysmenorrhea by university students in the south of Spain. In this cross-sectional observational study, 224 women participated, using an ad hoc self-report questionnaire about menstrual pain and self-care and including sociodemographic and gynecological variables. Some 76.8% of participants consumed analgesics and the majority self-medicated with non-steroidal anti-inflammatory drugs (NSAIDs) without consulting a health professional, with a correlation between pain intensity and the number of pills ingested during menstruation (r = 0.151, p < 0.05). The higher proportion of women who found their analgesia effective were those who took medication after being prescribed by a health care provider (60.8%) compared to those who self-medicated (40%; p < 0.01). Only 43.8% employed non-pharmaceutical methods, most commonly antalgic positions, massages and local heat. These choices were not related to the intensity of menstrual pain nor with the severity of the dysmenorrhea, nor did these most common methods prove to be the most effective. However, a higher percentage of women using non-pharmacological methods was identified in women with family members suffering from dysmenorrhea (73.2%) compared to those without (60%; p = 0.040), which may indicate that the choice of remedies is more related to learning self-care in the family context. This study identifies the need for education on self-care and management of menstrual pain.

Prediction of pain intensity with uterine morphological features and brain microstructural and functional properties in women with primary dysmenorrhea

Primary dysmenorrhea (PDM), defined as painful menstrual cramps of uterine origin, could cause brain structural and functional changes after long-term menstrual pain. Here, we aimed to investigate the predictive value of uterine morphological features and microstructural/functional properties of the brain extracted from periovulatory phases for the intensity of menstrual pain as rated by women with PDM during their subsequent menstrual period. Forty-five women with PDM were recruited and classified into the high and mild pain intensity groups. Pelvic MRI was employed to extract the uterine texture features. White matter diffusion properties, grey matter and functional connectivity features were extracted as brain features. Multivariate logistic regression models with iteration optimization were built for classifying different pain intensity groups. Texture features from myometrium and uterine junction zone had outstanding prediction performance with an area under the receiver operating characteristic (AUC) of 0.96 (P < 0.05, permutation test), and diffusion properties along the thalamic fiber bundles were the most discriminative features with AUC of 0.95. Applying features from uterus and brain together, we could gain better prediction performance. Our results indicated that accumulated differences in menstrual pain were associated not only with uterine structure but also diffusion properties of thalamic-related fiber tracts, suggesting that treatment options of PDM patients may be expanded from only being able to manage pain in the uterus focusing on the functional/structural modifications of the pain processing system.

Investigation the effect of oral Aloe Vera gel pills supplementation on the intensity of primary menstrual pain (Dysmenorrhea)

Introduction. This study was conducted to evaluate the effects of oral aloe vera gel pills supplementation on the intensity of menstrual pain. A randomized, single-blind clinical experimental plan was conducted amongst 150 single students aged 20 to 26 years who suffered from menstrual pain, at the Islamic Azad University of Medical Sciences from December 24, 2015 to October 22, 2016. The extent of pain was evaluated using the Cox Menstrual Symptom Scale (CMSC). Material and method. Each participant was randomly assigned to aloe vera gel pill or the anti-PG drug Ibuprofen, ending with 60 participants in each group equally. The first trial group received 10 mg of aloe vera gel orally four times daily until the pain grade reached one or less. The control group received Ibuprofen and three tablets orally three times a day. The participants were permitted to take another drug that they usually took for their pain relief, in addition to the allocated treatment in case of continued pain. At the end of the trial, these participants were excluded in data analysis. Results and discussions. Changes in the grade and the duration of the pain of participants were compared at the first and second months in both groups. Sample size was computed using alpha = 5 and absolute error equal to 0.24 for correlation between medication and pain with acceptable absolute precision formula (AAPF). Result of this study showed that the mean age was 22.1 +/- 1.4and 20.4 +/- 1.2 years in aloe vera gel pills and Ibuprofen groups, respectively. No significant difference was observed for the matched characteristics studied between the treated groups. the mean pain grade amongst aloe vera group was decreased from 2.81 +/- 0.65 to 2.02 +/- 0.34, while in Ibuprofen group from 2.48 +/- 0.4 to 1.32 +/- 0.15, respectively, using the described given dose. As result obtained that there was no statistically significant decrease in pain duration for the women who received Ibuprofen compared to those who used aloe vera. Also there was no significant difference in pain grade between the groups at the second month of intervention (p=0.61). Pain duration at the second month of trial was similar between the both groups (p=0.76). Conclusions. In conclusion we could suggest that aloe vera gel pill as a novel herbal pain killer represents an effective treatment for the menstrual pain with no important side effects, although further clinical trials are recommended to look at the possible side effects in an extended spectrum of subjects.