Onset Of Menarche Research Articles

Patterns of menstrual cycle, menstrual pain and medication usage in young women from high- and middle-income countries

Do patterns of the menstrual cycle, menstrual pain and the use of medication for menstrual pain differ between young women from high-income countries (HIC) and middle-income countries (MIC)? A multinational, multicentre, cross-sectional study using pen-and-paper questionnaires was conducted between 2016 and 2021 to assess patterns of the menstrual cycle, menstrual pain and the use of medication for menstrual pain. Various parameters were evaluated to identify high-risk factors for severe menstrual pain in women from two HIC (n = 1550) and nine MIC (n = 7139). From a total of 9114 young women, 4920 medical students (HIC n = 696, MIC n = 4224) and 3769 nursing students (HIC n = 854, MIC n = 2915) were included in this study. Compared with those from HIC, a significantly higher proportion of medical and nursing students from MIC reported cyclic pain (83.9% and 86.8%, respectively) and acyclic pain (33.8% and 31.9%, respectively) (both P < 0.001). Multivariate regression analysis revealed that low body mass index and early onset of menarche were independent risk factors for severe cyclic/acyclic pain among women from HIC, and a family history of menstrual pain was a risk factor for severe cyclic/acyclic pain among women from HIC and MIC. Differential patterns of the menstrual cycle, menstrual pain and use of medication for menstrual pain were found between young women from HIC and MIC. A proper educational programme may be necessary for these women and healthcare providers to understand the consequences of intractable cyclic/acyclic pain, in order to facilitate early detection and timely management of menstrual pain and its negative consequences, such as endometriosis.

Prediction of body mass index and skeletal maturity for early menarche risk at menarche onset: a cross-sectional study of Chinese girls

BackgroundThis study aimed to assess the predictive value of body mass index (BMI) and skeletal maturity for the occurrence of early menarche in Chinese girls.MethodsA cross-sectional analysis was conducted on...

Juvenile granulosa cell tumor of the ovary: A rare cause of precocious puberty in a toddler

Ovarian tumors are a rare cause of sexual precocity in female children. Functional neoplasms of the ovary are relatively infrequent, and only 5% occur before puberty. Although ovarian juvenile granulosa cell tumor (GCT) is a rare tumor described infrequently in pediatrics, the most common presentation of this tumor is precocious puberty. We report a 1⅟2 year-old girl with isosexual precocious puberty, who presented with a rapid onset of premature menarche, pubic hair, and vaginal bleeding, with an abdominal mass on clinical examination. Ultrasonography of the pelvis and abdomen showed a heterogeneously hypoechoic solid mass with cystic areas and internal vascularity. The child underwent a left oophorectomy. Microscopic features of the resected mass were characteristic of juvenile GCTs. Even though the most common cause of precocious puberty in girls is idiopathic, functional ovarian tumors must be considered, especially when the onset is at an early age and puberty is rapidly progressive. Early-stage disease has a good prognosis, and adjuvant chemotherapy is not indicated.

Prevalence and Factors of Early Onset of Menarche among Adolescent Girls Studying in Selected Schools at Bagalkot-A Descriptive Study

Prevalence and Factors of Early Onset of Menarche among Adolescent Girls Studying in Selected Schools at Bagalkot-A Descriptive Study

Early puberty: a review on its role as a risk factor for metabolic and mental disorders.

Accumulating evidence indicates that there is a trend of early puberty onset in humans. The early timing of puberty has raised concerns due to its association with significant negative health outcomes. However, overall impact and potential risk of early puberty remain uncertain. In this study, we conducted a comprehensive review of existing epidemiological studies to gain insights into the long-term adverse health effects associated with early puberty. Our objective was to provide a consolidated summary of these outcomes at a population level by considering studies that encompass various indicators of puberty. In all, early puberty has been identified as a potential risk factor for various metabolic diseases, such as obesity, diabetes, cardiovascular diseases (CVD). Children who experience early puberty are more likely to have a higher body mass index (BMI) during adulthood, increasing their risk of obesity. Early puberty also has been found to be an independent risk factor for diabetes mellitus, including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM), as earlier onset of menarche in girls and voice breaking in boys is associated with a higher prevalence of T2DM. Furthermore, evidence suggests that early puberty may contribute to an elevated risk of CVD, including conditions like coronary heart disease (CHD), stroke, angina, and hypertension. In addition, adolescents who experience early puberty, particularly girls, are more likely to suffer from mental problems, such as behavioral dysfunction and depression. Notably, early puberty has a more significant impact on girls than boys. Further research should consider the underlying mechanisms and potential preventive measures.

Studying the Influence of the Relationship of the Menarche's Debut and the time of Starting Sports

The article presents data on the study of the timing of the first menarche in 143 athletes of puberty age - representatives of various sports (artistic gymnastics - 15 athletes, rhythmic gymnastics - 14, volleyball - 19, basketball - 17, cycling - 13, rowing and canoe - 12, freestyle wrestling - 15, taekwondo - 14, boxing - 13, athletics (middle distance running) - 11 people) in comparison with the general population age and sex group of 145 people. The relationship between the timing of the formation of the ovarian-menstrual cycle in female athletes and the time of starting sports was established. The dynamics of the formation of the ovarian-menstrual cycle has been determined. It was revealed that in each of the groups presented, the female athletes had an extended period for the debut of menarche and the onset of the establishment of the ovarian-menstrual cycle. The most influencing on violations of the debut of menarche and the formation of ovarian-menstrual cycle among athletes are such sports as artistic and rhythmic gymnastics, rowing and canoeing. The time of the beginning of sports activities and the time of the onset of menarche in the aggregate are an etiological factor that causes disturbances in the dynamics of the formation of the ovarian-menstrual cycle and a malfunction in the reproductive system of athletes in general and is the result of the body's adaptation to the physical and psychological stresses corresponding to these sports.

Assessment of Knowledge, Attitudes, and Practices Regarding Menstrual Hygiene Management Among Adolescent Schoolgirls (10-19 Years) in the Saurashtra Region, Gujarat.

Background Menstrual health management proves pivotal for the adoption of hygienic practices and the embracement of womanhood from the onset of menarche. Menstrual hygiene is pivotal yet under-addressed among adolescent girls in India. This study aimed to assess the knowledge, attitudes, and practices regarding menstrual hygiene and influencing factors. Methodology A cross-sectional study was conducted among 361 adolescent schoolgirls aged 10-19 years in the Saurashtra region of Gujarat using a pretested questionnaire. Multistage sampling was used. In the first stage, six schools (three rural and three urban) were selected through random sampling. In the second stage, all adolescent girls aged 10-19 years in the selected schools who had attained menarche were invited to participate. Those who provided written assent were included in the study. The data were analyzed with descriptive statistics and logistic regression. A p-value <0.05 was considered significant. Results Knowledge about menstruation was evenly distributed as good (47.65%) and poor (52.35%). Most relied on mothers for information and considered menstruation a normal phenomenon. Attitudes reflected complex cultural perceptions. The use of sanitary pads was high (96.12%), although 39.89% used reused absorbents. Multivariate analysis revealed age 16-19 years (adjusted odds ratio (AOR) = 2.08, 95% confidence interval (CI) = 1.14-3.81), higher parental education, pit latrine usage (AOR = 6.7, 95% CI = 2.97-15.15), and knowledge about menstruation (AOR = 8.21, 95% CI = 4.56-14.78) as positive predictors of good menstrual practices. Conclusions Despite the widespread use of sanitary pads, the persisting knowledge gap and sociocultural influences lead to unhygienic practices. Improving awareness and attitudes through educational interventions among adolescent girls and mothers, in particular, addressing cultural taboos through the engagement of all stakeholders, and improving sanitation infrastructure in schools are imperative.

Age at menarche, type 2 diabetes and cardiovascular disease complications in US women aged under 65 years: NHANES 1999–2018

BackgroundDiabetes and diabetes complications are on the rise in US adults aged <65 years, while onset of menarche at a younger age is also increasing. We examined the associations of...

Determinants of menstrual hygiene among adolescent school girls in a rural area of Patna, Bihar, India: A cross-sectional study.

Adolescence is a transitional phase marked by the onset of menarche. Most adolescent girls have incomplete or inaccurate information about menstrual physiology and hygiene. There are several misconceptions and taboos linked with it, resulting in adverse health outcomes. However, numerous factors associated with menstrual hygiene are modifiable. If these are adequately identified and addressed, it can empower young girls to lead healthy life in a positive environment. (1) To assess the knowledge and practices regarding menstrual hygiene among adolescent school girls. (2) To determine the association of menstrual hygiene practices with sociodemographic and related factors. A descriptive cross-sectional study was conducted in rural Patna, Bihar, in which 300 eligible adolescent school-going menstruating girls (13-17 years) were recruited from four schools. They were interviewed using a predesigned questionnaire, and relevant information on sociodemographic profiles and menorrhoeal characteristics was obtained. Median scores were calculated for the knowledge and practices domain. Multiple logistic regression was used to determine the associated factors of menstrual hygiene practice. The mean age of girls was 14 ± 1.07 years, while the mean age of menarche was 12.37 ± 0.92 years. More than half (59.3%) were found to possess good knowledge (scores 7 and above) regarding menstruation and its physiology. Half (50.3%) of the girls had good menstrual hygiene practices (scores 9 and above). Multiple logistic regression model revealed that adolescent girls studying in government schools (AOR = 0.05, CI = 0.02-0.12) and those living in nuclear families (AOR = 0.05, CI = 0.02-0.12) were likely to be significantly associated with poor menstrual hygiene practices. Menstrual hygiene is still far from satisfactory; hence, it should be a vital aspect of the school health educational curriculum. There is an imperative need to design acceptable awareness/advocacy programs for adolescent girls in the future.

Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China

BackgroundEpidemiological studies have revealed multiple risk factors for metabolic syndrome. However, there are no consistent findings on the association between famine exposure, age at menarche, and the prevalence of metabolic syndrome. This cross-sectional study aimed to reveal the individual and combined effects of famine exposure and age at menarche on the prevalence of metabolic syndrome among elderly women.MethodsFour thousand seven hundred seventy participants between 60 and 93 years of age were selected from the China Health and Retirement Longitudinal Study. Statistical differences between the baseline characteristics of famine exposure, age at menarche, and metabolic syndrome were evaluated using the t-test, F-test, and Chi-square test. Three multivariable-adjusted logistic regression models were used to test the association between famine exposure, age of menarche, and the odds ratio of metabolic syndrome.ResultsTwo thousand one hundred ninety-eight (46.08%) participants had metabolic syndrome, while 2572 (53.92%) participants did not. Furthermore, 3068 (64.32%) women reported onset of menarche under 15 years of age, while 1702 (35.68%) women reported onset of menarche above 16 years of age. Regarding the separate association of famine exposure and age of menarche with metabolic syndrome, in model three, the adolescence/adulthood famine exposure group vs. no famine exposure group odds ratio was 2.45 (95% CI 2.02, 2.97), and the older than 16 years vs. younger than 15 years group odds ratio was 1.23 (95% CI 1.09, 1.39), which was the highest odds ratio among the three models. Regarding the combined association of famine exposure and age of menarche with metabolic syndrome, in model three, among the age of menarche ≤ 15 years group, the adolescence/adulthood famine exposure vs. no famine exposure group odds ratio was 2.45 (95% CI: 1.91, 3.14); among the menarche age ≥ 16 years group, the adolescence/adulthood famine exposure stages vs. exposed group odds ratio was 3.27 (95% CI: 2.44, 4.38), which was the highest odds ratio among the three models.ConclusionThese findings suggested that famine exposure and age at menarche, either separately or in combination, were positively associated with the prevalence of metabolic syndrome among older women.

Headache, Vertigo in a Teenage Dental Patient

A 13-year-old female patient presented to the dental office for routine dental checkup and correction of her proclined teeth through braces. Patient’s medical history suggested that the patient suffers from frequent episodes of headache, vertigo, dizziness and confusion. These episodes are random and have begun after the onset of menarche. Her physician diagnosed it as migraine and had prescribed medications which are helping with the headache but the episodes still happen at random. Routine lateral cephalometric x-ray done for orthodontic diagnosis, revealed a bony bridge on the posterosuperior articular process of atlas (C1 vertebra).

Assessment of menstrual health in adolescent and young adults with sickle cell disease.

Sickle cell disease (SCD) is associated with hypercoagulability, but adults with SCD also have an increased incidence of bleeding including heavy menstrual bleeding (HMB). HMB is common among adolescent females, but the impact of HMB in pediatric SCD is unclear. The objectives of this study were to examine menstrual health status, knowledge, and quality of life (QOL). We performed a single-institutional multi-clinic cross-sectional study comprised of a five-part survey in pediatric participants with SCD. The survey included the validated Menstrual Bleeding Questionnaire (MBQ) and Self-administered Bleeding Assessment Tool (Self-BAT). Forty-eight participants with a median age of 16years (range: 12-21years) completed the study. The mean age at onset of menarche was 13±1.3years. On the MBQ, 29% reported heavy/very heavy menstrual flow, 61% reported moderate or severe dysmenorrhea, and 96% had menses lasting less than 1week. The Self-BAT revealed that 42% of participants reported a history of HMB. Participants with severe dysmenorrhea or HMB had higher MBQ scores, corresponding to worse QOL. Despite this, less than 20% of participants had attempted any hormonal therapy for menstrual regulation. The odds of hormonal therapy utilization were comparable among participants on hydroxyurea versus not on hydroxyurea (odds ratio 1.58, 95% confidence interval [CI]: 0.33-7.56). The prevalence of HMB and dysmenorrhea is high among adolescents and young women with SCD. Strategies that incorporate menstrual health assessment into routine medical care in this population would help address this important area of pediatric health.

Knowledge Regarding Adolescent Health among Teenage Girls in a View to Develop Information Booklet

The WHO considered adolescents people between 10 to 19 years of age. Adolescence is one of the most speedy and formative phases of human life, and the characteristic physical, cognitive, social, emotional and sexual growth is part of the adolescence phase. It required more attention in national growth policies, programs and plans. It is important that adolescents should have adequate knowledge regarding their health. Considering this fact, the current study is being undertaken. The aim of the study is to assess knowledge about adolescent health among the teenage girls with view to develop information booklet. The research approach adopted for the current study was non- experimental descriptive approach. The study was conducted on teenage girls from selected schools of Pune city. Simple random sampling technique was used to select samples (n= 200). A structured questionnaire was used to collect the data from teenage girls which was validated by the experts and reliability was calculated. Formal permission was taken from IEC, BV(DU)CON, Pune to conduct the study and the same was obtained from selected schools under the study. The collected data was processed and analyzed using frequency and distribution method and association was calculated using Fisher test. Majority findings (80.5%) teenage girls were having good knowledge regarding adolescent health. Though majority (80.5%) teenage girls were having good knowledge regarding adolescent health ( reproductive and mental health). Few grey areas are still to highlighted and appropriated education need to be given, these areas were; first menstruation (44.5%), Estragon, androgen and progesterone (46.5%), female sex character (27.0%), sign of puberty (26.5%), late onset of menarche (29.0%), contraceptive pills (20.5%), suicidal thought (84.5%), cause by identify crisis and poor self-esteem (90.0%).

Reproductive health and reproductive behavior of adolescent girls in Tofalaria

BACKGROUND: The reproductive potential of adolescent girls includes several parameters, such as general and gynecological morbidity, physical and sexual development, psychosocial readiness for partnership and motherhood. Therefore, it is crucial to consider these parameters when assessing the reproductive capacity of adolescent girls in different settings.&#x0D; AIM: To study the reproductive health and reproductive behavior of girls residing in Tofalaria.&#x0D; MATERIAL AND METHODS: A total of 194 girls participated in the study, with 58 of them being Tofalars. These girls were aged between 11 and 17 years old and resided in the Nizhneudinsk district of the Irkutsk region. The study involved analyzing medical records, conducting examinations by an obstetrician-gynecologist, collecting clinical samples from the urogenital tract for microscopy to detect transmitted infections, and performing colposcopy.&#x0D; RESULTS: The average age of onset of menarche among the study participants was between 11.5 and 12.0 years. Tofalar girls were more likely to experience menstrual cycle disorders such as oligomenorrhea and abnormal uterine bleeding. Additionally, delayed puberty was more commonly observed among Tofalar girls. Reproductive behavior of the Tofalar girls was characterized by early engagement in relationships, promiscuity, high prevalence of sexually transmitted infections, and high proportion of unplanned pregnancies.&#x0D; CONCLUSION: There is a need to develop and implement a long-term strategy on preserving the reproductive health of adolescents and young people in the Irkutsk region through consolidating the efforts of civil society institutions and governmental agencies at both regional and municipal levels.

Relationship between age, menstrual cycle, and length of menstruation with anemia in adolescent girls in the Gresik district

Anemia in adolescents is defined as a low hemoglobin level (less than 12g/dl) in adolescent blood. The incidence of anemia in Indonesia is still quite high. In adolescents, anemia is more prevalent due to growth spurt, onset of menarche, poor nutrition, and poverty. Age has a significant relationship with the incidence of anemia in adolescents, especially in older girls. The menstrual cycle and length of menstruation play an important role in the amount of blood that flows out. This study aims to analyze the relationship between age, menstrual cycle, and length of menstruation with anemia in adolescent girls in the Gresik District. The type of research was quantitative analytic observational cross-sectional design. Respondents consisted of 661 adolescent girls aged 10-19 years old in elementary, junior high, and senior high school held UKS program in Gresik District. Hb data was obtained by POCT (Point of Care Test) and other data was obtained by questionnaires via google form. The result showed that 29% were diagnosed with anemia, and 71% were not. The category of adolescents was found 8.3% in early, 59.8% in middle, and 31.9% in late adolescents. Menstrual cycle was found 54.6% in the short cycle, 40.7% normal cycle, and 4.7% long cycle category. The length of menstruation was 1.1% in short category, 74.1% normal category, and 24.8% long category. The results of statistical using the chi-square test in analyzing the relationship between age with anemia obtained pvalue=0,065, menstrual cycle with anemia obtained pvalue=0,128, and length of menstruation with anemia obtained pvalue=0,330. There is no correlation between age, menstrual cycle, and length of menstruation with anemia in adolescent girls in Gresik District.

Assessment of pubertal onset and disorders of puberty in Indian children and youth with type-1 diabetes.

Disorders of pubertal development are enlisted as associated conditions in children and adolescents with type-1 diabetes (T1D). We conducted this study with objective (1) To estimate the median age at onset of puberty and luteinizing hormone (LH) and sex-steroid concentrations in Indian adolescents with T1D and (2) To assess the impact of puberty on glycemic control and insulin resistance (IR). This cross-sectional study included 399 children and youth aged 6-23 years with T1D. Demographic, anthropometric, biochemical and pelvic ultrasound data were collected using standard protocols. IR was calculated using estimated glucose disposal rate and puberty was assessed using Tanner staging. Median age at onset of thelarche, pubarche and menarche were 11.3, 11.4 and 12.8 years in girls and that of gonadarche and pubarche were 10.6 and 12.7 years for boys. The mean LH and sex-steroid concentrations of subjects with T1D were similar to healthy subjects at each stage of puberty. The cut-offs of LH and sex-steroids derived from healthy Indian children yielded high sensitivity and specificity in determining pubertal onset. The prevalence of precocity, delayed puberty, ovarian cysts and polycystic ovaries was 0.9 , 5.1, 5.1 and 8.6 %, respectively. Glycaemic control and insulin sensitivity was poor in pubertal subjects. The age at onset of puberty, LH, and sex-steroid concentrations in subjects with T1D were like otherwise healthy Indian children with poor glycemic control and IR in pubertal subjects. Although most complications of T1D are associated with poor glycemic control, pubertal disorders were significantly low despite the less-than-optimal glycemic control.

PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies.

Early puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases and hormone-dependent cancers. The decrease in age at menarche observed during the past decades has been linked to an increased exposure to endocrine-disrupting compounds (EDCs). Evidence for the association between PFAS and phthalate exposure and menarche onset, however, is inconsistent. We studied the association between PFAS and phthalate/DINCH exposure and age at menarche using data of 514 teenagers (12 to 18 years) from four aligned studies of the Human Biomonitoring for Europe initiative (HBM4EU): Riksmaten Adolescents 2016-2017 (Sweden), PCB cohort (follow-up; Slovakia), GerES V-sub (Germany), and FLEHS IV (Belgium). PFAS concentrations were measured in blood, and phthalate/DINCH concentrations in urine. We assessed the role of each individual pollutant within the context of the others, by using different multi-pollutant approaches, adjusting for age, age- and sex-standardized body mass index z-score and household educational level. Exposure to di(2-ethylhexyl) phthalate (DEHP), especially mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), was associated with an earlier age at menarche, with estimates per interquartile fold change in 5OH-MEHP ranging from -0.34 to -0.12 years in the different models. Findings from this study indicated associations between age at menarche and some specific EDCs at concentrations detected in the general European population, but due to the study design (menarche onset preceded the chemical measurements), caution is needed in the interpretation of causality.

Impact of Chemicals on the Age of Menarche: A Literature Review.

A growing body of evidence suggests that chemicals interfere with the age of onset of menarche. We conducted a review in order to demonstrate the relationship between several categories of chemicals and menarche. We searched for English language papers using the Medline/PubMed database until April 2023. The chemical factors found to affect menarche were prenatal and antenatal smoke, phthalates, phenols, organochlorines, perfluoroalkyls and polyfluoroalkyls, metals, air pollutants and polybrominated diphenyl ethers. Low or high exposure to each chemical compound could affect the age of menarche, leading to early or delayed menarche. Furthermore, the results show that intrauterine exposure may have a different impact from antenatal exposure. There is evidence that endocrine-disrupting chemicals affect the age of menarche, but more research needs to be conducted.

A clinical study of puberty menorrhagia in the modern era at a tertiary health-care center

ABSTRACT Background: Puberty Menorrhagia is the most common gynecological complication. Puberty menorrhagia when accompanied by serious systemic complications such as anemia and high blood protein (i.e., hypoproteinemia) poses substantial difficulties among gynecologists. The foundation of managing puberty menorrhagia is its early diagnosis and individualized treatment customized to each and every patient. The exclusion of pregnancy is mandatory in all cases, regardless of the history, and following up regularly along with a balanced diet and iron therapy goes a long way towards successful treatment. Objectives: To evaluate the etiology, clinical presentation, and therapeutic efficacy in patients suffering from puberty menorrhagia in our program. Materials and Methods: The prospective observation study method was opted for this study. Study participants were forty women who presented to JMF’s ACPM Medical College, Dhule between November 1, 2019 and October 31, 2020 with excessive vaginal bleeding between the onset of menarche and 19 years of age. All cases were evaluated using history, physical assessment, and pertinent laboratory investigations. Results: In our study, half of the patients (50%) were between the age group of 13 and 16 years. Nine out of every ten patients had hemoglobin levels of 10 g% or less, and 55% of patients were suffering from puberty menorrhagia for 6 months to a year. Our study suggests that polycystic ovary disease (25%) and anovulatory dysfunctional uterine bleeding (DUB) (47.5%) were the basic etiological factors, resulting in the puberty menorrhagia. Genitourinary tuberculosis (7.5%), idiopathic thrombocytopenic purpura (5%), ectocervical polyps (5%), hypothyroidism (7.5%), and Von Willebrand’s disease (2.5%) were found to be a common cause of excessive bleeding. The fundamental medical therapy for managing puberty menorrhagia comprises nonsteroidal anti-inflammatory drugs, tranexamic acids, and hormones. Conclusion: Menorrhagia during puberty is a distressing ailment for both the sufferer and her parents. The majority of instances are caused by self-limiting anovulatory DUB. For effective diagnosis and therapy, a thorough history, clinical examination, and investigation are required. Patient counseling is an integral aspect of management. Surgical approaches are preferred in a few cases, while long-term medical assistance is largely effective.

Menstrual dysfunction in women of reproductive age belonging to major ethnic groups in Eastern Siberia: a cross-sectional study

Aim. To determine the prevalence and features of menstrual dysfunction in premenopausal women of various ethnicities inhabitating Eastern Siberia.Materials and Methods. We conducted a cross-sectional study which included women of reproductive age (18-44 years) living in the Irkutsk region and the Republic of Buryatia. Out of 1134 women, 715 (63.1%) were Caucasians, 312 (27.5%) were Asians (Mongoloid), and 107 (9.4%) were of mixed ethnicity. The data have been collected during the annual physical examination carried out between March 2016 to May 2021,Results. The average age of menarche onset was 13.3 ± 1.4 years and did not differ significantly in Caucasians, Asians, and group of mixed ethnicities. The most frequent ages for menarche were 11 and 15 years among women of mixed ethnicity and Asians, respectively. Chronic abnormal uterine bleeding and dysmenorrhea was detected in 573/1134 (50.5%) and in 280/1134 (24.7%) of the examined women, respectively, without significant differences between the ethnicities. However, dysmenorrhea symptoms were more severe in Caucasians as compared to Asian women.Conclusion. The most frequent variant of menstrual dysfunction is chronic abnormal uterine bleeding. There were no significant differences in the prevalence of irregular menstrual cycles, oligo/anovulation, chronic abnormal uterine bleeding, and dysmenorrhea in women of reproductive age belonging to different ethnicities, although clinical manifestations of dysmenorrhea were most pronounced in Caucasians.