The devastating Chichi earthquake in Taiwan in 1999 highlighted the importance of disaster prevention and relief operations. In response to the challenge of extreme events and compound disasters, the National Science and Technology Center for Disaster Reduction (NCDR) contributes to operations at the Central Emergency Operation Center (CEOC) of Taiwan by providing integrated information and timely suggestions, and it delivers a common operational picture to central and local governments through a decision support system. This study was undertaken to explore the emergency response towards the reconnaissance of earthquake disasters in Taiwan to illustrate how resilient cities ensure rapid crisis response with a focus on the NCDR disaster response decision support system. This study examines the decision support system used following the 2016 ML 6.6 Meinong earthquake. The results demonstrate that the first line of relief for the emergency response commander is data-driven decision-making.